Chulbul M Ahmed

Chulbul M Ahmed,

RES AST PROF

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5070
Business Email: ahmed1@ufl.edu

Publications

2021
Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis.
Translational vision science & technology. 10(3) [DOI] 10.1167/tvst.10.3.25. [PMID] 34003962.
2020
A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis.
PloS one. 15(2) [DOI] 10.1371/journal.pone.0227524. [PMID] 32101556.
2020
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.582102. [PMID] 33193390.
2019
AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis.
Journal of clinical medicine. 8(12) [DOI] 10.3390/jcm8122082. [PMID] 31795515.
2019
Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase.
Mediators of inflammation. 2019 [DOI] 10.1155/2019/4143604. [PMID] 31275057.
2019
SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa.
Translational vision science & technology. 8(6) [DOI] 10.1167/tvst.8.6.30. [PMID] 31857914.
2018
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis.
Experimental eye research. 177:12-22 [DOI] 10.1016/j.exer.2018.07.020. [PMID] 30048621.
2018
Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview.
Advances in experimental medicine and biology. 1074:185-191 [DOI] 10.1007/978-3-319-75402-4_23. [PMID] 29721943.
2016
Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events.
Mediators of inflammation. 2016 [DOI] 10.1155/2016/9564814. [PMID] 28077919.
2016
Repurposing an orally available drug for the treatment of geographic atrophy.
Molecular vision. 22:294-310 [PMID] 27110092.
View on: PubMed
2016
Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide.
Investigative ophthalmology & visual science. 57(2):372-86 [DOI] 10.1167/iovs.15-17703. [PMID] 26842755.
2016
The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration.
Advances in experimental medicine and biology. 854:59-65 [DOI] 10.1007/978-3-319-17121-0_9. [PMID] 26427394.
2015
A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00574. [PMID] 26617608.
2015
SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00183. [PMID] 25954276.
2015
Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress.
Experimental eye research. 140:94-105 [DOI] 10.1016/j.exer.2015.07.022. [PMID] 26315784.
2014
Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 34(10):802-9 [DOI] 10.1089/jir.2014.0041. [PMID] 24811478.
2014
Type I interferon mimetics bypass vaccinia virus decoy receptor virulence factor for protection of mice against lethal infection.
Clinical and vaccine immunology : CVI. 21(8):1178-84 [DOI] 10.1128/CVI.00204-14. [PMID] 24964806.
2013
IFN signaling: how a non-canonical model led to the development of IFN mimetics.
Frontiers in immunology. 4 [DOI] 10.3389/fimmu.2013.00202. [PMID] 23898330.
2013
Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells.
Frontiers in immunology. 4 [DOI] 10.3389/fimmu.2013.00469. [PMID] 24391643.
2013
The role of a non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis: An example of Occam’s Broom?
JAK-STAT. 2(4) [DOI] 10.4161/jkst.26227. [PMID] 24416655.
2013
Type I IFN receptor controls activated TYK2 in the nucleus: implications for EAE therapy.
Journal of neuroimmunology. 254(1-2):101-9 [DOI] 10.1016/j.jneuroim.2012.10.006. [PMID] 23110939.
2012
Steroid-like signalling by interferons: making sense of specific gene activation by cytokines.
The Biochemical journal. 443(2):329-38 [DOI] 10.1042/BJ20112187. [PMID] 22452815.
2011
Controlling Nuclear Jaks and Stats for Specific Gene Activation by Ifn γ and Other Cytokines: A Possible Steroid-like Connection.
Journal of clinical & cellular immunology. 2(4) [PMID] 22924155.
View on: PubMed
2011
Controlling nuclear JAKs and STATs for specific gene activation by IFNγ.
Biochemical and biophysical research communications. 410(3):648-53 [DOI] 10.1016/j.bbrc.2011.06.047. [PMID] 21689637.
2011
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.
Journal of neuroimmunology. 232(1-2):108-18 [DOI] 10.1016/j.jneuroim.2010.10.018. [PMID] 21131060.
2010
Enhancement of antiviral immunity by small molecule antagonist of suppressor of cytokine signaling.
Journal of immunology (Baltimore, Md. : 1950). 185(2):1103-13 [DOI] 10.4049/jimmunol.0902895. [PMID] 20543109.
2009
HSV-1-induced SOCS-1 expression in keratinocytes: use of a SOCS-1 antagonist to block a novel mechanism of viral immune evasion.
Journal of immunology (Baltimore, Md. : 1950). 183(2):1253-62 [DOI] 10.4049/jimmunol.0900570. [PMID] 19542368.
2009
SOCS-1 mimetics protect mice against lethal poxvirus infection: identification of a novel endogenous antiviral system.
Journal of virology. 83(3):1402-15 [DOI] 10.1128/JVI.01138-08. [PMID] 19019946.
2008
Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic.
FEBS letters. 582(11):1569-74 [DOI] 10.1016/j.febslet.2008.03.054. [PMID] 18405666.
2007
Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist.
Journal of immunology (Baltimore, Md. : 1950). 178(8):5058-68 [PMID] 17404288.
View on: PubMed
2007
IFN mimetic as a therapeutic for lethal vaccinia virus infection: possible effects on innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950). 178(7):4576-83 [PMID] 17372016.
View on: PubMed
2006
Gamma interferon signaling: insights to development of interferon mimetics.
Cellular and molecular biology (Noisy-le-Grand, France). 52(1):71-6 [PMID] 16914098.
View on: PubMed
2006
IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1.
Journal of immunology (Baltimore, Md. : 1950). 177(1):315-21 [PMID] 16785527.
View on: PubMed
2006
The gamma interferon (IFN-gamma) mimetic peptide IFN-gamma (95-133) prevents encephalomyocarditis virus infection both in tissue culture and in mice.
Clinical and vaccine immunology : CVI. 13(8):944-52 [PMID] 16893996.
View on: PubMed
2005
Peptide mimetics of gamma interferon possess antiviral properties against vaccinia virus and other viruses in the presence of poxvirus B8R protein.
Journal of virology. 79(9):5632-9 [PMID] 15827178.
View on: PubMed
2005
Recombinant adenovirus-p21 attenuates proliferative responses associated with excessive scarring.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 13(5):480-90 [PMID] 16176456.
View on: PubMed
2004
Cancer gene therapy based on the abstracts of the 2003 ASCO meeting and recent publications.
Drugs of today (Barcelona, Spain : 1998). 40(8):723-31 [PMID] 15510243.
View on: PubMed
2003
Interferon gene therapy for the treatment of cancer and viral infections.
Drugs of today (Barcelona, Spain : 1998). 39(10):763-6 [DOI] 10.1358/dot.2003.39.10.799469. [PMID] 14668931.
2003
The role of IFNgamma nuclear localization sequence in intracellular function.
Journal of cell science. 116(Pt 15):3089-98 [PMID] 12799413.
View on: PubMed
2002
Interferon-alpha2b secretion by adenovirus-mediated gene delivery in rat, rabbit, and chimpanzee results in similar pharmacokinetic profiles.
Toxicology and applied pharmacology. 180(1):36-42 [PMID] 11922775.
View on: PubMed
2001
Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy.
Proceedings of the National Academy of Sciences of the United States of America. 98(1):277-82 [PMID] 11134537.
View on: PubMed
2001
Interferon alpha2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers.
Cancer gene therapy. 8(10):788-95 [PMID] 11687902.
View on: PubMed
2001
Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 21(6):399-408 [PMID] 11440637.
View on: PubMed
1999
In vivo tumor suppression by adenovirus-mediated interferon alpha2b gene delivery.
Human gene therapy. 10(1):77-84 [PMID] 10022532.
View on: PubMed

Patents

Issued April 2018
Type I Interferon Mimetics as Therapeutics for Cancer, Viral Infections, and Multiple Sclerosis (CIP)
#9,951,111
Published July 2016
SOCS Mimetics for the Treatment of Diseases
#US-2017-0008929
Published June 2016
Type I Interferon Mimetics as Therapeutics for Cancer, Viral Infections, and Other Diseases (CIP)
#US-2016-0289288

Education

Ph.D.
1981 · Indian Inst Sci, Bangalore, India

Contact Details

Phones:
Business:
(352) 273-5070
Emails:
Business:
ahmed1@ufl.edu