Repurposing an orally available drug for the treatment of geographic atrophy.
Molecular vision. 22:294-310 [PMID] 27110092.
Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 34(10):802-9 [DOI] 10.1089/jir.2014.0041. [PMID] 24811478.
Controlling Nuclear Jaks and Stats for Specific Gene Activation by Ifn γ and Other Cytokines: A Possible Steroid-like Connection.
Journal of clinical & cellular immunology. 2(4) [PMID] 22924155.
Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist.
Journal of immunology (Baltimore, Md. : 1950). 178(8):5058-68 [PMID] 17404288.
IFN mimetic as a therapeutic for lethal vaccinia virus infection: possible effects on innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950). 178(7):4576-83 [PMID] 17372016.
Gamma interferon signaling: insights to development of interferon mimetics.
Cellular and molecular biology (Noisy-le-Grand, France). 52(1):71-6 [PMID] 16914098.
IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1.
Journal of immunology (Baltimore, Md. : 1950). 177(1):315-21 [PMID] 16785527.
The gamma interferon (IFN-gamma) mimetic peptide IFN-gamma (95-133) prevents encephalomyocarditis virus infection both in tissue culture and in mice.
Clinical and vaccine immunology : CVI. 13(8):944-52 [PMID] 16893996.
Peptide mimetics of gamma interferon possess antiviral properties against vaccinia virus and other viruses in the presence of poxvirus B8R protein.
Journal of virology. 79(9):5632-9 [PMID] 15827178.
Recombinant adenovirus-p21 attenuates proliferative responses associated with excessive scarring.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 13(5):480-90 [PMID] 16176456.
Cancer gene therapy based on the abstracts of the 2003 ASCO meeting and recent publications.
Drugs of today (Barcelona, Spain : 1998). 40(8):723-31 [PMID] 15510243.
The role of IFNgamma nuclear localization sequence in intracellular function.
Journal of cell science. 116(Pt 15):3089-98 [PMID] 12799413.
Interferon-alpha2b secretion by adenovirus-mediated gene delivery in rat, rabbit, and chimpanzee results in similar pharmacokinetic profiles.
Toxicology and applied pharmacology. 180(1):36-42 [PMID] 11922775.
Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy.
Proceedings of the National Academy of Sciences of the United States of America. 98(1):277-82 [PMID] 11134537.
Interferon alpha2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers.
Cancer gene therapy. 8(10):788-95 [PMID] 11687902.
Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 21(6):399-408 [PMID] 11440637.
In vivo tumor suppression by adenovirus-mediated interferon alpha2b gene delivery.
Human gene therapy. 10(1):77-84 [PMID] 10022532.
Issued April 2018
Type I Interferon Mimetics as Therapeutics for Cancer, Viral Infections, and Multiple Sclerosis (CIP)#9,951,111
Published July 2016
SOCS Mimetics for the Treatment of Diseases#US-2017-0008929
Published June 2016
Type I Interferon Mimetics as Therapeutics for Cancer, Viral Infections, and Other Diseases (CIP)#US-2016-0289288
Ph.D.1981 · Indian Inst Sci, Bangalore, India