David C Bloom,
Hazel Kitzman Professor Of Genetics And Chair, College Of Medicine, Department Of Molecular Genetics And Microbiology
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-9524
Business Email:
dbloom@ufl.edu
About David C Bloom
Fun Fact: Foodie with a passion for extreme and unusual food elements and cuisines. The major focus of my research is to understand the viral and neuron-specific factors that allow herpes simplex virus (HSV) to establish and maintain latency in neurons. Our lab pioneered the concept that epigenetic modifications and CTCF chromatin insulators regulate the HSV-1 genome during latency. More recently we have developed the first scalable human neuron in vitro model of HSV latency and reactivation (LUHMES) that is allowing us for the first time to probe protein-RNA/DNA interactions in latently infected cells on a large scale. Current projects in the lab include: 1) analyzing interactions between viral lncRNAs and cellular proteins and determining their role(s) in regulating HSV latency, 2) studying the mechanism of HSV reactivation at the single cell level, and 3) development and commercialization of novel gene therapy approaches to treating recurrent HSV ocular and genital disease.
Related Links:
Teaching Profile
Courses Taught
2020-2024
GMS7133 Advanced Molecular Virology
2020,2023
BMS6634 GI and Hepatology
2008,2010-2023
GMS6196 Virology Journal Club
2013-2024
GMS6035 Advanced Virology II: RNA Viruses
2012-2019,2021-2022
GMS5905 Special Topics in Biomedical Sciences
2019
EGN4912 Engineering Directed Independent Research
2013,2015-2018
BCH7412 Epigenetics of Human Disease and Development
2018
GMS7980 Research for Doctoral Dissertation
2018,2024
GMS6034 Advanced Virology I: Genetics and RNA
2018,2024
BMS6300 Fund Micro and Immuno
2006-2007
GMS6181 Spec Topics Microbiol
2023-2024
PHA6183 Pharmaceutical Gene Delivery
2023-2024
BMS6635 Derm and Msk
2023-2024
BMS6020 Clinical Neuroscience
2024
BMS6631 Hematology
2024
GMS6036 Molecular Virology III: DNA Viruses
2024
BMS6642 The Resp Sys Hlth
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-5935-8494
Publications
2024
RNA-Seq time-course analysis of neural precursor cell transcriptome in response to herpes simplex Virus-1 infection.
Journal of neurovirology.
[DOI] 10.1007/s13365-024-01198-8.
[PMID] 38478163.
2023
A viral lncRNA tethers HSV-1 genomes at the nuclear periphery to establish viral latency
Journal of Virology.
97(12)
[DOI] 10.1128/jvi.01438-23.
[PMID] 37991364.
2023
HSV-1 LAT Promoter Deletion Viruses Exhibit Strain-Specific and LAT-Dependent Epigenetic Regulation of Latent Viral Genomes in Human Neurons
Journal of Virology.
97(2)
[DOI] 10.1128/jvi.01935-22.
[PMID] 36722973.
2023
Treatment of infection and inflammation associated with COVID-19, multi-drug resistant pneumonia and fungal sinusitis by nebulizing a nanosilver solution.
Nanomedicine : nanotechnology, biology, and medicine.
48
[DOI] 10.1016/j.nano.2023.102654.
[PMID] 36646192.
2023
Truncated ring-A amaryllidaceae alkaloid modulates the host cell integrated stress response, exhibiting antiviral activity to HSV-1 and SARSCoV-2.
Scientific reports.
13(1)
[DOI] 10.1038/s41598-023-28691-0.
[PMID] 36717567.
2023
Virology under the Microscope—a Call for Rational Discourse
mBio.
14(1)
[DOI] 10.1128/mbio.00188-23.
[PMID] 36700642.
2023
Virology under the Microscope—a Call for Rational Discourse
Journal of Virology.
97(2)
[DOI] 10.1128/jvi.00089-23.
[PMID] 36700640.
2023
Virology under the Microscope—a Call for Rational Discourse
mSphere.
8(2)
[DOI] 10.1128/msphere.00034-23.
[PMID] 36700653.
2022
A 77 Amino Acid Region in the N-Terminal Half of the HSV-1 E3 Ubiquitin Ligase ICP0 Contributes to Counteracting an Established Type 1 Interferon Response.
Microbiology spectrum.
10(4)
[DOI] 10.1128/spectrum.00593-22.
[PMID] 35730940.
2022
Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict β-coronaviral infection and replication.
Virology.
569:13-28
[DOI] 10.1016/j.virol.2022.01.002.
[PMID] 35219218.
2022
Deletion of the CTRL2 Insulator in HSV-1 Results in the Decreased Expression of Genes Involved in Axonal Transport and Attenuates Reactivation In Vivo.
Viruses.
14(5)
[DOI] 10.3390/v14050909.
[PMID] 35632655.
2022
Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides.
Frontiers in immunology.
13
[DOI] 10.3389/fimmu.2022.902956.
[PMID] 35799776.
2022
Signaling Pathway Reporter Screen with SARS-CoV-2 Proteins Identifies nsp5 as a Repressor of p53 Activity.
Viruses.
14(5)
[DOI] 10.3390/v14051039.
[PMID] 35632779.
2022
The Impaired Neurodevelopment of Human Neural Rosettes in HSV-1-Infected Early Brain Organoids.
Cells.
11(22)
[DOI] 10.3390/cells11223539.
[PMID] 36428968.
2022
Transneuronal tracing to map connectivity in injured and transplanted spinal networks.
Experimental neurology.
351
[DOI] 10.1016/j.expneurol.2022.113990.
[PMID] 35085573.
2022
Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection.
Organogenesis.
18(1)
[DOI] 10.1080/15476278.2022.2055354.
[PMID] 35384798.
2021
Correction for Zheng et al., “Patterns of Herpes Simplex Virus 1 Infection in Neural Progenitor Cells”.
Journal of virology.
95(4)
[DOI] 10.1128/JVI.02189-20.
[PMID] 33509936.
2021
Herpes Simplex Virus 1 MicroRNA miR-H8 Is Dispensable for Latency and Reactivation In Vivo.
Journal of virology.
95(4)
[DOI] 10.1128/JVI.02179-20.
[PMID] 33208453.
2021
Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: 2D or 3D?
Journal of virology.
95(5)
[DOI] 10.1128/JVI.02219-20.
[PMID] 33268524.
2020
Antiviral activity of 1,4-disubstituted-1,2,3-triazoles against HSV-1 in vitro.
Antiviral therapy.
25(8):399-410
[DOI] 10.3851/IMP3387.
[PMID] 33705354.
2020
Deletion of Herpes Simplex Virus 1 MicroRNAs miR-H1 and miR-H6 Impairs Reactivation.
Journal of virology.
94(15)
[DOI] 10.1128/JVI.00639-20.
[PMID] 32295910.
2020
Herpes Simplex Virus 1 Strains 17syn+ and KOS(M) Differ Greatly in Their Ability To Reactivate from Human Neurons In Vitro.
Journal of virology.
94(15)
[DOI] 10.1128/JVI.00796-20.
[PMID] 32461310.
2020
Herpes Simplex Viruses Whose Replication Can Be Deliberately Controlled as Candidate Vaccines.
Vaccines.
8(2)
[DOI] 10.3390/vaccines8020230.
[PMID] 32443425.
2020
Patterns of Herpes Simplex Virus 1 Infection in Neural Progenitor Cells.
Journal of virology.
94(16)
[DOI] 10.1128/JVI.00994-20.
[PMID] 32493817.
2020
Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus.
Antiviral therapy.
25(1):1-11
[DOI] 10.3851/IMP3315.
[PMID] 31099756.
2019
Lund Human Mesencephalic (LUHMES) Neuronal Cell Line Supports Herpes Simplex Virus 1 Latency In Vitro.
Journal of virology.
93(6)
[DOI] 10.1128/JVI.02210-18.
[PMID] 30602607.
2019
Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells.
Journal of virology.
93(9)
[DOI] 10.1128/JVI.00111-19.
[PMID] 30787148.
2019
Peripheral AAV Injection for Retrograde Transduction of Dorsal Root and Trigeminal Ganglia.
Methods in molecular biology (Clifton, N.J.).
1950:237-247
[DOI] 10.1007/978-1-4939-9139-6_13.
[PMID] 30783977.
2019
Personalized viral genomic investigation of herpes simplex virus 1 perinatal viremic transmission with dual fatality.
Cold Spring Harbor molecular case studies.
5(6)
[DOI] 10.1101/mcs.a004382.
[PMID] 31582464.
2019
The CCCTC Binding Factor, CTRL2, Modulates Heterochromatin Deposition and the Establishment of Herpes Simplex Virus 1 Latency In Vivo.
Journal of virology.
93(13)
[DOI] 10.1128/JVI.00415-19.
[PMID] 30996085.
2019
Virtual screening identified compounds that bind to cyclin dependent kinase 2 and prevent herpes simplex virus type 1 replication and reactivation in neurons.
Antiviral research.
172
[DOI] 10.1016/j.antiviral.2019.104621.
[PMID] 31634495.
2018
Depletion of the Insulator Protein CTCF Results in Herpes Simplex Virus 1 Reactivation In Vivo.
Journal of virology.
92(11)
[DOI] 10.1128/JVI.00173-18.
[PMID] 29514910.
2018
Generation of Three-Dimensional Human Neuronal Cultures: Application to Modeling CNS Viral Infections
Current Stem Cell Research & Therapy.
9(1)
[DOI] 10.1186/s13287-018-0881-6.
[PMID] 29751846.
2018
Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time.
The Journal of infectious diseases.
218(4):595-605
[DOI] 10.1093/infdis/jiy216.
[PMID] 29920588.
2018
Immunization by Replication-Competent Controlled Herpesvirus Vectors.
Journal of virology.
92(16)
[DOI] 10.1128/JVI.00616-18.
[PMID] 29899091.
2018
In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency.
Journal of virology.
92(16)
[DOI] 10.1128/JVI.00812-18.
[PMID] 29875240.
2018
R430: A potent inhibitor of DNA and RNA viruses
Scientific Reports.
8(1)
[DOI] 10.1038/s41598-018-33904-y.
[PMID] 30413769.
2018
Reactivation of Latent Epstein-Barr Virus: A Comparison after Exposure to Gamma, Proton, Carbon, and Iron Radiation.
International journal of molecular sciences.
19(10)
[DOI] 10.3390/ijms19102961.
[PMID] 30274169.
2018
The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication.
Journal of virology.
92(6)
[DOI] 10.1128/JVI.01884-17.
[PMID] 29263259.
2017
Comparison of three cell-based drug screening platforms for HSV-1 infection
Antiviral Research.
142:136-140
[DOI] 10.1016/j.antiviral.2017.03.016.
[PMID] 28342892.
2017
Development of Recombinant HSV-Based Vaccine Vectors.
Methods in molecular biology (Clifton, N.J.).
1581:55-78
[DOI] 10.1007/978-1-4939-6869-5_4.
[PMID] 28374243.
2017
HSV1 latent transcription and non-coding RNA: A critical retrospective.
Journal of neuroimmunology.
308:65-101
[DOI] 10.1016/j.jneuroim.2017.03.002.
[PMID] 28363461.
2017
Opinion: Why we need a centralized repository for isotopic data.
Proceedings of the National Academy of Sciences of the United States of America.
114(12):2997-3001
[DOI] 10.1073/pnas.1701742114.
[PMID] 28325883.
2017
Reliable Detection of Herpes Simplex Virus Sequence Variation by High-Throughput Resequencing.
Viruses.
9(8)
[DOI] 10.3390/v9080226.
[PMID] 28812996.
2016
Adeno-associated Virus Vectors Efficiently Transduce Mouse and Rabbit Sensory Neurons Coinfected with Herpes Simplex Virus 1 following Peripheral Inoculation.
Journal of virology.
90(17):7894-901
[DOI] 10.1128/JVI.01028-16.
[PMID] 27334582.
2016
Alphaherpesvirus Latency: A Dynamic State of Transcription and Reactivation.
Advances in virus research.
94:53-80
[DOI] 10.1016/bs.aivir.2015.10.001.
[PMID] 26997590.
2016
Herpes simplex virus type-1: replication, latency, reactivation and its antiviral targets.
Antiviral therapy.
21(4):277-86
[DOI] 10.3851/IMP3018.
[PMID] 26726828.
2016
Simultaneous visualization of two Citrus tristeza virus genotypes provides new insights into the structure of multi-component virus populations in a host.
Virology.
491:10-9
[DOI] 10.1016/j.virol.2016.01.017.
[PMID] 26874013.
2016
The importance of digitized biocollections as a source of trait data and a new VertNet resource.
Database : the journal of biological databases and curation.
2016
[DOI] 10.1093/database/baw158.
[PMID] 28025346.
2015
A Genomic Approach to Unravel Host-Pathogen Interaction in Chelonians: The Example of Testudinid Herpesvirus 3.
PloS one.
10(8)
[DOI] 10.1371/journal.pone.0134897.
[PMID] 26244892.
2015
A novel approach for addressing diseases not yielding to effective vaccination? Immunization by replication-competent controlled virus.
Expert review of vaccines.
14(5):637-51
[DOI] 10.1586/14760584.2015.1013941.
[PMID] 25676927.
2015
Broad-spectrum non-nucleoside inhibitors of human herpesviruses.
Antiviral research.
121:16-23
[DOI] 10.1016/j.antiviral.2015.06.005.
[PMID] 26079681.
2015
Inhibition of H3K27me3-specific histone demethylases JMJD3 and UTX blocks reactivation of herpes simplex virus 1 in trigeminal ganglion neurons.
Journal of virology.
89(6):3417-20
[DOI] 10.1128/JVI.03052-14.
[PMID] 25552720.
2015
Replication-Competent Controlled Herpes Simplex Virus.
Journal of virology.
89(20):10668-79
[DOI] 10.1128/JVI.01667-15.
[PMID] 26269179.
2014
Leveraging biological replicates to improve analysis in ChIP-seq experiments.
Computational and structural biotechnology journal.
9
[DOI] 10.5936/csbj.201401002.
[PMID] 24688750.
2013
Mutational inactivation of herpes simplex virus 1 microRNAs identifies viral mRNA targets and reveals phenotypic effects in culture.
Journal of virology.
87(12):6589-603
[DOI] 10.1128/JVI.00504-13.
[PMID] 23536669.
2013
Role of polycomb proteins in regulating HSV-1 latency.
Viruses.
5(7):1740-57
[DOI] 10.3390/v5071740.
[PMID] 23860385.
2012
Darwin Core: an evolving community-developed biodiversity data standard.
PloS one.
7(1)
[DOI] 10.1371/journal.pone.0029715.
[PMID] 22238640.
2012
From documents to datasets: A MediaWiki-based method of annotating and extracting species observations in century-old field notebooks.
ZooKeys.
(209):235-53
[DOI] 10.3897/zookeys.209.3247.
[PMID] 22859891.
2012
LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.
PloS one.
7(12)
[DOI] 10.1371/journal.pone.0053281.
[PMID] 23300908.
2012
Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues.
Neurobiology of disease.
48(2):212-21
[DOI] 10.1016/j.nbd.2012.03.001.
[PMID] 22426391.
2012
Respiratory function following bilateral mid-cervical contusion injury in the adult rat.
Experimental neurology.
235(1):197-210
[DOI] 10.1016/j.expneurol.2011.09.024.
[PMID] 21963673.
2011
Three Group Risk Stratification for Pediatric Brain Stem Gliomas Treated With Radiotherapy Based On Clinical Presentation and Imaging Characteristics
Pediatric Blood & Cancer.
57:720-721
2010
Braun Enteroenterostomy Is Associated With Reduced Delayed Gastric Emptying and Early Resumption of Oral Feeding Following Pancreaticoduodenectomy
Journal of Surgical Oncology.
101(5):351-355
[DOI] 10.1002/jso.21490.
[PMID] 20112274.
2010
Epigenetic regulation of latent HSV-1 gene expression.
Biochimica et biophysica acta.
1799(3-4):246-56
[DOI] 10.1016/j.bbagrm.2009.12.001.
[PMID] 20045093.
2009
A limited innate immune response is induced by a replication-defective herpes simplex virus vector following delivery to the murine central nervous system.
Journal of neurovirology.
15(5-6):411-24
[DOI] 10.3109/13550280903473452.
[PMID] 20095947.
2009
Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome.
Gene therapy.
16(9):1122-9
[DOI] 10.1038/gt.2009.83.
[PMID] 19571888.
2009
The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency.
Journal of virology.
83(16):8173-81
[DOI] 10.1128/JVI.00686-09.
[PMID] 19515780.
2008
Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat.
The Journal of comparative neurology.
511(5):692-709
[DOI] 10.1002/cne.21864.
[PMID] 18924146.
2008
Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy.
Molecular vision.
14:2087-96
[PMID] 19023450.
2008
During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genes.
Journal of virology.
82(12):6056-60
[DOI] 10.1128/JVI.02661-07.
[PMID] 18400860.
2008
Fak and Igf-Ir Interact To Provide Survival Signals in Human Pancreatic Adenocarcinoma Cells
Carcinogenesis.
29(6):1096-1107
[DOI] 10.1093/carcin/bgn026.
[PMID] 18263593.
2008
Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia.
Molecular vision.
14:1209-21
[PMID] 18615202.
2008
Ranavirus Infection of Free-Ranging and Captive Box Turtles and Tortoises in the United States
.
44:851-863
2008
Ranavirus infection of free-ranging and captive box turtles and tortoises in the United States.
Journal of wildlife diseases.
44(4):851-63
[PMID] 18957641.
2008
Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.
Journal of virology.
82(15):7467-74
[DOI] 10.1128/JVI.02720-07.
[PMID] 18508896.
2007
In vivo changes in the patterns of chromatin structure associated with the latent herpes simplex virus type 1 genome in mouse trigeminal ganglia can be detected at early times after butyrate treatment.
Journal of virology.
81(23):13248-53
[PMID] 17881451.
2006
A chromatin insulator-like element in the herpes simplex virus type 1 latency-associated transcript region binds CCCTC-binding factor and displays enhancer-blocking and silencing activities.
Journal of virology.
80(5):2358-68
[PMID] 16474142.
2006
Deacetylation of the herpes simplex virus type 1 latency-associated transcript (LAT) enhancer and a decrease in LAT abundance precede an increase in ICP0 transcriptional permissiveness at early times postexplant.
Journal of virology.
80(4):2063-8
[PMID] 16439563.
2006
Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice.
Journal of virology.
80(19):9414-23
[PMID] 16973547.
2005
Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods.
Folia morphologica.
64(3):130-44
[PMID] 16228947.
2005
Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine.
Brain research. Molecular brain research.
139(2):361-6
[PMID] 16039006.
2004
Experimental transmission of a herpesvirus in Greek tortoises (Testudo graeca).
Veterinary pathology.
41(1):50-61
[PMID] 14715968.
2004
HSV LAT and neuronal survival.
International reviews of immunology.
23(1-2):187-98
[PMID] 14690860.
2004
Specific histone tail modification and not DNA methylation is a determinant of herpes simplex virus type 1 latent gene expression.
Journal of virology.
78(3):1139-49
[PMID] 14722269.
2004
The herpes simplex virus type 1 latency-associated transcript (LAT) enhancer/rcr is hyperacetylated during latency independently of LAT transcription.
Journal of virology.
78(22):12508-18
[PMID] 15507638.
2004
Wide variations in herpes simplex virus type 1 inoculum dose and latency-associated transcript expression phenotype do not alter the establishment of latency in the rabbit eye model.
Journal of virology.
78(10):5038-44
[PMID] 15113885.
2003
Herpes simplex virus-1 and varicella-zoster virus latency in ganglia.
Journal of neurovirology.
9(2):194-204
[PMID] 12707850.
2003
Overlapping subdeletions within a 348-bp in the 5′ exon of the LAT region that facilitates epinephrine-induced reactivation of HSV-1 in the rabbit ocular model do not further define a functional element.
Virology.
312(1):151-8
[PMID] 12890628.
2002
Altering the expression kinetics of VP5 results in altered virulence and pathogenesis of herpes simplex virus type 1 in mice.
Journal of virology.
76(5):2199-205
[PMID] 11836397.
2002
The region of the HSV-1 latency-associated transcript required for epinephrine-induced reactivation in the rabbit does not include the 2.0-kb intron.
Virology.
292(1):59-69
[PMID] 11878908.
1993
A revised HindIII map and sequence analysis of a large ‘left-hand’ non-essential region of the rabbit poxvirus genome.
Virus research.
28(2):125-40
[PMID] 8391191.
1991
Identification and characterization of two nonessential regions of the rabbitpox virus genome involved in virulence.
Journal of virology.
65(3):1530-42
[PMID] 1847470.
1991
The nature of naturally occurring mutations in the hemagglutinin gene of vaccinia virus and the sequence of immediately adjacent genes.
Virus genes.
5(3):235-42
[PMID] 1771764.
Grants
May 2023
ACTIVE
Effects of HSV-1 reactivation from latency on aspects of neural precursor cells neurogenesis and accumulation of Alzheimer's molecular hallmarks
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH
via NATL INST OF HLTH NINDS
Jul 2021
– Dec 2021
Assessment of antiviral activity of non-toxic polymer-based disinfectant
Role: Principal Investigator
Funding: EXION LABS
Apr 2021
– May 2021
Assessment of Antiviral Activity of Silver Mask Material
Role: Principal Investigator
Funding: CYPRESS RIVER ADVISORS
Dec 2020
ACTIVE
Basic Microbiology and Infectious Disease
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Sep 2020
– Dec 2020
Assessment of Reactivation of HSV Oncolytic Vectors
Role: Principal Investigator
Funding: VIROGIN BIOTECH CANADA
Jul 2020
– Aug 2020
Analysis of Hypochlorous Acid Wound Cleanser for Anti-Viral Activity
Role: Principal Investigator
Funding: URGO MEDICAL
Jul 2020
ACTIVE
Effects of HSV-1 infection on neural progenitor cell biology in vitro and in vivo
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH
via NATL INST OF HLTH NINDS
Apr 2020
– Jun 2020
Analysis of Nanocrystalline Silver for Anti-viral Activity
Role: Principal Investigator
Funding: UNIV OF ALBERTA
Jan 2020
– Sep 2021
RNA polymerase II occupancy and activity in HSV-infected post-mitotic neurons
Role: Principal Investigator
Funding: LOUISIANA STATE UNIV
via NATL INST OF HLTH NIAID
Aug 2019
– Dec 2020
Phenotypic analyses of HSV-1 miRNAs: H1, H6, & H8
Role: Other
Funding: NATL INST OF HLTH NIAID
Mar 2019
ACTIVE
Molecular Genetics of HSV Reactivation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Nov 2018
– Oct 2023
CTCF-mediated HSV-1 gene expression during latency and reactivation
Role: Principal Investigator
Funding: UNIV OF WISCONSIN MADISON
via NATL INST OF HLTH NIAID
Oct 2018
– May 2020
Analysis of the specific effects of Tranexamic Acid on HSV infection
Role: Principal Investigator
Funding: ANTI PLASMIN TECHNOLOGIES
Sep 2016
– Aug 2018
Analysis of human-specific aspects of HSV-1 latency in human iPSC-derived neurons
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH
via NATL INST OF HLTH NINDS
Jun 2016
– May 2018
OR-DRPD-ROF2016: Visualizing viral entry into neurons and the brain: Changing the paradigm
Role: Co-Investigator
Funding: UF DSR OPPORTUNITY FUND
Jan 2016
– Dec 2016
Vector-delivered CRISPR/Cas as a cure for HSV-1 induced keratitis
Role: Principal Investigator
Funding: EDITAS MEDICINE
via NATL INST OF HLTH NIAID
Sep 2015
– Aug 2016
The Role of the LAT Locus in HSV-1 Infection of Human Skin Xenografts in Vivo
Role: Principal Investigator
Funding: STANFORD UNIV
via NATL INST OF HLTH NIAID
Jul 2015
– Jun 2018
Function of histone chaperones in HSV-1 chromatin sturcture during latency, establishing maintenance and reactivation
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Jun 2015
– Jun 2016
Effect of spaceflight on Herpesvirus genome stability and diversity
Role: Principal Investigator
Funding: NASA
Aug 2014
– Jul 2020
Basic Microbiology and Infectious Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2014
– Jan 2017
Determination of Roles of Microgravity and Ionizing Radiation on the Reactivation of Epstein-Barr Virus in vitro
Role: Principal Investigator
Funding: NASA STENNIS SPACE FLIGHT CTR
Jul 2013
ACTIVE
Evaluation of the suitability of SafeSwitch-controlled HSV as anti-herpetic"vaccines" or as immunization platform
Role: Principal Investigator
Funding: HSF PHARMACEUTICALS SA
Jan 2012
– Dec 2017
Regulation of lytic and latent infection by HSV-1 encoded miRNAs
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2010
– Oct 2020
HSV-1 Research Program – UFF Transfer Account
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2010
– Oct 2020
HSV-2 Research Program – UFF Transfer Account
Role: Principal Investigator
Funding: UF FOUNDATION
Contact Details
Phones:
- Business:
- (352) 273-9524
Emails:
- Business:
- dbloom@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100266
GAINESVILLE FL 32610 - Business Street:
-
1200 NEWELL DR
GAINESVILLE FL 32610