Stephanie Karst

Stephanie Karst,

PROF

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5627
Business Email: skarst@ufl.edu

Publications

2021
Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid.
PLoS pathogens. 17(3) [DOI] 10.1371/journal.ppat.1009402. [PMID] 33705489.
2020
Infectious Norovirus Is Chronically Shed by Immunocompromised Pediatric Hosts.
Viruses. 12(6) [DOI] 10.3390/v12060619. [PMID] 32516960.
2020
Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-16798-1. [PMID] 32528015.
2020
Survival of Human Norovirus Surrogates in Water upon Exposure to Thermal and Non-Thermal Antiviral Treatments.
Viruses. 12(4) [DOI] 10.3390/v12040461. [PMID] 32325896.
2020
The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon.
Nature microbiology. 5(1):84-92 [DOI] 10.1038/s41564-019-0602-7. [PMID] 31768030.
2019
Diverse Mechanisms Underlie Enhancement of Enteric Viruses by the Mammalian Intestinal Microbiota.
Viruses. 11(8) [DOI] 10.3390/v11080760. [PMID] 31426458.
2019
Editorial overview: Viruses and the microbiome.
Current opinion in virology. 37:iii-vi [DOI] 10.1016/j.coviro.2019.06.012. [PMID] 31331870.
2018
Enteric Viruses Hitch a Ride on the Evolutionary Highway.
Cell host & microbe. 23(1):5-6 [DOI] 10.1016/j.chom.2017.12.013. [PMID] 29324229.
2017
The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.
Nature microbiology. 2(12):1586-1591 [DOI] 10.1038/s41564-017-0057-7. [PMID] 29109476.
2016
A norovirus detection architecture based on isothermal amplification and expanded genetic systems.
Journal of virological methods. 237:64-71 [DOI] 10.1016/j.jviromet.2016.08.012. [PMID] 27546345.
2016
Norovirus antagonism of B-cell antigen presentation results in impaired control of acute infection.
Mucosal immunology. 9(6):1559-1570 [DOI] 10.1038/mi.2016.15. [PMID] 27007673.
2016
Norovirus mechanisms of immune antagonism.
Current opinion in virology. 16:24-30 [DOI] 10.1016/j.coviro.2015.11.005. [PMID] 26673810.
2016
Recent advances in understanding norovirus pathogenesis.
Journal of medical virology. 88(11):1837-43 [DOI] 10.1002/jmv.24559. [PMID] 27110852.
2016
The influence of commensal bacteria on infection with enteric viruses.
Nature reviews. Microbiology. 14(4):197-204 [DOI] 10.1038/nrmicro.2015.25. [PMID] 26853118.
2016
Viral Safeguard: The Enteric Virome Protects against Gut Inflammation.
Immunity. 44(4):715-8 [DOI] 10.1016/j.immuni.2016.04.004. [PMID] 27096311.
2015
A working model of how noroviruses infect the intestine.
PLoS pathogens. 11(2) [DOI] 10.1371/journal.ppat.1004626. [PMID] 25723501.
2015
Human norovirus culture in B cells.
Nature protocols. 10(12):1939-47 [DOI] 10.1038/nprot.2015.121. [PMID] 26513671.
2015
Identification of a novel cellular target and a co-factor for norovirus infection – B cells & commensal bacteria.
Gut microbes. 6(4):266-71 [DOI] 10.1080/19490976.2015.1052211. [PMID] 25997033.
2015
Multiplex gastrointestinal pathogen panels: implications for infection control.
Diagnostic microbiology and infectious disease. 82(2):154-7 [DOI] 10.1016/j.diagmicrobio.2015.01.007. [PMID] 25796558.
2015
Regulation of Norovirus Virulence by the VP1 Protruding Domain Correlates with B Cell Infection Efficiency.
Journal of virology. 90(6):2858-67 [DOI] 10.1128/JVI.02880-15. [PMID] 26719276.
2015
Spectrum of outpatient illness in a school-based cohort in Haiti, with a focus on diarrheal pathogens.
The American journal of tropical medicine and hygiene. 92(4):752-757 [DOI] 10.4269/ajtmh.14-0059. [PMID] 25732684.
2015
The molecular pathology of noroviruses.
The Journal of pathology. 235(2):206-16 [DOI] 10.1002/path.4463. [PMID] 25312350.
2015
Viruses in Rodent Colonies: Lessons Learned from Murine Noroviruses.
Annual review of virology. 2(1):525-48 [DOI] 10.1146/annurev-virology-100114-055204. [PMID] 26958927.
2015
What is the reservoir of emergent human norovirus strains?
Journal of virology. 89(11):5756-9 [DOI] 10.1128/JVI.03063-14. [PMID] 25787285.
2014
Advances in norovirus biology.
Cell host & microbe. 15(6):668-80 [DOI] 10.1016/j.chom.2014.05.015. [PMID] 24922570.
2014
Enteric bacteria promote human and mouse norovirus infection of B cells.
Science (New York, N.Y.). 346(6210):755-9 [DOI] 10.1126/science.1257147. [PMID] 25378626.
2014
The effect of malnutrition on norovirus infection.
mBio. 5(2):e01032-13 [DOI] 10.1128/mBio.01032-13. [PMID] 24595373.
2013
Identification of immune and viral correlates of norovirus protective immunity through comparative study of intra-cluster norovirus strains.
PLoS pathogens. 9(9) [DOI] 10.1371/journal.ppat.1003592. [PMID] 24039576.
2011
Comparative murine norovirus studies reveal a lack of correlation between intestinal virus titers and enteric pathology.
Virology. 421(2):202-10 [DOI] 10.1016/j.virol.2011.09.030. [PMID] 22018636.
2010
Pathogenesis of noroviruses, emerging RNA viruses.
Viruses. 2(3):748-81 [DOI] 10.3390/v2030748. [PMID] 21994656.
2009
Primary high-dose murine norovirus 1 infection fails to protect from secondary challenge with homologous virus.
Journal of virology. 83(13):6963-8 [DOI] 10.1128/JVI.00284-09. [PMID] 19403675.
2009
Type I and type II interferons inhibit the translation of murine norovirus proteins.
Journal of virology. 83(11):5683-92 [DOI] 10.1128/JVI.00231-09. [PMID] 19297466.
2007
Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses.
Journal of virology. 81(7):3251-63 [PMID] 17229692.
View on: PubMed
2006
Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells.
Journal of virology. 80(16):7816-31 [PMID] 16873239.
View on: PubMed
2004
Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages.
PLoS biology. 2(12) [PMID] 15562321.
View on: PubMed
2003
STAT1-dependent innate immunity to a Norwalk-like virus.
Science (New York, N.Y.). 299(5612):1575-8 [PMID] 12624267.
View on: PubMed
1999
Cell cycle control of reverse transcriptase activity for the yeast retrotransposon Ty3.
Biochemical and biophysical research communications. 254(3):679-84 [PMID] 9920800.
View on: PubMed

Grants

Dec 2020 ACTIVE
Basic Microbiology and Infectious Disease
Role: Faculty
Funding: NATL INST OF HLTH NIAID
Aug 2020 ACTIVE
Using a novel neonatal mouse model to determine mechanisms of norovirus-induced disease
Role: Other
Funding: NATL INST OF HLTH NIAID
Nov 2018 ACTIVE
Suppression of Enteric Norovirus Infection by Microbiota-Regulated Bile Acids
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2017 – May 2019
OR-DRPD-ROF2017: Elucidate the Underlying Mechanism by which Commensal Bacteria Stimulate Human Norovirus Infection of B cells
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Dec 2016 ACTIVE
Identification of Host and Viral Determinants of Human Norovirus B cell Infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Apr 2016 – Apr 2018
Refinement of the Human Norovirus B Cell Culture System
Role: Principal Investigator
Funding: TAKEDA VACCINES INC
Mar 2016 – Nov 2016
Identification of Host and Viral Determinants of Human Norovirus B cell Infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2015 – Jul 2017
Testing Putative Antiviral Compounds for Effectiveness against Human Norovirus Infection of B Cells
Role: Principal Investigator
Funding: Chimerix, Inc.
Feb 2015 – Jan 2020
Role of Intestinal Bacteria in Human Norovirus Infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2014 – May 2016
Intestinal Epithelial Cell Contributions to Permissiveness of Norovirus Infection of B cells
Role: Project Manager
Funding: UF DSR OPPORTUNITY FUND

Patents

Published May 2015
Novel B Cell Culture System for Murine and Human Noroviruses
#US2017/0088821

Teaching Profile

Courses Taught
2020-2021
GMS7133 Advanced Molecular Virology
2014-2021
GMS6121 Infectious Diseases
2019-2020
GMS6034 Advanced Virology I: Genetics and RNA
2018
GMS7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS6035 Advanced Virology II: RNA Viruses
2018
BMS6300 Fund Micro and Immuno

Contact Details

Phones:
Business:
(352) 273-5627
Emails:
Business:
skarst@ufl.edu