Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
Journal of virology. 90(19):8542-51 [DOI] 10.1128/JVI.00575-16. [PMID] 27440903.
Enhanced Transgene Expression From Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines in Vitro and in Murine Hepatocytes in Vivo
Journal Of Virology. 89(2):952-961 [DOI] 10.1128/JVI02581-14.
View on: Publisher’s Site
The Adeno-Associated Virus Genome Packaging Puzzle.
Journal of molecular and genetic medicine : an international journal of biomedical research. 9(3) [PMID] 26949410.
The 3D Structure of Adeno-Associated Virus Serotype 9 and Its Unique Properties
Molecular Therapy. 20
Adeno-Associated Virus-Mediated Knockdown of Pyruvate Dehydrogenase E1 Alpha in Specific Regions of the Rat Brain
Mitochondrion. 10 [DOI] 10.1016/j.mito.2009.12.01.
View on: Publisher’s Site
Efficacy of recombinant adeno-associated viral vectors serotypes 1, 2, and 5 for the transduction of pancreatic and colon carcinoma cells.
Anticancer research. 30(6):1931-5 [PMID] 20651336.
Absolute Control of Raav Mediated Gdnf Expression in the Nigrostriatal Tract Using a Single Vector Tetracycline Responsive Expression System
Molecular Therapy. 17
Adeno-Associated Virus-Mediated Knockdown of Pyruvate Dehydrogenase E1F(N)Over-Tilde At in in Specific Regions of the Rat Brain
Molecular Genetics and Metabolism. 98
Bilateral Nigral Raav5-Mediated Gdnf Over-Expression Activates Crh Neurons in the Paraventricular Nucleus of the Hypothalamus and Induces Robust Weight Loss in Obese Leptin-Resistant Rats
Molecular Therapy. 17
Examining Conserved Residues in the Aav2 Capsid, Linking Critical Regions On the Surface and in the Interior
Molecular Therapy. 17
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 7):715-8 [DOI] 10.1107/S1744309109021460. [PMID] 19574648.
Structural Studies of Adeno-Associated Virus Serotypes Towards Improved Gene Therapy Applications
Molecular Therapy. 17
Tight Durable Long-Term Doxycycline-Mediated Gdnf Regulation From a Single Raav Vector in the Nigrostiatal Tract
Cell Transplantation. 18:224-225
Towards Characterizing Vector-Host Interactions: Adeno-Associated Virus Capsids in Complex With Antibody Fragments
Molecular Therapy. 17
Weight Loss in Obese Leptin-Resistant Rats Induced By Activation of Crh Neurons in the Paraventricular Nucleus of the Hypothalamus By Overexpression of Substantial Nigral-Injected Raav5-Gdnf
Cell Transplantation. 18
Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.
Molecular therapy : the journal of the American Society of Gene Therapy. 16(9):1580-6 [DOI] 10.1038/mt.2008.148. [PMID] 18665160.
Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins.
Journal of virology. 82(3):1458-64 [PMID] 18057257.
Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus
Neurobiology of Learning and Memory. 89(4):379-396
Monocyte Gene Therapy in Alzheimer’S Disease App+Ps1 Transgenic Mice
Cell Transplantation. 17:470-471
Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.
Proceedings of the National Academy of Sciences of the United States of America. 105(22):7827-32 [DOI] 10.1073/pnas.0802866105. [PMID] 18511559.
Pres 30-Locating the Vp1 Structural Protein in Adeno-Associated Viruses
Pres 33-Ph Induced Conformational Changes On the Surface of the Aav1 Capsid: Implications for Capsid Trafficking and Uncoating
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America. 105(2):763-8 [DOI] 10.1073/pnas.0711053105. [PMID] 18178617.
Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments.
Neurobiology of learning and memory. 87(1):21-41 [PMID] 16829144.
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
Brain : a journal of neurology. 130(Pt 3):799-815 [PMID] 17303591.
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.
Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 12):1073-6 [PMID] 18084098.
Purification of host cell enzymes involved in adeno-associated virus DNA replication.
Journal of virology. 81(11):5777-87 [PMID] 17360744.
rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson’s disease.
Experimental neurology. 207(2):289-301 [PMID] 17678648.
Structure of adeno-associated virus serotype 8, a gene therapy vector.
Journal of virology. 81(22):12260-71 [PMID] 17728238.
Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(8):1504-11 [PMID] 17565350.
Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity.
Neurobiology of aging. 27(3):459-70 [PMID] 15964099.
Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults.
Human gene therapy. 17(12):1177-86 [PMID] 17115945.
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 12):1271-4 [PMID] 17142915.
Recombinant adeno-associated and adenoviral vectors for the transduction of pancreatic and colon carcinoma.
Anticancer research. 26(1A):311-7 [PMID] 16475712.
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
Journal of virology. 80(23):11556-70 [PMID] 16971437.
Altering AAV tropism with mosaic viral capsids.
Molecular therapy : the journal of the American Society of Gene Therapy. 11(6):856-65 [PMID] 15922956.
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson’s disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(4):769-77 [PMID] 15673656.
Custom adeno-associated virus capsids: the next generation of recombinant vectors with novel tropism.
Human gene therapy. 16(4):408-16 [PMID] 15871672.
Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 6):558-61 [PMID] 16511095.
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 10):917-21 [PMID] 16511195.
Reversal of dyskinesias in an animal model of Parkinson’s disease by continuous L-DOPA delivery using rAAV vectors.
Brain : a journal of neurology. 128(Pt 3):559-69 [PMID] 15659429.
Structure of adeno-associated virus type 4.
Journal of virology. 79(8):5047-58 [PMID] 15795290.
Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system.
Molecular therapy : the journal of the American Society of Gene Therapy. 12(6):1217-25 [PMID] 16213797.
Adeno-associated virus Rep78/Rep68 promotes localized melting of the rep binding element in the absence of adenosine triphosphate.
Chembiochem : a European journal of chemical biology. 5(3):324-32 [PMID] 14997524.
Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus.
Journal of virology. 78(12):6595-609 [PMID] 15163751.
Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain.
Journal of virology. 78(12):6344-59 [PMID] 15163728.
Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression.
Endocrinology. 145(4):2035-45 [PMID] 14715713.
Patterns of gene expression reveal a temporally orchestrated wound healing response in the injured spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(39):8562-76 [PMID] 15456830.
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system.
Molecular therapy : the journal of the American Society of Gene Therapy. 10(2):302-17 [PMID] 15294177.
Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease.
Molecular therapy : the journal of the American Society of Gene Therapy. 7(5 Pt 1):580-7 [PMID] 12718900.
Characterization of the adenoassociated virus Rep protein complex formed on the viral origin of DNA replication.
Virology. 313(2):364-76 [PMID] 12954205.
Gene therapy delivery of endostatin enhances the treatment efficacy of radiation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 66(1):1-9 [PMID] 12559515.
Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding.
Journal of virology. 77(12):6995-7006 [PMID] 12768018.
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson’s disease.
Proceedings of the National Academy of Sciences of the United States of America. 100(5):2884-9 [PMID] 12601150.
Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus).
Experimental neurology. 184(1):536-48 [PMID] 14637123.
Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver.
Gene therapy. 10(18):1551-8 [PMID] 12907946.
Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo.
Cancer gene therapy. 9(6):513-21 [PMID] 12032662.
Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2.
Journal of virology. 76(22):11505-17 [PMID] 12388712.
Comparison of the EF-1 alpha and the CMV promoter for engineering stable tumor cell lines using recombinant adeno-associated virus.
Anticancer research. 22(6A):3325-30 [PMID] 12530082.
Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats.
Neurobiology of disease. 9(2):187-204 [PMID] 11895371.
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(7):2780-91 [PMID] 11923443.
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.
Methods (San Diego, Calif.). 28(2):158-67 [PMID] 12413414.
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America. 99(7):4708-13 [PMID] 11917105.
Streamlined large-scale production of recombinant adeno-associated virus (rAAV) vectors.
Methods in enzymology. 346:413-30 [PMID] 11883083.
Studies of the mechanism of transactivation of the adeno-associated virus p19 promoter by Rep protein.
Journal of virology. 76(16):8225-35 [PMID] 12134028.
Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor.
Experimental neurology. 177(1):1-8 [PMID] 12429205.
Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study.
Regulatory peptides. 99(2-3):69-77 [PMID] 11384767.
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
Gene therapy. 8(17):1343-6 [PMID] 11571571.
Adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system.
Advances in virus research. 55:507-28 [PMID] 11050954.
Cre-mediated recombination in the pituitary gland.
Genesis (New York, N.Y. : 2000). 28(3-4):167-74 [PMID] 11105060.
Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change.
Regulatory peptides. 92(1-3):97-105 [PMID] 11024571.
Mechanism of Rep-mediated adeno-associated virus origin nicking.
Journal of virology. 74(17):7762-71 [PMID] 10933682.
Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism.
Journal of virology. 74(18):8635-47 [PMID] 10954565.
NGF gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats.
Brain research. 875(1-2):144-51 [PMID] 10967308.
Production and purification of recombinant adeno-associated virus.
Methods in enzymology. 316:743-61 [PMID] 10800712.
Biochemical characterization of adeno-associated virus rep68 DNA helicase and ATPase activities.
Journal of virology. 73(2):1580-90 [PMID] 9882364.
Charge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants.
Journal of virology. 73(11):9433-45 [PMID] 10516052.
Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer.
Brain research. 832(1-2):136-44 [PMID] 10375659.
High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap.
Gene therapy. 6(6):986-93 [PMID] 10455400.
Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and Trk receptor levels in the adult rat basal forebrain.
Neuroscience. 90(3):815-21 [PMID] 10218782.
Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged beta-glucuronidase expression in situ and correction of liver pathology in mucopolysaccharidosis type VII mice.
Human gene therapy. 10(1):85-94 [PMID] 10022533.
Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer.
Brain research. 847(2):314-20 [PMID] 10575102.
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield.
Gene therapy. 6(6):973-85 [PMID] 10455399.
Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification.
Journal of virology. 73(11):9325-36 [PMID] 10516041.
Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve.
Archives of ophthalmology (Chicago, Ill. : 1960). 117(7):929-37 [PMID] 10408459.
Cellular proteins required for adeno-associated virus DNA replication in the absence of adenovirus coinfection.
Journal of virology. 72(4):2777-87 [PMID] 9525597.
Developing VDEPT for DT-diaphorase (NQO1) using an AAV vector plasmid.
International journal of radiation oncology, biology, physics. 42(4):909-12 [PMID] 9845120.
Expression of adeno-associated virus integrated transgene within the mammalian vestibular organs.
The American journal of otology. 19(3):390-5 [PMID] 9596192.
In vitro packaging of adeno-associated virus DNA.
Journal of virology. 72(4):3241-7 [PMID] 9525651.
Long-term in vivo cochlear transgene expression mediated by recombinant adeno-associated virus.
Gene therapy. 5(2):277-81 [PMID] 9578849.
Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors.
Experimental neurology. 150(2):183-94 [PMID] 9527887.
Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors.
Proceedings of the National Academy of Sciences of the United States of America. 95(24):14384-8 [PMID] 9826709.
Characterization of recombinant adeno-associated virus-2 as a vehicle for gene delivery and expression into vascular cells.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 45(2):87-98 [PMID] 9084579.
Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus.
Proceedings of the National Academy of Sciences of the United States of America. 94(13):6916-21 [PMID] 9192666.
Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters.
Gene therapy. 4(1):16-24 [PMID] 9068791.
Gene therapy for murine mucopolysaccharidosis type VII.
Neuromuscular disorders : NMD. 7(5):352-60 [PMID] 9267850.
Green fluorescent protein as a reporter for gene transfer studies in the cochlea.
Hearing research. 114(1-2):139-47 [PMID] 9447928.
Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap.
Journal of virology. 71(11):8780-9 [PMID] 9343238.
The adeno-associated virus (AAV) Rep protein acts as both a repressor and an activator to regulate AAV transcription during a productive infection.
Journal of virology. 71(2):1079-88 [PMID] 8995628.
The adeno-associated virus type 2 p40 promoter requires a proximal Sp1 interaction and a p19 CArG-like element to facilitate Rep transactivation.
Journal of virology. 71(6):4300-9 [PMID] 9151818.
The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter.
Journal of virology. 71(3):1747-56 [PMID] 9032303.
A “humanized” green fluorescent protein cDNA adapted for high-level expression in mammalian cells.
Journal of virology. 70(7):4646-54 [PMID] 8676491.
Development of in vivo gene therapy for hearing disorders: introduction of adeno-associated virus into the cochlea of the guinea pig.
Gene therapy. 3(7):588-92 [PMID] 8818645.
Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats.
Journal of virology. 70(3):1542-53 [PMID] 8627673.
Regulated high-level human beta-globin gene expression in erythroid cells following recombinant adeno-associated virus-mediated gene transfer.
Gene therapy. 2(5):336-43 [PMID] 7671109.
Adeno-associated virus (AAV) vectors: will they work?
The Journal of clinical investigation. 94(4) [PMID] 7929808.
Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein.
Journal of virology. 68(8):4988-97 [PMID] 8035498.
In vitro replication of adeno-associated virus DNA.
Journal of virology. 68(2):1128-38 [PMID] 8289342.
Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat.
Journal of virology. 68(8):4998-5006 [PMID] 8035499.
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein.
Journal of virology. 67(10):6096-104 [PMID] 8396670.
Analysis of mutations in adeno-associated virus Rep protein in vivo and in vitro.
Journal of virology. 66(7):4050-7 [PMID] 1318396.
Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization.
Journal of virology. 66(2):1119-28 [PMID] 1309894.
Use of adeno-associated virus as a general transduction vector for mammalian cells.
Current topics in microbiology and immunology. 158:97-129 [PMID] 1316261.
Sequences required for coordinate induction of adeno-associated virus p19 and p40 promoters by Rep protein.
Journal of virology. 65(6):2936-45 [PMID] 2033660.
Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome.
Journal of virology. 64(12):6204-13 [PMID] 2173787.
In vitro resolution of covalently joined AAV chromosome ends.
Cell. 60(1):105-13 [PMID] 2153052.
Purification and characterization of HeLa endonuclease R. A G-specific mammalian endonuclease.
The Journal of biological chemistry. 265(19):10836-41 [PMID] 2358441.
Site-specific integration by adeno-associated virus.
Proceedings of the National Academy of Sciences of the United States of America. 87(6):2211-5 [PMID] 2156265.
Substrate specificity of HeLa endonuclease R. A G-specific mammalian endonuclease.
The Journal of biological chemistry. 265(19):10842-50 [PMID] 2358442.
The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity.
Cell. 61(3):447-57 [PMID] 2159383.
Factors that bind to adeno-associated virus terminal repeats.
Journal of virology. 63(7):3095-104 [PMID] 2542617.
Adeno-associated virus general transduction vectors: analysis of proviral structures.
Journal of virology. 62(6):1963-73 [PMID] 2835501.
In vitro excision of adeno-associated virus DNA from recombinant plasmids: isolation of an enzyme fraction from HeLa cells that cleaves DNA at poly(G) sequences.
Molecular and cellular biology. 8(6):2513-22 [PMID] 2841582.
Comparison of the DNA sequence and secondary structure of the herpes simplex virus L/S junction and the adeno-associated virus terminal repeat.
Journal of theoretical biology. 115(4):477-94 [PMID] 2995732.
Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants.
Journal of virology. 51(2):329-39 [PMID] 6086948.
The genetics of adeno-associated virus.
Advances in experimental medicine and biology. 179:151-61 [PMID] 6098150.
Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells.
Proceedings of the National Academy of Sciences of the United States of America. 81(20):6466-70 [PMID] 6093102.
Characterization of am404, an amber mutation in the simian virus 40 T antigen gene.
Journal of virology. 47(1):202-16 [PMID] 6191041.
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV.
Cell. 33(1):135-43 [PMID] 6088052.
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells.
Proceedings of the National Academy of Sciences of the United States of America. 79(6):2077-81 [PMID] 6281795.
Construction of a specific amber codon in the simian virus 40 T-antigen gene by site-directed mutagenesis.
Journal of virology. 36(2):611-6 [PMID] 6253682.
Construction of an SV40-derived cloning vector.
Gene. 11(1-2):63-77 [PMID] 6254855.
Persistence of phage lambda DNA in genomes of mouse cells transformed by lambda-carrying SV40 vectors.
Gene. 6(2):107-22 [PMID] 225241.
Studies on the biochemical basis of spontaneous mutation. II. The incorporation of a base and its analogue into DNA by wild-type, mutator and antimutator DNA polymerases.
Journal of molecular biology. 88(2):409-21 [PMID] 4616089.
Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4.
The Journal of biological chemistry. 247(22):7116-22 [PMID] 4565077.
Nov 2015 – Feb 2017
A NEW METHOD FOR DELIVERING TEMOZOLOMIDE ACROSS THE BRAINBARRIERS FOR GLIOBLASTOMA
Role: Principal Investigator
Funding: PARDEE FOU, ELSA U
Sep 2014 – Aug 2019
The role of pH and protease activity in AAV viral transduction
Funding: NATL INST OF HLTH NIGMS
Issued August 2014
Improved rAAV Expression systems for Genetic Modification of Specific Capsid Proteins#8,802,080
Published July 2014
A Method For Producing Recombinant AAV2 Vectors With Genetic Modification In Specific Capsid Proteins DIV#US2015/0005369
Published January 2009
Methods for Targeting Modified rAAV Vectors to Mammalian Cells#US2009/0286321
Published January 2009
rAAV Expression Systems and Methods of Use#US-2009-0148949-A1
Published January 2009
Viral Vector-Based Gene Therapy Methods and Compositions#US-2009-0148411-A1
Published February 2007
Human Disease Modeling Using Somatic Gene Transfer#US-2007-0157324 A1
Issued August 2006
Human Disease Modeling Using Somatic Gene Transfer#7,098,374
Issued August 2006
Production of Pseudotyped Recombinant AAV Virions#7,094,604
Published September 2005
Improved rAAV Vectors#US2006/0292117A1
Published January 2005
A Modified Baculovirus Expression System for Production of Pseudotyped rAAV Vector#US-2006-0166363-A1
Issued August 2004
Methods for Large-Scale Production of Recombinant AAV Vectors#6,783,972
Published June 2004
Human Disease Modeling Using Somatic Gene Transfer#20040205833
Published December 2003
Methods of Preparing Recombinant Adeno-Associated Virus Compositions#2004/0121444-A1
Issued December 2003
Method of Preparing Recombinant Adeno-Associated Virus Compositions#6,660,514
Issued September 2003
Temperature Sensitive Regulation of Viral Vector Production#6,627,617
Published June 2003
Production of Pseudotyped Recombinant AAV Virions#2007-0015238-A1
Issued November 2000
Method of Preparing Recombinant AAV Compositions#6,146,874
Issued February 2000
Humanized Green Fluorescent Protein Genes and Methods#6,020,192
Issued October 1999
Humanized Green Fluorescent Protein Genes and Methods#5,968,750
Issued February 1999
Humanized Green Fluorescent Protein Genes And Methods#5,874,304
Issued August 1992
AAV Transduction Vectors Hybrid Gene Vector of Foreign Dna Ligated into Adeno-associated Virus-2 Genome#5,139,941
GMS7980 Research for Doctoral Dissertation
GMS6251 Molecular Therapy I ? Vectors and Molecular Mechanisms
GMS6036 Molecular Virology III: DNA Viruses