Paradoxical leanness in the imprinting-centre deletion mouse model for Prader-Willi syndrome.
The Journal of endocrinology. 232(1):123-135 [PMID] 27799465.
The Roles of E2F6 and Dna Methylation in the Regulation of Gene Expression During Germ Cell Development
A targeted deletion upstream of Snrpn does not result in an imprinting defect.
Mammalian genome : official journal of the International Mammalian Genome Society. 18(4):255-62 [PMID] 17514346.
A human imprinting centre demonstrates conserved acquisition but diverged maintenance of imprinting in a mouse model for Angelman syndrome imprinting defects.
Human molecular genetics. 15(3):393-404 [PMID] 16368707.
DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages.
Development (Cambridge, England). 133(17):3411-8 [PMID] 16887828.
DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells.
Stem cells (Dayton, Ohio). 23(9):1314-23 [PMID] 16051982.
Evidence for genetic modifiers of postnatal lethality in PWS-IC deletion mice.
Human molecular genetics. 13(23):2971-7 [PMID] 15459179.
Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation.
Developmental biology. 258(1):201-8 [PMID] 12781693.
Activin and TGFbeta limit murine primordial germ cell proliferation.
Developmental biology. 207(2):470-5 [PMID] 10068477.
Differentiation of murine premigratory primordial germ cells in culture.
Biology of reproduction. 61(4):1146-51 [PMID] 10491656.
A mouse model for Prader-Willi syndrome imprinting-centre mutations.
Nature genetics. 19(1):25-31 [PMID] 9590284.
Primordial germ cells, stem cells and testicular cancer.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 106(1):134-41 [PMID] 9524571.
Role of fibroblast growth factors and their receptors in mouse primordial germ cell growth.
Biology of reproduction. 59(5):1224-9 [PMID] 9780331.
Two CDC25 homologues are differentially expressed during mouse development.
Development (Cambridge, England). 121(7):2047-56 [PMID] 7635051.
Characterization of activated and normal mouse Mos gene in murine 3T3 cells.
Oncogene. 7(12):2489-98 [PMID] 1461652.
Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.
Genes & development. 6(10):1832-42 [PMID] 1383087.
Long-term proliferation of mouse primordial germ cells in culture.
Nature. 359(6395):550-1 [PMID] 1383830.
Requirement for mast cell growth factor for primordial germ cell survival in culture.
Nature. 352(6338):809-11 [PMID] 1715518.
May 2019 ACTIVE
A mouse model to assess genetic therapies for Prader-Willi syndrome
Role: Principal Investigator
Funding: FOU FOR PRADER-WILLI RESEARCH
Jul 2013 – Mar 2020
Imprinting defects leading to Angelman and Prader Willi syndromes
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
GMS6001 Fundamentals of Biomedical Sciences I
BMS6003 Genetics and Health
GMS6013 Developmental Genetics
BCH7412 Epigenetics of Human Disease and Development
GMS7980 Research for Doctoral Dissertation
GMS6905 Independent Studies in Medical Sciences
GMS6331 Stem Cell Biology