James L Resnick

James L Resnick,

PROFESSOR

Department: Molecular Genetics & Microbiology
Business Phone: (352) 392-3258
Business Email: jresnick@ufl.edu

Publications

2018
Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.
Human molecular genetics. 27(23):4051-4060 [DOI] 10.1093/hmg/ddy296. [PMID] 30124848.
2018
Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats.
British journal of anaesthesia. 121(2):406-416 [DOI] 10.1016/j.bja.2018.04.034. [PMID] 30032879.
2017
Paradoxical leanness in the imprinting-centre deletion mouse model for Prader-Willi syndrome.
The Journal of endocrinology. 232(1):123-135 [PMID] 27799465.
View on: PubMed
2015
Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis.
Reproductive sciences (Thousand Oaks, Calif.). 22(2):250-7 [DOI] 10.1177/1933719114542026. [PMID] 25031318.
2015
Correction for Lewis et al., Angelman syndrome imprinting center encodes a transcriptional promoter.
Proceedings of the National Academy of Sciences of the United States of America. 112(22) [DOI] 10.1073/pnas.1500034112. [PMID] 25588880.
2014
Influence of the Prader-Willi syndrome imprinting center on the DNA methylation landscape in the mouse brain.
Epigenetics. 9(11):1540-56 [DOI] 10.4161/15592294.2014.969667. [PMID] 25482058.
2013
Differential gene expression reveals mitochondrial dysfunction in an imprinting center deletion mouse model of Prader-Willi syndrome.
Clinical and translational science. 6(5):347-55 [DOI] 10.1111/cts.12083. [PMID] 24127921.
2013
Recommendations for the investigation of animal models of Prader-Willi syndrome.
Mammalian genome : official journal of the International Mammalian Genome Society. 24(5-6):165-78 [DOI] 10.1007/s00335-013-9454-2. [PMID] 23609791.
2013
Regulatory elements associated with paternally-expressed genes in the imprinted murine Angelman/Prader-Willi syndrome domain.
PloS one. 8(2) [DOI] 10.1371/journal.pone.0052390. [PMID] 23390487.
2012
Immunomagnetic purification of murine primordial germ cells.
Methods in molecular biology (Clifton, N.J.). 925:61-6 [DOI] 10.1007/978-1-62703-011-3_4. [PMID] 22907490.
2012
Temporal and developmental requirements for the Prader-Willi imprinting center.
Proceedings of the National Academy of Sciences of the United States of America. 109(9):3446-50 [DOI] 10.1073/pnas.1115057109. [PMID] 22331910.
2011
A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center.
Human molecular genetics. 20(17):3461-6 [DOI] 10.1093/hmg/ddr262. [PMID] 21659337.
2011
Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.
PLoS genetics. 7(12) [DOI] 10.1371/journal.pgen.1002422. [PMID] 22242001.
2010
Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC.
Neurogenetics. 11(2):145-51 [DOI] 10.1007/s10048-009-0226-9. [PMID] 19894069.
2010
Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome.
The European journal of neuroscience. 31(1):156-64 [DOI] 10.1111/j.1460-9568.2009.07048.x. [PMID] 20092561.
2009
Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar size.
Human molecular genetics. 18(22):4227-38 [DOI] 10.1093/hmg/ddp373. [PMID] 19656775.
2008
The Roles of E2F6 and Dna Methylation in the Regulation of Gene Expression During Germ Cell Development
.
2007
A targeted deletion upstream of Snrpn does not result in an imprinting defect.
Mammalian genome : official journal of the International Mammalian Genome Society. 18(4):255-62 [PMID] 17514346.
View on: PubMed
2006
A human imprinting centre demonstrates conserved acquisition but diverged maintenance of imprinting in a mouse model for Angelman syndrome imprinting defects.
Human molecular genetics. 15(3):393-404 [PMID] 16368707.
View on: PubMed
2006
DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages.
Development (Cambridge, England). 133(17):3411-8 [PMID] 16887828.
View on: PubMed
2005
DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells.
Stem cells (Dayton, Ohio). 23(9):1314-23 [PMID] 16051982.
View on: PubMed
2004
Evidence for genetic modifiers of postnatal lethality in PWS-IC deletion mice.
Human molecular genetics. 13(23):2971-7 [PMID] 15459179.
View on: PubMed
2003
Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation.
Developmental biology. 258(1):201-8 [PMID] 12781693.
View on: PubMed
1999
Activin and TGFbeta limit murine primordial germ cell proliferation.
Developmental biology. 207(2):470-5 [PMID] 10068477.
View on: PubMed
1999
Differentiation of murine premigratory primordial germ cells in culture.
Biology of reproduction. 61(4):1146-51 [PMID] 10491656.
View on: PubMed
1998
A mouse model for Prader-Willi syndrome imprinting-centre mutations.
Nature genetics. 19(1):25-31 [PMID] 9590284.
View on: PubMed
1998
Primordial germ cells, stem cells and testicular cancer.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 106(1):134-41 [PMID] 9524571.
View on: PubMed
1998
Role of fibroblast growth factors and their receptors in mouse primordial germ cell growth.
Biology of reproduction. 59(5):1224-9 [PMID] 9780331.
View on: PubMed
1995
Two CDC25 homologues are differentially expressed during mouse development.
Development (Cambridge, England). 121(7):2047-56 [PMID] 7635051.
View on: PubMed
1992
Characterization of activated and normal mouse Mos gene in murine 3T3 cells.
Oncogene. 7(12):2489-98 [PMID] 1461652.
View on: PubMed
1992
Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.
Genes & development. 6(10):1832-42 [PMID] 1383087.
View on: PubMed
1992
Long-term proliferation of mouse primordial germ cells in culture.
Nature. 359(6395):550-1 [PMID] 1383830.
View on: PubMed
1991
Requirement for mast cell growth factor for primordial germ cell survival in culture.
Nature. 352(6338):809-11 [PMID] 1715518.
View on: PubMed

Grants

May 2019 ACTIVE
A mouse model to assess genetic therapies for Prader-Willi syndrome
Role: Principal Investigator
Funding: FOU FOR PRADER-WILLI RESEARCH
Jul 2013 – Mar 2020
Imprinting defects leading to Angelman and Prader Willi syndromes
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS

Teaching Profile

Courses Taught
2013-2021
GMS6001 Fundamentals of Biomedical Sciences I
2019-2021
BMS6003 Genetics and Health
2019,2021
GMS6013 Developmental Genetics
2013,2015-2018
BCH7412 Epigenetics of Human Disease and Development
2018
GMS7980 Research for Doctoral Dissertation
2017
GMS6905 Independent Studies in Medical Sciences
2014-2016
GMS6331 Stem Cell Biology

Contact Details

Phones:
Business:
(352) 392-3258
Emails:
Business:
jresnick@ufl.edu