Scott Tibbetts

Scott Tibbetts,

Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5628
Business Email: stibbe@ufl.edu

About Scott Tibbetts

Fun Fact: I love traveling, travel photography, and learning about other cultures through experiences, conversations, and food; being able to be a part of a multi-cultural team is one of my favorite aspects of academic science. Our lab studies gammaherpesviruses – viruses such as Epstein-Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV, HHV-8), which are associated with multiple types of human malignancies, including lymphomas, carcinomas, and sarcoma. Our research harnesses the power of the closely related murine gammaherpesvirus (MHV68) in vivo system to gain insight into the mechanisms by which viral noncoding RNAs contribute to latency and tumorigenesis, and to define the molecular and pathogenic strategies that these viruses use to evade the immune system and manipulate B cell biology in order to establish lifelong latent infections. The long-term goals of these studies are to better understand the complex interplay between these viruses and the host immune response, and define how alterations in this relationship can result in the development of lymphoproliferative diseases and lymphoma, and elucidate new targets for prevention of gammaherpesvirus malignancies.

Related Links:

Teaching Profile

Courses Taught
2020-2024
GMS7133 Advanced Molecular Virology
2018-2024
GMS6921 Immunology/Microbiology Journal Colloquy
2014-2024
GMS6121 Infectious Diseases
2013-2022,2024
GMS6036 Molecular Virology III: DNA Viruses
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016-2018
GMS6034 Advanced Virology I: Genetics and RNA
2018,2024
BMS6300 Fund Micro and Immuno
2021,2024
BMS6816 Cancer Bio Clin Oncol

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-8889-1642

Publications

2024
Correction for Rasmussen et al., “Virology—the path forward”
Journal of Virology. 98(3) [DOI] 10.1128/jvi.00074-24. [PMID] 38334328.
2024
Virology—the path forward
Journal of Virology. 98(1) [DOI] 10.1128/jvi.01791-23. [PMID] 38168672.
2023
B cell expression of E3 ubiquitin ligase Cul4b promotes chronic gammaherpesvirus infection in vivo
Journal of Virology. 97(12) [DOI] 10.1128/jvi.01008-23. [PMID] 37962378.
2023
DESIGN AND GENERATION OF A RECOMBINANT GAMMAHERPESVIRUS ENCODING shRNA FROM A NATIVE VIRAL tRNA PROMOTER
Trakya University Journal of Natural Sciences. 24(1):63-70 [DOI] 10.23902/trkjnat.1191873.
2023
Virology under the Microscope—a Call for Rational Discourse
mSphere. 8(2) [DOI] 10.1128/msphere.00034-23. [PMID] 36700653.
2023
Virology under the Microscope—a Call for Rational Discourse
mBio. 14(1) [DOI] 10.1128/mbio.00188-23. [PMID] 36700642.
2023
Virology under the Microscope—a Call for Rational Discourse
Journal of Virology. 97(2) [DOI] 10.1128/jvi.00089-23. [PMID] 36700640.
2022
A Polymorphism in the Epstein-Barr Virus EBER2 Noncoding RNA Drives In Vivo Expansion of Latently Infected B Cells
mBio. 13(3) [DOI] 10.1128/mbio.00836-22. [PMID] 35642944.
2022
Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses
Proceedings of the National Academy of Sciences. 119(32) [DOI] 10.1073/pnas.2123362119. [PMID] 35921433.
2021
Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68.
Annual review of virology. 8(1):349-371 [DOI] 10.1146/annurev-virology-011921-082615. [PMID] 34586873.
2021
EBV miRNAs are potent effectors of tumor cell transcriptome remodeling in promoting immune escape
PLOS Pathogens. 17(5) [DOI] 10.1371/journal.ppat.1009217. [PMID] 33956915.
2021
Empirical Validation of Overlapping Virus lncRNAs and Coding Transcripts by Northern Blot.
Methods in molecular biology (Clifton, N.J.). 2348:243-253 [DOI] 10.1007/978-1-0716-1581-2_17. [PMID] 34160812.
2020
Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-59269-9. [PMID] 32047224.
2019
A Gammaherpesvirus MicroRNA Targets EWSR1 (Ewing Sarcoma Breakpoint Region 1) In Vivo To Promote Latent Infection of Germinal Center B Cells.
mBio. 10(4) [DOI] 10.1128/mBio.00996-19. [PMID] 31363027.
2019
Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.
Journal of virology. 93(6) [DOI] 10.1128/JVI.01952-18. [PMID] 30567979.
2019
Epstein–Barr virus EBER1 and murine gammaherpesvirus TMER4 share conserved in vivo function to promote B cell egress and dissemination
Proceedings of the National Academy of Sciences. 116(51):25392-25394 [DOI] 10.1073/pnas.1915752116. [PMID] 31796588.
2019
Gammaherpesvirus Readthrough Transcription Generates a Long Non-Coding RNA That Is Regulated by Antisense miRNAs and Correlates with Enhanced Lytic Replication In Vivo.
Non-coding RNA. 5(1) [DOI] 10.3390/ncrna5010006. [PMID] 30634714.
2019
Gammaherpesvirus RNAs Come Full Circle.
mBio. 10(2) [DOI] 10.1128/mBio.00071-19. [PMID] 30940699.
2019
Genome-wide Transcript Structure Resolution Reveals Abundant Alternate Isoform Usage from Murine Gammaherpesvirus 68.
Cell reports. 27(13):3988-4002.e5 [DOI] 10.1016/j.celrep.2019.05.086. [PMID] 31242428.
2019
Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery
PLOS Pathogens. 15(8) [DOI] 10.1371/journal.ppat.1007843. [PMID] 31393953.
2018
Connivance, Complicity, or Collusion? The Role of Noncoding RNAs in Promoting Gammaherpesvirus Tumorigenesis.
Trends in cancer. 4(11):729-740 [DOI] 10.1016/j.trecan.2018.09.005. [PMID] 30352676.
2018
Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.
PLoS pathogens. 14(9) [DOI] 10.1371/journal.ppat.1007319. [PMID] 30252914.
2018
Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.
Biochemistry. 57(7):1096-1107 [DOI] 10.1021/acs.biochem.7b01171. [PMID] 29227673.
2018
Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR-/-) That Is Blocked by Interleukin-10.
Viruses. 10(10) [DOI] 10.3390/v10100518. [PMID] 30249047.
2018
The Epstein Barr virus circRNAome.
PLoS pathogens. 14(8) [DOI] 10.1371/journal.ppat.1007206. [PMID] 30080890.
2018
Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice
PLOS Pathogens. 14(2) [DOI] 10.1371/journal.ppat.1006843. [PMID] 29390024.
2016
A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency.
mSphere. 1(2) [PMID] 27110595.
2016
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.
Cell reports. 16(2):405-418 [DOI] 10.1016/j.celrep.2016.05.083. [PMID] 27346349.
2016
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
The Journal of biological chemistry. 291(6):2874-87 [DOI] 10.1074/jbc.M115.704841. [PMID] 26620556.
2016
Recent advances in understanding norovirus pathogenesis.
Journal of medical virology. 88(11):1837-43 [DOI] 10.1002/jmv.24559. [PMID] 27110852.
2015
Emerging Roles of Herpesvirus microRNAs During In Vivo Infection and Pathogenesis.
Current pathobiology reports. 3(3):209-217 [PMID] 26246961.
2015
Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo.
mBio. 6(1):e01670-14 [DOI] 10.1128/mBio.01670-14. [PMID] 25691585.
2015
Human norovirus culture in B cells.
Nature protocols. 10(12):1939-47 [DOI] 10.1038/nprot.2015.121. [PMID] 26513671.
2015
Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice.
PLoS pathogens. 11(6) [DOI] 10.1371/journal.ppat.1005001. [PMID] 26107716.
2014
A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.
PLoS pathogens. 10(2) [DOI] 10.1371/journal.ppat.1003916. [PMID] 24516386.
2014
Enteric bacteria promote human and mouse norovirus infection of B cells.
Science (New York, N.Y.). 346(6210):755-9 [DOI] 10.1126/science.1257147. [PMID] 25378626.
2014
Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo.
mBio. 5(3):e00981-14 [DOI] 10.1128/mBio.00981-14. [PMID] 24865551.
2013
Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection.
Antimicrobial agents and chemotherapy. 57(9):4114-27 [DOI] 10.1128/AAC.02594-12. [PMID] 23774438.
2012
Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo.
PLoS pathogens. 8(9) [DOI] 10.1371/journal.ppat.1002906. [PMID] 22969427.
2010
Immature and transitional B cells are latency reservoirs for a gammaherpesvirus.
Journal of virology. 84(24):13045-52 [DOI] 10.1128/JVI.01455-10. [PMID] 20926565.
2010
Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication.
PLoS pathogens. 6(7) [DOI] 10.1371/journal.ppat.1001001. [PMID] 20686657.
2010
Use of a virus-encoded enzymatic marker reveals that a stable fraction of memory B cells expresses latency-associated nuclear antigen throughout chronic gammaherpesvirus infection.
Journal of virology. 84(15):7523-34 [DOI] 10.1128/JVI.02572-09. [PMID] 20484501.
2008
A replication-defective gammaherpesvirus efficiently establishes long-term latency in macrophages but not in B cells in vivo.
Journal of virology. 82(17):8500-8 [DOI] 10.1128/JVI.00186-08. [PMID] 18562537.
2006
A gamma-herpesvirus deficient in replication establishes chronic infection in vivo and is impervious to restriction by adaptive immune cells.
Virology. 353(1):210-9 [PMID] 16797052.
2006
Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.
PLoS pathogens. 2(5) [PMID] 16733540.
2006
Gamma interferon blocks gammaherpesvirus reactivation from latency.
Journal of virology. 80(1):192-200 [PMID] 16352543.
2005
Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice.
Journal of virology. 79(23):14668-79 [PMID] 16282467.
2004
Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gammaherpesvirus latency.
Journal of virology. 78(13):6836-45 [PMID] 15194759.
2003
Effective vaccination against long-term gammaherpesvirus latency.
Journal of virology. 77(4):2522-9 [PMID] 12551990.
2003
Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection.
Journal of virology. 77(13):7696-701 [PMID] 12805472.
1999
Peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture.
Transplantation. 68(5):685-92 [PMID] 10507489.

Grants

Jun 2022 ACTIVE
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2021 ACTIVE
Gammaherpesvirus miRNA suppression of EWSR1 in GC B cell infection and lymphomagenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jul 2018 – Aug 2019
The Role of a Gammaherpesvirus Noncoding RNA in Dissemination, Chronic Infection and Virus-Induced Vasculitis
Role: Other
Funding: AMER HEART ASSOCIATION
Feb 2017 – Jan 2022
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Faculty
Funding: NATL INST OF HLTH NCI
Feb 2015 – Oct 2023
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015 – Dec 2020
Role of MHV68 miRNAs in latency and pathogenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2006 – May 2023
Davis Cancer Researach Equipment
Role: Project Manager
Funding: UF FOUNDATION

Contact Details

Phones:
Business:
(352) 273-5628
Emails:
Business:
stibbe@ufl.edu
Addresses:
Business Mailing:
PO Box 100266
GAINESVILLE FL 32610
Business Street:
OFFICE R2-291
LAB R2-285
1200 Newell Dr.
GAINESVILLE FL 32610