Lizi Wu

Lizi Wu,

Ph.D.

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-8205
Business Email: lzwu@ufl.edu

Publications

2021
Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma.
Signal transduction and targeted therapy. 6(1) [DOI] 10.1038/s41392-020-00388-0. [PMID] 33473104.
2020
Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(4):4970-4983 [DOI] 10.1096/fj.201902382R. [PMID] 32057145.
2020
LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding.
Science advances. 6(8) [DOI] 10.1126/sciadv.aaw4651. [PMID] 32128389.
2019
MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma.
Oral oncology. 98:147-155 [DOI] 10.1016/j.oraloncology.2019.09.005. [PMID] 31606723.
2018
CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells.
Oncogene. 37(14):1885-1895 [DOI] 10.1038/s41388-017-0104-0. [PMID] 29353885.
2018
Notch1 activation enhances proliferation via activation of cdc2 and delays differentiation of myeloid progenitors.
Leukemia research. 72:34-44 [DOI] 10.1016/j.leukres.2018.07.022. [PMID] 30086426.
2018
Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer
Journal of the National Cancer Institute. 111(7):664-674 [DOI] 10.1093/jnci/djy166. [PMID] 30423141.
2016
cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth.
The Journal of clinical investigation. 126(6):2267-79 [DOI] 10.1172/JCI85250. [PMID] 27140397.
2016
Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells.
The Journal of clinical investigation. 126(11):4174-4186 [DOI] 10.1172/JCI86623. [PMID] 27721239.
2016
Mof Acetylates the Histone Demethylase Lsd1 to Suppress Epithelial-To-Mesenchymal Transition
Cell Reports. 15(12):2665-2678 [DOI] 10.1016/j.celrep.2016.05.050.
2015
A Microrna-1280/Jag2 Network Comprises a Novel Biological Target in High-Risk Medulloblastoma
Oncotarget. 6(5):2709-2724
2015
FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.
Cancer letters. 362(1):70-82 [DOI] 10.1016/j.canlet.2015.03.037. [PMID] 25827072.
2015
Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells.
BMC cancer. 15 [DOI] 10.1186/s12885-015-1827-3. [PMID] 26503699.
2015
Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer.
Journal of the National Cancer Institute. 107(1) [DOI] 10.1093/jnci/dju358. [PMID] 25465874.
2014
A Unifying Gene Signature for Adenoid Cystic Cancer Identifies Parallel Myb-Dependent and Myb-Independent Therapeutic Targets
Oncotarget. 5(24):12528-12542
2014
CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.
Leukemia. 28(1):155-65 [DOI] 10.1038/leu.2013.115. [PMID] 23588715.
2014
Crtc1/Maml2 Gain-Of-Function Interactions With Myc Create a Gene Signature Predictive of Cancers With Creb-Myc Involvement
Proceedings of the National Academy of Sciences. 111(32):E3260-E3268 [DOI] 10.1073/pnas.1319176111. [PMID] 25071166.
2013
Blockage of Notch signaling inhibits the migration and proliferation of retinal pigment epithelial cells.
TheScientificWorldJournal. 2013 [DOI] 10.1155/2013/178708. [PMID] 24453806.
2013
Brief report: Blockade of Notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration.
Stem cells (Dayton, Ohio). 31(4):823-8 [DOI] 10.1002/stem.1319. [PMID] 23307608.
2013
DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia.
Oncogene. 32(40):4845-53 [DOI] 10.1038/onc.2012.482. [PMID] 23108395.
2013
Overexpression of Six1 leads to retardation of myogenic differentiation in C2C12 myoblasts.
Molecular biology reports. 40(1):217-23 [DOI] 10.1007/s11033-012-2052-7. [PMID] 23079703.
2013
Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program.
The Journal of biological chemistry. 288(9):6238-47 [DOI] 10.1074/jbc.M112.429605. [PMID] 23349461.
2013
The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.
The Journal of biological chemistry. 288(38):27680-27691 [DOI] 10.1074/jbc.M113.482349. [PMID] 23928305.
2012
Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.
Oncogene. 31(4):469-79 [DOI] 10.1038/onc.2011.247. [PMID] 21706049.
2012
Crm1 Blockade By Novel Inhibitors of Nuclear Export (Sines) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis
Blood. 120
2012
DNA methyltransferase inhibitor CDA-II inhibits myogenic differentiation.
Biochemical and biophysical research communications. 422(3):522-6 [DOI] 10.1016/j.bbrc.2012.05.068. [PMID] 22627135.
2012
Notch1-mediated tumor suppression in cervical cancer with the involvement of SST signaling and its application in enhanced SSTR-targeted therapeutics.
The oncologist. 17(2):220-32 [DOI] 10.1634/theoncologist.2011-0269. [PMID] 22291092.
2011
Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation.
Proceedings of the National Academy of Sciences of the United States of America. 108(37):15231-6 [DOI] 10.1073/pnas.1104662108. [PMID] 21896759.
2010
Essential Role for the Maml1 Co-Activator in T-All.
Blood. 116
2010
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
Genes & cancer. 1(8):822-35 [DOI] 10.1177/1947601910383564. [PMID] 21127729.
2010
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.
The Journal of clinical investigation. 120(1):103-14 [DOI] 10.1172/JCI37964. [PMID] 20038814.
2010
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.
Gastroenterology. 139(6):2113-23 [DOI] 10.1053/j.gastro.2010.08.040. [PMID] 20801121.
2010
The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival.
The Journal of biological chemistry. 285(19):14356-65 [DOI] 10.1074/jbc.M109.078865. [PMID] 20231278.
2008
Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.
Oncogene. 27(38):5138-47 [DOI] 10.1038/onc.2008.228. [PMID] 18758483.
2007
The notch regulator MAML1 interacts with p53 and functions as a coactivator.
The Journal of biological chemistry. 282(16):11969-81 [PMID] 17317671.
View on: PubMed
2007
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Blood. 110(10):3618-23 [PMID] 17699740.
View on: PubMed
2006
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Genes & development. 20(6):675-88 [PMID] 16510869.
View on: PubMed
2005
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
The EMBO journal. 24(13):2391-402 [PMID] 15961999.
View on: PubMed
2004
Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.
Gene. 328:153-65 [PMID] 15019995.
View on: PubMed
2004
Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
Seminars in cancer biology. 14(5):348-56 [PMID] 15288260.
View on: PubMed
2003
Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(29):9547-56 [PMID] 14573534.
View on: PubMed
2003
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Nature genetics. 33(2):208-13 [PMID] 12539049.
View on: PubMed
2002
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Molecular and cellular biology. 22(21):7688-700 [PMID] 12370315.
View on: PubMed
2001
The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.
The Journal of biological chemistry. 276(48):44889-97 [PMID] 11572863.
View on: PubMed
2000
Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling.
Journal of cell science. 113 Pt 23:4313-8 [PMID] 11069775.
View on: PubMed
2000
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Nature genetics. 26(4):484-9 [PMID] 11101851.
View on: PubMed
1999
Identification of two major histocompatibility complex class Ib genes, Q7 and Q9, as the Ped gene in the mouse.
Biology of reproduction. 60(5):1114-9 [PMID] 10208972.
View on: PubMed
1998
Differential expression of Ped gene candidates in preimplantation mouse embryos.
Biology of reproduction. 59(4):941-52 [PMID] 9746747.
View on: PubMed
1998
Ooplasmic transfer in mature human oocytes.
Molecular human reproduction. 4(3):269-80 [PMID] 9570273.
View on: PubMed
1998
Role of the Ped gene and apoptosis genes in control of preimplantation development.
Journal of assisted reproduction and genetics. 15(5):331-7 [PMID] 9604770.
View on: PubMed
1996
Sequence and transcription of Qa-2-encoding genes in mouse lymphocytes and blastocysts.
Immunogenetics. 45(2):97-107 [PMID] 8952959.
View on: PubMed
1995
Mapping of the SLA complex class III region by pulsed field gel electrophoresis.
Mammalian genome : official journal of the International Mammalian Genome Society. 6(9):607-10 [PMID] 8535067.
View on: PubMed

Grants

Apr 2021 ACTIVE
Team-based Interdisciplinary Cancer Research Training Program
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2020 ACTIVE
Signaling and Targeting of CRTC1-MAML2 Fusion Oncoprotein in Salivary Gland
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Feb 2019 ACTIVE
Aberrant CRTC activation as a unique vulnerability of lung cancer with LKB1 inactivation
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Sep 2018 ACTIVE
OR-DRPD-ROF2018: Identification of the first extracellular nicotinamide adenine dinucleotide-binding receptor in animal cells
Role: Co-Investigator
Funding: UF RESEARCH
Apr 2015 – Mar 2018
A novel noncoding RNA and human lung cancers with inactivated LKB1 signaling
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Aug 2014 – May 2020
Signaling and targeting of CRTC1-MAML2 fusion oncoprotein in salivary gland tumor
Role: Principal Investigator
Funding: NATL INST OF HLTH
Feb 2012 – Mar 2018
Sponholtz Family Cancer Research Fund – #F14006
Role: Project Manager
Funding: UF FOU
Mar 2006 ACTIVE
Davis Cancer Researach Equipment
Role: Project Manager
Funding: UF FOU

Teaching Profile

Courses Taught
2009-2021
GMS7194 Biotechnology Seminar
2013-2021
GMS6036 Molecular Virology III: DNA Viruses
2014-2015,2017-2021
GMS6065 Fundamentals of Cancer Biology
2014,2017-2021
GMS6338 Recent Advances in Cancer Metastasis
2018
GMS7980 Research for Doctoral Dissertation
2018
ZOO7980 Research for Doctoral Dissertation
2013,2015-2017,2017
GMS6051 Signal Transduction
2011-2012
GMS5905 Special Topics in Biomedical Sciences
2010
GMS6905 Independent Studies in Medical Sciences

Contact Details

Phones:
Business:
(352) 273-8205
Emails:
Business:
lzwu@ufl.edu