Lei Zhou

Lei Zhou,

Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-8169
Business Email: leizhou@ufl.edu

Publications

2021
Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti.
Communications biology. 4(1) [DOI] 10.1038/s42003-020-01614-9. [PMID] 33452408.
2019
A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death.
Development (Cambridge, England). 146(9) [DOI] 10.1242/dev.166603. [PMID] 30952666.
2019
P53 and Apoptosis in the Drosophila Model.
Advances in experimental medicine and biology. 1167:105-112 [DOI] 10.1007/978-3-030-23629-8_6. [PMID] 31520351.
2018
Anti-inflammaging effects of human alpha-1 antitrypsin.
Aging cell. 17(1) [DOI] 10.1111/acel.12694. [PMID] 29045001.
2017
Printing-Induced Cell Injury Evaluation During Laser Printing of 3T3 Mouse Fibroblasts
Biofabrication. 9(2) [DOI] 10.1088/1758-5090/aa6ed9.
2017
Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis.
Cancer genetics. 216-217:20-28 [DOI] 10.1016/j.cancergen.2017.05.003. [PMID] 29025592.
2016
HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.
Cell reports. 14(1):103-114 [DOI] 10.1016/j.celrep.2015.12.007. [PMID] 26725110.
2016
Integrating Domain Specific Knowledge and Network Analysis to Predict Drug Sensitivity of Cancer Cell Lines.
PloS one. 11(9) [DOI] 10.1371/journal.pone.0162173. [PMID] 27607242.
2016
Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.
Nucleic acids research. 44(15):7173-88 [DOI] 10.1093/nar/gkw327. [PMID] 27141965.
2015
An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia.
Oncogene. 34(18):2385-97 [DOI] 10.1038/onc.2014.160. [PMID] 24931167.
2015
Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop.
PLoS genetics. 11(7) [DOI] 10.1371/journal.pgen.1005400. [PMID] 26230084.
2015
Differential Temporal Effects of Sclerostin Antibody and Parathyroid Hormone on Cancellous and Cortical Bone and Quantitative Differences in Effects on the Osteoblast Lineage in Young Intact Rats
Bone. 81:380-391 [DOI] 10.1016/j.bone.2015.08.007. [PMID] 26261096.
2015
Pro-apoptotic gene regulation and its activation by gamma-irradiation in the Caribbean fruit fly, Anastrepha suspensa.
Apoptosis : an international journal on programmed cell death. 20(1):1-9 [DOI] 10.1007/s10495-014-1055-3. [PMID] 25433919.
2015
STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation.
Oncotarget. 6(33):34718-31 [DOI] 10.18632/oncotarget.5303. [PMID] 26460617.
2014
hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells.
Cancer research. 74(3):775-86 [DOI] 10.1158/0008-5472.CAN-13-1400. [PMID] 24247718.
2014
Leveraging biological replicates to improve analysis in ChIP-seq experiments.
Computational and structural biotechnology journal. 9 [DOI] 10.5936/csbj.201401002. [PMID] 24688750.
2013
Genome-wide identification of chromatin transitional regions reveals diverse mechanisms defining the boundary of facultative heterochromatin.
PloS one. 8(6) [DOI] 10.1371/journal.pone.0067156. [PMID] 23840609.
2013
P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.
PLoS pathogens. 9(2) [DOI] 10.1371/journal.ppat.1003137. [PMID] 23408884.
2013
The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.
The Journal of biological chemistry. 288(38):27680-27691 [DOI] 10.1074/jbc.M113.482349. [PMID] 23928305.
2012
(-)-Epigallocatechin-3-Gallate Sensitizes Human Promyelocytic Hl-60 Cells To X-Ray Irradiation and Alters Expression of Pro-Apoptotic Genes
The FASEB's Journal. 26
2012
C-Scan Photoacoustic Microscopy for in Vivo Imaging of Drosophila Pupae
Applied Physics Letters. 101(1) [DOI] 10.1063/1.4732797.
2011
A barrier-only boundary element delimits the formation of facultative heterochromatin in Drosophila melanogaster and vertebrates.
Molecular and cellular biology. 31(13):2729-41 [DOI] 10.1128/MCB.05165-11. [PMID] 21518956.
2011
Extra sex combs, chromatin, and cancer: exploring epigenetic regulation and tumorigenesis in Drosophila.
Journal of genetics and genomics = Yi chuan xue bao. 38(10):453-60 [DOI] 10.1016/j.jgg.2011.09.007. [PMID] 22035866.
2011
In vivo monitoring of stem cells in Drosophila pupae using the radiative transfer equation-based fluorescence molecular tomography.
Molecular imaging and biology. 13(5):868-73 [DOI] 10.1007/s11307-010-0434-6. [PMID] 20922571.
2011
Induction of reaper ortholog mx in mosquito midgut cells following baculovirus infection.
Cell death and differentiation. 18(8):1337-45 [DOI] 10.1038/cdd.2011.8. [PMID] 21331076.
2010
Emergency Department Care in Evaluation of Nursing Home Patients
Journal of Investigative Medicine. 58
2010
Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway.
PloS one. 5(11) [DOI] 10.1371/journal.pone.0014018. [PMID] 21103379.
2010
Split Bond Ratings and Information Opacity Premiums
Financial Management. 39:515-532
2009
A lepidopteran orthologue of reaper reveals functional conservation and evolution of IAP antagonists.
Insect molecular biology. 18(3):341-51 [DOI] 10.1111/j.1365-2583.2009.00878.x. [PMID] 19523066.
2009
By design or by chance: cell death during Drosophila embryogenesis.
Apoptosis : an international journal on programmed cell death. 14(8):935-42 [DOI] 10.1007/s10495-009-0360-8. [PMID] 19466551.
2009
Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.
Cancer research. 69(23):9105-11 [DOI] 10.1158/0008-5472.CAN-09-2775. [PMID] 19920201.
2008
Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis.
PloS one. 3(2) [DOI] 10.1371/journal.pone.0001613. [PMID] 18286170.
2008
Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos.
Developmental cell. 14(4):481-93 [DOI] 10.1016/j.devcel.2008.01.018. [PMID] 18410726.
2008
RAX is required for fly neuronal development and mouse embryogenesis.
Mechanisms of development. 125(9-10):777-85 [DOI] 10.1016/j.mod.2008.06.009. [PMID] 18634873.
2007
BLISS 2.0: a web-based tool for predicting conserved regulatory modules in distantly-related orthologous sequences.
Bioinformatics (Oxford, England). 23(23):3249-50 [PMID] 17660203.
View on: PubMed
2006
BLISS: binding site level identification of shared signal-modules in DNA regulatory sequences.
BMC bioinformatics. 7 [PMID] 16756683.
View on: PubMed
2006
Expression of Pseudomonas aeruginosa toxin ExoS effectively induces apoptosis in host cells.
Infection and immunity. 74(12):6557-70 [PMID] 16966406.
View on: PubMed
2005
Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes.
EMBO reports. 6(8):769-74 [PMID] 16041319.
View on: PubMed
2005
The ‘unique key’ feature of the Iap-binding motifs in RHG proteins.
Cell death and differentiation. 12(8):1148-51 [PMID] 15905883.
View on: PubMed
2003
Distinct pathways mediate UV-induced apoptosis in Drosophila embryos.
Developmental cell. 4(4):599-605 [PMID] 12689597.
View on: PubMed
2003
JXP4BIGI: a generalized, Java XML-based approach for biological information gathering and integration.
Bioinformatics (Oxford, England). 19(18):2351-8 [PMID] 14668218.
View on: PubMed
2003
Molecular mechanisms of irradiation-induced apoptosis.
Frontiers in bioscience : a journal and virtual library. 8:d9-19 [PMID] 12456331.
View on: PubMed
2002
Drosophila sickle is a novel grim-reaper cell death activator.
Current biology : CB. 12(2):131-5 [PMID] 11818064.
View on: PubMed

Grants

Feb 2020 ACTIVE
OR-DRPD-UFLIPS-G-2019 Understanding the Functional mechanism of hAAT in Drosophila
Role: Principal Investigator
Funding: L&L BIOTECHNOLOGY
Jan 2018 ACTIVE
An Imputation-Consistency Algorithm for Biomedical Complex Data Analysis
Role: Principal Investigator
Funding: PURDUE UNIV via NATL INST OF HLTH NIGMS
Jan 2015 – Dec 2018
The regulation of cell death in vivo
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL via NATL INST OF HLTH NIGMS
Jul 2014 – Jan 2016
Seed Grant- "Integrating Omics Data with Domain Specific Knowledge for Predicting Cellular Sensitivity to Chemotherapy and Radiotherapy"
Role: Principal Investigator
Funding: *UF INFORMATICS INSTITUTE
Jan 2014 – Mar 2019
Rapid Induction of apoptosis against viral infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS

Teaching Profile

Courses Taught
2006-2013,2015-2021
GMS6014 Applications of Bioinformatics to Genetics
2014-2015,2017-2020
GMS6065 Fundamentals of Cancer Biology
2009-2010,2012-2017,2015-2021,2017-2021,2019-2021,2021
GMS6232 Advanced Applications of Bioinformatics in Genetics
2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
MCB7979 Advanced Research
2015-2017
GMS6895 CTS Journal Club
2012-2016
GMS6920 Genetics Journal Colloquy
2016
GMS6644 Apoptosis
2007
GMS6181 Spec Topics Microbiol

Contact Details

Phones:
Business:
(352) 273-8169
Emails:
Business:
leizhou@ufl.edu