Tao Zu

Tao Zu,

Research Assistant Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5847
Business Email: taozu@ufl.edu

Publications

2021
Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice.
Human molecular genetics. 29(24):3900-3918 [DOI] 10.1093/hmg/ddaa279. [PMID] 33378537.
2021
The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats.
Human molecular genetics. 30(11):1020-1029 [DOI] 10.1093/hmg/ddab098. [PMID] 33856033.
2020
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Neuron. 105(4):645-662.e11 [DOI] 10.1016/j.neuron.2019.11.007. [PMID] 31831332.
2020
Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.
Proceedings of the National Academy of Sciences of the United States of America. 117(31):18591-18599 [DOI] 10.1073/pnas.2005748117. [PMID] 32690681.
2020
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.
Neuron. 108(4):784-796.e3 [DOI] 10.1016/j.neuron.2020.09.009. [PMID] 33022226.
2018
Repeat-Associated Non-ATG Translation in Neurological Diseases.
Cold Spring Harbor perspectives in biology. 10(12) [DOI] 10.1101/cshperspect.a033019. [PMID] 29891563.
2018
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F.
The EMBO journal. 37(19) [DOI] 10.15252/embj.201899023. [PMID] 30206144.
2017
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.
Neuron. 95(6):1292-1305.e5 [DOI] 10.1016/j.neuron.2017.08.039. [PMID] 28910618.
2016
C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD.
Neuron. 90(3):521-34 [DOI] 10.1016/j.neuron.2016.04.005. [PMID] 27112499.
2015
RAN Translation in Huntington Disease.
Neuron. 88(4):667-77 [DOI] 10.1016/j.neuron.2015.10.038. [PMID] 26590344.
2014
Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion.
Neurobiology of aging. 35(10):2419.e17-21 [DOI] 10.1016/j.neurobiolaging.2014.04.009. [PMID] 24819148.
2014
Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(30):9891-904 [DOI] 10.1523/JNEUROSCI.0876-14.2014. [PMID] 25057192.
2013
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.
Proceedings of the National Academy of Sciences of the United States of America. 110(51):E4968-77 [DOI] 10.1073/pnas.1315438110. [PMID] 24248382.
2011
Non-Atg-Initiated Translation Directed By Microsatellite Expansions
Proceedings of the National Academy of Sciences. 108(1):260-265 [DOI] 10.1073/pnas.1013343108. [PMID] 21173221.
2008
Antisense RNA sequences modulating the ataxin-1 message: molecular model of gene therapy for spinocerebellar ataxia type 1, a dominant-acting unstable trinucleotide repeat disease.
Cell transplantation. 17(7):723-34 [PMID] 19044200.
View on: PubMed
2008
The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7.
Proceedings of the National Academy of Sciences of the United States of America. 105(4):1291-6 [DOI] 10.1073/pnas.0711257105. [PMID] 18216249.
2006
Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.
Nature genetics. 38(7):758-69 [PMID] 16804541.
View on: PubMed
2006
RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Cell. 127(4):697-708 [PMID] 17110330.
View on: PubMed
2006
Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(39):9975-82 [PMID] 17005861.
View on: PubMed
2004
Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(40):8853-61 [PMID] 15470152.
View on: PubMed
2003
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Neuron. 38(3):375-87 [PMID] 12741986.
View on: PubMed

Patents

Published March 2014
Use and Treatment of Di-Amino Acid Repeat-Containing Proteins Associated with ALS
#US2016-0025747-A1

Contact Details

Phones:
Business:
(352) 273-5847
Emails:
Business:
taozu@ufl.edu