The Renne Lab has recently contributed two significant new publications that advance our understanding of gamma herpesvirus biology and mechanisms of viral persistence. These studies highlight important insights into viral transcriptomes and introduce promising approaches for disrupting viral latency.
New Publications
Cross-Species Insights Into Gamma Herpesvirus Transcriptomes: Long-Read and Multi-Omics Perspectives
This publication provides a comprehensive look at gamma herpesvirus transcriptomes using state-of-the-art long-read and multi‑omics technologies. The findings deepen our molecular understanding of how these viruses operate across different species.
Targeted Protein Degradation of the Latency-Associated Nuclear Antigen Evicts Kaposi Sarcoma-Associated Herpesvirus Episomes From Infected Cells In Vitro
This study explores a targeted protein degradation strategy capable of removing KSHV episomes from infected cells. The work offers a potential framework for therapeutic disruption of herpesvirus latency.