Chulbul M Ahmed,
Research Assistant Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-5070
Business Email:
ahmed1@ufl.edu
Publications
2024
Corneal application of SOCS1/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1416181.
[PMID] 39104531.
2023
Binocular benefit following monocular subretinal AAV injection in a mouse model of autosomal dominant retinitis pigmentosa (adRP).
Vision research.
206
[DOI] 10.1016/j.visres.2023.108189.
[PMID] 36773475.
2023
Disparate viral pandemics from COVID19 to monkeypox and beyond: a simple, effective and universal therapeutic approach hiding in plain sight.
Frontiers in immunology.
14
[DOI] 10.3389/fimmu.2023.1208828.
[PMID] 38106428.
2023
Suppressor of cytokine signaling 3-derived peptide as a therapeutic for inflammatory and oxidative stress-induced damage to the retina.
Molecular vision.
29:338-356
[PMID] 38264613.
2022
Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides.
Frontiers in immunology.
13
[DOI] 10.3389/fimmu.2022.902956.
[PMID] 35799776.
2021
Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis.
Translational vision science & technology.
10(3)
[DOI] 10.1167/tvst.10.3.25.
[PMID] 34003962.
2020
A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis.
PloS one.
15(2)
[DOI] 10.1371/journal.pone.0227524.
[PMID] 32101556.
2020
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.582102.
[PMID] 33193390.
2019
AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis.
Journal of clinical medicine.
8(12)
[DOI] 10.3390/jcm8122082.
[PMID] 31795515.
2019
Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase.
Mediators of inflammation.
2019
[DOI] 10.1155/2019/4143604.
[PMID] 31275057.
2019
SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa.
Translational vision science & technology.
8(6)
[DOI] 10.1167/tvst.8.6.30.
[PMID] 31857914.
2018
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis.
Experimental eye research.
177:12-22
[DOI] 10.1016/j.exer.2018.07.020.
[PMID] 30048621.
2018
Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview.
Advances in experimental medicine and biology.
1074:185-191
[DOI] 10.1007/978-3-319-75402-4_23.
[PMID] 29721943.
2016
Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events.
Mediators of inflammation.
2016
[DOI] 10.1155/2016/9564814.
[PMID] 28077919.
2016
Repurposing an orally available drug for the treatment of geographic atrophy.
Molecular vision.
22:294-310
[PMID] 27110092.
2016
Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide.
Investigative ophthalmology & visual science.
57(2):372-86
[DOI] 10.1167/iovs.15-17703.
[PMID] 26842755.
2016
The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration.
Advances in experimental medicine and biology.
854:59-65
[DOI] 10.1007/978-3-319-17121-0_9.
[PMID] 26427394.
2015
A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00574.
[PMID] 26617608.
2015
SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00183.
[PMID] 25954276.
2015
Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress.
Experimental eye research.
140:94-105
[DOI] 10.1016/j.exer.2015.07.022.
[PMID] 26315784.
2014
Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
34(10):802-9
[DOI] 10.1089/jir.2014.0041.
[PMID] 24811478.
2014
Type I interferon mimetics bypass vaccinia virus decoy receptor virulence factor for protection of mice against lethal infection.
Clinical and vaccine immunology : CVI.
21(8):1178-84
[DOI] 10.1128/CVI.00204-14.
[PMID] 24964806.
2013
IFN signaling: how a non-canonical model led to the development of IFN mimetics.
Frontiers in immunology.
4
[DOI] 10.3389/fimmu.2013.00202.
[PMID] 23898330.
2013
Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells.
Frontiers in immunology.
4
[DOI] 10.3389/fimmu.2013.00469.
[PMID] 24391643.
2013
The role of a non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis: An example of Occam’s Broom?
JAK-STAT.
2(4)
[DOI] 10.4161/jkst.26227.
[PMID] 24416655.
2013
Type I IFN receptor controls activated TYK2 in the nucleus: implications for EAE therapy.
Journal of neuroimmunology.
254(1-2):101-9
[DOI] 10.1016/j.jneuroim.2012.10.006.
[PMID] 23110939.
2012
Steroid-like signalling by interferons: making sense of specific gene activation by cytokines.
The Biochemical journal.
443(2):329-38
[DOI] 10.1042/BJ20112187.
[PMID] 22452815.
2011
Controlling Nuclear Jaks and Stats for Specific Gene Activation by Ifn γ and Other Cytokines: A Possible Steroid-like Connection.
Journal of clinical & cellular immunology.
2(4)
[PMID] 22924155.
2011
Controlling nuclear JAKs and STATs for specific gene activation by IFNγ.
Biochemical and biophysical research communications.
410(3):648-53
[DOI] 10.1016/j.bbrc.2011.06.047.
[PMID] 21689637.
2011
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.
Journal of neuroimmunology.
232(1-2):108-18
[DOI] 10.1016/j.jneuroim.2010.10.018.
[PMID] 21131060.
2010
Enhancement of antiviral immunity by small molecule antagonist of suppressor of cytokine signaling.
Journal of immunology (Baltimore, Md. : 1950).
185(2):1103-13
[DOI] 10.4049/jimmunol.0902895.
[PMID] 20543109.
2009
HSV-1-induced SOCS-1 expression in keratinocytes: use of a SOCS-1 antagonist to block a novel mechanism of viral immune evasion.
Journal of immunology (Baltimore, Md. : 1950).
183(2):1253-62
[DOI] 10.4049/jimmunol.0900570.
[PMID] 19542368.
2009
SOCS-1 mimetics protect mice against lethal poxvirus infection: identification of a novel endogenous antiviral system.
Journal of virology.
83(3):1402-15
[DOI] 10.1128/JVI.01138-08.
[PMID] 19019946.
2008
Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic.
FEBS letters.
582(11):1569-74
[DOI] 10.1016/j.febslet.2008.03.054.
[PMID] 18405666.
2007
Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist.
Journal of immunology (Baltimore, Md. : 1950).
178(8):5058-68
[PMID] 17404288.
2007
IFN mimetic as a therapeutic for lethal vaccinia virus infection: possible effects on innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950).
178(7):4576-83
[PMID] 17372016.
2006
Gamma interferon signaling: insights to development of interferon mimetics.
Cellular and molecular biology (Noisy-le-Grand, France).
52(1):71-6
[PMID] 16914098.
2006
IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1.
Journal of immunology (Baltimore, Md. : 1950).
177(1):315-21
[PMID] 16785527.
2006
The gamma interferon (IFN-gamma) mimetic peptide IFN-gamma (95-133) prevents encephalomyocarditis virus infection both in tissue culture and in mice.
Clinical and vaccine immunology : CVI.
13(8):944-52
[PMID] 16893996.
2005
Peptide mimetics of gamma interferon possess antiviral properties against vaccinia virus and other viruses in the presence of poxvirus B8R protein.
Journal of virology.
79(9):5632-9
[PMID] 15827178.
2005
Recombinant adenovirus-p21 attenuates proliferative responses associated with excessive scarring.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
13(5):480-90
[PMID] 16176456.
2004
Cancer gene therapy based on the abstracts of the 2003 ASCO meeting and recent publications.
Drugs of today (Barcelona, Spain : 1998).
40(8):723-31
[PMID] 15510243.
2003
Interferon gene therapy for the treatment of cancer and viral infections.
Drugs of today (Barcelona, Spain : 1998).
39(10):763-6
[PMID] 14668931.
2003
The role of IFNgamma nuclear localization sequence in intracellular function.
Journal of cell science.
116(Pt 15):3089-98
[PMID] 12799413.
2002
Interferon-alpha2b secretion by adenovirus-mediated gene delivery in rat, rabbit, and chimpanzee results in similar pharmacokinetic profiles.
Toxicology and applied pharmacology.
180(1):36-42
[PMID] 11922775.
2001
Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy.
Proceedings of the National Academy of Sciences of the United States of America.
98(1):277-82
[PMID] 11134537.
2001
Interferon alpha2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers.
Cancer gene therapy.
8(10):788-95
[PMID] 11687902.
2001
Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
21(6):399-408
[PMID] 11440637.
1999
In vivo tumor suppression by adenovirus-mediated interferon alpha2b gene delivery.
Human gene therapy.
10(1):77-84
[PMID] 10022532.
Education
Ph.D.
1981
·
Indian Inst Sci, Bangalore, India
Contact Details
Phones:
- Business:
- (352) 273-5070
Emails:
- Business:
- ahmed1@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100266
GAINESVILLE FL 32610 - Business Street:
-
1200 NEWELL DRIVE, R1-281
GAINESVILLE FL 32610