Sumita Bhaduri-McIntosh, M.D., Ph.D.
Professor, Pediatric Infectious Diseases
Department:
MD-PEDS-INFECTIOUS DISEASES
Business Phone:
(352) 294-8591
Business Email:
sbhaduri@peds.ufl.edu
Teaching Profile
Courses Taught
2024
PHY6910 Supervised Research
2024
PHY7980 Research for Doctoral Dissertation
2024
PHY6905 Individual Work
2024-2025
PHY7979 Advanced Research
Board Certifications
-
Pediatric Infectious DiseasesAmerican Board of Pediatrics
Clinical Profile
Infectious Diseases, Immunodeficiency-associated cancers (transplant-related, HIV-related), Viral cancers, Infectious Mononucleosis
Specialties
- Pediatric Infectious Disease
Areas of Interest
- Congenital cytomegalovirus
- Congenital syphilis
- Congenital toxoplasmosis
- Ear infection – chronic
- HIV/AIDS
- Herpes – oral
- Nontuberculous Mycobacteria
- Swollen lymph nodes
- Traveling with Children
Research Profile
We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.
Open Researcher and Contributor ID (ORCID)
0000-0003-2946-9497
Publications
Academic Articles
2024
KAP1/TRIM28 – antiviral and proviral protagonist of herpesvirus biology.
Trends in microbiology.
32(12):1179-1189
[DOI] 10.1016/j.tim.2024.05.007.
[PMID] 38871562.
2024
Polymerase theta is a synthetic lethal target for killing Epstein-Barr virus lymphomas
Journal of Virology.
98(7)
[DOI] 10.1128/jvi.00572-24.
[PMID] 38860782.
2023
ATM, KAP1 and the Epstein–Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication
Nucleic Acids Research.
51(20):11104-11122
[DOI] 10.1093/nar/gkad823.
[PMID] 37852757.
2023
Beta human papillomavirus 8E6 promotes alternative end joining.
eLife.
12
[DOI] 10.7554/eLife.81923.
[PMID] 36692284.
2023
Inflammation and Epstein–Barr Virus at the Crossroads of Multiple Sclerosis and Post-Acute Sequelae of COVID-19 Infection
Viruses.
15(4)
[DOI] 10.3390/v15040949.
[PMID] 37112929.
2023
Is Kawasaki Disease Caused by a Respiratory Virus?
The Pediatric infectious disease journal.
42(6):468-472
[DOI] 10.1097/INF.0000000000003889.
[PMID] 37171979.
2023
Virology under the Microscope—a Call for Rational Discourse
Journal of Virology.
97(2)
[DOI] 10.1128/jvi.00089-23.
[PMID] 36700640.
2023
Virology under the Microscope—a Call for Rational Discourse
mBio.
14(1)
[DOI] 10.1128/mbio.00188-23.
[PMID] 36700642.
2023
Virology under the Microscope—a Call for Rational Discourse
mSphere.
8(2)
[DOI] 10.1128/msphere.00034-23.
[PMID] 36700653.
2022
DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks
Clinical Cancer Research.
28(4):756-769
[DOI] 10.1158/1078-0432.ccr-21-2863.
2022
IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency
Journal of Virology.
96(17)
[DOI] 10.1128/jvi.01028-22.
[PMID] 35969079.
2022
SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway
Virology.
568:13-22
[DOI] 10.1016/j.virol.2022.01.003.
[PMID] 35066302.
2022
The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells
Virology.
566:136-142
[DOI] 10.1016/j.virol.2021.12.002.
2021
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.
Blood.
138(26):2838-2852
[DOI] 10.1182/blood.2021011707.
[PMID] 34255814.
2021
A heterochromatin inducing protein differentially recognizes self versus foreign genomes
PLOS Pathogens.
17(3)
[DOI] 10.1371/journal.ppat.1009447.
[PMID] 33730092.
2021
An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles.
Frontiers in microbiology.
12
[DOI] 10.3389/fmicb.2021.708404.
[PMID] 34434177.
2021
Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus
Viruses.
13(5)
[DOI] 10.3390/v13050846.
[PMID] 34066537.
2021
Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency
Journal of Virology.
95(13)
[DOI] 10.1128/jvi.02466-20.
2020
A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents
Journal of Virology.
94(21)
[DOI] 10.1128/jvi.01179-20.
2020
A promiscuous inflammasome sparks replication of a common tumor virus
Proceedings of the National Academy of Sciences.
117(3):1722-1730
[DOI] 10.1073/pnas.1919133117.
[PMID] 31919284.
2020
Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus.
Journal of virology.
94(7)
[DOI] 10.1128/JVI.01966-19.
[PMID] 31941784.
2020
Post Transplant Lymphoproliferative Disorder risk factors in children: Analysis of a 23-year single-institutional experience.
Pediatric transplantation.
24(5)
[DOI] 10.1111/petr.13747.
[PMID] 32497335.
2020
Selective Targeting of Virus Replication by Proton Pump Inhibitors.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-60544-y.
[PMID] 32132561.
2020
STAT3 activates the anti-apoptotic form of caspase 9 in oncovirus-infected B lymphocytes.
Virology.
540:160-164
[DOI] 10.1016/j.virol.2019.11.017.
[PMID] 31928997.
2020
STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes
PLOS Pathogens.
16(10)
[DOI] 10.1371/journal.ppat.1008849.
[PMID] 33002095.
2019
Evolutionary effects of the AID/APOBEC family of mutagenic enzymes on human gamma-herpesviruses.
Virus evolution.
5(1)
[DOI] 10.1093/ve/vey040.
[PMID] 30792902.
2019
Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes
PLOS Pathogens.
15(12)
[DOI] 10.1371/journal.ppat.1008228.
[PMID] 31841561.
2019
Retrograde Regulation by the Viral Protein Kinase Epigenetically Sustains the Epstein-Barr Virus Latency-to-Lytic Switch To Augment Virus Production.
Journal of virology.
93(17)
[DOI] 10.1128/JVI.00572-19.
[PMID] 31189703.
2018
KRAB-ZFP Repressors Enforce Quiescence of Oncogenic Human Herpesviruses.
Journal of virology.
92(14)
[DOI] 10.1128/JVI.00298-18.
[PMID] 29695433.
2017
Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells
PLOS Pathogens.
13(3)
[DOI] 10.1371/journal.ppat.1006249.
[PMID] 28249048.
2017
Engineering Structurally Interacting RNA (sxRNA).
Scientific reports.
7
[DOI] 10.1038/srep45393.
[PMID] 28350000.
2016
A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases.
Frontiers in microbiology.
7
[DOI] 10.3389/fmicb.2016.01052.
[PMID] 27458446.
2016
Anti-TNFα therapy for inflammatory bowel diseases is associated with Epstein-Barr virus lytic activation.
Journal of medical virology.
88(2):312-8
[DOI] 10.1002/jmv.24331.
[PMID] 26307954.
2015
Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes.
Journal of virology.
89(9):5002-11
[DOI] 10.1128/JVI.00121-15.
[PMID] 25717101.
2015
STAT3 Regulates Lytic Activation of Kaposi’s Sarcoma-Associated Herpesvirus.
Journal of virology.
89(22):11347-55
[DOI] 10.1128/JVI.02008-15.
[PMID] 26339061.
2014
B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferation.
Journal of virology.
88(1):516-24
[DOI] 10.1128/JVI.02601-13.
[PMID] 24173212.
2014
Human B cell immortalization for monoclonal antibody production.
Methods in molecular biology (Clifton, N.J.).
1131:183-9
[DOI] 10.1007/978-1-62703-992-5_11.
[PMID] 24515466.
2014
Serum IgA to Epstein-Barr virus early antigen-diffuse identifies Hodgkin’s lymphoma.
Journal of medical virology.
86(9):1621-8
[DOI] 10.1002/jmv.23761.
[PMID] 24122847.
2014
STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America.
111(13):4946-51
[DOI] 10.1073/pnas.1400683111.
[PMID] 24639502.
2013
Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.
Journal of virology.
87(21):11438-46
[DOI] 10.1128/JVI.01762-13.
[PMID] 23966384.
2011
Establishment of Epstein-Barr virus growth-transformed lymphoblastoid cell lines.
Journal of visualized experiments : JoVE.
(57)
[DOI] 10.3791/3321.
[PMID] 22090023.
2011
Identification of a sub-population of B cells that proliferates after infection with Epstein-Barr virus.
Virology journal.
8
[DOI] 10.1186/1743-422X-8-84.
[PMID] 21352549.
2010
Upregulation of STAT3 marks Burkitt lymphoma cells refractory to Epstein-Barr virus lytic cycle induction by HDAC inhibitors.
Journal of virology.
84(2):993-1004
[DOI] 10.1128/JVI.01745-09.
[PMID] 19889776.
2009
Stimulus duration and response time independently influence the kinetics of lytic cycle reactivation of Epstein-Barr virus.
Journal of virology.
83(20):10694-709
[DOI] 10.1128/JVI.01172-09.
[PMID] 19656890.
2008
Epstein-Barr virus-mediated dysregulation of human microRNA expression.
Cell cycle (Georgetown, Tex.).
7(22):3595-600
[PMID] 19001862.
2008
Repertoire and frequency of immune cells reactive to Epstein-Barr virus-derived autologous lymphoblastoid cell lines.
Blood.
111(3):1334-43
[PMID] 17942757.
2007
Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection.
The Journal of infectious diseases.
195(4):483-92
[PMID] 17230407.
2006
Cells lytically infected with Epstein-Barr virus are detected and separable by immunoglobulins from EBV-seropositive individuals.
Journal of virological methods.
137(1):103-14
[PMID] 16843536.
2006
Purulent pericarditis caused by group a streptococcus.
Texas Heart Institute journal.
33(4):519-22
[PMID] 17215986.
2005
Human herpesvirus-8: clinical features of an emerging viral pathogen.
The Pediatric infectious disease journal.
24(1):81-2
[PMID] 15665715.
1998
Plasmodium falciparum: import of a phosphate carrier protein into heterologous mitochondria.
Experimental parasitology.
88(3):252-4
[PMID] 9562431.
1996
Molecular characterization of a Plasmodium falciparum gene encoding the mitochondrial phosphate carrier.
Molecular and biochemical parasitology.
78(1-2):297-301
[PMID] 8813702.
Grants
Sep 2023
ACTIVE
Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2023
– Jun 2024
Lytic Induction Project
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Sep 2022
ACTIVE
Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Mar 2022
– Aug 2022
Studying the capacity of the EBV protein kinase (BGLF4) plus ganciclovir vs acyclovir to induce cell killing in non-EBV infected A549 cells.
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Dec 2021
– Dec 2021
Studying the capacity of the EBV protein kinase (BGLF4) plus ganciclovir to induce cell killing in non-EBV infected 293 cells.
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Nov 2021
– Sep 2022
Nanotinostat and ganciclovir in an oncolytic strategy against EBV-lymphomas
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Sep 2021
– Sep 2023
Epstein-Barr virus and B-cell co-opted functions of the endogenous retrovirus envelope protein, Syncytin-1
Role: Other
Funding: NATL INST OF HLTH NIDCR
Dec 2017
– Apr 2020
Host determinants of Epstein-Barr virus lytic cycle activation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Contact Details
Phones:
- Business:
- (352) 294-8591
Emails:
- Business:
- sbhaduri@peds.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100296
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610