Sumita Bhaduri-McIntosh

Sumita Bhaduri-McIntosh, M.D., Ph.D.

Professor, Pediatric Infectious Diseases

Department: MD-PEDS-INFECTIOUS DISEASES
Business Phone: (352) 294-8591
Business Email: sbhaduri@peds.ufl.edu

Teaching Profile

Courses Taught
2024
PHY6910 Supervised Research
2024
PHY7980 Research for Doctoral Dissertation
2024
PHY6905 Individual Work
2024
PHY7979 Advanced Research

Board Certifications

  • Pediatric Infectious Diseases
    American Board of Pediatrics

Clinical Profile

Specialties
  • Pediatric Infectious Disease
Areas of Interest
  • Congenital cytomegalovirus
  • Congenital syphilis
  • Congenital toxoplasmosis
  • Ear infection – chronic
  • HIV/AIDS
  • Herpes – oral
  • Nontuberculous Mycobacteria
  • Swollen lymph nodes
  • Traveling with children

Research Profile

We study Epstein-Barr virus (EBV), the first human cancer-causing virus to be discovered. EBV causes infectious mononucleosis and is causal or linked to several B lymphocyte- and epithelial cell-cancers. Some of our experiments are designed to explore how EBV disturbs and exploits cellular physiology to drive unscheduled cell proliferation, a central feature of cancer. Other experiments are directed at understanding how this virus persists successfully in over 95% of humans. Both lines of investigation have revealed several targets for anti-cancer and anti-viral intervention.

Open Researcher and Contributor ID (ORCID)

0000-0003-2946-9497

Publications

2023
ATM, KAP1 and the Epstein–Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication
Nucleic Acids Research. 51(20):11104-11122 [DOI] 10.1093/nar/gkad823. [PMID] 37852757.
2023
Beta human papillomavirus 8E6 promotes alternative end joining.
eLife. 12 [DOI] 10.7554/eLife.81923. [PMID] 36692284.
2023
Inflammation and Epstein–Barr Virus at the Crossroads of Multiple Sclerosis and Post-Acute Sequelae of COVID-19 Infection
Viruses. 15(4) [DOI] 10.3390/v15040949. [PMID] 37112929.
2023
Is Kawasaki Disease Caused by a Respiratory Virus?
The Pediatric infectious disease journal. 42(6):468-472 [DOI] 10.1097/INF.0000000000003889. [PMID] 37171979.
2023
Virology under the Microscope—a Call for Rational Discourse
mSphere. 8(2) [DOI] 10.1128/msphere.00034-23. [PMID] 36700653.
2023
Virology under the Microscope—a Call for Rational Discourse
mBio. 14(1) [DOI] 10.1128/mbio.00188-23. [PMID] 36700642.
2023
Virology under the Microscope—a Call for Rational Discourse
Journal of Virology. 97(2) [DOI] 10.1128/jvi.00089-23. [PMID] 36700640.
2022
DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks
Clinical Cancer Research. 28(4):756-769 [DOI] 10.1158/1078-0432.ccr-21-2863.
2022
IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency
Journal of Virology. 96(17) [DOI] 10.1128/jvi.01028-22. [PMID] 35969079.
2022
SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway
Virology. 568:13-22 [DOI] 10.1016/j.virol.2022.01.003. [PMID] 35066302.
2022
The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells
Virology. 566:136-142 [DOI] 10.1016/j.virol.2021.12.002.
2021
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.
Blood. 138(26):2838-2852 [DOI] 10.1182/blood.2021011707. [PMID] 34255814.
2021
A heterochromatin inducing protein differentially recognizes self versus foreign genomes
PLOS Pathogens. 17(3) [DOI] 10.1371/journal.ppat.1009447. [PMID] 33730092.
2021
An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles.
Frontiers in microbiology. 12 [DOI] 10.3389/fmicb.2021.708404. [PMID] 34434177.
2021
Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus
Viruses. 13(5) [DOI] 10.3390/v13050846. [PMID] 34066537.
2021
Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency
Journal of Virology. 95(13) [DOI] 10.1128/jvi.02466-20.
2020
A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents
Journal of Virology. 94(21) [DOI] 10.1128/jvi.01179-20.
2020
A promiscuous inflammasome sparks replication of a common tumor virus
Proceedings of the National Academy of Sciences. 117(3):1722-1730 [DOI] 10.1073/pnas.1919133117. [PMID] 31919284.
2020
Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus.
Journal of virology. 94(7) [DOI] 10.1128/JVI.01966-19. [PMID] 31941784.
2020
Post Transplant Lymphoproliferative Disorder risk factors in children: Analysis of a 23-year single-institutional experience.
Pediatric transplantation. 24(5) [DOI] 10.1111/petr.13747. [PMID] 32497335.
2020
Selective Targeting of Virus Replication by Proton Pump Inhibitors.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-60544-y. [PMID] 32132561.
2020
STAT3 activates the anti-apoptotic form of caspase 9 in oncovirus-infected B lymphocytes.
Virology. 540:160-164 [DOI] 10.1016/j.virol.2019.11.017. [PMID] 31928997.
2020
STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes
PLOS Pathogens. 16(10) [DOI] 10.1371/journal.ppat.1008849. [PMID] 33002095.
2019
Evolutionary effects of the AID/APOBEC family of mutagenic enzymes on human gamma-herpesviruses.
Virus evolution. 5(1) [DOI] 10.1093/ve/vey040. [PMID] 30792902.
2019
Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes
PLOS Pathogens. 15(12) [DOI] 10.1371/journal.ppat.1008228. [PMID] 31841561.
2019
Retrograde Regulation by the Viral Protein Kinase Epigenetically Sustains the Epstein-Barr Virus Latency-to-Lytic Switch To Augment Virus Production.
Journal of virology. 93(17) [DOI] 10.1128/JVI.00572-19. [PMID] 31189703.
2018
KRAB-ZFP Repressors Enforce Quiescence of Oncogenic Human Herpesviruses.
Journal of virology. 92(14) [DOI] 10.1128/JVI.00298-18. [PMID] 29695433.
2017
Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells
PLOS Pathogens. 13(3) [DOI] 10.1371/journal.ppat.1006249. [PMID] 28249048.
2017
Engineering Structurally Interacting RNA (sxRNA).
Scientific reports. 7 [DOI] 10.1038/srep45393. [PMID] 28350000.
2016
A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases.
Frontiers in microbiology. 7 [DOI] 10.3389/fmicb.2016.01052. [PMID] 27458446.
2016
Anti-TNFα therapy for inflammatory bowel diseases is associated with Epstein-Barr virus lytic activation.
Journal of medical virology. 88(2):312-8 [DOI] 10.1002/jmv.24331. [PMID] 26307954.
2015
Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes.
Journal of virology. 89(9):5002-11 [DOI] 10.1128/JVI.00121-15. [PMID] 25717101.
2015
STAT3 Regulates Lytic Activation of Kaposi’s Sarcoma-Associated Herpesvirus.
Journal of virology. 89(22):11347-55 [DOI] 10.1128/JVI.02008-15. [PMID] 26339061.
2014
B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferation.
Journal of virology. 88(1):516-24 [DOI] 10.1128/JVI.02601-13. [PMID] 24173212.
2014
Human B cell immortalization for monoclonal antibody production.
Methods in molecular biology (Clifton, N.J.). 1131:183-9 [DOI] 10.1007/978-1-62703-992-5_11. [PMID] 24515466.
2014
Serum IgA to Epstein-Barr virus early antigen-diffuse identifies Hodgkin’s lymphoma.
Journal of medical virology. 86(9):1621-8 [DOI] 10.1002/jmv.23761. [PMID] 24122847.
2014
STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America. 111(13):4946-51 [DOI] 10.1073/pnas.1400683111. [PMID] 24639502.
2013
Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes.
Journal of virology. 87(21):11438-46 [DOI] 10.1128/JVI.01762-13. [PMID] 23966384.
2011
Establishment of Epstein-Barr virus growth-transformed lymphoblastoid cell lines.
Journal of visualized experiments : JoVE. (57) [DOI] 10.3791/3321. [PMID] 22090023.
2011
Identification of a sub-population of B cells that proliferates after infection with Epstein-Barr virus.
Virology journal. 8 [DOI] 10.1186/1743-422X-8-84. [PMID] 21352549.
2010
Upregulation of STAT3 marks Burkitt lymphoma cells refractory to Epstein-Barr virus lytic cycle induction by HDAC inhibitors.
Journal of virology. 84(2):993-1004 [DOI] 10.1128/JVI.01745-09. [PMID] 19889776.
2009
Stimulus duration and response time independently influence the kinetics of lytic cycle reactivation of Epstein-Barr virus.
Journal of virology. 83(20):10694-709 [DOI] 10.1128/JVI.01172-09. [PMID] 19656890.
2008
Epstein-Barr virus-mediated dysregulation of human microRNA expression.
Cell cycle (Georgetown, Tex.). 7(22):3595-600 [PMID] 19001862.
2008
Repertoire and frequency of immune cells reactive to Epstein-Barr virus-derived autologous lymphoblastoid cell lines.
Blood. 111(3):1334-43 [PMID] 17942757.
2007
Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection.
The Journal of infectious diseases. 195(4):483-92 [PMID] 17230407.
2006
Cells lytically infected with Epstein-Barr virus are detected and separable by immunoglobulins from EBV-seropositive individuals.
Journal of virological methods. 137(1):103-14 [PMID] 16843536.
2006
Purulent pericarditis caused by group a streptococcus.
Texas Heart Institute journal. 33(4):519-22 [PMID] 17215986.
2005
Human herpesvirus-8: clinical features of an emerging viral pathogen.
The Pediatric infectious disease journal. 24(1):81-2 [PMID] 15665715.
1998
Plasmodium falciparum: import of a phosphate carrier protein into heterologous mitochondria.
Experimental parasitology. 88(3):252-4 [PMID] 9562431.
1996
Molecular characterization of a Plasmodium falciparum gene encoding the mitochondrial phosphate carrier.
Molecular and biochemical parasitology. 78(1-2):297-301 [PMID] 8813702.

Grants

Sep 2023 ACTIVE
Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2023 ACTIVE
Lytic Induction Project
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Sep 2022 ACTIVE
Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Mar 2022 – Aug 2022
Studying the capacity of the EBV protein kinase (BGLF4) plus ganciclovir vs acyclovir to induce cell killing in non-EBV infected A549 cells.
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Dec 2021 – Dec 2021
Studying the capacity of the EBV protein kinase (BGLF4) plus ganciclovir to induce cell killing in non-EBV infected 293 cells.
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Nov 2021 – Sep 2022
Nanotinostat and ganciclovir in an oncolytic strategy against EBV-lymphomas
Role: Principal Investigator
Funding: VIRACTA THERAPEUTICS
Sep 2021 – Sep 2023
Epstein-Barr virus and B-cell co-opted functions of the endogenous retrovirus envelope protein, Syncytin-1
Role: Other
Funding: NATL INST OF HLTH NIDCR
Dec 2017 – Apr 2020
Host determinants of Epstein-Barr virus lytic cycle activation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID

Contact Details

Phones:
Business:
(352) 294-8591
Emails:
Addresses:
Business Mailing:
PO Box 100296
GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER RD
GAINESVILLE FL 32610