Steeve Boulant

Steeve Boulant,

Associate Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-7534
Business Email: s.boulant@ufl.edu

About Steeve Boulant

Fun Fact: I speak English and French and used to be a chef in a restaurant in Lyon, France. We study how the intestinal epithelium combats enteric pathogens. We believe that to gain a comprehensive understanding of the molecular mechanisms regulating gut homeostasis (finely tuned balance between response against enteric pathogens vs. tolerance of commensals), an integrative system approach needs to be implemented and exploited. To achieve this, we combine stem cell biology, virology, genomics, bioengineering, and cell biology to dissect host-pathogen interactions at the intestinal mucosa surface. Our long-term goal is to develop technologies and cross-disciplinary pipelines to tailor pharmacological interventions to both the host (patient specific, cell type specific, or pathology specific) and the pathogen (norovirus, coronavirus, rotavirus, astrovirus). Our work satellites around three axes: impact of the gut specific microenvironment on host-pathogen interactions, single-cell approach to define host-enteric pathogen interactions in tissue and tissue-like environments, and molecular definition of cellular polarity and its impact on intestinal epithelium functions and host-pathogen interactions.

Accomplishments

Heisenberg fellowship
2020 · DFG (German research foundation)
Loefler Frosch price for promising virologist
2019 · German Society of Virology

Teaching Profile

Courses Taught
2022-2024
GMS7191 Research Conference
2024
GMS6035 Advanced Virology II: RNA Viruses
2024
GMS6034 Advanced Virology I: Genetics and RNA

Research Profile

We study how enteric viral pathogens (rotavirus, norovirus, astrovirus…) infect and replicate in the human gastro-intestinal tract. We aim at defining how host/enteric pathogen interactions is coordinated at the molecular level in space and time and how these complex interactions can either lead to pathology development or resolution of viral infection. Our goal is to exploit these mechanisms to develop novel antiviral therapeutic approaches and pharmacological interventions to treat inflammatory bowel diseases. We use a multidisciplinary approach combining molecular and cellular biology, state-of-the-art live single molecule imaging, bio-engineering (to simulate the physiological microenvironment) and single cell transcriptomic approaches. Our integrative research approach allows us to address within a tissue how individual cell types communicate together to coordinate different antiviral strategies to ultimately lead to viral clearance while maintaining tissue homeostasis.

See more at: https://www.boulantlab.com/

Open Researcher and Contributor ID (ORCID)

0000-0001-8614-4993

Areas of Interest
  • enteric virus, immune response, interferon, Organ-on-a-chip, single cell sequencing, hypoxia microenvironment, organoids

Publications

2024
Differential signaling by type-I and type-III interferons in mucosa
Current Opinion in Immunology. 86 [DOI] 10.1016/j.coi.2023.102400.
2024
Glucosylceramide in bunyavirus particles is essential for virus binding to host cells.
Cellular and molecular life sciences : CMLS. 81(1) [DOI] 10.1007/s00018-023-05103-0. [PMID] 38300320.
2024
The population context is a driver of the heterogeneous response of epithelial cells to interferons
Molecular Systems Biology. 20(3):242-275 [DOI] 10.1038/s44320-024-00011-2. [PMID] 38273161.
2023
Extended methods for spatial cell classification with DBSCAN-CellX.
Scientific reports. 13(1) [DOI] 10.1038/s41598-023-45190-4. [PMID] 37914751.
2023
Hypoxia and HIF-1α promote lytic de novo KSHV infection
Journal of Virology. 97(11) [DOI] 10.1128/jvi.00972-23. [PMID] 37909728.
2023
Regionalization of the antiviral response in the gastrointestinal tract to provide spatially controlled host/pathogen interactions
mBio. [DOI] 10.1128/mbio.02791-22. [PMID] 37260237.
2023
Transcriptomics-inferred dynamics of SARS-CoV-2 interactions with host epithelial cells
Science Signaling. 16(804) [DOI] 10.1126/scisignal.abl8266.
2023
Virology under the Microscope—a Call for Rational Discourse
Journal of Virology. 97(2) [DOI] 10.1128/jvi.00089-23. [PMID] 36700640.
2023
Virology under the Microscope—a Call for Rational Discourse
mBio. 14(1) [DOI] 10.1128/mbio.00188-23. [PMID] 36700642.
2023
Virology under the Microscope—a Call for Rational Discourse
mSphere. 8(2) [DOI] 10.1128/msphere.00034-23. [PMID] 36700653.
2022
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells.
Cell metabolism. 34(6):857-873.e9 [DOI] 10.1016/j.cmet.2022.04.009. [PMID] 35561674.
2022
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.
Cell. 185(13):2354-2369.e17 [DOI] 10.1016/j.cell.2022.04.028. [PMID] 35568036.
2022
A Model for Network-Based Identification and Pharmacological Targeting of Aberrant, Replication-Permissive Transcriptional Programs Induced by Viral Infection.
Research square. [DOI] 10.21203/rs.3.rs-1287631/v1. [PMID] 35132404.
2022
A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection.
Communications biology. 5(1) [DOI] 10.1038/s42003-022-03663-8. [PMID] 35854100.
2022
Author Correction: Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection.
Nature communications. 13(1) [DOI] 10.1038/s41467-022-31290-8. [PMID] 35750667.
2022
Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense.
Frontiers in immunology. 13 [DOI] 10.3389/fimmu.2022.1030812. [PMID] 36189214.
2022
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors
Molecular Therapy. 30(5):2005-2023 [DOI] 10.1016/j.ymthe.2022.01.024. [PMID] 35038579.
2022
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.
Nature genetics. 54(8):1103-1116 [DOI] 10.1038/s41588-022-01113-z. [PMID] 35835913.
2022
Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells
Journal of Virology. 96(7) [DOI] 10.1128/jvi.01705-21. [PMID] 35262371.
2022
Mapping the epithelial-immune cell interactome upon infection in the gut and the upper airways.
NPJ systems biology and applications. 8(1) [DOI] 10.1038/s41540-022-00224-x. [PMID] 35501398.
2022
Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection.
Nature communications. 13(1) [DOI] 10.1038/s41467-022-30313-8. [PMID] 35538121.
2022
Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells.
STAR protocols. 3(4) [DOI] 10.1016/j.xpro.2022.101872. [PMID] 36595951.
2022
The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters
mBio. 13(2) [DOI] 10.1128/mbio.03705-21. [PMID] 35229634.
2022
The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms.
Cancer science. 113(5):1575-1586 [DOI] 10.1111/cas.15301. [PMID] 35179814.
2022
Type III and Not Type I Interferons Efficiently Prevent the Spread of Rotavirus in Human Intestinal Epithelial Cells
Journal of Virology. 96(17) [DOI] 10.1128/jvi.00706-22. [PMID] 36000839.
2022
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING.
Cell death & disease. 13(8) [DOI] 10.1038/s41419-022-05124-w. [PMID] 35933402.
2021
Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions.
Journal of visualized experiments : JoVE. (175) [DOI] 10.3791/62857. [PMID] 34570087.
2021
Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.772588. [PMID] 34868037.
2021
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.
Nature communications. 12(1) [DOI] 10.1038/s41467-021-25519-1. [PMID] 34493730.
2021
Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2021.07.09.21260221. [PMID] 34282422.
2021
Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs.
Cellular and molecular life sciences : CMLS. 78(16):5953-5976 [DOI] 10.1007/s00018-021-03889-5. [PMID] 34223911.
2021
Invasiveness of Escherichia coli Is Associated with an IncFII Plasmid
Pathogens. 10(12) [DOI] 10.3390/pathogens10121645. [PMID] 34959600.
2021
Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera: A semi-quantitative, high throughput, microscopy-based assay expands existing approaches to measure SARS-CoV-2 specific antibody levels in human sera.
BioEssays : news and reviews in molecular, cellular and developmental biology. 43(3) [DOI] 10.1002/bies.202000257. [PMID] 33377226.
2021
Role of Clathrin Light Chains in Regulating Invadopodia Formation
Cells. 10(2) [DOI] 10.3390/cells10020451. [PMID] 33672612.
2021
SARS‐CoV‐2 infection remodels the host protein thermal stability landscape
Molecular Systems Biology. 17(2) [DOI] 10.15252/msb.202010188. [PMID] 33590968.
2021
Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responses
Science Immunology. 6(59) [DOI] 10.1126/sciimmunol.abd5318. [PMID] 33990378.
2021
Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut.
Molecular systems biology. 17(4) [DOI] 10.15252/msb.202110232. [PMID] 33904651.
2021
Single‐cell transcriptomics reveals immune response of intestinal cell types to viral infection
Molecular Systems Biology. 17(7) [DOI] 10.15252/msb.20209833. [PMID] 34309190.
2021
The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity.
PLoS pathogens. 17(6) [DOI] 10.1371/journal.ppat.1009687. [PMID] 34181691.
2021
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
The EMBO Journal. 40(16) [DOI] 10.15252/embj.2021107821. [PMID] 34159616.
2020
3D Correlative Cryo-Structured Illumination Fluorescence and Soft X-ray Microscopy Elucidates Reovirus Intracellular Release Pathway.
Cell. 182(2):515-530.e17 [DOI] 10.1016/j.cell.2020.05.051. [PMID] 32610083.
2020
A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples
Science Translational Medicine. 12(556) [DOI] 10.1126/scitranslmed.abc7075. [PMID] 32719001.
2020
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Cell reports. 32(1) [DOI] 10.1016/j.celrep.2020.107863. [PMID] 32610043.
2020
Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection
Cells. 9(9) [DOI] 10.3390/cells9092085. [PMID] 32932592.
2020
Eden growth models for flat clathrin lattices with vacancies
New Journal of Physics. 22(7) [DOI] 10.1088/1367-2630/ab99e1.
2020
Enhanced Uptake and Endosomal Release of LbL Microcarriers Functionalized with Reversible Fusion Proteins.
ACS applied bio materials. 3(3):1553-1567 [DOI] 10.1021/acsabm.9b01168. [PMID] 35021646.
2020
Forces during cellular uptake of viruses and nanoparticles at the ventral side.
Nature communications. 11(1) [DOI] 10.1038/s41467-019-13877-w. [PMID] 31896744.
2020
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.608645. [PMID] 33362795.
2020
Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies.
Cell host & microbe. 28(6):853-866.e5 [DOI] 10.1016/j.chom.2020.11.003. [PMID] 33245857.
2020
Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2020.07.19.210955. [PMID] 32743577.
2020
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor.
Nature genetics. 52(12):1283-1293 [DOI] 10.1038/s41588-020-00731-9. [PMID] 33077916.
2020
Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses
Viruses. 12(4) [DOI] 10.3390/v12040400. [PMID] 32260371.
2020
NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-17101-y. [PMID] 32612175.
2020
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-19619-7. [PMID] 33208793.
2020
The origin of diarrhea in rotavirus infection.
Science (New York, N.Y.). 370(6519):909-910 [DOI] 10.1126/science.abf1914. [PMID] 33214264.
2019
Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells
Nature Microbiology. 5(1):181-191 [DOI] 10.1038/s41564-019-0594-3.
2019
Differential Regulation of Type I and Type III Interferon Signaling.
International journal of molecular sciences. 20(6) [DOI] 10.3390/ijms20061445. [PMID] 30901970.
2019
Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression
Molecular and Cellular Biology. 39(14) [DOI] 10.1128/mcb.00553-18.
2019
Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses.
Molecular therapy. Methods & clinical development. 12:202-222 [DOI] 10.1016/j.omtm.2019.01.003. [PMID] 30766894.
2019
Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells
Cells. 8(8) [DOI] 10.3390/cells8080870. [PMID] 31405163.
2019
Type-Specific Crosstalk Modulates Interferon Signaling in Intestinal Epithelial Cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 39(10):650-660 [DOI] 10.1089/jir.2019.0040. [PMID] 31199715.
2018
A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas.
International journal of cancer. 143(5):1176-1187 [DOI] 10.1002/ijc.31404. [PMID] 29582423.
2018
Assaying the Contribution of Membrane Tension to Clathrin-Mediated Endocytosis.
Methods in molecular biology (Clifton, N.J.). 1847:37-50 [DOI] 10.1007/978-1-4939-8719-1_4. [PMID] 30129008.
2018
Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-03533-0. [PMID] 29549258.
2018
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance
PLOS Pathogens. 14(11) [DOI] 10.1371/journal.ppat.1007420. [PMID] 30485383.
2018
Reversible Fusion Proteins as a Tool to Enhance Uptake of Virus-Functionalized LbL Microcarriers.
Biomacromolecules. 19(8):3212-3223 [DOI] 10.1021/acs.biomac.8b00360. [PMID] 29966082.
2018
Rubella Virus Strain-Associated Differences in the Induction of Oxidative Stress Are Independent of Their Interferon Activation.
Viruses. 10(10) [DOI] 10.3390/v10100540. [PMID] 30282907.
2018
Surface Immobilization of Viruses and Nanoparticles Elucidates Early Events in Clathrin-Mediated Endocytosis.
ACS infectious diseases. 4(11):1585-1600 [DOI] 10.1021/acsinfecdis.8b00134. [PMID] 30200751.
2017
Bin1 directly remodels actin dynamics through its BAR domain.
EMBO reports. 18(11):2051-2066 [DOI] 10.15252/embr.201744137. [PMID] 28893863.
2017
Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network.
Cellular microbiology. 19(12) [DOI] 10.1111/cmi.12765. [PMID] 28672089.
2017
miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea.
Gut. 66(9):1537-1538 [DOI] 10.1136/gutjnl-2016-311477. [PMID] 28082316.
2017
Reovirus inhibits interferon production by sequestering IRF3 into viral factories.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-11469-6. [PMID] 28883463.
2017
Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00459. [PMID] 28484457.
2016
HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites.
Journal of virology. 90(15):6709-6723 [DOI] 10.1128/JVI.00504-16. [PMID] 27170757.
2016
Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling.
Cellular microbiology. 18(12):1831-1845 [DOI] 10.1111/cmi.12626. [PMID] 27279006.
2015
Dynamics of virus-receptor interactions in virus binding, signaling, and endocytosis.
Viruses. 7(6):2794-815 [DOI] 10.3390/v7062747. [PMID] 26043381.
2014
Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
Nature immunology. 15(8):717-26 [DOI] 10.1038/ni.2915. [PMID] 24952503.
2013
Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking.
Antiviral research. 100(1):215-9 [DOI] 10.1016/j.antiviral.2013.08.008. [PMID] 23981392.
2013
Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking.
Cellular microbiology. 15(11):1866-82 [DOI] 10.1111/cmi.12155. [PMID] 23701235.
2013
Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells.
Molecular biology of the cell. 24(8):1196-207 [DOI] 10.1091/mbc.E12-12-0852. [PMID] 23427267.
2012
Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers.
Cell reports. 2(5):1111-9 [DOI] 10.1016/j.celrep.2012.09.025. [PMID] 23103167.
2012
Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments.
mBio. 3(1) [DOI] 10.1128/mBio.00301-11. [PMID] 22318319.
2012
Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.
Journal of virology. 86(4):2089-95 [DOI] 10.1128/JVI.06720-11. [PMID] 22156516.
2012
The first five seconds in the life of a clathrin-coated pit.
Cell. 150(3):495-507 [DOI] 10.1016/j.cell.2012.05.047. [PMID] 22863004.
2011
Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.
Nature cell biology. 13(9):1124-31 [DOI] 10.1038/ncb2307. [PMID] 21841790.
2011
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
Nature immunology. 12(8):770-7 [DOI] 10.1038/ni.2050. [PMID] 21685908.
2011
Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking.
Traffic (Copenhagen, Denmark). 12(9):1179-95 [DOI] 10.1111/j.1600-0854.2011.01233.x. [PMID] 21736684.
2010
Lipid metabolism and HCV infection.
Viruses. 2(5):1195-1217 [DOI] 10.3390/v2051195. [PMID] 21994676.
2010
Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication.
Journal of virology. 84(4):1771-84 [DOI] 10.1128/JVI.01510-09. [PMID] 20007282.
2010
Peroxisomes are signaling platforms for antiviral innate immunity.
Cell. 141(4):668-81 [DOI] 10.1016/j.cell.2010.04.018. [PMID] 20451243.
2010
Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein.
The Journal of general virology. 91(Pt 1):122-32 [DOI] 10.1099/vir.0.015909-0. [PMID] 19793905.
2009
Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein.
The Journal of biological chemistry. 284(20):13778-13791 [DOI] 10.1074/jbc.M807873200. [PMID] 19269968.
2009
Subcellular localizations of the hepatitis C virus alternate reading frame proteins.
Virus research. 139(1):106-10 [DOI] 10.1016/j.virusres.2008.09.011. [PMID] 18996421.
2008
Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner.
Traffic (Copenhagen, Denmark). 9(8):1268-82 [DOI] 10.1111/j.1600-0854.2008.00767.x. [PMID] 18489704.
2008
Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production.
The Journal of biological chemistry. 283(24):16850-9 [DOI] 10.1074/jbc.M802273200. [PMID] 18424431.
2008
Transcriptional slippage prompts recoding in alternate reading frames in the hepatitis C virus (HCV) core sequence from strain HCV-1.
The Journal of general virology. 89(Pt 7):1569-1578 [DOI] 10.1099/vir.0.83614-0. [PMID] 18559926.
2008
Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication.
Journal of virology. 82(5):2182-95 [PMID] 18094154.
2007
Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus.
The Journal of general virology. 88(Pt 8):2204-2213 [DOI] 10.1099/vir.0.82898-0. [PMID] 17622624.
2007
Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuries.
The Journal of general virology. 88(Pt 4):1149-1162 [DOI] 10.1099/vir.0.82575-0. [PMID] 17374758.
2007
The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly.
The Journal of biological chemistry. 282(51):37158-69 [PMID] 17942391.
2006
Structural determinants that target the hepatitis C virus core protein to lipid droplets.
The Journal of biological chemistry. 281(31):22236-22247 [DOI] 10.1074/jbc.M601031200. [PMID] 16704979.
2005
Hepatitis C virus core protein acts as a trans-modulating factor on internal translation initiation of the viral RNA.
The Journal of biological chemistry. 280(18):17737-48 [PMID] 15760888.
2005
Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features.
Journal of virology. 79(17):11353-65 [PMID] 16103187.
2004
The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro.
Nucleic acids research. 32(8):2623-31 [PMID] 15141033.
2003
Unusual multiple recoding events leading to alternative forms of hepatitis C virus core protein from genotype 1b.
The Journal of biological chemistry. 278(46):45785-92 [PMID] 12952944.

Contact Details

Phones:
Business:
(352) 273-7534
Emails:
Business:
s.boulant@ufl.edu
Addresses:
Business Mailing:
PO Box 100266
GAINESVILLE FL 32610
Business Street:
1200 NEWELL DR
ARB BLDG
GAINESVILLE FL 32610