George L Drusano,
DIR & PROF
Department:
MD-INST FOR THERAPEUTIC INNOV
Business Phone:
(407) 313-7060
Business Email:
gdrusano@ufl.edu
Accomplishments
Recipient University of Florida Research Foundation Professorship
2018
·
University of Florida
Paul Ehrlich Magic Bullet Award
2015
·
Paracelsus University, Nurnberg, Germany
ICAAC Award
2013
·
American Society for Microbiology
Recipient, Maxwell Finland Award; Dr. Anthony Fauci a prior recipient
2012
·
National Foundation for Infectious Diseases
Editor, Mbio
2010-2015
·
American Society for Microbiology
Communicating Chair, Gordon Research Conference: New antibacterial drug discovery and development
2010
·
Gordon Research Conference
Fellow, American Academy of Microbiology
2009
·
American Society of Microbiology
Distinguished Investigator
2003
·
American College of Clinical Pharmacology
Editor, Antimicrobial Agents and Chemotherapy
1989-1997
·
American Society for Microbiology
Teaching Profile
Courses Taught
2021,2023-2024
PHA6133 Translational Clinical Pharmacology
Publications
Academic Articles
2024
FDA, CDC, and NIH Co-sponsored Public Workshop Summary-Development Considerations of Antimicrobial Drugs for the Treatment of Gonorrhea.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[DOI] 10.1093/cid/ciae386.
[PMID] 39045871.
2024
Omadacycline is active in vitro and in vivo against ciprofloxacin-resistant Bacillus anthracis.
Antimicrobial agents and chemotherapy.
68(9)
[DOI] 10.1128/aac.00595-24.
[PMID] 39133023.
2024
Pharmacodynamic evaluation of ceftriaxone single-dose therapy (0.125-1 g) to eradicate ceftriaxone-susceptible and ceftriaxone-resistant Neisseria gonorrhoeae strains in a hollow fibre infection model for gonorrhoea.
The Journal of antimicrobial chemotherapy.
79(5):1006-1013
[DOI] 10.1093/jac/dkae063.
[PMID] 38497988.
2024
Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models.
Antimicrobial agents and chemotherapy.
68(3)
[DOI] 10.1128/aac.01394-23.
[PMID] 38289076.
2023
A five-day treatment course of zanamivir for the flu with a single, self-administered, painless microneedle array patch: Revolutionizing delivery of poorly membrane-permeable therapeutics.
International journal of pharmaceutics.
641
[DOI] 10.1016/j.ijpharm.2023.123081.
[PMID] 37230371.
2023
Combination Therapy with UV-4B and Molnupiravir Enhances SARS-CoV-2 Suppression.
Viruses.
15(5)
[DOI] 10.3390/v15051175.
[PMID] 37243261.
2023
Correction: 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases.
Chemical science.
14(34)
[DOI] 10.1039/d3sc90150e.
[PMID] 37655038.
2023
Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice.
Antimicrobial agents and chemotherapy.
67(5)
[DOI] 10.1128/aac.00197-23.
[PMID] 37022153.
2023
Pharmacodynamics of zoliflodacin plus doxycycline combination therapy against Neisseria gonorrhoeae in a gonococcal hollow-fiber infection model.
Frontiers in pharmacology.
14
[DOI] 10.3389/fphar.2023.1291885.
[PMID] 38130409.
2022
Combination Therapy to Kill Mycobacterium tuberculosis in Its Nonreplicating Persister Phenotype.
Antimicrobial agents and chemotherapy.
66(10)
[DOI] 10.1128/aac.00695-22.
[PMID] 36165631.
2022
Evaluating the effect of clofazimine against Mycobacterium tuberculosis given alone or in combination with pretomanid, bedaquiline or linezolid.
International journal of antimicrobial agents.
59(2)
[DOI] 10.1016/j.ijantimicag.2021.106509.
[PMID] 34958863.
2022
Individualized Patient Care Through Model-Informed Precision Dosing: Reflections on Training Future Practitioners.
The AAPS journal.
24(6)
[DOI] 10.1208/s12248-022-00769-z.
[PMID] 36380020.
2022
Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections.
Frontiers in pharmacology.
13
[DOI] 10.3389/fphar.2022.1035841.
[PMID] 36452226.
2022
Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model.
Frontiers in pharmacology.
13
[DOI] 10.3389/fphar.2022.874176.
[PMID] 35496288.
2022
Why Molnupiravir Fails in Hospitalized Patients.
mBio.
13(6)
[DOI] 10.1128/mbio.02916-22.
[PMID] 36374076.
2021
“One-Two Punch”: Synergistic ß-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
73(8):1532-1536
[DOI] 10.1093/cid/ciab535.
[PMID] 34113990.
2021
2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode.
ACS infectious diseases.
7(9):2697-2706
[DOI] 10.1021/acsinfecdis.1c00194.
[PMID] 34355567.
2021
2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases.
Chemical science.
12(8):2898-2908
[DOI] 10.1039/d0sc05172a.
[PMID] 34164056.
2021
Building Optimal Three-Drug Combination Chemotherapy Regimens To Eradicate Mycobacterium tuberculosis in Its Slow-Growth Acid Phase.
Antimicrobial agents and chemotherapy.
65(10)
[DOI] 10.1128/AAC.00693-21.
[PMID] 34339275.
2021
Combating Multidrug-Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling.
Clinical pharmacology and therapeutics.
109(4):1000-1020
[DOI] 10.1002/cpt.2205.
[PMID] 33576025.
2021
Dose Fractionation of Moxifloxacin for Treatment of Tuberculosis: Impact of Dosing Interval and Elimination Half-Life on Microbial Kill and Resistance Suppression.
Antimicrobial agents and chemotherapy.
65(4)
[DOI] 10.1128/AAC.02533-20.
[PMID] 33468465.
2021
Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed blaPDC in a Hollow-Fiber Infection Model.
Antimicrobial agents and chemotherapy.
65(6)
[DOI] 10.1128/AAC.00124-21.
[PMID] 33782013.
2021
Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model.
Frontiers in pharmacology.
12
[DOI] 10.3389/fphar.2021.682135.
[PMID] 34093206.
2021
Polymyxin B Pharmacodynamics in the Hollow-Fiber Infection Model: What You See May Not Be What You Get.
Antimicrobial agents and chemotherapy.
65(8)
[DOI] 10.1128/AAC.01853-20.
[PMID] 34097487.
2021
The case for precision dosing: medical conservatism does not justify inaction.
The Journal of antimicrobial chemotherapy.
76(7):1661-1665
[DOI] 10.1093/jac/dkab086.
[PMID] 33843994.
2021
The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens.
Antimicrobial agents and chemotherapy.
65(2)
[DOI] 10.1128/AAC.02172-20.
[PMID] 33199386.
2021
Vancomycin Area Under the Curve-Guided Dosing and Monitoring for Adult and Pediatric Patients With Suspected or Documented Serious Methicillin-Resistant Staphylococcus aureus Infections: Putting the Safety of Our Patients First.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
72(9):1497-1501
[DOI] 10.1093/cid/ciaa1744.
[PMID] 33740042.
2020
Building Optimal Three-Drug Combination Chemotherapy Regimens.
Antimicrobial agents and chemotherapy.
64(11)
[DOI] 10.1128/AAC.01610-20.
[PMID] 32900682.
2020
Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models?
Antimicrobial agents and chemotherapy.
64(12)
[DOI] 10.1128/AAC.01376-20.
[PMID] 32958720.
2020
Development of New Antimicrobials for Urogenital Gonorrhea Therapy: Clinical Trial Design Considerations.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
70(7):1495-1500
[DOI] 10.1093/cid/ciz899.
[PMID] 31538646.
2020
First Penicillin-Binding Protein Occupancy Patterns for 15 β-Lactams and β-Lactamase Inhibitors in Mycobacterium abscessus.
Antimicrobial agents and chemotherapy.
65(1)
[DOI] 10.1128/AAC.01956-20.
[PMID] 33106266.
2020
Methodological features of clinical pharmacokinetic-pharmacodynamic studies of antibacterials and antifungals: a systematic review.
The Journal of antimicrobial chemotherapy.
75(6):1374-1389
[DOI] 10.1093/jac/dkaa005.
[PMID] 32083674.
2020
Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae.
mBio.
11(1)
[DOI] 10.1128/mBio.03189-19.
[PMID] 32047131.
2020
Optimising treatments for sexually transmitted infections: surveillance, pharmacokinetics and pharmacodynamics, therapeutic strategies, and molecular resistance prediction.
The Lancet. Infectious diseases.
20(8):e181-e191
[DOI] 10.1016/S1473-3099(20)30171-7.
[PMID] 32569625.
2020
Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum-β-Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy.
64(6)
[DOI] 10.1128/AAC.00180-20.
[PMID] 32253209.
2020
Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea-challenges and opportunities.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
26(12):1630-1635
[DOI] 10.1016/j.cmi.2020.08.006.
[PMID] 32798687.
2020
Pharmacokinetics of tedizolid, sutezolid, and sutezolid-M1 in non-human primates.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
151
[DOI] 10.1016/j.ejps.2020.105421.
[PMID] 32531349.
2020
Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST).
Antimicrobial agents and chemotherapy.
64(2)
[DOI] 10.1128/AAC.01495-19.
[PMID] 31767718.
2019
Breakpoint determination when multiple organisms are tested for effect targets.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
130:196-199
[DOI] 10.1016/j.ejps.2019.01.033.
[PMID] 30711687.
2019
Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa.
The Journal of infectious diseases.
220(4):666-676
[DOI] 10.1093/infdis/jiz149.
[PMID] 31099835.
2019
Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis.
International journal of antimicrobial agents.
54(3):292-300
[DOI] 10.1016/j.ijantimicag.2019.06.021.
[PMID] 31279154.
2019
Comparable Efficacy and Better Safety of Double β-Lactam Combination Therapy versus β‑Lactam plus Aminoglycoside in Gram-Negative Bacteria in Randomized, Controlled Trials.
Antimicrobial agents and chemotherapy.
63(7)
[DOI] 10.1128/AAC.00425-19.
[PMID] 30988147.
2019
Considerations for Dose Selection and Clinical Pharmacokinetics/Pharmacodynamics for the Development of Antibacterial Agents.
Antimicrobial agents and chemotherapy.
63(5)
[DOI] 10.1128/AAC.02309-18.
[PMID] 30833427.
2019
Dose optimization of moxifloxacin and linezolid against tuberculosis using mathematical modeling and simulation.
International journal of antimicrobial agents.
53(3):275-283
[DOI] 10.1016/j.ijantimicag.2018.10.012.
[PMID] 30385322.
2019
Effect of Moxifloxacin plus Pretomanid against Mycobacterium tuberculosis in Log Phase, Acid Phase, and Nonreplicating-Persister Phase in an In Vitro Assay.
Antimicrobial agents and chemotherapy.
63(1)
[DOI] 10.1128/AAC.01695-18.
[PMID] 30397058.
2019
Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis.
Clinical pharmacokinetics.
58(2):143-156
[DOI] 10.1007/s40262-018-0678-x.
[PMID] 29936678.
2019
GC-072: A Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens.
Antimicrobial agents and chemotherapy.
63(12)
[DOI] 10.1128/AAC.00834-19.
[PMID] 31548183.
2019
Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans.
Antimicrobial agents and chemotherapy.
63(5)
[DOI] 10.1128/AAC.02307-18.
[PMID] 30833428.
2019
In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae.
The Journal of antimicrobial chemotherapy.
74(12):3521-3529
[DOI] 10.1093/jac/dkz376.
[PMID] 31730160.
2019
Is Daptomycin plus Ceftaroline the Way To Go for Methicillin-Resistant Staphylococcus aureus Bacteremia?
Antimicrobial agents and chemotherapy.
63(11)
[DOI] 10.1128/AAC.01725-19.
[PMID] 31640979.
2019
Natural history of Acinetobacter baumannii infection in mice.
PloS one.
14(7)
[DOI] 10.1371/journal.pone.0219824.
[PMID] 31318907.
2019
Pharmacodynamics of Ceftazidime plus Avibactam against KPC-2-Bearing Isolates of Klebsiella pneumoniae in a Hollow Fiber Infection Model.
Antimicrobial agents and chemotherapy.
63(8)
[DOI] 10.1128/AAC.00462-19.
[PMID] 31160285.
2018
Activity of Moxifloxacin against Mycobacterium tuberculosis in Acid Phase and Nonreplicative-Persister Phenotype Phase in a Hollow-Fiber Infection Model.
Antimicrobial agents and chemotherapy.
62(12)
[DOI] 10.1128/AAC.01470-18.
[PMID] 30249693.
2018
Antiviral Effects of Clinically-Relevant Interferon-α and Ribavirin Regimens against Dengue Virus in the Hollow Fiber Infection Model (HFIM).
Viruses.
10(6)
[DOI] 10.3390/v10060317.
[PMID] 29890736.
2018
Determination of the Dynamically Linked Indices of Fosfomycin for Pseudomonas aeruginosa in the Hollow Fiber Infection Model.
Antimicrobial agents and chemotherapy.
62(6)
[DOI] 10.1128/AAC.02627-17.
[PMID] 29581114.
2018
Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia.
Antimicrobial agents and chemotherapy.
62(1)
[DOI] 10.1128/AAC.01323-17.
[PMID] 29038277.
2018
Effect of Linezolid Plus Bedaquiline Against Mycobacterium Tuberculosis in Log Phase, Acid Phase, and Nonreplicating-Persister Phase in An in Vitro Assay
Antimicrobial Agents and Chemotherapy.
62(8)
[DOI] 10.1128/AAC.00856-18;e00856-18.
2018
Effect of Linezolid plus Bedaquiline against Mycobacterium tuberculosis in Log Phase, Acid Phase, and Nonreplicating-Persister Phase in an In Vitro Assay.
Antimicrobial agents and chemotherapy.
62(8)
[DOI] 10.1128/AAC.00856-18.
[PMID] 29866874.
2018
Erratum for Drusano et al., “Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia”.
Antimicrobial agents and chemotherapy.
62(4)
[DOI] 10.1128/AAC.00198-18.
[PMID] 29588353.
2018
First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy.
62(6)
[DOI] 10.1128/AAC.00282-18.
[PMID] 29712652.
2018
Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model.
Antimicrobial agents and chemotherapy.
62(8)
[DOI] 10.1128/AAC.00221-18.
[PMID] 29866864.
2018
Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
111:443-449
[DOI] 10.1016/j.ejps.2017.10.027.
[PMID] 29079337.
2018
The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model.
Antimicrobial agents and chemotherapy.
62(12)
[DOI] 10.1128/AAC.01682-18.
[PMID] 30249700.
2017
Evaluation of Combination Drug Therapy for Treatment of Antibiotic-Resistant Inhalation Anthrax in a Murine Model.
Antimicrobial agents and chemotherapy.
61(9)
[DOI] 10.1128/AAC.00788-17.
[PMID] 28696235.
2017
Pre-clinical in vitro infection models.
Current opinion in pharmacology.
36:100-106
[DOI] 10.1016/j.coph.2017.09.011.
[PMID] 29035729.
2017
Reply to Scagnolari et al.
The Journal of infectious diseases.
215(3):493-494
[DOI] 10.1093/infdis/jiw580.
[PMID] 28003357.
2017
Searching for synergy: Identifying optimal antiviral combination therapy using Hepatitis C virus (HCV) agents in a replicon system.
Antiviral research.
146:149-152
[DOI] 10.1016/j.antiviral.2017.09.001.
[PMID] 28882564.
2017
Sofosbuvir (SOF) Suppresses Ledipasvir (LDV)-resistant Mutants during SOF/LDV Combination Therapy against Genotype 1b Hepatitis C Virus (HCV).
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-15007-2.
[PMID] 29089577.
2017
Stepping Off the Resistance Treadmill.
The Journal of infectious diseases.
216(2):150-152
[DOI] 10.1093/infdis/jix212.
[PMID] 28475769.
2016
Chikungunya Virus: In Vitro Response to Combination Therapy With Ribavirin and Interferon Alfa 2a.
The Journal of infectious diseases.
214(8):1192-7
[DOI] 10.1093/infdis/jiw358.
[PMID] 27496974.
2016
From lead optimization to NDA approval for a new antimicrobial: Use of pre-clinical effect models and pharmacokinetic/pharmacodynamic mathematical modeling.
Bioorganic & medicinal chemistry.
24(24):6401-6408
[DOI] 10.1016/j.bmc.2016.08.034.
[PMID] 27612961.
2016
Natural History of Francisella tularensis in Aerosol-Challenged BALB/c Mice.
Antimicrobial agents and chemotherapy.
60(3):1834-40
[DOI] 10.1128/AAC.02887-15.
[PMID] 26824958.
2016
Pharmacodynamics for antifungal drug development: an approach for acceleration, risk minimization and demonstration of causality.
The Journal of antimicrobial chemotherapy.
71(11):3008-3019
[PMID] 27494925.
2015
Combination treatment with meropenem plus levofloxacin is synergistic against Pseudomonas aeruginosa infection in a murine model of pneumonia.
The Journal of infectious diseases.
211(8):1326-33
[DOI] 10.1093/infdis/jiu603.
[PMID] 25362196.
2015
Evaluation of Daptomycin Exposure and Efficacy and Safety Endpoints To Support Risk-versus-Benefit Considerations.
Antimicrobial agents and chemotherapy.
60(3):1600-7
[DOI] 10.1128/AAC.02967-15.
[PMID] 26711755.
2015
In memoriam: William A. Craig.
Antimicrobial agents and chemotherapy.
59(6)
[DOI] 10.1128/AAC.00849-15.
[PMID] 25896702.
2015
Pharmacodynamic evaluation of the activities of six parenteral vancomycin products available in the United States.
Antimicrobial agents and chemotherapy.
59(1):622-32
[DOI] 10.1128/AAC.03710-14.
[PMID] 25385113.
2015
Pharmacodynamics of fosfomycin: insights into clinical use for antimicrobial resistance.
Antimicrobial agents and chemotherapy.
59(9):5602-10
[DOI] 10.1128/AAC.00752-15.
[PMID] 26124169.
2015
Pharmacokinetic determinants of virological response to raltegravir in the in vitro pharmacodynamic hollow-fiber infection model system.
Antimicrobial agents and chemotherapy.
59(7):3771-7
[DOI] 10.1128/AAC.00469-15.
[PMID] 25870053.
2015
Pharmacokinetic-pharmacodynamic analysis for efficacy of ceftaroline fosamil in patients with acute bacterial skin and skin structure infections.
Antimicrobial agents and chemotherapy.
59(1):372-80
[DOI] 10.1128/AAC.02531-14.
[PMID] 25367904.
2015
Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy.
mBio.
6(6):e01741-15
[DOI] 10.1128/mBio.01741-15.
[PMID] 26530386.
2015
Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 1.
Antimicrobial agents and chemotherapy.
60(3):1183-93
[DOI] 10.1128/AAC.02177-15.
[PMID] 26711759.
2015
Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 2.
Antimicrobial agents and chemotherapy.
60(3):1194-201
[DOI] 10.1128/AAC.02231-15.
[PMID] 26711766.
2014
Activities of ceftazidime and avibactam against β-lactamase-producing Enterobacteriaceae in a hollow-fiber pharmacodynamic model.
Antimicrobial agents and chemotherapy.
58(6):3366-72
[DOI] 10.1128/AAC.00080-14.
[PMID] 24687507.
2014
Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis.
PloS one.
9(7)
[DOI] 10.1371/journal.pone.0101311.
[PMID] 25003557.
2014
Are vancomycin trough concentrations adequate for optimal dosing?
Antimicrobial agents and chemotherapy.
58(1):309-16
[DOI] 10.1128/AAC.01653-13.
[PMID] 24165176.
2014
Evaluation of imipenem for prophylaxis and therapy of Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague.
Antimicrobial agents and chemotherapy.
58(6):3276-84
[DOI] 10.1128/AAC.02420-14.
[PMID] 24687492.
2014
In memoriam: John P. Quinn, MD.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
58(5):748-50
[DOI] 10.1093/cid/cit801.
[PMID] 24336826.
2014
Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.
The Lancet. Infectious diseases.
14(6):498-509
[DOI] 10.1016/S1473-3099(14)70036-2.
[PMID] 24768475.
2014
Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model.
The Journal of infectious diseases.
210(8):1319-24
[DOI] 10.1093/infdis/jiu237.
[PMID] 24760199.
2014
Quantifying the matrix of relationships between reduced vancomycin susceptibility phenotypes and outcomes among patients with MRSA bloodstream infections treated with vancomycin .
The Journal of antimicrobial chemotherapy.
69(9):2547-55
[DOI] 10.1093/jac/dku135.
[PMID] 24840624.
2014
Use of pharmacokinetic/pharmacodynamic systems analyses to inform dose selection of tedizolid phosphate.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
58 Suppl 1:S28-34
[DOI] 10.1093/cid/cit615.
[PMID] 24343829.
2014
Vancomycin exposure in patients with methicillin-resistant Staphylococcus aureus bloodstream infections: how much is enough?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
59(5):666-75
[DOI] 10.1093/cid/ciu398.
[PMID] 24867791.
2013
Hollow-fiber pharmacodynamic studies and mathematical modeling to predict the efficacy of amoxicillin for anthrax postexposure prophylaxis in pregnant women and children.
Antimicrobial agents and chemotherapy.
57(12):5946-60
[DOI] 10.1128/AAC.02616-12.
[PMID] 24041894.
2013
Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia.
Antimicrobial agents and chemotherapy.
57(6):2788-92
[DOI] 10.1128/AAC.02624-12.
[PMID] 23571540.
2013
Natural history of Yersinia pestis pneumonia in aerosol-challenged BALB/c mice.
Antimicrobial agents and chemotherapy.
57(5):2010-5
[DOI] 10.1128/AAC.02504-12.
[PMID] 23403418.
2013
Saving lives with optimal antimicrobial chemotherapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
56(2):245-7
[DOI] 10.1093/cid/cis863.
[PMID] 23074312.
2012
Abstracts of the 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012). July 8-12, 2012. Noordwijkerhout, The Netherlands.
Journal of veterinary pharmacology and therapeutics.
35 Suppl 3:1-182
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Dose range evaluation of Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, in combination with amphotericin B-desoxycholate for treatment of murine systemic candidiasis.
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Pharmacodynamics of ceftaroline fosamil for complicated skin and skin structure infection: rationale for improved anti-methicillin-resistant Staphylococcus aureus activity.
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Antifungal pharmacokinetics and pharmacodynamics: bridging from the bench to bedside.
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Back to the future: using aminoglycosides again and how to dose them optimally.
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Population pharmacokinetic modeling and Monte Carlo simulation of varying doses of intravenous metronidazole.
Diagnostic microbiology and infectious disease.
55(4):303-9
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2006
Quinolone efflux pumps play a central role in emergence of fluoroquinolone resistance in Streptococcus pneumoniae.
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Sex differences in CYP3A activity using intravenous and oral midazolam.
Clinical pharmacology and therapeutics.
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The crisis of resistance: identifying drug exposures to suppress amplification of resistant mutant subpopulations.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
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Bacterial-population responses to drug-selective pressure: examination of garenoxacin’s effect on Pseudomonas aeruginosa.
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Effective antimicrobial regimens for use in humans for therapy of Bacillus anthracis infections and postexposure prophylaxis.
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Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.
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Explaining the poor bacteriologic eradication rate of single-dose ceftriaxone in group a streptococcal tonsillopharyngitis: a reverse engineering solution using pharmacodynamic modeling.
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Infection site concentrations: their therapeutic importance and the macrolide and macrolide-like class of antibiotics.
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Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation.
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Pharmacodynamic evidence that ciprofloxacin failure against tuberculosis is not due to poor microbial kill but to rapid emergence of resistance.
Antimicrobial agents and chemotherapy.
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Pharmacodynamics of an 800-mg dose of telithromycin in patients with community-acquired pneumonia caused by extracellular pathogens.
Diagnostic microbiology and infectious disease.
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Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity.
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Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update.
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Surface response modeling to examine the combination of amphotericin B deoxycholate and 5-fluorocytosine for treatment of invasive candidiasis.
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A 48-week duration of therapy with pegylated interferon alpha 2b plus ribavirin may be too short to maximize long-term response among patients infected with genotype-1 hepatitis C virus.
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Antimicrobial pharmacodynamics: critical interactions of ‘bug and drug’.
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Optimizing antimicrobial pharmacodynamics: dosage strategies for meropenem.
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Pharmacodynamic profiling of piperacillin in the presence of tazobactam in patients through the use of population pharmacokinetic models and Monte Carlo simulation.
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Phenotypic drug susceptibility assay for influenza virus neuraminidase inhibitors.
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Relationship between fluoroquinolone area under the curve: minimum inhibitory concentration ratio and the probability of eradication of the infecting pathogen, in patients with nosocomial pneumonia.
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Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling.
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Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy.
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In vitro-in vivo model for evaluating the antiviral activity of amprenavir in combination with ritonavir administered at 600 and 100 milligrams, respectively, every 12 hours.
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Integration of population pharmacokinetics, a pharmacodynamic target, and microbiologic surveillance data to generate a rational empiric dosing strategy for cefepime against Pseudomonas aeruginosa.
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Optimal sampling schedule design for populations of patients.
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Pharmacokinetics and pharmacodynamics of cefepime in patients with various degrees of renal function.
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Predicting efficacy of antiinfectives with pharmacodynamics and Monte Carlo simulation.
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Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine, and tenofovir.
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Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.
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Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacodynamic variable.
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Pharmacodynamic and pharmacokinetic considerations in antimicrobial selection: focus on telithromycin.
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Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing.
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Pharmacodynamics of daptomycin in a murine thigh model of Staphylococcus aureus infection.
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Susceptibilities of human cytomegalovirus clinical isolates to BAY38-4766, BAY43-9695, and ganciclovir.
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Use of preclinical data for selection of a phase II/III dose for evernimicin and identification of a preclinical MIC breakpoint.
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A population pharmacokinetic analysis of the penetration of the prostate by levofloxacin.
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The triple combination indinavir-zidovudine-lamivudine is highly synergistic.
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Use of drug effect interaction modeling with Monte Carlo simulation to examine the impact of dosing interval on the projected antiviral activity of the combination of abacavir and amprenavir.
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Correlation of quantitative bone marrow and blood cultures in AIDS patients with disseminated Mycobacterium avium complex infection.
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Interaction between fluconazole and amphotericin B in mice with systemic infection due to fluconazole-susceptible or -resistant strains of Candida albicans.
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Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria.
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Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity.
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The safety and efficacy of granulocyte-macrophage colony-stimulating factor (Sargramostim) added to indinavir- or ritonavir-based antiretroviral therapy: a randomized double-blind, placebo-controlled trial.
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Levofloxacin population pharmacokinetics and creation of a demographic model for prediction of individual drug clearance in patients with serious community-acquired infection.
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Mathematical modeling of the interrelationship of CD4 lymphocyte count and viral load changes induced by the protease inhibitor indinavir.
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Pharmacokinetic studies of fluconazole in rabbits characterizing doses which achieve peak levels in serum and area under the concentration-time curve values which mimic those of high-dose fluconazole in humans.
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Pharmacokinetics and pharmacodynamics of fluoroquinolones.
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Pharmacokinetics of sparfloxacin in the serum and vitreous humor of rabbits: physicochemical properties that regulate penetration of quinolone antimicrobials.
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Rapid ganciclovir susceptibility assay using flow cytometry for human cytomegalovirus clinical isolates.
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Modeling of the change in CD4 lymphocyte counts in patients before and after administration of the human immunodeficiency virus protease inhibitor indinavir.
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A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir).
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Acute thrombocytopenia secondary to the administration of the peptidomimetic HIV protease inhibitor MK-639(L735524).
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Modeling combinations of antiretroviral agents in vitro with integration of pharmacokinetics: guidance in regimen choice for clinical trial evaluation.
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Determination of robust ocular pharmacokinetic parameters in serum and vitreous humor of albino rabbits following systemic administration of ciprofloxacin from sparse data sets by using IT2S, a population pharmacokinetic modeling program.
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Serum inhibitory and bactericidal activity against methicillin-resistant Staphylococcus aureus in volunteers receiving novobiocin and rifampin alone and in combination.
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Use of human renal proximal tubule cell cultures for studying foscarnet-induced nephrotoxicity in vitro.
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[PMID] 3890730.
1985
Potential of imipenem as single-agent empiric antibiotic therapy of febrile neutropenic patients with cancer.
The American journal of medicine.
78(6A):62-72
[PMID] 3859217.
1985
Safety and tolerability of multiple doses of imipenem/cilastatin.
Clinical pharmacology and therapeutics.
37(5):539-43
[PMID] 3886256.
1984
Bactericidal activity of ceftazidime in serum compared with that of ticarcillin combined with amikacin.
Antimicrobial agents and chemotherapy.
26(3):339-42
[PMID] 6439114.
1984
Comparison of the pharmacokinetics of ceftazidime and moxalactam and their microbiological correlates in volunteers.
Antimicrobial agents and chemotherapy.
26(3):388-93
[PMID] 6391372.
1984
Effect of saturable clearance during high-dose mezlocillin therapy.
Antimicrobial agents and chemotherapy.
26(5):686-8
[PMID] 6517555.
1984
Improved micromethod for mezlocillin quantitation in serum and urine by high-pressure liquid chromatography.
Antimicrobial agents and chemotherapy.
26(5):775-7
[PMID] 6517560.
1984
Integration of selected pharmacologic and microbiologic properties of three new beta-lactam antibiotics: a hypothesis for rational comparison.
Reviews of infectious diseases.
6(3):357-63
[PMID] 6330835.
1984
Multiple-dose pharmacokinetics of imipenem-cilastatin.
Antimicrobial agents and chemotherapy.
26(5):715-21
[PMID] 6595963.
1984
Postantibiotic effect of imipenem on Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy.
26(5):678-82
[PMID] 6440477.
1984
The acylampicillins: mezlocillin, piperacillin, and azlocillin.
Reviews of infectious diseases.
6(1):13-32
[PMID] 6369480.
1984
The plasma pharmacokinetics of high dose (1 g) imipenem coadministered with 1 g cilastatin in six normal volunteers.
European journal of clinical microbiology.
3(5):468-70
[PMID] 6594235.
1984
The serum bactericidal activity of latamoxef (moxalactam), cefoperazone and cefotaxime.
The Journal of antimicrobial chemotherapy.
14(5):491-7
[PMID] 6096348.
1982
A prospective randomized controlled trial of cefoxitin versus clindamycin-aminoglycoside in mixed anaerobic-aerobic infections.
Surgery, gynecology & obstetrics.
154(5):715-20
[PMID] 7041297.
1981
Effect of carbon dioxide and pH on susceptibility of Bacteroides fragilis group to erythromycin.
Antimicrobial agents and chemotherapy.
19(2):335-6
[PMID] 6812492.
1981
Lactobacillus prophylaxis for diarrhea due to enterotoxigenic Escherichia coli.
Antimicrobial agents and chemotherapy.
20(1):104-8
[PMID] 6792978.
Grants
Aug 2024
ACTIVE
Translational development of new agents alone and in combination to combat Gram-negative pathogens important in Ventilator- Associated Bacterial Pneumonia: Leveraging the Gram-negative toolbox that is
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2024
ACTIVE
Batelle Accelerated Therapeutics for the Treatment of Emerging and Multidrug-Resistant Bacteria (BAT-TEAM)
Role: Co-Investigator
Funding: BATTELLE MEMORIAL INST
via DEFENSE THREAT REDUCTION AGENCY
May 2024
ACTIVE
Evaluation of the contribution of SPR719 to the killing and resistance prevention activity of azithromycin plus ethambutol-based antibiotic regimens (12-arm hollow fiber study).
Role: Co-Investigator
Funding: SPERO THERAPEUTICS
Jan 2023
ACTIVE
Optimizing Multi-drug Mycobacterium tuberculosis Therapy for Rapid Sterilization and Resistance Suppression
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2022
ACTIVE
Battelle Accelerated Therapeutics for the Treatment of Emerging and Multidrug-Resistant Bacteria (BAT-TEAM)
Role: Co-Investigator
Funding: BATTELLE MEMORIAL INST
via DEFENSE THREAT REDUCTION AGENCY
Jul 2022
ACTIVE
Development of a PO-administered beta-lactam-tarocin combination agent to treat methicillin susceptible and methicillin resistant staphylococci.
Role: Co-Investigator
Funding: PROKARYOTICS
via NATL INST OF HLTH NIAID
Aug 2021
– Aug 2022
Pharmacokinetic-Pharmacodynamic Studies to Support Dose Selection for Tebipenem for the Treatment of Mycobacterium avium Complex Pulmonary Disease
Role: Principal Investigator
Funding: SPERO THERAPEUTICS
Mar 2021
ACTIVE
Development of CZ-02s (AIIPS), a New Class of Antibacterial for the Treatment of Drug-Resistant Bacterial Infections, including those caused by Multidrug-Resistant Yersinia pestis, Francisella tularensis, and Burkholderia mallei
Role: Co-Investigator
Funding: ADVANCED TECHNOLOGY INTERNATIONAL
via DEFENSE THREAT REDUCTION AGENCY
Nov 2020
– Jan 2022
Evaluation of escape mutants to ADG20 against SARS-CoV-2 virus using a hollow fiber infection model system
Role: Co-Investigator
Funding: ADAGIO THERAPEUTICS
Nov 2020
– Dec 2021
Project Bioshield
Role: Principal Investigator
Funding: SPERO THERAPEUTICS
Jun 2020
– May 2023
A Mechanism Based Approach to Metallo beta-Lactamase Inhibition
Role: Principal Investigator
Funding: CASE WESTERN RESERVE UNIV
via NATL INST OF HLTH NIAID
Apr 2020
– Sep 2024
Battelle Subcontract 778380 SAB Year 1
Role: Co-Investigator
Funding: BATTELLE MEMORIAL INST
via DEFENSE THREAT REDUCTION AGENCY
Dec 2019
– Nov 2024
Novel Strategies for Antibiotic Combinations to Combat Gram-negative Superbugs
Role: Co-Investigator
Funding: STATE UNIV OF NEW YORK BUFFALO
via NATL INST OF HLTH NIAID
Nov 2019
– Oct 2021
Ceftazidime/Avibactam plus Aminoglycoside for Ceftazidime/Avibactam Resistant KPC-3 Klebsiella pneumonia
Role: Principal Investigator
Funding: ALLERGAN SALES
Apr 2019
– Mar 2022
SBIR: Microneedle Delivery of Zanamivir for Treatment of Influenza Infections
Role: Co-Investigator
Funding: THERAPEUTIC SYSTEMS RES LABORATORIES
via NATL INST OF HLTH NIAID
Aug 2018
– Jul 2024
Combating resistant superbugs by understanding the molecular determinants of target site penetration and binding
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2018
– Mar 2019
Confirmatory Efficacy Study in Bp Infected Mice
Role: Co-Investigator
Funding: EMERGENT BIOSOLUTIONS
via DEFENSE THREAT REDUCTION AGENCY
Jun 2018
– May 2021
Broad spectrum antibacterials selectively targeting an un-drugged site on the ribosome
Role: Co-Investigator
Funding: CURZA
via NATL INST OF HLTH NIAID
Feb 2018
– Oct 2018
Evaluation of the improved GC-072 formulation plasma and lung ELF PK in uninfected and the Bp infected mice model
Role: Co-Investigator
Funding: EMERGENT BIOSOLUTIONS
via DEFENSE THREAT REDUCTION AGENCY
Jan 2018
– Jun 2019
CZ-02 pharmacodynamic studies, A New Class of Antibiotics Selectively Inhibiting Bacterial Protein Synthesis
Role: Co-Investigator
Funding: CURZA
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Nov 2017
– Oct 2023
Next-generation combination dosing strategies to combat resistant Acinetobacter baumannii
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2017
– Dec 2021
A Preclinical Mouse Model of Acinetobacter buamannii Infection For Antibacterial Development
Role: Co-Investigator
Funding: UNIV OF SOUTHERN CALIFORNIA
via US FOOD AND DRUG ADMN
Sep 2017
– Sep 2018
Pharmacokinetic analysis of nonhuman primate data for US Army
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Jun 2017
– Jun 2019
Can ceftazidime-avibactam be pharmacodynamically-optimized to prevent emergence of resistance by KPC3-expressing Enterobacteriaceae?
Role: Co-Investigator
Funding: ALLERGAN SALES
Aug 2016
– Jul 2022
Optimizing combination therapy for accelerate clinical cure of tuberculosis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Aug 2016
– Sep 2017
Dose-fractionation study for AKPN001 (ATCC 43816) for plazomicin and the pharmacokinetics-pharmacodynamics of amikacin
Role: Co-Investigator
Funding: ACHAOGEN
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Jul 2016
– May 2018
Pharmacokinetics-Pharmacodynamics of RG-6080, a Potent Non-Beta-Lactam Beta-Lactamase Inhibitor, In Combination with Meropenem, Piperacillin, and/or Cefepime for the Killing of Multidrug-Resistant Enterobacteriaceae and Pseudomonas aeruginosa in Neutropen
Role: Co-Project Director/Principal Investigator
Funding: F HOFFMANN LA ROCHE
Dec 2015
– May 2021
Rapid Identification of Optimal Combination Regimens for Pseudomonas aeruginosa
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Oct 2014
– Dec 2017
HDTRA114-CBM-06-1-0052 titled GC-072: The First Oral Antibiotic for the Treatment of Acute Melioidosis and Select Agents
Role: Principal Investigator
Funding: EMERGENT BIOSOLUTIONS
via US DEPT OF DEFENSE
May 2014
– May 2017
ITI Consulting Agreements
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Jul 2011
– Dec 2016
Contract NO. HHSN2722001000043C Targeted Clinical Trials to Reduce the Risk of Antimicrobial Resistance.
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2011
– May 2017
Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and SelectAgents
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Contact Details
Phones:
- Business:
- (407) 313-7060
Emails:
- Business:
- gdrusano@ufl.edu
Addresses:
- Business Mailing:
-
6550 SANGER RD
ORLANDO FL 32827 - Business Street:
-
6550 SANGER RD
ORLANDO FL 32827