About Paul A Gulig
For over 35 years, my career has been studying molecular pathogenesis, the use of genetic manipulation of microorganisms to understand the way that they cause disease. As a graduate student, I studied immune responses to Haemophilus influenzae type b with the goal of aiding vaccine development. As a postdoctoral fellow, I studied molecular pathogenesis of Salmonella enterica serovar Typhimurium, focusing on the virulence plasmid in mouse models. I brought this work with me to the University of Florida. I later transitioned into Vibrio vulnificus pathogenesis, working to determine how this “flesh eating” bacterium found in oysters and estuarine waters replicates so rapidly in human tissues causing life-threatening infection. I then moved to a beneficial bacterium, Oxalobacter formigenes, that helps prevent kidney stones by stimulating the excretion of oxalate into the intestines from the blood. I am now in drug discovery, attempting to develop new antibiotics that inhibit the beta-lactamase of Pseudomonas aeruginosa so as to enable beta-lactam antibiotics to be restored in their effectiveness. However, I have closed my lab, so this work is done collaboratively with colleagues across the UF campus.