Malcolm Maden,
Ph.D.
Teaching Profile
Courses Taught
2020
ZOO6927 Special Topics in Zoology
2019-2024
ZOO4926 Special Topics in Zoology
2020-2021,2023
GMS6331 Stem Cell Biology
2014-2019,2021-2024
ZOO3603C Evolutionary Developmental Biology
2018
GMS7980 Research for Doctoral Dissertation
2009-2014,2016-2018
ZOO3713C Functional Vertebrate Anatomy
2018
ZOO7980 Research for Doctoral Dissertation
2011-2012
BSC1920 First Year Introduction: Biology at UF
2021
ZOO4911 Undergraduate Research in Zoology
2021
BSC4910 Individual Mentored Research in Biology
2021
GMS6336 Advanced Stem Cell Biology: Regenerative Medicine
2022
GMS6335 Advanced Stem Cell Biology: Tissue Engineering
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-7178-5309
Publications
2024
Identification and Analysis of Axolotl Homologs for Proteins Implicated in Human Neurodegenerative Proteinopathies.
Genes.
15(3)
[DOI] 10.3390/genes15030310.
[PMID] 38540368.
2023
African Spiny Mice (Acomys) Exhibit Mild Osteoarthritis Following Meniscal Injury.
Cartilage.
14(1):94-105
[DOI] 10.1177/19476035221149146.
[PMID] 36802989.
2023
Bite Wounds and Dominance Structures in Male and Female African Spiny Mice (Acomys cahirinus): Implications for Animal Welfare and the Generalizability of Experimental Results.
Animals : an open access journal from MDPI.
14(1)
[DOI] 10.3390/ani14010064.
[PMID] 38200795.
2023
Osteoderms in a mammal the spiny mouse Acomys and the independent evolution of dermal armor
iScience.
26(6)
[DOI] 10.1016/j.isci.2023.106779.
[PMID] 37378333.
2023
Retinoic Acid-Induced Limb Duplications.
Methods in molecular biology (Clifton, N.J.).
2562:249-258
[DOI] 10.1007/978-1-0716-2659-7_17.
[PMID] 36272081.
2023
Salamanders as Key Models for Development and Regeneration Research.
Methods in molecular biology (Clifton, N.J.).
2562:1-23
[DOI] 10.1007/978-1-0716-2659-7_1.
[PMID] 36272065.
2022
Tumor suppressors inhibit reprogramming of African spiny mouse ( Acomys) fibroblasts to induced pluripotent stem cells.
Wellcome open research.
7
[DOI] 10.12688/wellcomeopenres.18034.1.
[PMID] 36060301.
2021
A profusion of neural stem cells in the brain of the spiny mouse, Acomys cahirinus
Journal of Anatomy.
238(5):1191-1202
[DOI] 10.1111/joa.13373.
[PMID] 33277722.
2021
Functional heart recovery in an adult mammal, the spiny mouse.
International journal of cardiology.
338:196-203
[DOI] 10.1016/j.ijcard.2021.06.015.
[PMID] 34126132.
2021
Retinoic Acid Receptors and the Control of Positional Information in the Regenerating Axolotl Limb.
Cells.
10(9)
[DOI] 10.3390/cells10092174.
[PMID] 34571821.
2021
Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
npj Regenerative Medicine.
6(1)
[DOI] 10.1038/s41536-020-00111-1.
[PMID] 33397999.
2020
Author Correction: Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-65513-z.
[PMID] 32433574.
2020
Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-019-56823-y.
[PMID] 31932597.
2020
Model systems for regeneration: the spiny mouse, Acomys cahirinus
Development.
147(4)
[DOI] 10.1242/dev.167718.
[PMID] 32098790.
2020
Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus.
The Journal of comparative neurology.
528(9):1535-1547
[DOI] 10.1002/cne.24836.
[PMID] 31820438.
2020
RA Signaling in Limb Development and Regeneration in Different Species.
Sub-cellular biochemistry.
95:87-117
[DOI] 10.1007/978-3-030-42282-0_4.
[PMID] 32297297.
2020
Regeneration in the spiny mouse, Acomys, a new mammalian model.
Current opinion in genetics & development.
64:31-36
[DOI] 10.1016/j.gde.2020.05.019.
[PMID] 32599302.
2020
Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis.
PloS one.
15(10)
[DOI] 10.1371/journal.pone.0241617.
[PMID] 33125436.
2019
Comparative transcriptomic analysis of dermal wound healing reveals de novo skeletal muscle regeneration in Acomys cahirinus
PLOS ONE.
14(5)
[DOI] 10.1371/journal.pone.0216228.
[PMID] 31141508.
2019
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Science.
364(6436):184-188
[DOI] 10.1126/science.aar2038.
[PMID] 30846611.
2019
Insights into the regeneration of skin from Acomys, the spiny mouse
Experimental Dermatology.
28(4):436-441
[DOI] 10.1111/exd.13847.
2018
Optimal skin regeneration after full thickness thermal burn injury in the spiny mouse, Acomys cahirinus.
Burns : journal of the International Society for Burn Injuries.
44(6):1509-1520
[DOI] 10.1016/j.burns.2018.05.018.
[PMID] 29903601.
2018
Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-27178-7.
[PMID] 29892004.
2018
The evolution of regeneration – where does that leave mammals?
The International journal of developmental biology.
62(6-7-8):369-372
[DOI] 10.1387/ijdb.180031mm.
[PMID] 29938749.
2018
Unique behavior of dermal cells from regenerative mammal, the African Spiny Mouse, in response to substrate stiffness.
Journal of biomechanics.
81:149-154
[DOI] 10.1016/j.jbiomech.2018.10.005.
[PMID] 30361050.
2017
Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl
Development.
[DOI] 10.1242/dev.139873.
2016
Cellular events during scar-free skin regeneration in the spiny mouse, Acomys.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
24(1):75-88
[DOI] 10.1111/wrr.12385.
[PMID] 26606280.
2015
A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys.
PloS one.
10(11)
[DOI] 10.1371/journal.pone.0142931.
[PMID] 26606282.
2015
Tissue specific reactions to positional discontinuities in the regenerating axolotl limb.
Regeneration (Oxford, England).
2(3):137-147
[PMID] 26755943.
2014
Experimentally induced metamorphosis in axolotls reduces regenerative rate and fidelity.
Regeneration (Oxford, England).
1(1):2-14
[DOI] 10.1002/reg2.8.
[PMID] 27499857.
2014
Mapping hematopoiesis in a fully regenerative vertebrate: the axolotl.
Blood.
124(8):1232-41
[DOI] 10.1182/blood-2013-09-526970.
[PMID] 24802774.
2014
New insights into vertebrate skin regeneration.
International review of cell and molecular biology.
310:129-69
[DOI] 10.1016/B978-0-12-800180-6.00004-9.
[PMID] 24725426.
2013
Cellular plasticity during vertebrate appendage regeneration.
Current topics in microbiology and immunology.
367:53-74
[DOI] 10.1007/82_2012_288.
[PMID] 23239234.
2013
Proliferation zones in the axolotl brain and regeneration of the telencephalon.
Neural development.
8
[DOI] 10.1186/1749-8104-8-1.
[PMID] 23327114.
2013
Who needs stem cells if you can dedifferentiate?
Cell stem cell.
13(6):640-1
[DOI] 10.1016/j.stem.2013.11.020.
[PMID] 24315436.
2012
Gene expression patterns specific to the regenerating limb of the Mexican axolotl.
Biology open.
1(10):937-48
[DOI] 10.1242/bio.20121594.
[PMID] 23213371.
2012
Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates.
PloS one.
7(4)
[DOI] 10.1371/journal.pone.0032875.
[PMID] 22485136.
2012
Skin shedding and tissue regeneration in African spiny mice (Acomys).
Nature.
489(7417):561-5
[DOI] 10.1038/nature11499.
[PMID] 23018966.
2012
The influence of fundamental traits on mechanisms controlling appendage regeneration.
Biological reviews of the Cambridge Philosophical Society.
87(2):330-45
[DOI] 10.1111/j.1469-185X.2011.00199.x.
[PMID] 21929739.
2012
Visualization of retinoic acid signaling in transgenic axolotls during limb development and regeneration.
Developmental biology.
368(1):63-75
[DOI] 10.1016/j.ydbio.2012.05.015.
[PMID] 22627291.
2011
Is a regenerative approach viable for the treatment of COPD?
British journal of pharmacology.
163(1):106-15
[DOI] 10.1111/j.1476-5381.2011.01246.x.
[PMID] 21265829.
2010
A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.
Neurobiology of disease.
37(1):147-55
[DOI] 10.1016/j.nbd.2009.09.018.
[PMID] 19800972.
2010
Kidneys of Alb/TGF-beta1 transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity.
Nephron. Experimental nephrology.
114(4):e127-32
[DOI] 10.1159/000276587.
[PMID] 20110732.
2010
The expression of Stra6 and Rdh10 in the avian embryo and their contribution to the generation of retinoid signatures.
The International journal of developmental biology.
54(8-9):1267-75
[DOI] 10.1387/ijdb.093009sr.
[PMID] 20563989.
2009
Cells keep a memory of their tissue origin during axolotl limb regeneration.
Nature.
460(7251):60-5
[DOI] 10.1038/nature08152.
[PMID] 19571878.
2009
Plasticity of Cells During Axolotl Limb Regeneration
Mechanisms of Development.
126:S295-S296
[DOI] 10.1016/j.mod.2009.06.803.
2009
Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways.
Developmental biology.
326(2):305-13
[DOI] 10.1016/j.ydbio.2008.11.018.
[PMID] 19100254.
2008
Axolotl/newt.
Methods in molecular biology (Clifton, N.J.).
461:467-80
[DOI] 10.1007/978-1-60327-483-8_32.
[PMID] 19030817.
2008
Retinoic acid induced alveolar regeneration: critical differences in strain sensitivity.
American journal of respiratory cell and molecular biology.
38(2):185-91
[PMID] 17717321.
2008
Retinoids in nonmammalian embryos.
Methods in molecular biology (Clifton, N.J.).
461:541-59
[DOI] 10.1007/978-1-60327-483-8_37.
[PMID] 19030822.
2008
Structural Alveolar Phenotype and in Vivo Lung Physiology of the Retinoic Acid Receptor Beta Knockout Mouse
Thorax.
63
2007
RALDH-independent generation of retinoic acid during vertebrate embryogenesis by CYP1B1.
Development (Cambridge, England).
134(7):1369-83
[PMID] 17329364.
2007
Retinoic acid in the development, regeneration and maintenance of the nervous system.
Nature reviews. Neuroscience.
8(10):755-65
[PMID] 17882253.
2007
Retinoic acid is a potential dorsalising signal in the late embryonic chick hindbrain.
BMC developmental biology.
7
[PMID] 18093305.
2007
Retinoic acid is required for specification of the ventral eye field and for Rathke’s pouch in the avian embryo.
The International journal of developmental biology.
51(3):191-200
[PMID] 17486539.
2007
The retinoic acid metabolising gene, CYP26B1, patterns the cartilaginous cranial neural crest in zebrafish.
The International journal of developmental biology.
51(5):351-60
[PMID] 17616924.
2006
Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth.
Developmental biology.
298(1):167-75
[PMID] 16860305.
2006
Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord.
Human molecular genetics.
15(21):3107-18
[PMID] 16984961.
2006
Retinoic acid receptor beta2 promotes functional regeneration of sensory axons in the spinal cord.
Nature neuroscience.
9(2):243-50
[PMID] 16388307.
2006
Retinoids and spinal cord development.
Journal of neurobiology.
66(7):726-38
[PMID] 16688770.
2006
Retinoids have differing efficacies on alveolar regeneration in a dexamethasone-treated mouse.
American journal of respiratory cell and molecular biology.
35(2):260-7
[PMID] 16574940.
2005
The control of morphogen signalling: regulation of the synthesis and catabolism of retinoic acid in the developing embryo.
Developmental biology.
285(1):224-37
[PMID] 16054125.
2005
The mechanisms of dorsoventral patterning in the vertebrate neural tube.
Developmental biology.
282(1):1-13
[PMID] 15936325.
2004
Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain.
The European journal of neuroscience.
20(4):896-902
[PMID] 15305858.
2004
Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes.
Developmental dynamics : an official publication of the American Association of Anatomists.
230(3):509-17
[PMID] 15188435.
2004
Retinoic acid and the control of dorsoventral patterning in the avian spinal cord.
Developmental biology.
269(2):433-46
[PMID] 15110711.
2004
Retinoic acid in alveolar development, maintenance and regeneration.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
359(1445):799-808
[PMID] 15293808.
2004
Retinoids in lung development and regeneration.
Current topics in developmental biology.
61:153-89
[PMID] 15350401.
2003
Expression of the retinoic acid catabolising enzyme CYP26B1 in the chick embryo and its regulation by retinoic acid.
Gene expression patterns : GEP.
3(5):621-7
[PMID] 12971996.
2003
Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension.
Neuron.
40(1):65-79
[PMID] 14527434.
2003
Regeneration: every clot has a thrombin lining.
Current biology : CB.
13(13):R517-8
[PMID] 12842028.
2003
Retinoic acid signalling centres in the avian embryo identified by sites of expression of synthesising and catabolising enzymes.
Developmental dynamics : an official publication of the American Association of Anatomists.
227(1):114-27
[PMID] 12701104.
2003
Retinoic acid, a regeneration-inducing molecule.
Developmental dynamics : an official publication of the American Association of Anatomists.
226(2):237-44
[PMID] 12557202.
2002
Alveolar proliferation, retinoid synthesizing enzymes, and endogenous retinoids in the postnatal mouse lung. Different roles for Aldh-1 and Raldh-2.
American journal of respiratory cell and molecular biology.
26(1):67-73
[PMID] 11751205.
2002
Retinoic acid receptor beta2 and neurite outgrowth in the adult mouse spinal cord in vitro.
Journal of cell science.
115(Pt 19):3779-86
[PMID] 12235288.
1993
Cellular Retinole Acid Binding Protein In the Periodontal Ligament.
Journal of periodontology.
64(5):392-396
[DOI] 10.1902/jop.1993.64.5.392.
[PMID] 29539736.
1984
Axial characteristics of nerve induced supernumerary limbs in the axolotl.
Wilhelm Roux's archives of developmental biology.
193(6):394-401
[DOI] 10.1007/BF00848230.
[PMID] 28305105.
Grants
Jan 2022
ACTIVE
Investigating cardiac repair in a new adult mammalian model for regeneration, the spiny mouse, Acomys cahirinus
Role: Principal Investigator
Funding: NATL SCIENCE FOU
Sep 2019
– Aug 2022
Genetic Modification to Harness the Regenerative Power of the African Spiny Mouse
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Aug 2019
– Jul 2022
A Single cell expression atlas of muscle and dermis during regeneration after wounding in Acomys cahirinus – an adult mammal model for de novo muscle regeneration
Role: Co-Investigator
Funding: NATL INST OF HLTH OD
Aug 2018
– Dec 2022
Model Systems of Mammalian Regeneration
Role: Faculty
Funding: NATL INST OF HLTH NIGMS
Mar 2017
– Dec 2018
Identifying the genetic changes which induce tissue and organ regeneration in a novel mammalian model system.
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Sep 2016
– Dec 2021
Strain-mediated activation of dermal regeneration and fibrosis
Role: Co-Investigator
Funding: NATL SCIENCE FOU
Feb 2016
– Jan 2020
Functional analysis of signaling pathways controlling limb regeneration.
Role: Principal Investigator
Funding: NATL SCIENCE FOU
Jul 2015
– May 2022
Axolotl Hematopoiesis: A Regeneration Model
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Dec 2013
– Feb 2018
The transformative potential of the regenerating spiny mouse
Role: Principal Investigator
Funding: UF FOUNDATION
via KECK FOUNDATION, W.M.
Contact Details
Phones:
- Business:
- (352) 273-7875
Emails:
- Business:
- malcmaden@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 118525
GAINESVILLE FL 32611 - Business Street:
-
220 BARTRAM HALL
GAINESVILLE FL 32611