Malcolm Maden

Malcolm Maden,

Ph.D.

Department: LS-BIOLOGY
Business Phone: (352) 273-7875
Business Email: malcmaden@ufl.edu

Teaching Profile

Courses Taught
2020
ZOO6927 Special Topics in Zoology
2019-2022
ZOO4926 Special Topics in Zoology
2020-2021
GMS6331 Stem Cell Biology
2014-2019,2021-2023
ZOO3603C Evolutionary Developmental Biology
2018
GMS7980 Research for Doctoral Dissertation
2009-2014,2016-2018
ZOO3713C Functional Vertebrate Anatomy
2018
ZOO7980 Research for Doctoral Dissertation
2011-2012
BSC1920 First Year Introduction: Biology at UF
2021
ZOO4911 Undergraduate Research in Zoology
2021
BSC4910 Individual Mentored Research in Biology
2021
GMS6336 Advanced Stem Cell Biology: Regenerative Medicine
2022
GMS6335 Advanced Stem Cell Biology: Tissue Engineering

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-7178-5309

Publications

2021
A profusion of neural stem cells in the brain of the spiny mouse, Acomys cahirinus
Journal of Anatomy. 238(5):1191-1202 [DOI] 10.1111/joa.13373. [PMID] 33277722.
2021
Functional heart recovery in an adult mammal, the spiny mouse.
International journal of cardiology. 338:196-203 [DOI] 10.1016/j.ijcard.2021.06.015. [PMID] 34126132.
2021
Retinoic Acid Receptors and the Control of Positional Information in the Regenerating Axolotl Limb.
Cells. 10(9) [DOI] 10.3390/cells10092174. [PMID] 34571821.
2021
Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin
npj Regenerative Medicine. 6(1) [DOI] 10.1038/s41536-020-00111-1. [PMID] 33397999.
2020
Author Correction: Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-65513-z. [PMID] 32433574.
2020
Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus.
Scientific reports. 10(1) [DOI] 10.1038/s41598-019-56823-y. [PMID] 31932597.
2020
Model systems for regeneration: the spiny mouse, Acomys cahirinus
Development. 147(4) [DOI] 10.1242/dev.167718. [PMID] 32098790.
2020
Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus.
The Journal of comparative neurology. 528(9):1535-1547 [DOI] 10.1002/cne.24836. [PMID] 31820438.
2020
RA Signaling in Limb Development and Regeneration in Different Species.
Sub-cellular biochemistry. 95:87-117 [DOI] 10.1007/978-3-030-42282-0_4. [PMID] 32297297.
2020
Regeneration in the spiny mouse, Acomys, a new mammalian model.
Current opinion in genetics & development. 64:31-36 [DOI] 10.1016/j.gde.2020.05.019. [PMID] 32599302.
2020
Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis.
PloS one. 15(10) [DOI] 10.1371/journal.pone.0241617. [PMID] 33125436.
2019
Comparative transcriptomic analysis of dermal wound healing reveals de novo skeletal muscle regeneration in Acomys cahirinus
PLOS ONE. 14(5) [DOI] 10.1371/journal.pone.0216228. [PMID] 31141508.
2019
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Science. 364(6436):184-188 [DOI] 10.1126/science.aar2038. [PMID] 30846611.
2019
Insights into the regeneration of skin from Acomys , the spiny mouse
Experimental Dermatology. 28(4):436-441 [DOI] 10.1111/exd.13847.
2018
Optimal skin regeneration after full thickness thermal burn injury in the spiny mouse, Acomys cahirinus.
Burns : journal of the International Society for Burn Injuries. 44(6):1509-1520 [DOI] 10.1016/j.burns.2018.05.018. [PMID] 29903601.
2018
Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-27178-7. [PMID] 29892004.
2018
The evolution of regeneration – where does that leave mammals?
The International journal of developmental biology. 62(6-7-8):369-372 [DOI] 10.1387/ijdb.180031mm. [PMID] 29938749.
2018
Unique behavior of dermal cells from regenerative mammal, the African Spiny Mouse, in response to substrate stiffness.
Journal of biomechanics. 81:149-154 [DOI] 10.1016/j.jbiomech.2018.10.005. [PMID] 30361050.
2017
Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl
Development. [DOI] 10.1242/dev.139873.
2016
Cellular events during scar-free skin regeneration in the spiny mouse, Acomys.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 24(1):75-88 [DOI] 10.1111/wrr.12385. [PMID] 26606280.
2015
A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys.
PloS one. 10(11) [DOI] 10.1371/journal.pone.0142931. [PMID] 26606282.
2015
Tissue specific reactions to positional discontinuities in the regenerating axolotl limb.
Regeneration (Oxford, England). 2(3):137-147 [PMID] 26755943.
2014
Experimentally induced metamorphosis in axolotls reduces regenerative rate and fidelity.
Regeneration (Oxford, England). 1(1):2-14 [DOI] 10.1002/reg2.8. [PMID] 27499857.
2014
Mapping hematopoiesis in a fully regenerative vertebrate: the axolotl.
Blood. 124(8):1232-41 [DOI] 10.1182/blood-2013-09-526970. [PMID] 24802774.
2014
New insights into vertebrate skin regeneration.
International review of cell and molecular biology. 310:129-69 [DOI] 10.1016/B978-0-12-800180-6.00004-9. [PMID] 24725426.
2013
Cellular plasticity during vertebrate appendage regeneration.
Current topics in microbiology and immunology. 367:53-74 [DOI] 10.1007/82_2012_288. [PMID] 23239234.
2013
Proliferation zones in the axolotl brain and regeneration of the telencephalon.
Neural development. 8 [DOI] 10.1186/1749-8104-8-1. [PMID] 23327114.
2013
Who needs stem cells if you can dedifferentiate?
Cell stem cell. 13(6):640-1 [DOI] 10.1016/j.stem.2013.11.020. [PMID] 24315436.
2012
Gene expression patterns specific to the regenerating limb of the Mexican axolotl.
Biology open. 1(10):937-48 [DOI] 10.1242/bio.20121594. [PMID] 23213371.
2012
Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates.
PloS one. 7(4) [DOI] 10.1371/journal.pone.0032875. [PMID] 22485136.
2012
Skin shedding and tissue regeneration in African spiny mice (Acomys).
Nature. 489(7417):561-5 [DOI] 10.1038/nature11499. [PMID] 23018966.
2012
The influence of fundamental traits on mechanisms controlling appendage regeneration.
Biological reviews of the Cambridge Philosophical Society. 87(2):330-45 [DOI] 10.1111/j.1469-185X.2011.00199.x. [PMID] 21929739.
2012
Visualization of retinoic acid signaling in transgenic axolotls during limb development and regeneration.
Developmental biology. 368(1):63-75 [DOI] 10.1016/j.ydbio.2012.05.015. [PMID] 22627291.
2011
Is a regenerative approach viable for the treatment of COPD?
British journal of pharmacology. 163(1):106-15 [DOI] 10.1111/j.1476-5381.2011.01246.x. [PMID] 21265829.
2010
A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.
Neurobiology of disease. 37(1):147-55 [DOI] 10.1016/j.nbd.2009.09.018. [PMID] 19800972.
2010
Kidneys of Alb/TGF-beta1 transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity.
Nephron. Experimental nephrology. 114(4):e127-32 [DOI] 10.1159/000276587. [PMID] 20110732.
2010
The expression of Stra6 and Rdh10 in the avian embryo and their contribution to the generation of retinoid signatures.
The International journal of developmental biology. 54(8-9):1267-75 [DOI] 10.1387/ijdb.093009sr. [PMID] 20563989.
2009
Cells keep a memory of their tissue origin during axolotl limb regeneration.
Nature. 460(7251):60-5 [DOI] 10.1038/nature08152. [PMID] 19571878.
2009
New Aspects of the Control of Retinoic Acid Synthesis in the Chick Embryo
Developmental Biology. 331(2) [DOI] 10.1016/j.ydbio.2009.05.052.
2009
Plasticity of Cells During Axolotl Limb Regeneration
Mechanisms of Development. 126:S295-S296 [DOI] 10.1016/j.mod.2009.06.803.
2009
Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways.
Developmental biology. 326(2):305-13 [DOI] 10.1016/j.ydbio.2008.11.018. [PMID] 19100254.
2008
Axolotl/newt.
Methods in molecular biology (Clifton, N.J.). 461:467-80 [DOI] 10.1007/978-1-60327-483-8_32. [PMID] 19030817.
2008
Retinoic acid induced alveolar regeneration: critical differences in strain sensitivity.
American journal of respiratory cell and molecular biology. 38(2):185-91 [PMID] 17717321.
2008
Retinoids in nonmammalian embryos.
Methods in molecular biology (Clifton, N.J.). 461:541-59 [DOI] 10.1007/978-1-60327-483-8_37. [PMID] 19030822.
2008
Structural Alveolar Phenotype and in Vivo Lung Physiology of the Retinoic Acid Receptor Beta Knockout Mouse
Thorax. 63
2007
RALDH-independent generation of retinoic acid during vertebrate embryogenesis by CYP1B1.
Development (Cambridge, England). 134(7):1369-83 [PMID] 17329364.
2007
Retinoic acid in the development, regeneration and maintenance of the nervous system.
Nature reviews. Neuroscience. 8(10):755-65 [PMID] 17882253.
2007
Retinoic acid is a potential dorsalising signal in the late embryonic chick hindbrain.
BMC developmental biology. 7 [PMID] 18093305.
2007
Retinoic acid is required for specification of the ventral eye field and for Rathke’s pouch in the avian embryo.
The International journal of developmental biology. 51(3):191-200 [PMID] 17486539.
2007
The retinoic acid metabolising gene, CYP26B1, patterns the cartilaginous cranial neural crest in zebrafish.
The International journal of developmental biology. 51(5):351-60 [PMID] 17616924.
2006
Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth.
Developmental biology. 298(1):167-75 [PMID] 16860305.
2006
Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord.
Human molecular genetics. 15(21):3107-18 [PMID] 16984961.
2006
Retinoic acid receptor beta2 promotes functional regeneration of sensory axons in the spinal cord.
Nature neuroscience. 9(2):243-50 [PMID] 16388307.
2006
Retinoids and spinal cord development.
Journal of neurobiology. 66(7):726-38 [PMID] 16688770.
2006
Retinoids have differing efficacies on alveolar regeneration in a dexamethasone-treated mouse.
American journal of respiratory cell and molecular biology. 35(2):260-7 [PMID] 16574940.
2005
The control of morphogen signalling: regulation of the synthesis and catabolism of retinoic acid in the developing embryo.
Developmental biology. 285(1):224-37 [PMID] 16054125.
2005
The mechanisms of dorsoventral patterning in the vertebrate neural tube.
Developmental biology. 282(1):1-13 [PMID] 15936325.
2004
Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain.
The European journal of neuroscience. 20(4):896-902 [PMID] 15305858.
2004
Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes.
Developmental dynamics : an official publication of the American Association of Anatomists. 230(3):509-17 [PMID] 15188435.
2004
Retinoic acid and the control of dorsoventral patterning in the avian spinal cord.
Developmental biology. 269(2):433-46 [PMID] 15110711.
2004
Retinoic acid in alveolar development, maintenance and regeneration.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 359(1445):799-808 [PMID] 15293808.
2004
Retinoids in lung development and regeneration.
Current topics in developmental biology. 61:153-89 [PMID] 15350401.
2003
Expression of the retinoic acid catabolising enzyme CYP26B1 in the chick embryo and its regulation by retinoic acid.
Gene expression patterns : GEP. 3(5):621-7 [PMID] 12971996.
2003
Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension.
Neuron. 40(1):65-79 [PMID] 14527434.
2003
Regeneration: every clot has a thrombin lining.
Current biology : CB. 13(13):R517-8 [PMID] 12842028.
2003
Retinoic acid signalling centres in the avian embryo identified by sites of expression of synthesising and catabolising enzymes.
Developmental dynamics : an official publication of the American Association of Anatomists. 227(1):114-27 [PMID] 12701104.
2003
Retinoic acid, a regeneration-inducing molecule.
Developmental dynamics : an official publication of the American Association of Anatomists. 226(2):237-44 [PMID] 12557202.
2002
Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients.
Journal of cell science. 115(Pt 24):4735-41 [PMID] 12432062.
2002
Alveolar proliferation, retinoid synthesizing enzymes, and endogenous retinoids in the postnatal mouse lung. Different roles for Aldh-1 and Raldh-2.
American journal of respiratory cell and molecular biology. 26(1):67-73 [PMID] 11751205.
2002
Deficits in the posterior pharyngeal endoderm in the absence of retinoids.
Developmental dynamics : an official publication of the American Association of Anatomists. 225(1):54-60 [PMID] 12203720.
2002
Positional information: knowing where you are in a limb.
Current biology : CB. 12(22):R773-5 [PMID] 12445402.
2002
Retinoic acid and limb regeneration–a personal view.
The International journal of developmental biology. 46(7):883-6 [PMID] 12455625.
2002
Retinoic acid receptor beta2 and neurite outgrowth in the adult mouse spinal cord in vitro.
Journal of cell science. 115(Pt 19):3779-86 [PMID] 12235288.
2002
Retinoid signalling in the development of the central nervous system.
Nature reviews. Neuroscience. 3(11):843-53 [PMID] 12415292.
2002
Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung.
American journal of physiology. Lung cellular and molecular physiology. 282(3):L468-76 [PMID] 11839540.
1993
Cellular Retinole Acid Binding Protein In the Periodontal Ligament.
Journal of periodontology. 64(5):392-396 [DOI] 10.1902/jop.1993.64.5.392. [PMID] 29539736.
1984
Axial characteristics of nerve induced supernumerary limbs in the axolotl.
Wilhelm Roux's archives of developmental biology. 193(6):394-401 [DOI] 10.1007/BF00848230. [PMID] 28305105.
Insights into the evolution of dermal armour: osteoderms in a mammal, the spiny mouse,Acomys
. [DOI] 10.1101/2022.10.17.512575.
Social dominance status and social stability in spiny mice (Acomys cahirinus) and its relation to ear-hole regeneration and glucocorticoids
. [DOI] 10.1101/2022.09.13.507818.
Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis
. [DOI] 10.1101/2020.05.07.083287.

Grants

Jan 2022 ACTIVE
Investigating cardiac repair in a new adult mammalian model for regeneration, the spiny mouse, Acomys cahirinus
Role: Principal Investigator
Funding: NATL SCIENCE FOU
Sep 2019 – Aug 2022
Genetic Modification to Harness the Regenerative Power of the African Spiny Mouse
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Aug 2019 – Jul 2022
A Single cell expression atlas of muscle and dermis during regeneration after wounding in Acomys cahirinus – an adult mammal model for de novo muscle regeneration
Role: Co-Investigator
Funding: NATL INST OF HLTH OD
Aug 2018 ACTIVE
Model Systems of Mammalian Regeneration
Role: Faculty
Funding: NATL INST OF HLTH NIGMS
Mar 2017 – Dec 2018
Identifying the genetic changes which induce tissue and organ regeneration in a novel mammalian model system.
Role: Principal Investigator
Funding: NATL INST OF HLTH OD
Sep 2016 – Dec 2021
Strain-mediated activation of dermal regeneration and fibrosis
Role: Co-Investigator
Funding: NATL SCIENCE FOU
Feb 2016 – Jan 2020
Functional analysis of signaling pathways controlling limb regeneration.
Role: Principal Investigator
Funding: NATL SCIENCE FOU
Jul 2015 – May 2022
Axolotl Hematopoiesis: A Regeneration Model
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Dec 2013 – Feb 2018
The transformative potential of the regenerating spiny mouse
Role: Principal Investigator
Funding: UF FOUNDATION via KECK FOUNDATION, W.M.

Contact Details

Phones:
Business:
(352) 273-7875
Emails:
Business:
malcmaden@ufl.edu
Addresses:
Business Mailing:
PO Box 118525
GAINESVILLE FL 32611