Julie M Moore

Julie M Moore,

Professor And Chair

Department: Department of Infectious Diseases & Immunology
Business Phone: (352) 294-4111
Business Email: juliemoore@ufl.edu

Accomplishments

Advanced Leadership for Academic Professionals Program
2021-2022 · University of Florida
Women’s Leadership Fellow
2016-2017 · University of Georgia
Creative Teaching Award
2016 · University of Georgia
Fellow for Innovative Teaching
2014-2015 · UGA Center for Teaching and Learning
Focus on Faculty recognition
2014 · University of Georgia
Pfizer Award for Excellence in Research
2006 · University of Georgia
J. Hatten Howard, III Teaching Award
2004 · Undergraduate Honors Program at the University of Georgia
John M. Bowen Award for Excellence in Animal/Biomedical Research
2002 · University of Georgia
ASM/NCID Postdoctoral Fellowship
1995-1997 · Centers for Disease Control and Prevention
Graduated Summa Cum Laude
1987 · St. Lawrence University
Elected
1985 · Phi Beta Kappa, International Honors Society

Teaching Profile

Courses Taught
2020
VME4906 Problems in Veterinary Science
2020
VME6934 Topics in Veterinary Medical Sciences
2022-2023
VME6933 Seminar in Infectious Diseases and Experimental Pathology
2022
VEM5131 Vet Molecular Biology

Research Profile

Dr. Moore’s research interests center on understanding the immunopathogenesis of malaria and advancing knowledge of placental biology through study of malaria in pregnancy. The laboratory uses a combination of field-based studies (in Kenya), mouse models and in vitro models of villous placenta-malaria parasite interactions to elucidate the complex interactions between the parasite, the placenta and maternal physiology that result in compromised pregnancy. Of particular interest is the intersection between malaria-driven inflammation, coagulation and oxidative stress in the placenta, and how these contribute to cell death and dysfunctional placenta. Similar mechanistic studies are also being conducted in models of cerebral malaria. The lab is also exploring, through collaborative studies with Drs. Connie Mulligan and Chris Dutton at UF, how maternal factors such as pre-natal stress impact the development of the infant gut microbiome and how such impacts further determine infant susceptibility to malaria in the first year of life. The latter studies compliment work in mouse models that shows modulation of the gut microbiome determines both the course of malaria infection and fetal outcomes. The goals of these projects are to advance understanding of the fundamental biology of the host-parasite interaction in malaria and identify novel host-directed therapeutic options for mitigating the effects of malaria infection during pregnancy and other forms of severe malaria.

Open Researcher and Contributor ID (ORCID)

0000-0002-5031-3270

Publications

2022
A novel murine model of post-implantation malaria-induced preterm birth.
PloS one. 17(3) [DOI] 10.1371/journal.pone.0256060. [PMID] 35312688.
2022
Polymorphic Molecular Signatures in Variable Regions of the Plasmodium falciparum var2csa DBL3x Domain Are Associated with Virulence in Placental Malaria.
Pathogens (Basel, Switzerland). 11(5) [DOI] 10.3390/pathogens11050520. [PMID] 35631041.
2021
Hemozoin: a Complex Molecule with Complex Activities
Current Clinical Microbiology Reports. 8(2):87-102 [DOI] 10.1007/s40588-021-00166-8. [PMID] 35096512.
2021
Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.682668. [PMID] 34737733.
2019
A novel murine model for assessing fetal and birth outcomes following transgestational maternal malaria infection
Scientific Reports. 9(1) [DOI] 10.1038/s41598-019-55588-8. [PMID] 31862902.
2019
Composition of the gut microbiota transcends genetic determinants of malaria infection severity and influences pregnancy outcome
EBioMedicine. 44:639-655 [DOI] 10.1016/j.ebiom.2019.05.052. [PMID] 31160271.
2017
Helicobacter Infection Significantly Alters Pregnancy Success in Laboratory Mice.
Journal of the American Association for Laboratory Animal Science : JAALAS. 56(3):322-329 [PMID] 28535868.
2017
Oxidative Stress: A Potential Therapeutic Target in Placental Malaria.
ImmunoHorizons. 1(4):29-41 [DOI] 10.4049/immunohorizons.1700002. [PMID] 28890952.
2016
Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage.
Development (Cambridge, England). 143(22):4127-4136 [PMID] 27729407.
2015
Parasite accumulation in placenta of non-immune baboons during Plasmodium knowlesi infection.
Malaria journal. 14 [DOI] 10.1186/s12936-015-0631-5. [PMID] 25889709.
2012
Maternal malaria induces a procoagulant and antifibrinolytic state that is embryotoxic but responsive to anticoagulant therapy.
PloS one. 7(2) [DOI] 10.1371/journal.pone.0031090. [PMID] 22347435.
2012
Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.
PloS one. 7(2) [DOI] 10.1371/journal.pone.0031565. [PMID] 22347496.
2012
Vertical transmission of Babesia microti, United States.
Emerging infectious diseases. 18(8):1318-21 [DOI] 10.3201/eid1808.110988. [PMID] 22840424.
2009
Association of malaria-induced murine pregnancy failure with robust peripheral and placental cytokine responses.
Infection and immunity. 77(11):4998-5006 [DOI] 10.1128/IAI.00617-09. [PMID] 19687196.
2009
C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.
PloS one. 4(3) [DOI] 10.1371/journal.pone.0004953. [PMID] 19308263.
2009
Human immunodeficiency virus co-infection increases placental parasite density and transplacental malaria transmission in Western Kenya.
The American journal of tropical medicine and hygiene. 80(1):119-25 [PMID] 19141849.
2009
Malaria-induced murine pregnancy failure: distinct roles for IFN-gamma and TNF.
Journal of immunology (Baltimore, Md. : 1950). 183(8):5342-9 [DOI] 10.4049/jimmunol.0901669. [PMID] 19783682.
2008
Elevated gamma interferon-producing NK cells, CD45RO memory-like T cells, and CD4 T cells are associated with protection against malaria infection in pregnancy.
Infection and immunity. 76(4):1678-85 [DOI] 10.1128/IAI.01420-07. [PMID] 18250175.
2008
Immunologic activation of human syncytiotrophoblast by Plasmodium falciparum.
Malaria journal. 7 [DOI] 10.1186/1475-2875-7-42. [PMID] 18312657.
2007
LPS induces secretion of chemokines by human syncytiotrophoblast cells in a MAPK-dependent manner.
Journal of reproductive immunology. 73(1):20-7 [PMID] 16870263.
2006
Murine malaria infection induces fetal loss associated with accumulation of Plasmodium chabaudi AS-infected erythrocytes in the placenta.
Infection and immunity. 74(5):2839-48 [PMID] 16622222.
2005
Immunohistological characterization of macrophage migration inhibitory factor expression in Plasmodium falciparum-infected placentas.
Infection and immunity. 73(6):3287-93 [PMID] 15908353.
2005
Modulation of immune responses during HIV-malaria co-infection in pregnancy.
Trends in parasitology. 21(6):284-91 [PMID] 15922250.
2004
Hemozoin differentially regulates proinflammatory cytokine production in human immunodeficiency virus-seropositive and -seronegative women with placental malaria.
Infection and immunity. 72(12):7022-9 [PMID] 15557625.
2003
In vivo acquisition of hemozoin by placental blood mononuclear cells suppresses PGE2, TNF-alpha, and IL-10.
Biochemical and biophysical research communications. 311(4):839-46 [PMID] 14623257.
2003
Levels of macrophage inflammatory protein 1 alpha (MIP-1 alpha) and MIP-1 beta in intervillous blood plasma samples from women with placental malaria and human immunodeficiency virus infection.
Clinical and diagnostic laboratory immunology. 10(4):631-6 [PMID] 12853396.
2002
Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women.
The Journal of infectious diseases. 185(1):127-31 [PMID] 11756993.
2002
Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood.
The Journal of infectious diseases. 186(9):1371-5 [PMID] 12402212.

Grants

Sep 2022 ACTIVE
Exploring the etiology of oxidative damage and cell death in placental malaria
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2019 – May 2022
OR-DRPD-ROF2019: Prenatal stress, the gut microbiota and infant susceptibility to malaria
Role: Principal Investigator
Funding: UF RESEARCH

Education

Doctor of Philosophy in Biomedical Science
1995 · University of Connecticut Health Center

Contact Details

Phones:
Business:
(352) 294-4111
Emails:
Business:
juliemoore@ufl.edu
Addresses:
Business Mailing:
PO Box 110880
GAINESVILLE FL 32611