Rolf Renne

Rolf Renne,

Associate Director for Basic Science, Henry E. Innes Professor of Cancer Research

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-8204
Business Email: rrenne@ufl.edu

About Rolf Renne

Rolf Renne, Ph.D., is a Professor in the Department of Molecular Genetics and Microbiology, and has studiesd different aspects of Kaposi’s sarcoma-associated herpesvirus (KSHV) since 1995. His current focus is on epigenetic regulation of viral latency and the role of long and small non-coding RNAs in viral biology. His laboratory is using genomics, genetics, and ribonomics approaches to study how viral-encoded genes and microRNAs contribute to KSHV biology and tumorigenesis.

Dr. Renne received his Master’s (1989) and Ph.D. (1993) degrees from the Albert-Ludwigs University of Freiburg, Germany. He performed most of his Ph.D. thesis work at the University of California Davis with Dr. Paul Luciw in the field of Retrovirology. Next, he joined the laboratory of Dr. Don Ganem, UCSF, where he contributed to early work on establishing tissue culture models for KSHV. In 1999, he joined the faculty at Case Western Reserve University, where he focused on molecular aspects such as DNA binding and DNA replication of the KSHV latency-associated nuclear antigen (LANA) and the establishment of the only available KS xenograft model. In 2004, he moved to the University of Florida, where his laboratory was one of four to identify KSHV-encoded microRNAs. More recently, Dr. Renne has contributed to studies on HSV-1, EBV, HHV-6, MHV-68, and poxviruses. Dr. Renne has been continuously funded by multiple NCI grants since 2004, and in 2017, was awarded a multi-investigator NCI Program project together with Drs. Scott Tibbetts (UF), and Erik Flemington (Tulane University). This P01 Project was successfully renewed in 2022. Dr. Renne is on the editorial board of Journal of Virology, Virology, and serves on multiple NIH special emphasis panels. In 2009, he co-chaired the 11th International Workshop on KSHV and related agents and in 2015 the 40th International Herpesvirus Workshop. The unifying theme of his research projects is to deepen our understanding on how latent gamma-herpesvirus gene products including microRNAs and long noncoding RNAs contribute to viral tumorigenesis. While his focus is on Kaposi’s sarcoma, Primary effusion lymphomas, he also collaborates on EBV-associated cancer, and animal models such as MHV68 and various noninfectious cancers including breast cancer and melanoma. In 2017, he was appointed Associate Director for Basic Science at the UF Health Cancer Center, and in 2019 was named the Henry E. Innes Professor of Cancer Research. In 2021, he was appointed member of the NCI panel A for Cancer Center reviews.

Related Links:
Additional Positions:
Henry E. Innes Professor of Cancer Research
2019 – Current ·
Associate Director for Basic Science
2017 – Current ·

Teaching Profile

Courses Taught
2020-2024
GMS7133 Advanced Molecular Virology
2008,2010-2023
GMS6036 Molecular Virology III: DNA Viruses
2008,2010-2014,2014-2024
GMS6034 Advanced Virology I: Genetics and RNA
2013-2014,2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
VME7980 Research for Doctoral Dissertation
2008,2010-2013,2013-2023,2021-2024
GMS6035 Advanced Virology II: RNA Viruses
2015,2017-2018
GMS5905 Special Topics in Biomedical Sciences
2014-2016
BCH6415 Advanced Molecular and Cell Biology
2010
GMS6971 Research for Master’s Thesis
2010
GMS6910 Supervised Research
2023
GMS6905 Independent Studies in Medical Sciences

Research Profile

Fun Fact: My dream is to sail around the world one day. The long-term goal of our research is to understand how latency-associated genes of Kaposi’s Sarcoma-associated Herpesvirus (KSHV), including short (microRNAs) and long noncoding RNAs contribute to viral latency and tumorigenesis. KSHV causes Kaposi’s sarcoma and multiple B cell malignancies in immunosuppressed patients. In South Saharan Africa KS is the most prevalent cancer in man. KSHV has been discovered nearly 30 years ago, however to this date we have not been able to develop an efficient therapeutic approach that targets the virus directly. Studying KSHV is complicated by the fact that we have no practical animal models to study pathogenesis. Hence, to decipher the role of virally encoded long and short noncoding RNAs in tumorigenesis, we have created a highly collaborative approach to comparatively study noncoding RNAs in KSHV, Epstein-Barr Virus, the other human gamma-herpesvirus associated with cancer in humans (with Dr. Flemington at Tulane) and MHV-68 a natural Mouse gamma-herpesvirus associated with B cell lymphomas in mice (with Dr. Scott Tibbetts, MGM UF). Using genetics, genomics, proteomics, and ribonomics-based approaches, we have identified a number of pathways and molecular mechanisms of how noncoding RNAs contribute to pathogenesis of all three viruses. The long-term goal is to identify viral RNAs expressed by the virus or host RNAs perturbed by viral infection that represent tumor vulnerabilities and can be therapeutically targeted

Open Researcher and Contributor ID (ORCID)

0000-0001-7391-8806

Publications

2024
Circulating microRNA Biomarkers of Thiazide Response in Hypertension
Journal of the American Heart Association. 13(4) [DOI] 10.1161/jaha.123.032433.
2024
The model student: GPT-4 performance on graduate biomedical science exams.
Scientific reports. 14(1) [DOI] 10.1038/s41598-024-55568-7. [PMID] 38453979.
2023
Hybkit: a Python API and command-line toolkit for hybrid sequence data from chimeric RNA methods
Bioinformatics. 39(12) [DOI] 10.1093/bioinformatics/btad721. [PMID] 38006335.
2023
Identifying locally actionable strategies to increase participant acceptability and feasibility to participate in Phase I cancer clinical trials.
Health expectations : an international journal of public participation in health care and health policy. 27(1) [DOI] 10.1111/hex.13920. [PMID] 38041447.
2023
Investigating miR-9 as a mediator in laryngeal cancer health disparities.
Frontiers in oncology. 13 [DOI] 10.3389/fonc.2023.1096882. [PMID] 37081981.
2023
Sex-biased expression is associated with chromatin state in D. melanogaster and D. simulans.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.01.13.523946. [PMID] 36711631.
2023
Sex-Biased Expression Is Associated With Chromatin State in Drosophila melanogaster and Drosophila simulans.
Molecular biology and evolution. 40(5) [DOI] 10.1093/molbev/msad078. [PMID] 37116218.
2023
Virology under the Microscope—a Call for Rational Discourse
mBio. 14(1) [DOI] 10.1128/mbio.00188-23. [PMID] 36700642.
2023
Virology under the Microscope—a Call for Rational Discourse
Journal of Virology. 97(2) [DOI] 10.1128/jvi.00089-23. [PMID] 36700640.
2023
Virology under the Microscope—a Call for Rational Discourse
mSphere. 8(2) [DOI] 10.1128/msphere.00034-23. [PMID] 36700653.
2022
DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of Kaposi’s Sarcoma Associated Herpesvirus by Interacting with Viral mRNAs
Viruses. 14(10) [DOI] 10.3390/v14102083. [PMID] 36298642.
2022
Metabolic signatures associated with oncolytic myxoma viral infections.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-15562-3. [PMID] 35871072.
2021
A noncanonical microRNA derived from the snaR-A noncoding RNA targets a metastasis inhibitor.
RNA (New York, N.Y.). 27(6):694-709 [DOI] 10.1261/rna.078694.121. [PMID] 33795480.
2021
Cross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells
Cancers. 13(5) [DOI] 10.3390/cancers13051096. [PMID] 33806450.
2021
EBV miRNAs are potent effectors of tumor cell transcriptome remodeling in promoting immune escape
PLOS Pathogens. 17(5) [DOI] 10.1371/journal.ppat.1009217. [PMID] 33956915.
2021
Kaposi’s Sarcoma-associated Herpesvirus microRNA mutants modulate cancer hallmark phenotypic differences in human endothelial cells.
Journal of virology. 95(10) [DOI] 10.1128/JVI.02022-20. [PMID] 33568509.
2021
Modified Cross-Linking, Ligation, and Sequencing of Hybrids (qCLASH) to Identify MicroRNA Targets.
Current protocols. 1(10) [DOI] 10.1002/cpz1.257. [PMID] 34610213.
2021
Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a
PLOS Genetics. 17(12) [DOI] 10.1371/journal.pgen.1009934. [PMID] 34914716.
2020
Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Drug metabolism and disposition: the biological fate of chemicals. 48(7):563-569 [DOI] 10.1124/dmd.120.090639. [PMID] 32357971.
2020
Human Cytomegalovirus Latency and Myelosuppression: A microRNA-Dependent Yin and Yang Regulatory Loop.
Cell host & microbe. 27(1):8-10 [DOI] 10.1016/j.chom.2019.12.008. [PMID] 31951824.
2019
Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.
Journal of virology. 93(6) [DOI] 10.1128/JVI.01952-18. [PMID] 30567979.
2019
Downregulation of the human peripheral myelin protein 22 gene by miR-29a in cellular models of Charcot-Marie-Tooth disease.
Gene therapy. 26(12):455-464 [DOI] 10.1038/s41434-019-0098-z. [PMID] 31455873.
2019
Gammaherpesvirus RNAs Come Full Circle.
mBio. 10(2) [DOI] 10.1128/mBio.00071-19. [PMID] 30940699.
2019
Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery
PLOS Pathogens. 15(8) [DOI] 10.1371/journal.ppat.1007843. [PMID] 31393953.
2019
PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment.
PLoS pathogens. 15(12) [DOI] 10.1371/journal.ppat.1008221. [PMID] 31881074.
2018
Computational analysis of ribonomics datasets identifies long non-coding RNA targets of γ-herpesviral miRNAs.
Nucleic acids research. 46(16):8574-8589 [DOI] 10.1093/nar/gky459. [PMID] 29846699.
2018
Connivance, Complicity, or Collusion? The Role of Noncoding RNAs in Promoting Gammaherpesvirus Tumorigenesis.
Trends in cancer. 4(11):729-740 [DOI] 10.1016/j.trecan.2018.09.005. [PMID] 30352676.
2018
Contemporary Ribonomics Methods for Viral microRNA Target Analysis.
Non-coding RNA. 4(4) [DOI] 10.3390/ncrna4040031. [PMID] 30424002.
2018
Modified Cross-Linking, Ligation, and Sequencing of Hybrids (qCLASH) Identifies Kaposi’s Sarcoma-Associated Herpesvirus MicroRNA Targets in Endothelial Cells.
Journal of virology. 92(8) [DOI] 10.1128/JVI.02138-17. [PMID] 29386283.
2018
The Epstein Barr virus circRNAome.
PLoS pathogens. 14(8) [DOI] 10.1371/journal.ppat.1007206. [PMID] 30080890.
2018
Visualization of molecular biology: The LANA tether.
Proceedings of the National Academy of Sciences of the United States of America. 115(19):4816-4818 [DOI] 10.1073/pnas.1804797115. [PMID] 29691321.
2017
microRNA dependent and independent deregulation of long non-coding RNAs by an oncogenic herpesvirus
PLOS Pathogens. 13(7) [DOI] 10.1371/journal.ppat.1006508. [PMID] 28715488.
2016
A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency.
mSphere. 1(2) [PMID] 27110595.
2016
A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway.
Oncotarget. 7(22):32286-305 [DOI] 10.18632/oncotarget.8591. [PMID] 27058419.
2016
A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants.
Viruses. 8(2) [DOI] 10.3390/v8020054. [PMID] 26907327.
2016
Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi’s Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes.
mBio. 7(1):e02109-15 [DOI] 10.1128/mBio.02109-15. [PMID] 26814175.
2016
Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi’s sarcoma-associated herpesvirus.
Oncotarget. 7(9):10459-71 [DOI] 10.18632/oncotarget.7227. [PMID] 26859574.
2016
The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA.
PLoS pathogens. 12(4) [DOI] 10.1371/journal.ppat.1005605. [PMID] 27128969.
2015
A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling.
PLoS pathogens. 11(9) [DOI] 10.1371/journal.ppat.1005171. [PMID] 26402907.
2015
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
Journal of virology. 89(1):713-29 [DOI] 10.1128/JVI.02570-14. [PMID] 25355872.
2015
Identification of the physiological gene targets of the essential lytic replicative Kaposi’s sarcoma-associated herpesvirus ORF57 protein.
Journal of virology. 89(3):1688-702 [DOI] 10.1128/JVI.02663-14. [PMID] 25410858.
2015
Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Induces the Oncogenic miR-17-92 Cluster and Down-Regulates TGF-β Signaling.
PLoS pathogens. 11(11) [DOI] 10.1371/journal.ppat.1005255. [PMID] 26545119.
2015
Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection.
Journal of virology. 89(5):2972-8 [DOI] 10.1128/JVI.03248-14. [PMID] 25540365.
2014
A systems biology approach identified different regulatory networks targeted by KSHV miR-K12-11 in B cells and endothelial cells.
BMC genomics. 15(1) [DOI] 10.1186/1471-2164-15-668. [PMID] 25106478.
2014
A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets.
Oncotarget. 5(24):12528-42 [PMID] 25587024.
2014
Genomic and Proteomic Analysis of Transcription Factor Tfii-I Reveals Insight Into the Response To Cellular Stress
Nucleic acids research. 42(12):7625-7641 [DOI] 10.1093/nar/gku467. [PMID] 24875474.
2014
Helminth Infection Reactivates Latent Gamma-Herpesvirus Via Cytokine Competition At a Viral Promoter
Science. 345(6196):573-577 [DOI] 10.1126/science.1254517. [PMID] 24968940.
2014
HITS-CLIP and PAR-CLIP advance viral miRNA targetome analysis.
Critical reviews in eukaryotic gene expression. 24(2):101-16 [PMID] 24940765.
2014
KSHV miRNAs decrease expression of lytic genes in latently infected PEL and endothelial cells by targeting host transcription factors.
Viruses. 6(10):4005-23 [DOI] 10.3390/v6104005. [PMID] 25341664.
2014
LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex.
PLoS pathogens. 10(7) [DOI] 10.1371/journal.ppat.1004240. [PMID] 25033463.
2014
Leveraging biological replicates to improve analysis in ChIP-seq experiments.
Computational and structural biotechnology journal. 9 [DOI] 10.5936/csbj.201401002. [PMID] 24688750.
2014
Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo.
mBio. 5(3):e00981-14 [DOI] 10.1128/mBio.00981-14. [PMID] 24865551.
2013
Epigenetic diversity of Kaposi’s sarcoma-associated herpesvirus.
Nucleic acids research. 41(5):2993-3009 [DOI] 10.1093/nar/gkt033. [PMID] 23361465.
2013
Kaposi’s sarcoma-associated herpesvirus microRNA single-nucleotide polymorphisms identified in clinical samples can affect microRNA processing, level of expression, and silencing activity.
Journal of virology. 87(22):12237-48 [DOI] 10.1128/JVI.01202-13. [PMID] 24006441.
2013
Persistent human herpesvirus-6 infection in patients with an inherited form of the virus.
Journal of medical virology. 85(11):1940-6 [DOI] 10.1002/jmv.23685. [PMID] 23893753.
2013
γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis.
Current opinion in virology. 3(3):266-75 [DOI] 10.1016/j.coviro.2013.05.013. [PMID] 23743127.
2012
Ago HITS-CLIP expands understanding of Kaposi’s sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
PLoS pathogens. 8(8) [DOI] 10.1371/journal.ppat.1002884. [PMID] 22927820.
2012
Biological characterization and next-generation genome sequencing of the unclassified Cotia virus SPAn232 (Poxviridae).
Journal of virology. 86(9):5039-54 [DOI] 10.1128/JVI.07162-11. [PMID] 22345477.
2011
A Kaposi’s sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rγnull mice.
Journal of virology. 85(19):9877-86 [DOI] 10.1128/JVI.05558-11. [PMID] 21813606.
2011
Viral miRNAs and immune evasion.
Biochimica et biophysica acta. 1809(11-12):708-14 [DOI] 10.1016/j.bbagrm.2011.06.012. [PMID] 21757042.
2011
Viral miRNAs.
Methods in molecular biology (Clifton, N.J.). 721:43-66 [DOI] 10.1007/978-1-61779-037-9_3. [PMID] 21431678.
2010
Epigenetic regulation of Kaposi’s sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway.
Journal of virology. 84(6):2697-706 [DOI] 10.1128/JVI.01997-09. [PMID] 20071580.
2010
KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.
Genes & development. 24(2):195-205 [DOI] 10.1101/gad.553410. [PMID] 20080955.
2010
Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi’s sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins.
The Journal of general virology. 91(Pt 9):2203-15 [DOI] 10.1099/vir.0.020958-0. [PMID] 20484563.
2010
Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress.
PLoS pathogens. 6(1) [DOI] 10.1371/journal.ppat.1000742. [PMID] 20126446.
2010
Viral miRNAs: tools for immune evasion.
Current opinion in microbiology. 13(4):540-5 [DOI] 10.1016/j.mib.2010.05.017. [PMID] 20580307.
2009
Involvement of SSRP1 in latent replication of Kaposi’s sarcoma-associated herpesvirus.
Journal of virology. 83(21):11051-63 [DOI] 10.1128/JVI.00907-09. [PMID] 19710137.
2009
Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29a.
Glia. 57(12):1265-79 [DOI] 10.1002/glia.20846. [PMID] 19170179.
2009
Role of virus-encoded microRNAs in herpesvirus biology.
Trends in microbiology. 17(12):544-53 [DOI] 10.1016/j.tim.2009.09.002. [PMID] 19828316.
2008
KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor.
Blood. 111(9):4731-40 [DOI] 10.1182/blood-2007-09-110544. [PMID] 18199825.
2007
Analysis of viral cis elements conferring Kaposi’s sarcoma-associated herpesvirus episome partitioning and maintenance.
Journal of virology. 81(18):9825-37 [PMID] 17626102.
2007
Conservation of virally encoded microRNAs in Kaposi sarcoma–associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease.
The Journal of infectious diseases. 195(5):645-59 [PMID] 17262705.
2007
Identification of cellular genes targeted by KSHV-encoded microRNAs.
PLoS pathogens. 3(5) [PMID] 17500590.
2007
Kaposi’s sarcoma-associated herpesvirus encodes an ortholog of miR-155.
Journal of virology. 81(23):12836-45 [PMID] 17881434.
2006
Gene expression profiling in lung tissues from mice exposed to cigarette smoke, lipopolysaccharide, or smoke plus lipopolysaccharide by inhalation.
Inhalation toxicology. 18(8):555-68 [PMID] 16717027.
2006
Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi’s sarcoma-associated herpesvirus latency in vitro and in vivo.
Journal of virology. 80(10):4833-46 [PMID] 16641275.
2005
Characterization of the minimal replicator of Kaposi’s sarcoma-associated herpesvirus latent origin.
Journal of virology. 79(4):2637-42 [PMID] 15681465.
2005
Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi’s sarcoma-associated herpesvirus.
Journal of virology. 79(14):9301-5 [PMID] 15994824.
2005
The latency-associated nuclear antigen of Kaposi’s sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest.
The Journal of biological chemistry. 280(5):3862-74 [PMID] 15525642.
2004
Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi’s sarcoma-associated herpesvirus.
The Journal of biological chemistry. 279(16):16822-31 [PMID] 14742422.
2002
Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replication.
The Journal of biological chemistry. 277(30):27401-11 [PMID] 12015325.
1980
Morphologic and biochemical effects of intratracheally administered oil shale in rats.
Journal of environmental pathology and toxicology. 3(5-6):397-406 [PMID] 7441092.

Grants

Jun 2023 ACTIVE
UF Health Cancer Center Support Grant
Role: Other
Funding: NATL INST OF HLTH NCI
Aug 2022 ACTIVE
Investigating miR-9-5p and its targets as interventional and clinicopathologic predictors of laryngeal cancer racial disparate outcomes
Role: Other
Funding: US ARMY MED RES ACQUISITION
Jun 2022 ACTIVE
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jan 2022 ACTIVE
MicroRNA turnover induced by target RNAs in Colorectal Cancer
Role: Co-Investigator
Funding: AMERICAN CANCER SOCIETY
Jan 2019 – Oct 2020
UFF F006200 Innes Professorship
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2018 ACTIVE
The Role of H3.3 histone variant in the pathogenesis of oral Kaposi's Sarcoma
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Feb 2017 – Jan 2022
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jul 2015 ACTIVE
Florida Academic Cancer Center Alliance Seed Grants
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Feb 2015 – Oct 2023
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015 – Dec 2020
Role of MHV68 miRNAs in latency and pathogenesis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2014 – Jun 2017
Histone variant H3.3 and KSHV LANA in the pathogenesis of oral Kaposis sarcoma
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Aug 2013 – Aug 2016
Identification of KSHV miRNA targets in endothelial cells and characterization miRNA knockout viruses
Role: Principal Investigator
Funding: NATL INST OF HLTH
Dec 2012 – Jan 2019
Studying the role of KSHV-encoded miRNAs
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Mar 2011 – Feb 2017
LANA and Cellular Gene Expression
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Mar 2006 – May 2023
Davis Cancer Researach Equipment
Role: Project Manager
Funding: UF FOUNDATION

Education

PhD, Retrovirology/Foamy Viruses
1989-1993 · Albert-Ludwigs University
MS, Biology
1984-1989 · Albert-Ludwigs University

Contact Details

Phones:
Business:
(352) 273-8204
Emails:
Business:
rrenne@ufl.edu
Administrative Specialist II:
Addresses:
Business Mailing:
PO BOX 103610
GAINESVILLE FL 326110001
Business Street:
1200 NEWELL DR RM R4 295
ACADEMIC RESEARCH BLDG
GAINESVILLE FL 32610