James L Resnick,
Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 392-3258
Business Email:
jresnick@ufl.edu
About James L Resnick
Related Links:
Teaching Profile
Courses Taught
2013-2023
GMS6001 Fundamentals of Biomedical Sciences I
2019-2023
BMS6003 Genetics and Health
2019,2021
GMS6013 Developmental Genetics
2013,2015-2018
BCH7412 Epigenetics of Human Disease and Development
2018
GMS7980 Research for Doctoral Dissertation
2017
GMS6905 Independent Studies in Medical Sciences
2014-2016
GMS6331 Stem Cell Biology
2023
GMS5905 Special Topics in Biomedical Sciences
Publications
2022
Health Problems in Adults with Prader-Willi Syndrome of Different Genetic Subtypes: Cohort Study, Meta-Analysis and Review of the Literature.
Journal of clinical medicine.
11(14)
[DOI] 10.3390/jcm11144033.
[PMID] 35887798.
2021
The Diagnostic Journey of a Patient with Prader-Willi-Like Syndrome and a Unique Homozygous SNURF-SNRPN Variant; Bio-Molecular Analysis and Review of the Literature.
Genes.
12(6)
[DOI] 10.3390/genes12060875.
[PMID] 34200226.
2019
A mouse model of Angelman syndrome imprinting defects.
Human molecular genetics.
28(2):220-229
[DOI] 10.1093/hmg/ddy345.
[PMID] 30260400.
2018
Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.
Human molecular genetics.
27(23):4051-4060
[DOI] 10.1093/hmg/ddy296.
[PMID] 30124848.
2018
Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats.
British journal of anaesthesia.
121(2):406-416
[DOI] 10.1016/j.bja.2018.04.034.
[PMID] 30032879.
2017
Paradoxical leanness in the imprinting-centre deletion mouse model for Prader-Willi syndrome.
The Journal of endocrinology.
232(1):123-135
[PMID] 27799465.
2015
Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis.
Reproductive sciences (Thousand Oaks, Calif.).
22(2):250-7
[DOI] 10.1177/1933719114542026.
[PMID] 25031318.
2015
Angelman syndrome imprinting center encodes a transcriptional promoter.
Proceedings of the National Academy of Sciences of the United States of America.
112(22):6871-5
[DOI] 10.1073/pnas.1411261111.
[PMID] 25378697.
2015
Correction for Lewis et al., Angelman syndrome imprinting center encodes a transcriptional promoter.
Proceedings of the National Academy of Sciences of the United States of America.
112(22)
[DOI] 10.1073/pnas.1500034112.
[PMID] 25588880.
2014
Influence of the Prader-Willi syndrome imprinting center on the DNA methylation landscape in the mouse brain.
Epigenetics.
9(11):1540-56
[DOI] 10.4161/15592294.2014.969667.
[PMID] 25482058.
2013
Differential gene expression reveals mitochondrial dysfunction in an imprinting center deletion mouse model of Prader-Willi syndrome.
Clinical and translational science.
6(5):347-55
[DOI] 10.1111/cts.12083.
[PMID] 24127921.
2013
Recommendations for the investigation of animal models of Prader-Willi syndrome.
Mammalian genome : official journal of the International Mammalian Genome Society.
24(5-6):165-78
[DOI] 10.1007/s00335-013-9454-2.
[PMID] 23609791.
2013
Regulatory elements associated with paternally-expressed genes in the imprinted murine Angelman/Prader-Willi syndrome domain.
PloS one.
8(2)
[DOI] 10.1371/journal.pone.0052390.
[PMID] 23390487.
2012
Immunomagnetic purification of murine primordial germ cells.
Methods in molecular biology (Clifton, N.J.).
925:61-6
[DOI] 10.1007/978-1-62703-011-3_4.
[PMID] 22907490.
2012
Temporal and developmental requirements for the Prader-Willi imprinting center.
Proceedings of the National Academy of Sciences of the United States of America.
109(9):3446-50
[DOI] 10.1073/pnas.1115057109.
[PMID] 22331910.
2011
A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center.
Human molecular genetics.
20(17):3461-6
[DOI] 10.1093/hmg/ddr262.
[PMID] 21659337.
2011
Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.
PLoS genetics.
7(12)
[DOI] 10.1371/journal.pgen.1002422.
[PMID] 22242001.
2010
Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC.
Neurogenetics.
11(2):145-51
[DOI] 10.1007/s10048-009-0226-9.
[PMID] 19894069.
2010
Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome.
The European journal of neuroscience.
31(1):156-64
[DOI] 10.1111/j.1460-9568.2009.07048.x.
[PMID] 20092561.
2009
Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar size.
Human molecular genetics.
18(22):4227-38
[DOI] 10.1093/hmg/ddp373.
[PMID] 19656775.
2008
The Roles of E2F6 and Dna Methylation in the Regulation of Gene Expression During Germ Cell Development
.
2007
A targeted deletion upstream of Snrpn does not result in an imprinting defect.
Mammalian genome : official journal of the International Mammalian Genome Society.
18(4):255-62
[PMID] 17514346.
2006
A human imprinting centre demonstrates conserved acquisition but diverged maintenance of imprinting in a mouse model for Angelman syndrome imprinting defects.
Human molecular genetics.
15(3):393-404
[PMID] 16368707.
2006
DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages.
Development (Cambridge, England).
133(17):3411-8
[PMID] 16887828.
2005
DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells.
Stem cells (Dayton, Ohio).
23(9):1314-23
[PMID] 16051982.
2004
Evidence for genetic modifiers of postnatal lethality in PWS-IC deletion mice.
Human molecular genetics.
13(23):2971-7
[PMID] 15459179.
2003
Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation.
Developmental biology.
258(1):201-8
[PMID] 12781693.
1999
Activin and TGFbeta limit murine primordial germ cell proliferation.
Developmental biology.
207(2):470-5
[PMID] 10068477.
1999
Differentiation of murine premigratory primordial germ cells in culture.
Biology of reproduction.
61(4):1146-51
[PMID] 10491656.
1998
A mouse model for Prader-Willi syndrome imprinting-centre mutations.
Nature genetics.
19(1):25-31
[PMID] 9590284.
1998
Primordial germ cells, stem cells and testicular cancer.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
106(1):134-41
[PMID] 9524571.
1998
Role of fibroblast growth factors and their receptors in mouse primordial germ cell growth.
Biology of reproduction.
59(5):1224-9
[PMID] 9780331.
1995
Two CDC25 homologues are differentially expressed during mouse development.
Development (Cambridge, England).
121(7):2047-56
[PMID] 7635051.
1992
Characterization of activated and normal mouse Mos gene in murine 3T3 cells.
Oncogene.
7(12):2489-98
[PMID] 1461652.
1992
Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.
Genes & development.
6(10):1832-42
[PMID] 1383087.
1992
Long-term proliferation of mouse primordial germ cells in culture.
Nature.
359(6395):550-1
[PMID] 1383830.
1991
Requirement for mast cell growth factor for primordial germ cell survival in culture.
Nature.
352(6338):809-11
[PMID] 1715518.
Grants
May 2019
– Nov 2022
A mouse model to assess genetic therapies for Prader-Willi syndrome
Role: Principal Investigator
Funding: FOU FOR PRADER-WILLI RESEARCH
Jul 2013
– Mar 2020
Imprinting defects leading to Angelman and Prader Willi syndromes
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Contact Details
Phones:
- Business:
- (352) 392-3258
Emails:
- Business:
- jresnick@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100266
GAINESVILLE FL 32610 - Business Street:
-
RG-295 ARB
GAINESVILLE FL 32610