Frederick S Southwick, M.D.
PROF
Department:
MD-HOSPITAL MEDICINE DIVISION
Business Phone:
(352) 246-8465
Business Email:
southf@epi.ufl.edu
Accomplishments
Advanced Leadership Initiative Fellow
2010
·
Harvard Business School
Award for distinguished research accomplishments
2001
·
University of Florida Research Foundation
Elected Outstanding
2001
·
Department of Medicine House Staff
Teaching Excellence Award
2001
·
University of Florida
Elected Member
2000
·
Association of Professors of Medicine
Teaching Profile
Courses Taught
2013-2018
MDT7200 Elect Top/Medicine
2016,2018
MDC7200 Medicine Clerkship
2018
MDC7203 Senior Medicine Clerk
2018,2024-2025
BMS6300 Fund Micro and Immuno
2010-2013
MEL7948 Elect Top/Medicine
2021-2025
PAS5020 Intro to Medicine 2
2024-2025
BMS6091 Hlth Outcomes Plcy 1
2024-2025
BMS6642 The Resp Sys Hlth
2024-2025
BMS6633 The Cv System
2025
BMS6851 Health Systems Science 1B
Board Certifications
-
Infectious DiseasesAmerican Board of Internal Medicine
-
Internal MedicineAmerican Board of Internal Medicine
Clinical Profile
Specialties
- Hospital Medicine
- Infectious Disease
Areas of Interest
- Anthrax
- Atypical pneumonia
- Community-acquired pneumonia in adults
- Hospital-acquired pneumonia
- Immunodeficiency disorders
- Infectious diseases
- Meningitis
- Sepsis
- Urinary tract infection – adults
Publications
Academic Articles
2023
Comparison of the clinical characteristics of SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) infected patients from a single hospitalist service.
BMC infectious diseases.
23(1)
[DOI] 10.1186/s12879-023-08714-x.
[PMID] 37907849.
2023
Correction: Comparison of the clinical characteristics of SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) infected patients from a single hospitalist service.
BMC infectious diseases.
23(1)
[DOI] 10.1186/s12879-023-08827-3.
[PMID] 38087225.
2023
Home Monitoring for Fever: An Inexpensive Screening Method to Prevent Household Spread of COVID-19.
Journal of biotechnology and biomedicine.
6(3):392-400
[DOI] 10.26502/jbb.2642-91280101.
[PMID] 38745997.
2023
Lessons in clinical reasoning – pitfalls, myths, and pearls: a case of crushing, substernal chest pain.
Diagnosis (Berlin, Germany).
10(3):316-321
[DOI] 10.1515/dx-2022-0017.
[PMID] 37441731.
2022
Applying Lean principles to create a high throughput mass COVID-19 vaccination site.
BMJ open quality.
11(1)
[DOI] 10.1136/bmjoq-2021-001617.
[PMID] 35131743.
2022
Prospective application of the interdisciplinary bedside rounding checklist ‘TEMP’ is associated with reduced infections and length of hospital stay.
BMJ open quality.
11(4)
[DOI] 10.1136/bmjoq-2022-002045.
[PMID] 36588303.
2021
Improving the Definition of Coronavirus Disease 2019-Related Deaths.
The Journal of infectious diseases.
224(3):375-376
[DOI] 10.1093/infdis/jiab271.
[PMID] 34000024.
2021
In response: neuraxial and peripheral misconnection events leading to wrong-route medication errors.
Regional anesthesia and pain medicine.
46(12):1117-1118
[DOI] 10.1136/rapm-2021-102672.
[PMID] 33858913.
2021
Increasing adherence to a standardized rounding procedure in two hospital in-patient units.
Journal of applied behavior analysis.
54(4):1514-1525
[DOI] 10.1002/jaba.865.
[PMID] 34289103.
2021
Neuraxial and peripheral misconnection events leading to wrong-route medication errors: a comprehensive literature review.
Regional anesthesia and pain medicine.
46(2):176-181
[DOI] 10.1136/rapm-2020-101836.
[PMID] 33144409.
2020
Health Care Provider Factors Associated with Patient-Reported Adverse Events and Harm.
Joint Commission journal on quality and patient safety.
46(5):282-290
[DOI] 10.1016/j.jcjq.2020.02.004.
[PMID] 32362355.
2020
Infectious diseases occurring in the context of substance use disorders: A concise review.
Journal of the neurological sciences.
411
[DOI] 10.1016/j.jns.2020.116719.
[PMID] 32070807.
2020
No human exists in isolation or as an island: The outcomes of a multidisciplinary, global, and context-specific COVID-19 consortium.
American journal of disaster medicine.
15(3):219-222
[DOI] 10.5055/ajdm.2020.0350.
[PMID] 33270212.
2020
The Loss of Social Connectedness as a Major Contributor to Physician Burnout: Applying Organizational and Teamwork Principles for Prevention and Recovery.
JAMA psychiatry.
77(5):449-450
[DOI] 10.1001/jamapsychiatry.2019.4800.
[PMID] 32074385.
2019
Teaching novice clinicians how to reduce diagnostic waste and errors by applying the Toyota Production System.
Diagnosis (Berlin, Germany).
6(2):179-185
[DOI] 10.1515/dx-2018-0081.
[PMID] 30875320.
2018
Learning From Patients’ Experiences Related To Diagnostic Errors Is Essential For Progress In Patient Safety.
Health affairs (Project Hope).
37(11):1821-1827
[DOI] 10.1377/hlthaff.2018.0698.
[PMID] 30395513.
2018
The Loss of a Sense of Control as a Major Contributor to Physician Burnout: A Neuropsychiatric Pathway to Prevention and Recovery.
JAMA psychiatry.
75(7):665-666
[DOI] 10.1001/jamapsychiatry.2018.0566.
[PMID] 29799941.
2016
The lazy leukocyte syndrome revisited.
Blood.
128(17):2112-2113
[PMID] 27789436.
2015
A patient-initiated voluntary online survey of adverse medical events: the perspective of 696 injured patients and families.
BMJ quality & safety.
24(10):620-9
[DOI] 10.1136/bmjqs-2015-003980.
[PMID] 26092166.
2014
Applying athletic principles to medical rounds to improve teaching and patient care.
Academic medicine : journal of the Association of American Medical Colleges.
89(7):1018-23
[DOI] 10.1097/ACM.0000000000000278.
[PMID] 24979169.
2014
Exserohilum rostratum: characterization of a cross-kingdom pathogen of plants and humans.
PloS one.
9(10)
[DOI] 10.1371/journal.pone.0108691.
[PMID] 25285444.
2013
Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
Cellular microbiology.
15(3):353-367
[DOI] 10.1111/cmi.12051.
[PMID] 23083060.
2012
All’S Not Fair in Science and Publishing
Scientist.
26:24-25
2012
Anthrax lethal and edema toxins fail to directly impair human platelet function.
The Journal of infectious diseases.
205(3):453-7
[DOI] 10.1093/infdis/jir763.
[PMID] 22158563.
2012
Bacillus anthracis’ lethal toxin induces broad transcriptional responses in human peripheral monocytes.
BMC immunology.
13
[DOI] 10.1186/1471-2172-13-33.
[PMID] 22747600.
2012
Perspective: a business school view of medical interprofessional rounds: transforming rounding groups into rounding teams.
Academic medicine : journal of the Association of American Medical Colleges.
87(12):1768-71
[DOI] 10.1097/ACM.0b013e318271f8da.
[PMID] 23095926.
2011
The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one.
6(4)
[DOI] 10.1371/journal.pone.0018890.
[PMID] 21573031.
2010
Brucella, voles, and emerging pathogens.
The Journal of infectious diseases.
202(1):1-2
[DOI] 10.1086/653085.
[PMID] 20497041.
2010
Commentary: IDSA guidelines for improving the teaching of preclinical medical microbiology and infectious diseases.
Academic medicine : journal of the Association of American Medical Colleges.
85(1):19-22
[DOI] 10.1097/ACM.0b013e3181c485c5.
[PMID] 20042815.
2009
Bacillus anthracis edema toxin impairs neutrophil actin-based motility.
Infection and immunity.
77(6):2455-64
[DOI] 10.1128/IAI.00839-08.
[PMID] 19349425.
2009
Commentary: “Who was caring for Mary?” revisited: a call for all academic physicians caring for patients to focus on systems and quality improvement.
Academic medicine : journal of the Association of American Medical Colleges.
84(12):1648-50
[DOI] 10.1097/ACM.0b013e3181bf9f80.
[PMID] 19940566.
2008
Methicillin-resistant Staphylococcus aureus infection in a college football team: risk factors outside the locker room and playing field.
Infection control and hospital epidemiology.
29(5):450-3
[DOI] 10.1086/587971.
[PMID] 18419370.
2007
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.
The EMBO journal.
26(9):2240-50
[PMID] 17446863.
2007
Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook.
Transactions of the American Clinical and Climatological Association.
118:115-22
[PMID] 18528495.
2006
A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing.
The EMBO journal.
25(19):4458-67
[PMID] 16977317.
2005
Anthrax lethal toxin paralyzes neutrophil actin-based motility.
The Journal of infectious diseases.
192(5):837-45
[PMID] 16088833.
2005
Gelsolin mediates calcium-dependent disassembly of Listeria actin tails.
Proceedings of the National Academy of Sciences of the United States of America.
102(6):1921-6
[PMID] 15671163.
2005
Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation.
The Journal of biological chemistry.
280(12):11379-86
[PMID] 15642729.
2003
Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc.
Cell motility and the cytoskeleton.
54(1):41-55
[PMID] 12451594.
2003
CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
Infection and immunity.
71(11):6582-90
[PMID] 14573680.
2003
Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
The Journal of biological chemistry.
278(27):24629-35
[PMID] 12730212.
2002
A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.
Archives of biochemistry and biophysics.
406(2):296-301
[PMID] 12361718.
2002
Actin-based phagosome motility.
Cell motility and the cytoskeleton.
53(2):81-8
[PMID] 12211106.
2002
Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America.
99(26):16782-7
[PMID] 12464680.
2002
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
Molecular medicine (Cambridge, Mass.).
8(1):56-64
[PMID] 11984006.
2001
Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing.
The Journal of cell biology.
154(4):775-84
[PMID] 11514591.
2001
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Nature cell biology.
3(10):897-904
[PMID] 11584271.
2001
Who was caring for Mary? 1993.
Obstetrics and gynecology.
98(6):1140-2
[PMID] 11755567.
2000
Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.
Proceedings of the National Academy of Sciences of the United States of America.
97(13):6936-8
[PMID] 10860951.
2000
Shigella actin-based motility in the presence of truncated vinculin.
Cell motility and the cytoskeleton.
45(4):272-8
[PMID] 10744860.
1999
Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
Molecular cell biology research communications : MCBRC.
1(3):176-81
[PMID] 10425223.
1999
Energetics of nucleotide hydrolysis in polymer assembly/disassembly: the cases of actin and tubulin.
Methods in enzymology.
308:93-111
[PMID] 10507002.
1999
Profilin promotes barbed-end actin filament assembly without lowering the critical concentration.
The Journal of biological chemistry.
274(52):36963-72
[PMID] 10601251.
1998
Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells.
Infection and immunity.
66(8):3775-82
[PMID] 9673261.
1998
Listeria and Shigella actin-based motility in host cells.
Transactions of the American Clinical and Climatological Association.
109:160-72; discussion 172
[PMID] 9601135.
1998
Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2.
Proceedings of the National Academy of Sciences of the United States of America.
95(23):13917-22
[PMID] 9811901.
1997
ABM-1 and ABM-2 homology sequences: consensus docking sites for actin-based motility defined by oligoproline regions in Listeria ActA surface protein and human VASP.
Biochemical and biophysical research communications.
231(3):686-91
[PMID] 9070872.
1997
Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): implications for actin-based Listeria motility.
Biochemistry.
36(27):8384-92
[PMID] 9204886.
1997
Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility.
The Journal of cell biology.
138(6):1255-64
[PMID] 9298981.
1996
Intracellular pathogenesis of listeriosis.
The New England journal of medicine.
334(12):770-6
[PMID] 8592552.
1996
Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.
Biochemistry.
35(11):3518-24
[PMID] 8639502.
1996
Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility.
The Journal of cell biology.
133(1):49-59
[PMID] 8601612.
1995
Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.
The Journal of biological chemistry.
270(1):45-8
[PMID] 7814409.
1995
Inhibition of Listeria locomotion by mosquito oostatic factor, a natural oligoproline peptide uncoupler of profilin action.
Infection and immunity.
63(1):182-90
[PMID] 7806356.
1995
Listeria monocytogenes intracellular migration: inhibition by profilin, vitamin D-binding protein and DNase I.
Cell motility and the cytoskeleton.
30(1):38-49
[PMID] 7728867.
1995
Septic thrombophlebitis of major dural venous sinuses.
Current clinical topics in infectious diseases.
15:179-203
[PMID] 7546367.
1994
Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.
Proceedings of the National Academy of Sciences of the United States of America.
91(11):5168-72
[PMID] 8197202.
1994
Calcium regulation of actin filament capping and monomer binding by macrophage capping protein.
The Journal of biological chemistry.
269(19):13997-4002
[PMID] 8188679.
1994
Dynamic remodeling of the actin cytoskeleton: lessons learned from Listeria locomotion.
BioEssays : news and reviews in molecular, cellular and developmental biology.
16(12):885-91
[PMID] 7840767.
1994
The human actin-regulatory protein cap G: gene structure and chromosome location.
Genomics.
23(3):560-5
[PMID] 7851883.
1993
Acute bacterial meningitis in adults. A review of 493 episodes.
The New England journal of medicine.
328(1):21-8
[PMID] 8416268.
1993
Diminished actin polymerization by neutrophils from newborn infants.
Pediatric research.
33(1):27-31
[PMID] 8433856.
1993
Who was caring for Mary?
Annals of internal medicine.
118(2):146-8
[PMID] 8123053.
1992
Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes.
Infection and immunity.
60(9):3609-19
[PMID] 1500169.
1992
Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
The Journal of biological chemistry.
267(23):16545-52
[PMID] 1322908.
1991
Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway.
Journal of immunology (Baltimore, Md. : 1950).
146(12):4282-8
[PMID] 1828264.
1991
Stimulation of human polymorphonuclear leukocyte phosphatidylinositol-4-phosphate kinase by concanavalin A and formyl-methionyl-leucyl-phenylalanine is calcium-independent. Correlation with maintenance of actin assembly.
Journal of immunology (Baltimore, Md. : 1950).
147(7):2270-5
[PMID] 1655888.
1990
Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag period.
Biochemistry.
29(9):2232-40
[PMID] 2337601.
1990
Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
Proceedings of the National Academy of Sciences of the United States of America.
87(16):6068-72
[PMID] 2117270.
1990
Septic cortical thrombophlebitis.
The Journal of infectious diseases.
161(6):1216-20
[PMID] 2189005.
1990
The actin released from profilin–actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes.
The Journal of cell biology.
110(6):1965-73
[PMID] 2351690.
1989
Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
The Journal of cell biology.
109(4 Pt 1):1561-9
[PMID] 2507552.
1989
The relationship between CR3 deficiency and neutrophil actin assembly.
Blood.
73(7):1973-9
[PMID] 2523744.
1988
Contractile proteins in leukocytes.
Methods in enzymology.
162:246-71
[PMID] 3226309.
1988
Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members.
The Journal of clinical investigation.
82(5):1525-31
[PMID] 3183050.
1987
Platelet-activating factor both stimulates and “primes” human polymorphonuclear leukocyte actin filament assembly.
Blood.
70(6):1921-7
[PMID] 3118991.
1986
Rabbit alveolar macrophages contain a Ca2+-sensitive, 41,000-dalton protein which reversibly blocks the “barbed” ends of actin filaments but does not sever them.
The Journal of biological chemistry.
261(30):14191-5
[PMID] 3021731.
1985
Effects of macrophage profilin on actin in the presence and absence of acumentin and gelsolin.
The Journal of biological chemistry.
260(12):7402-9
[PMID] 2987255.
1985
Nonmuscle actin-binding proteins.
Annual review of cell biology.
1:353-402
[PMID] 3030380.
1984
An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells.
The Journal of cell biology.
99(3):886-93
[PMID] 6206079.
1984
Sphenoid sinusitis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
38(4):214-6
[PMID] 6498309.
1984
The motor of leukocytes.
Federation proceedings.
43(12):2760-3
[PMID] 6540718.
1983
Contractile proteins in leukocyte function.
Seminars in hematology.
20(4):305-21
[PMID] 6316556.
1983
Sphenoid sinusitis. A review of 30 cases.
The New England journal of medicine.
309(19):1149-54
[PMID] 6621661.
1982
Acumentin, a protein in macrophages which caps the “pointed” end of action filaments.
Nature.
297(5864):303-7
[PMID] 6281657.
1982
Acumentin, an actin-modulating protein of rabbit pulmonary macrophages.
Biochemistry.
21(24):6321-6
[PMID] 7150562.
1981
A variant of chronic granulomatous disease: deficient oxidative metabolism due to a low-affinity NADPH oxidase.
The New England journal of medicine.
305(22):1329-33
[PMID] 6270561.
1981
Isolation of an inhibitor of actin polymerization from human polymorphonuclear leukocytes.
The Journal of biological chemistry.
256(6):3030-6
[PMID] 6894143.
1980
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.
The New England journal of medicine.
302(21):1163-8
[PMID] 7366657.
1980
Hemophilus influenzae in hospitalized adults: current perspectives.
The American journal of medicine.
69(2):219-26
[PMID] 6967696.
1979
Defective leukocyte metabolism.
The New England journal of medicine.
301(8)
[PMID] 460358.
1977
Multifactorial index of cardiac risk in noncardiac surgical procedures.
The New England journal of medicine.
297(16):845-50
[PMID] 904659.
Education
Fellowship – Infectious Disease
1980
·
Massachusetts General Hospital
Residency – Internal Medicine
1976
·
Massachusetts General Hospital
Residency – Internal Medicine
1975
·
Boston City Hospital
Internship – Internal Medicine
1974
·
Boston City Hospital
Medical Degree
1973
·
Columbia University
Contact Details
Phones:
- Business:
- (352) 246-8465
Emails:
- Business:
- southf@epi.ufl.edu
Addresses:
- Business Mailing:
-
6362 NW 41ST AVE
GAINESVILLE FL 32606 - Business Street:
-
PO Box 100238
Division of Hospitalist Medicine
GAINESVILLE FL 32610