Maurice S Swanson

Maurice S Swanson,

Professor And Associate Program Director

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-8076
Business Email: mswanson@ufl.edu

Teaching Profile

Courses Taught
2018,2022-2023
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016-2018
GMS6290 Genetics/Genomics Program Graduate Seminar
2014-2015
BCH6415 Advanced Molecular and Cell Biology
2013-2014
GMS6001 Fundamentals of Biomedical Sciences I
2013
BCH7410 Advanced Gene Regulation
2021
GMS5905 Special Topics in Biomedical Sciences

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-6245-5367

Areas of Interest
  • Aging
  • Developmental regulation of RNA processing
  • Genetics of Neurological diseases
  • Mammalian genome repetitive elements
  • Mechanisms of Regeneration
  • Myotonic Dystrophy
  • Neurological disorders
  • RNA binding proteins

Publications

2023
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.
Brain : a journal of neurology. [DOI] 10.1093/brain/awad148. [PMID] 37143315.
2022
Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing
Biology Open. 11(1) [DOI] 10.1242/bio.058978. [PMID] 35019138.
2022
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
PLOS Biology. 20(4) [DOI] 10.1371/journal.pbio.3001615. [PMID] 35476669.
2021
Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level.
Pathogens & immunity. 6(2):27-49 [DOI] 10.20411/pai.v6i2.460. [PMID] 34541432.
2021
Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2020.04.10.029454. [PMID] 33880475.
2021
RNA structure probing to characterize RNA–protein interactions on low abundance pre-mRNA in living cells
RNA. 27(3):343-358 [DOI] 10.1261/rna.077263.120. [PMID] 33310817.
2020
Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
Current biology : CB. 30(14):2651-2664.e5 [DOI] 10.1016/j.cub.2020.04.085. [PMID] 32470361.
2020
HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy.
Proceedings of the National Academy of Sciences of the United States of America. 117(10):5472-5477 [DOI] 10.1073/pnas.1907297117. [PMID] 32086392.
2020
Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
Nature Communications. 11(1) [DOI] 10.1038/s41467-020-15962-x. [PMID] 32332745.
2020
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Nature Biomedical Engineering. 5(2):157-168 [DOI] 10.1038/s41551-020-00607-7. [PMID] 32929188.
2020
UTteR control through miRs: fine-tuning ATXN1 levels to prevent ataxia
Genes & Development. 34(17-18):1107-1109 [DOI] 10.1101/gad.343020.120. [PMID] 32873576.
2019
Cell-type-specific dysregulation of RNA alternative splicing in short tandem repeat mouse knockin models of myotonic dystrophy.
Genes & development. 33(23-24):1635-1640 [DOI] 10.1101/gad.328963.119. [PMID] 31624084.
2019
Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression.
Cerebral cortex (New York, N.Y. : 1991). 29(7):2978-2997 [DOI] 10.1093/cercor/bhy164. [PMID] 30060068.
2019
Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy.
International journal of molecular sciences. 20(13) [DOI] 10.3390/ijms20133365. [PMID] 31323950.
2018
Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.
Neurobiology of disease. 112:35-48 [DOI] 10.1016/j.nbd.2018.01.003. [PMID] 29331264.
2018
Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-21371-4. [PMID] 29511296.
2018
Intron retention induced by microsatellite expansions as a disease biomarker.
Proceedings of the National Academy of Sciences of the United States of America. 115(16):4234-4239 [DOI] 10.1073/pnas.1716617115. [PMID] 29610297.
2018
MBNL splicing activity depends on RNA binding site structural context.
Nucleic acids research. 46(17):9119-9133 [DOI] 10.1093/nar/gky565. [PMID] 29955876.
2018
Myotonic Dystrophy and Developmental Regulation of RNA Processing.
Comprehensive Physiology. 8(2):509-553 [DOI] 10.1002/cphy.c170002. [PMID] 29687899.
2018
Precise temporal regulation of alternative splicing during neural development.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-04559-0. [PMID] 29875359.
2018
STRring up Cancer with lncRNA.
Molecular cell. 72(3):399-401 [DOI] 10.1016/j.molcel.2018.10.026. [PMID] 30388407.
2017
Aberrant Myokine Signaling in Congenital Myotonic Dystrophy.
Cell reports. 21(5):1240-1252 [DOI] 10.1016/j.celrep.2017.10.018. [PMID] 29091763.
2017
Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.
Genes & development. 31(11):1122-1133 [DOI] 10.1101/gad.300590.117. [PMID] 28698297.
2017
Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy.
Cell reports. 19(13):2718-2729 [DOI] 10.1016/j.celrep.2017.06.006. [PMID] 28658620.
2017
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.
Cell. 170(5):899-912.e10 [DOI] 10.1016/j.cell.2017.07.010. [PMID] 28803727.
2017
Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9.
Molecular cell. 68(3):479-490.e5 [DOI] 10.1016/j.molcel.2017.09.033. [PMID] 29056323.
2017
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.
Neuron. 95(6):1292-1305.e5 [DOI] 10.1016/j.neuron.2017.08.039. [PMID] 28910618.
2017
SFMetaDB: a comprehensive annotation of mouse RNA splicing factor RNA-Seq datasets.
Database : the journal of biological databases and curation. 2017 [DOI] 10.1093/database/bax071. [PMID] 29220461.
2016
Distal Alternative Last Exons Localize mRNAs to Neural Projections.
Molecular cell. 61(6):821-33 [DOI] 10.1016/j.molcel.2016.01.020. [PMID] 26907613.
2016
RNA mis-splicing in disease.
Nature reviews. Genetics. 17(1):19-32 [DOI] 10.1038/nrg.2015.3. [PMID] 26593421.
2016
Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.
Nature communications. 7 [DOI] 10.1038/ncomms11067. [PMID] 27063795.
2016
Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications. 4(1) [DOI] 10.1186/s40478-016-0393-5. [PMID] 27863507.
2015
Abnormal splicing switch of DMD’s penultimate exon compromises muscle fibre maintenance in myotonic dystrophy.
Nature communications. 6 [DOI] 10.1038/ncomms8205. [PMID] 26018658.
2015
Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells.
Stem cells (Dayton, Ohio). 33(6):1829-38 [DOI] 10.1002/stem.1970. [PMID] 25702800.
2015
Global insights into alternative polyadenylation regulation.
RNA biology. 12(6):597-602 [DOI] 10.1080/15476286.2015.1040974. [PMID] 25892335.
2015
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain.
Cell reports. 12(7):1159-68 [DOI] 10.1016/j.celrep.2015.07.029. [PMID] 26257173.
2015
MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response.
Nature communications. 6 [DOI] 10.1038/ncomms10084. [PMID] 26670661.
2015
Muscleblind-like 1 is required for normal heart valve development in vivo.
BMC developmental biology. 15 [DOI] 10.1186/s12861-015-0087-4. [PMID] 26472242.
2015
Rectifying RNA splicing errors in hereditary neurodegenerative disease.
Proceedings of the National Academy of Sciences of the United States of America. 112(9):2637-8 [DOI] 10.1073/pnas.1500976112. [PMID] 25691745.
2014
Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.
Molecular cell. 56(2):311-322 [DOI] 10.1016/j.molcel.2014.08.027. [PMID] 25263597.
2014
RNA-binding protein misregulation in microsatellite expansion disorders.
Advances in experimental medicine and biology. 825:353-88 [DOI] 10.1007/978-1-4939-1221-6_10. [PMID] 25201111.
2014
RNA-protein interactions in unstable microsatellite diseases.
Brain research. 1584:3-14 [DOI] 10.1016/j.brainres.2014.03.039. [PMID] 24709120.
2013
Compound loss of muscleblind-like function in myotonic dystrophy.
EMBO molecular medicine. 5(12):1887-900 [DOI] 10.1002/emmm.201303275. [PMID] 24293317.
2013
Generation of neural cells from DM1 induced pluripotent stem cells as cellular model for the study of central nervous system neuropathogenesis.
Cellular reprogramming. 15(2):166-77 [DOI] 10.1089/cell.2012.0086. [PMID] 23550732.
2013
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Brain : a journal of neurology. 136(Pt 3):957-70 [DOI] 10.1093/brain/aws367. [PMID] 23404338.
2013
Prediction of clustered RNA-binding protein motif sites in the mammalian genome.
Nucleic acids research. 41(14):6793-807 [DOI] 10.1093/nar/gkt421. [PMID] 23685613.
2013
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
Human molecular genetics. 22(17):3547-58 [DOI] 10.1093/hmg/ddt209. [PMID] 23660517.
2013
Splicing biomarkers of disease severity in myotonic dystrophy.
Annals of neurology. 74(6):862-72 [DOI] 10.1002/ana.23992. [PMID] 23929620.
2012
Muscleblind-like 1 knockout mice reveal novel splicing defects in the myotonic dystrophy brain.
PloS one. 7(3) [DOI] 10.1371/journal.pone.0033218. [PMID] 22427994.
2012
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy.
Neuron. 75(3):437-50 [DOI] 10.1016/j.neuron.2012.05.029. [PMID] 22884328.
2012
Myosin light chain phosphorylation is critical for adaptation to cardiac stress.
Circulation. 126(22):2575-88 [DOI] 10.1161/CIRCULATIONAHA.112.116202. [PMID] 23095280.
2011
Developments in RNA splicing and disease.
Cold Spring Harbor perspectives in biology. 3(1) [DOI] 10.1101/cshperspect.a000778. [PMID] 21084389.
2011
Non-ATG-initiated translation directed by microsatellite expansions.
Proceedings of the National Academy of Sciences of the United States of America. 108(1):260-5 [DOI] 10.1073/pnas.1013343108. [PMID] 21173221.
2011
Silence is not always golden.
Genetic testing and molecular biomarkers. 15(7-8) [DOI] 10.1089/gtmb.2011.1521. [PMID] 21762002.
2010
[Double the trouble: bidirectional expression of the SCA8 CAG/CTG expansion mutation – evidence for RNA and protein gain of function effects].
Rinsho shinkeigaku = Clinical neurology. 50(11):982-3 [PMID] 21921535.
2010
Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.
Nature structural & molecular biology. 17(2):187-93 [DOI] 10.1038/nsmb.1720. [PMID] 20098426.
2010
Partners in crime: bidirectional transcription in unstable microsatellite disease.
Human molecular genetics. 19(R1):R77-82 [DOI] 10.1093/hmg/ddq132. [PMID] 20368264.
2009
Mechanisms of RNA-mediated disease.
The Journal of biological chemistry. 284(12):7419-23 [DOI] 10.1074/jbc.R800025200. [PMID] 18957432.
2009
Pathogenic RNAs in microsatellite expansion disease.
Neuroscience letters. 466(2):99-102 [DOI] 10.1016/j.neulet.2009.07.079. [PMID] 19647781.
2009
RNA gain-of-function in spinocerebellar ataxia type 8.
PLoS genetics. 5(8) [DOI] 10.1371/journal.pgen.1000600. [PMID] 19680539.
2009
Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.
Human molecular genetics. 18(8):1471-81 [DOI] 10.1093/hmg/ddp058. [PMID] 19223393.
2007
Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy.
The Journal of clinical investigation. 117(12):3952-7 [PMID] 18008009.
2007
Essential role for Dicer during skeletal muscle development.
Developmental biology. 311(2):359-68 [PMID] 17936265.
2007
Fragile X tremor/ataxia syndrome: blame the messenger!
Neuron. 55(4):535-7 [PMID] 17698005.
2007
Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.
The Journal of general physiology. 129(1):79-94 [PMID] 17158949.
2007
Muscleblind isoforms are functionally distinct and regulate alpha-actinin splicing.
Differentiation; research in biological diversity. 75(5):427-40 [PMID] 17309604.
2007
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
Nucleic acids research. 35(16):5474-86 [PMID] 17702765.
2006
Constraints on the structure of (CUG)97 RNA from magic-angle-spinning solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English). 45(34):5620-3 [PMID] 16856200.
2006
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy.
Human molecular genetics. 15(13):2087-97 [PMID] 16717059.
2006
MicroRNAs in mammalian development and tumorigenesis.
Birth defects research. Part C, Embryo today : reviews. 78(2):172-9 [PMID] 16847882.
2006
Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy.
Proceedings of the National Academy of Sciences of the United States of America. 103(31):11748-53 [PMID] 16864772.
2005
Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy.
Journal of cell science. 118(Pt 13):2923-33 [PMID] 15961406.
2005
Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.
Developmental dynamics : an official publication of the American Association of Anatomists. 233(3):783-93 [PMID] 15830352.
2005
Nuclear RNA foci in the heart in myotonic dystrophy.
Circulation research. 97(11):1152-5 [PMID] 16254211.
2005
Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.
The Journal of biological chemistry. 280(26):24532-8 [PMID] 15894541.
2004
(1)H, (15)N and (13)C chemical shift assignments of RNA repeats binding protein — CUGBP1ab.
Journal of biomolecular NMR. 30(3):371-2 [PMID] 15756469.
2004
Identification of NH…N hydrogen bonds by magic angle spinning solid state NMR in a double-stranded RNA associated with myotonic dystrophy.
Nucleic acids research. 32(3):1177-83 [PMID] 14973225.
2004
Muscleblind proteins regulate alternative splicing.
The EMBO journal. 23(15):3103-12 [PMID] 15257297.
2004
Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons.
Human molecular genetics. 13(24):3079-88 [PMID] 15496431.
2004
Small molecule regulators of protein arginine methyltransferases.
The Journal of biological chemistry. 279(23):23892-9 [PMID] 15056663.
2004
Toxic RNA in the nucleus: unstable microsatellite expression in neuromuscular disease.
Progress in molecular and subcellular biology. 35:57-77 [PMID] 15113079.
2003
A muscleblind knockout model for myotonic dystrophy.
Science (New York, N.Y.). 302(5652):1978-80 [PMID] 14671308.
2003
Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3.
Gene expression patterns : GEP. 3(4):459-62 [PMID] 12915312.
2003
Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2.
Annals of neurology. 54(6):760-8 [PMID] 14681885.
2002
Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export.
The EMBO journal. 21(7):1800-10 [PMID] 11927564.
2001
Identification of an autoimmune serum containing antibodies against the Barr body.
Proceedings of the National Academy of Sciences of the United States of America. 98(15):8703-8 [PMID] 11438711.
2000
A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II.
Genetics. 154(2):557-71 [PMID] 10655211.
2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America. 97(7):3073-8 [PMID] 10737787.
2000
Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.
The EMBO journal. 19(17):4439-48 [PMID] 10970838.
2000
Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.
The Journal of infectious diseases. 181(3):946-53 [PMID] 10720517.
1999
hnRNP complexes: composition, structure, and function.
Current opinion in cell biology. 11(3):363-71 [PMID] 10395553.
1999
Preparation of heterogeneous nuclear ribonucleoprotein complexes.
Methods in molecular biology (Clifton, N.J.). 118:299-308 [PMID] 10549532.
1999
Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein.
Nucleic acids research. 27(17):3534-42 [PMID] 10446244.
1998
Control of cleavage site selection during mRNA 3′ end formation by a yeast hnRNP.
The EMBO journal. 17(24):7454-68 [PMID] 9857200.
1998
Expression of Legionella pneumophila virulence traits in response to growth conditions.
Infection and immunity. 66(7):3029-34 [PMID] 9632562.
1998
The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex.
Molecular and cellular biology. 18(3):1711-24 [PMID] 9488488.
1997
Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice.
Proceedings of the National Academy of Sciences of the United States of America. 94(24):13221-6 [PMID] 9371827.
1996
A plant viral coat protein RNA binding consensus sequence contains a crucial arginine.
The EMBO journal. 15(18):5077-84 [PMID] 8890181.
1996
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
Nucleic acids research. 24(22):4407-14 [PMID] 8948631.
1996
Myotonic dystrophy: discussion of molecular mechanism.
Cold Spring Harbor symposia on quantitative biology. 61:607-14 [PMID] 9246487.
1994
Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.
The Journal of cell biology. 127(5):1173-84 [PMID] 7962083.
1994
Early intervention in low-birth-weight premature infants. Results through age 5 years from the Infant Health and Development Program.
JAMA. 272(16):1257-62 [PMID] 7933370.
1994
The effect of weight-loss on estimated breast-cancer risk and sex-hormone levels.
Oncology reports. 1(3):613-7 [PMID] 21607413.
1993
NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability.
Molecular and cellular biology. 13(5):2730-41 [PMID] 8474438.
1993
PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae.
Molecular and cellular biology. 13(10):6102-13 [PMID] 8413212.
1993
The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins.
Nucleic acids research. 21(3):439-46 [PMID] 8441656.
1992
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.
Genetics. 132(2):325-36 [PMID] 1330823.
1991
Improved xenograft survival with continuous infusion deoxyspergualin and RATG.
Journal of investigative surgery : the official journal of the Academy of Surgical Research. 4(1):59-67 [PMID] 1863589.
1991
In vivo detection of snRNP-rich organelles in the nuclei of mammalian cells.
The EMBO journal. 10(7):1863-73 [PMID] 1710980.
1991
SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat.
Molecular and cellular biology. 11(8) [PMID] 2072920.
1990
Heterogeneous nuclear ribonucleoprotein complexes.
Molecular biology reports. 14(2-3):79-82 [PMID] 1972976.
1990
Purification and characterization of proteins of heterogeneous nuclear ribonucleoprotein complexes by affinity chromatography.
Methods in enzymology. 181:326-31 [PMID] 2143257.
1990
Recent studies on hnRNP complexes.
Molecular biology reports. 14(2-3) [PMID] 2362581.
1990
Reevaluation of total-lymphoid irradiation and cyclosporine therapy in the Syrian hamster-to-Lewis rat cardiac xenograft model.
Transplantation. 49(3):639-41 [PMID] 2180153.
1990
SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.
Molecular and cellular biology. 10(9):4935-41 [PMID] 2201908.
1990
The asymptomatic patient with suspected myocardial contusion.
American journal of surgery. 160(6):638-42; discussion 642 [PMID] 2252127.
1989
A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.
The Journal of cell biology. 109(6 Pt 1):2575-87 [PMID] 2687284.
1989
Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
Proceedings of the National Academy of Sciences of the United States of America. 86(24):9788-92 [PMID] 2557628.
1989
RNA-binding proteins as developmental regulators.
Genes & development. 3(4):431-7 [PMID] 2470643.
1988
Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities.
Molecular and cellular biology. 8(5):2237-41 [PMID] 3386636.
1988
Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.
Trends in biochemical sciences. 13(3):86-91 [PMID] 3072706.
1988
RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.
The EMBO journal. 7(11):3519-29 [PMID] 3208740.
1987
Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.
Molecular and cellular biology. 7(5):1731-9 [PMID] 3110598.
1986
Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family.
Proceedings of the National Academy of Sciences of the United States of America. 83(7):2007-11 [PMID] 3457372.
1986
mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence.
Molecular and cellular biology. 6(8):2932-43 [PMID] 3537727.
1985
Developmental expression of nuclear genes that encode mitochondrial proteins: insect cytochromes c.
Proceedings of the National Academy of Sciences of the United States of America. 82(7):1964-8 [PMID] 2984675.

Grants

Sep 2023 ACTIVE
Understanding and targeting common mechanisms of myotonic dystrophy types 1 and 2 using novel repeat expansion mouse models
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2023 ACTIVE
Mouse Dmpk CTG expansion knock in models for myotonic dystrophy (MDA 1070134)
Role: Other
Funding: MUSCULAR DYSTROPHY ASSO
Jan 2023 ACTIVE
Regenerative failure in myotonic dystrophy: pathomechanisms and insights from a novel model of improved regeneration
Role: Other
Funding: MYOTONIC DYSTROPHY FOU
Jan 2023 ACTIVE
Therapeutic strategies for microsatellite expansion diseases using RNA-targeting
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO via NATL INST OF HLTH NINDS
Aug 2021 – Aug 2022
Mouse humanized models for myotonic dystrophy type 1 for therapy development
Role: Principal Investigator
Funding: KATE THERAPEUTICS
Jul 2021 ACTIVE
Brain Choroid Plexus Dysregulation and Cerebral Atrophy in DM1
Role: Other
Funding: MYOTONIC DYSTROPHY FOU
Jan 2020 – Jan 2023
Provenance Initiatives Fund at the Center for NeuroGenetics
Role: Co-Investigator
Funding: UF FOUNDATION
Jul 2019 ACTIVE
RNA Processing-Mediated Mechanisms of CNS Dysfunction in Myotonic Dystrophy
Role: Faculty
Funding: NATL INST OF HLTH NINDS
Jun 2019 – Aug 2019
International Myotonic Dystrophy Consortium Meeting IDMC-12
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Sep 2018 – Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center
Role: Principal Investigator
Funding: UNIV OF ROCHESTER via NATL INST OF HLTH NINDS
Sep 2018 – Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center (Administrative Core)
Role: Principal Investigator
Funding: UNIV OF ROCHESTER via NATL INST OF HLTH NINDS
Sep 2018 – Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center (Project 3 Preclinical Model and Therapies for DM2).
Role: Principal Investigator
Funding: UNIV OF ROCHESTER via NATL INST OF HLTH NINDS
Sep 2018 – Aug 2023
Senator Paul D. Wellstone Muscular dystrophy Speciallzed Research Center (Project 2 Disease Progress and Biomarkers)
Role: Principal Investigator
Funding: UNIV OF ROCHESTER via NATL INST OF HLTH NINDS
Feb 2018 – Jan 2021
Pre-mRNA Misprocessing in Myotonic Dystrophy and Amyotrophic Lateral Sclerosis
Role: Other
Funding: MUSCULAR DYSTROPHY ASSO
Jan 2018 – Dec 2019
Congenital myotonic dystrophy:pathomechanism and therapeutic development
Role: Other
Funding: WYCK FOUNDATION
Sep 2017 – May 2022
Therapeutic strategies for microsatellite expansion diseases using RNA-targeting CRISPR/Cas
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO via NATL INST OF HLTH NINDS
Aug 2017 – Apr 2022
Determining the factors that control dose-dependent splicing regulation by a master regulator
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Feb 2017 – Jan 2020
Novel Mouse Knockin Models for Myotonic Dystrophy
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Aug 2016 – Jun 2022
Molecular Characterization of ALS/FTD in a novel C9orf72 BAC mouse model.
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Feb 2016 – Jan 2018
Myotonic Dystrophy Type 2: Mouse Models, pathomechanism and therapy
Role: Principal Investigator
Funding: WYCK FOUNDATION
Jan 2015 – Jan 2018
MBI Research Program MGOLD2
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2013 – Jun 2019
Myotonic Dystrophy: Molecular Pathophysiology and CNS Effects
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Aug 2013 – Jul 2016
Circadian Clock Dysregulation in Myotonic Dystrophy
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Jul 2013 – Jun 2018
Research Program MGOLD project 2
Role: Principal Investigator
Funding: UF FOUNDATION
Aug 2010 – Jun 2016
RNA Dominance in Human Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH

Education

PhD
1979 · University of California Berkeley
MA
1976 · University of California Santa Barbara

Contact Details

Phones:
Business:
(352) 273-8076
Emails:
Business:
mswanson@ufl.edu
Addresses:
Business Mailing:
2033 MOWRY RD
GAINESVILLE FL 32610
Business Street:
Cancer Genetics Research Complex
College of Medicine, 2033 Mowry Rd
DEPT. OF MOLECULAR GENETICS AND MICROBIOLOGY
GAINESVILLE FL 326103610