Maurice S Swanson,
Professor And Associate Program Director
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-8076
Business Email:
mswanson@ufl.edu
About Maurice S Swanson
Teaching Profile
Courses Taught
2018,2022-2023
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016-2018
GMS6290 Genetics/Genomics Program Graduate Seminar
2014-2015
BCH6415 Advanced Molecular and Cell Biology
2013-2014
GMS6001 Fundamentals of Biomedical Sciences I
2013
BCH7410 Advanced Gene Regulation
2021
GMS5905 Special Topics in Biomedical Sciences
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-6245-5367
Areas of Interest
- Aging
- Developmental regulation of RNA processing
- Genetics of Neurological diseases
- Mammalian genome repetitive elements
- Mechanisms of Regeneration
- Myotonic Dystrophy
- Neurological disorders
- RNA binding proteins
Publications
2023
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.
Brain : a journal of neurology.
[DOI] 10.1093/brain/awad148.
[PMID] 37143315.
2022
Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing
Biology Open.
11(1)
[DOI] 10.1242/bio.058978.
[PMID] 35019138.
2022
The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
PLOS Biology.
20(4)
[DOI] 10.1371/journal.pbio.3001615.
[PMID] 35476669.
2021
Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level.
Pathogens & immunity.
6(2):27-49
[DOI] 10.20411/pai.v6i2.460.
[PMID] 34541432.
2021
Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2020.04.10.029454.
[PMID] 33880475.
2021
RNA structure probing to characterize RNA–protein interactions on low abundance pre-mRNA in living cells
RNA.
27(3):343-358
[DOI] 10.1261/rna.077263.120.
[PMID] 33310817.
2020
Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
Current biology : CB.
30(14):2651-2664.e5
[DOI] 10.1016/j.cub.2020.04.085.
[PMID] 32470361.
2020
HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy.
Proceedings of the National Academy of Sciences of the United States of America.
117(10):5472-5477
[DOI] 10.1073/pnas.1907297117.
[PMID] 32086392.
2020
Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
Nature Communications.
11(1)
[DOI] 10.1038/s41467-020-15962-x.
[PMID] 32332745.
2020
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Nature Biomedical Engineering.
5(2):157-168
[DOI] 10.1038/s41551-020-00607-7.
[PMID] 32929188.
2020
UTteR control through miRs: fine-tuning ATXN1 levels to prevent ataxia
Genes & Development.
34(17-18):1107-1109
[DOI] 10.1101/gad.343020.120.
[PMID] 32873576.
2019
Cell-type-specific dysregulation of RNA alternative splicing in short tandem repeat mouse knockin models of myotonic dystrophy.
Genes & development.
33(23-24):1635-1640
[DOI] 10.1101/gad.328963.119.
[PMID] 31624084.
2019
Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression.
Cerebral cortex (New York, N.Y. : 1991).
29(7):2978-2997
[DOI] 10.1093/cercor/bhy164.
[PMID] 30060068.
2019
Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy.
International journal of molecular sciences.
20(13)
[DOI] 10.3390/ijms20133365.
[PMID] 31323950.
2018
Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.
Neurobiology of disease.
112:35-48
[DOI] 10.1016/j.nbd.2018.01.003.
[PMID] 29331264.
2018
Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-21371-4.
[PMID] 29511296.
2018
Intron retention induced by microsatellite expansions as a disease biomarker.
Proceedings of the National Academy of Sciences of the United States of America.
115(16):4234-4239
[DOI] 10.1073/pnas.1716617115.
[PMID] 29610297.
2018
MBNL splicing activity depends on RNA binding site structural context.
Nucleic acids research.
46(17):9119-9133
[DOI] 10.1093/nar/gky565.
[PMID] 29955876.
2018
Myotonic Dystrophy and Developmental Regulation of RNA Processing.
Comprehensive Physiology.
8(2):509-553
[DOI] 10.1002/cphy.c170002.
[PMID] 29687899.
2018
Precise temporal regulation of alternative splicing during neural development.
Nature communications.
9(1)
[DOI] 10.1038/s41467-018-04559-0.
[PMID] 29875359.
2018
STRring up Cancer with lncRNA.
Molecular cell.
72(3):399-401
[DOI] 10.1016/j.molcel.2018.10.026.
[PMID] 30388407.
2017
Aberrant Myokine Signaling in Congenital Myotonic Dystrophy.
Cell reports.
21(5):1240-1252
[DOI] 10.1016/j.celrep.2017.10.018.
[PMID] 29091763.
2017
Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.
Genes & development.
31(11):1122-1133
[DOI] 10.1101/gad.300590.117.
[PMID] 28698297.
2017
Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy.
Cell reports.
19(13):2718-2729
[DOI] 10.1016/j.celrep.2017.06.006.
[PMID] 28658620.
2017
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.
Cell.
170(5):899-912.e10
[DOI] 10.1016/j.cell.2017.07.010.
[PMID] 28803727.
2017
Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9.
Molecular cell.
68(3):479-490.e5
[DOI] 10.1016/j.molcel.2017.09.033.
[PMID] 29056323.
2017
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.
Neuron.
95(6):1292-1305.e5
[DOI] 10.1016/j.neuron.2017.08.039.
[PMID] 28910618.
2017
SFMetaDB: a comprehensive annotation of mouse RNA splicing factor RNA-Seq datasets.
Database : the journal of biological databases and curation.
2017
[DOI] 10.1093/database/bax071.
[PMID] 29220461.
2016
Distal Alternative Last Exons Localize mRNAs to Neural Projections.
Molecular cell.
61(6):821-33
[DOI] 10.1016/j.molcel.2016.01.020.
[PMID] 26907613.
2016
RNA mis-splicing in disease.
Nature reviews. Genetics.
17(1):19-32
[DOI] 10.1038/nrg.2015.3.
[PMID] 26593421.
2016
Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.
Nature communications.
7
[DOI] 10.1038/ncomms11067.
[PMID] 27063795.
2016
Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype.
Acta neuropathologica communications.
4(1)
[DOI] 10.1186/s40478-016-0393-5.
[PMID] 27863507.
2015
Abnormal splicing switch of DMD’s penultimate exon compromises muscle fibre maintenance in myotonic dystrophy.
Nature communications.
6
[DOI] 10.1038/ncomms8205.
[PMID] 26018658.
2015
Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells.
Stem cells (Dayton, Ohio).
33(6):1829-38
[DOI] 10.1002/stem.1970.
[PMID] 25702800.
2015
Global insights into alternative polyadenylation regulation.
RNA biology.
12(6):597-602
[DOI] 10.1080/15476286.2015.1040974.
[PMID] 25892335.
2015
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain.
Cell reports.
12(7):1159-68
[DOI] 10.1016/j.celrep.2015.07.029.
[PMID] 26257173.
2015
MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response.
Nature communications.
6
[DOI] 10.1038/ncomms10084.
[PMID] 26670661.
2015
Muscleblind-like 1 is required for normal heart valve development in vivo.
BMC developmental biology.
15
[DOI] 10.1186/s12861-015-0087-4.
[PMID] 26472242.
2015
Rectifying RNA splicing errors in hereditary neurodegenerative disease.
Proceedings of the National Academy of Sciences of the United States of America.
112(9):2637-8
[DOI] 10.1073/pnas.1500976112.
[PMID] 25691745.
2014
Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.
Molecular cell.
56(2):311-322
[DOI] 10.1016/j.molcel.2014.08.027.
[PMID] 25263597.
2014
RNA-binding protein misregulation in microsatellite expansion disorders.
Advances in experimental medicine and biology.
825:353-88
[DOI] 10.1007/978-1-4939-1221-6_10.
[PMID] 25201111.
2014
RNA-protein interactions in unstable microsatellite diseases.
Brain research.
1584:3-14
[DOI] 10.1016/j.brainres.2014.03.039.
[PMID] 24709120.
2013
Compound loss of muscleblind-like function in myotonic dystrophy.
EMBO molecular medicine.
5(12):1887-900
[DOI] 10.1002/emmm.201303275.
[PMID] 24293317.
2013
Generation of neural cells from DM1 induced pluripotent stem cells as cellular model for the study of central nervous system neuropathogenesis.
Cellular reprogramming.
15(2):166-77
[DOI] 10.1089/cell.2012.0086.
[PMID] 23550732.
2013
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Brain : a journal of neurology.
136(Pt 3):957-70
[DOI] 10.1093/brain/aws367.
[PMID] 23404338.
2013
Prediction of clustered RNA-binding protein motif sites in the mammalian genome.
Nucleic acids research.
41(14):6793-807
[DOI] 10.1093/nar/gkt421.
[PMID] 23685613.
2013
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
Human molecular genetics.
22(17):3547-58
[DOI] 10.1093/hmg/ddt209.
[PMID] 23660517.
2013
Splicing biomarkers of disease severity in myotonic dystrophy.
Annals of neurology.
74(6):862-72
[DOI] 10.1002/ana.23992.
[PMID] 23929620.
2012
Muscleblind-like 1 knockout mice reveal novel splicing defects in the myotonic dystrophy brain.
PloS one.
7(3)
[DOI] 10.1371/journal.pone.0033218.
[PMID] 22427994.
2012
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy.
Neuron.
75(3):437-50
[DOI] 10.1016/j.neuron.2012.05.029.
[PMID] 22884328.
2012
Myosin light chain phosphorylation is critical for adaptation to cardiac stress.
Circulation.
126(22):2575-88
[DOI] 10.1161/CIRCULATIONAHA.112.116202.
[PMID] 23095280.
2011
Developments in RNA splicing and disease.
Cold Spring Harbor perspectives in biology.
3(1)
[DOI] 10.1101/cshperspect.a000778.
[PMID] 21084389.
2011
Non-ATG-initiated translation directed by microsatellite expansions.
Proceedings of the National Academy of Sciences of the United States of America.
108(1):260-5
[DOI] 10.1073/pnas.1013343108.
[PMID] 21173221.
2011
Silence is not always golden.
Genetic testing and molecular biomarkers.
15(7-8)
[DOI] 10.1089/gtmb.2011.1521.
[PMID] 21762002.
2010
[Double the trouble: bidirectional expression of the SCA8 CAG/CTG expansion mutation – evidence for RNA and protein gain of function effects].
Rinsho shinkeigaku = Clinical neurology.
50(11):982-3
[PMID] 21921535.
2010
Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.
Nature structural & molecular biology.
17(2):187-93
[DOI] 10.1038/nsmb.1720.
[PMID] 20098426.
2010
Partners in crime: bidirectional transcription in unstable microsatellite disease.
Human molecular genetics.
19(R1):R77-82
[DOI] 10.1093/hmg/ddq132.
[PMID] 20368264.
2009
Mechanisms of RNA-mediated disease.
The Journal of biological chemistry.
284(12):7419-23
[DOI] 10.1074/jbc.R800025200.
[PMID] 18957432.
2009
Pathogenic RNAs in microsatellite expansion disease.
Neuroscience letters.
466(2):99-102
[DOI] 10.1016/j.neulet.2009.07.079.
[PMID] 19647781.
2009
RNA gain-of-function in spinocerebellar ataxia type 8.
PLoS genetics.
5(8)
[DOI] 10.1371/journal.pgen.1000600.
[PMID] 19680539.
2009
Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.
Human molecular genetics.
18(8):1471-81
[DOI] 10.1093/hmg/ddp058.
[PMID] 19223393.
2007
Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy.
The Journal of clinical investigation.
117(12):3952-7
[PMID] 18008009.
2007
Essential role for Dicer during skeletal muscle development.
Developmental biology.
311(2):359-68
[PMID] 17936265.
2007
Fragile X tremor/ataxia syndrome: blame the messenger!
Neuron.
55(4):535-7
[PMID] 17698005.
2007
Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.
The Journal of general physiology.
129(1):79-94
[PMID] 17158949.
2007
Muscleblind isoforms are functionally distinct and regulate alpha-actinin splicing.
Differentiation; research in biological diversity.
75(5):427-40
[PMID] 17309604.
2007
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
Nucleic acids research.
35(16):5474-86
[PMID] 17702765.
2006
Constraints on the structure of (CUG)97 RNA from magic-angle-spinning solid-state NMR spectroscopy.
Angewandte Chemie (International ed. in English).
45(34):5620-3
[PMID] 16856200.
2006
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy.
Human molecular genetics.
15(13):2087-97
[PMID] 16717059.
2006
MicroRNAs in mammalian development and tumorigenesis.
Birth defects research. Part C, Embryo today : reviews.
78(2):172-9
[PMID] 16847882.
2006
Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy.
Proceedings of the National Academy of Sciences of the United States of America.
103(31):11748-53
[PMID] 16864772.
2005
Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy.
Journal of cell science.
118(Pt 13):2923-33
[PMID] 15961406.
2005
Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.
Developmental dynamics : an official publication of the American Association of Anatomists.
233(3):783-93
[PMID] 15830352.
2005
Nuclear RNA foci in the heart in myotonic dystrophy.
Circulation research.
97(11):1152-5
[PMID] 16254211.
2005
Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.
The Journal of biological chemistry.
280(26):24532-8
[PMID] 15894541.
2004
(1)H, (15)N and (13)C chemical shift assignments of RNA repeats binding protein — CUGBP1ab.
Journal of biomolecular NMR.
30(3):371-2
[PMID] 15756469.
2004
Identification of NH…N hydrogen bonds by magic angle spinning solid state NMR in a double-stranded RNA associated with myotonic dystrophy.
Nucleic acids research.
32(3):1177-83
[PMID] 14973225.
2004
Muscleblind proteins regulate alternative splicing.
The EMBO journal.
23(15):3103-12
[PMID] 15257297.
2004
Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons.
Human molecular genetics.
13(24):3079-88
[PMID] 15496431.
2004
Small molecule regulators of protein arginine methyltransferases.
The Journal of biological chemistry.
279(23):23892-9
[PMID] 15056663.
2004
Toxic RNA in the nucleus: unstable microsatellite expression in neuromuscular disease.
Progress in molecular and subcellular biology.
35:57-77
[PMID] 15113079.
2003
A muscleblind knockout model for myotonic dystrophy.
Science (New York, N.Y.).
302(5652):1978-80
[PMID] 14671308.
2003
Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3.
Gene expression patterns : GEP.
3(4):459-62
[PMID] 12915312.
2003
Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2.
Annals of neurology.
54(6):760-8
[PMID] 14681885.
2002
Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export.
The EMBO journal.
21(7):1800-10
[PMID] 11927564.
2001
Identification of an autoimmune serum containing antibodies against the Barr body.
Proceedings of the National Academy of Sciences of the United States of America.
98(15):8703-8
[PMID] 11438711.
2000
A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II.
Genetics.
154(2):557-71
[PMID] 10655211.
2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
Proceedings of the National Academy of Sciences of the United States of America.
97(7):3073-8
[PMID] 10737787.
2000
Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.
The EMBO journal.
19(17):4439-48
[PMID] 10970838.
2000
Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.
The Journal of infectious diseases.
181(3):946-53
[PMID] 10720517.
1999
hnRNP complexes: composition, structure, and function.
Current opinion in cell biology.
11(3):363-71
[PMID] 10395553.
1999
Preparation of heterogeneous nuclear ribonucleoprotein complexes.
Methods in molecular biology (Clifton, N.J.).
118:299-308
[PMID] 10549532.
1999
Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein.
Nucleic acids research.
27(17):3534-42
[PMID] 10446244.
1998
Control of cleavage site selection during mRNA 3′ end formation by a yeast hnRNP.
The EMBO journal.
17(24):7454-68
[PMID] 9857200.
1998
Expression of Legionella pneumophila virulence traits in response to growth conditions.
Infection and immunity.
66(7):3029-34
[PMID] 9632562.
1998
The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex.
Molecular and cellular biology.
18(3):1711-24
[PMID] 9488488.
1997
Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice.
Proceedings of the National Academy of Sciences of the United States of America.
94(24):13221-6
[PMID] 9371827.
1996
A plant viral coat protein RNA binding consensus sequence contains a crucial arginine.
The EMBO journal.
15(18):5077-84
[PMID] 8890181.
1996
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
Nucleic acids research.
24(22):4407-14
[PMID] 8948631.
1996
Myotonic dystrophy: discussion of molecular mechanism.
Cold Spring Harbor symposia on quantitative biology.
61:607-14
[PMID] 9246487.
1994
Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.
The Journal of cell biology.
127(5):1173-84
[PMID] 7962083.
1994
Early intervention in low-birth-weight premature infants. Results through age 5 years from the Infant Health and Development Program.
JAMA.
272(16):1257-62
[PMID] 7933370.
1994
The effect of weight-loss on estimated breast-cancer risk and sex-hormone levels.
Oncology reports.
1(3):613-7
[PMID] 21607413.
1993
NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability.
Molecular and cellular biology.
13(5):2730-41
[PMID] 8474438.
1993
PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae.
Molecular and cellular biology.
13(10):6102-13
[PMID] 8413212.
1993
The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins.
Nucleic acids research.
21(3):439-46
[PMID] 8441656.
1992
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.
Genetics.
132(2):325-36
[PMID] 1330823.
1991
Improved xenograft survival with continuous infusion deoxyspergualin and RATG.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
4(1):59-67
[PMID] 1863589.
1991
In vivo detection of snRNP-rich organelles in the nuclei of mammalian cells.
The EMBO journal.
10(7):1863-73
[PMID] 1710980.
1991
SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat.
Molecular and cellular biology.
11(8)
[PMID] 2072920.
1990
Heterogeneous nuclear ribonucleoprotein complexes.
Molecular biology reports.
14(2-3):79-82
[PMID] 1972976.
1990
Purification and characterization of proteins of heterogeneous nuclear ribonucleoprotein complexes by affinity chromatography.
Methods in enzymology.
181:326-31
[PMID] 2143257.
1990
Reevaluation of total-lymphoid irradiation and cyclosporine therapy in the Syrian hamster-to-Lewis rat cardiac xenograft model.
Transplantation.
49(3):639-41
[PMID] 2180153.
1990
SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.
Molecular and cellular biology.
10(9):4935-41
[PMID] 2201908.
1990
The asymptomatic patient with suspected myocardial contusion.
American journal of surgery.
160(6):638-42; discussion 642
[PMID] 2252127.
1989
A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.
The Journal of cell biology.
109(6 Pt 1):2575-87
[PMID] 2687284.
1989
Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
Proceedings of the National Academy of Sciences of the United States of America.
86(24):9788-92
[PMID] 2557628.
1989
RNA-binding proteins as developmental regulators.
Genes & development.
3(4):431-7
[PMID] 2470643.
1988
Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities.
Molecular and cellular biology.
8(5):2237-41
[PMID] 3386636.
1988
Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.
Trends in biochemical sciences.
13(3):86-91
[PMID] 3072706.
1988
RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.
The EMBO journal.
7(11):3519-29
[PMID] 3208740.
1987
Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.
Molecular and cellular biology.
7(5):1731-9
[PMID] 3110598.
1986
Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family.
Proceedings of the National Academy of Sciences of the United States of America.
83(7):2007-11
[PMID] 3457372.
1986
mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence.
Molecular and cellular biology.
6(8):2932-43
[PMID] 3537727.
1985
Developmental expression of nuclear genes that encode mitochondrial proteins: insect cytochromes c.
Proceedings of the National Academy of Sciences of the United States of America.
82(7):1964-8
[PMID] 2984675.
Grants
Sep 2023
ACTIVE
Understanding and targeting common mechanisms of myotonic dystrophy types 1 and 2 using novel repeat expansion mouse models
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2023
ACTIVE
Mouse Dmpk CTG expansion knock in models for myotonic dystrophy (MDA 1070134)
Role: Other
Funding: MUSCULAR DYSTROPHY ASSO
Jan 2023
ACTIVE
Regenerative failure in myotonic dystrophy: pathomechanisms and insights from a novel model of improved regeneration
Role: Other
Funding: MYOTONIC DYSTROPHY FOU
Jan 2023
ACTIVE
Therapeutic strategies for microsatellite expansion diseases using RNA-targeting
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO
via NATL INST OF HLTH NINDS
Aug 2021
– Aug 2022
Mouse humanized models for myotonic dystrophy type 1 for therapy development
Role: Principal Investigator
Funding: KATE THERAPEUTICS
Jul 2021
ACTIVE
Brain Choroid Plexus Dysregulation and Cerebral Atrophy in DM1
Role: Other
Funding: MYOTONIC DYSTROPHY FOU
Jan 2020
– Jan 2023
Provenance Initiatives Fund at the Center for NeuroGenetics
Role: Co-Investigator
Funding: UF FOUNDATION
Jul 2019
ACTIVE
RNA Processing-Mediated Mechanisms of CNS Dysfunction in Myotonic Dystrophy
Role: Faculty
Funding: NATL INST OF HLTH NINDS
Jun 2019
– Aug 2019
International Myotonic Dystrophy Consortium Meeting IDMC-12
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Sep 2018
– Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Sep 2018
– Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center (Administrative Core)
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Sep 2018
– Aug 2023
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center (Project 3 Preclinical Model and Therapies for DM2).
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Sep 2018
– Aug 2023
Senator Paul D. Wellstone Muscular dystrophy Speciallzed Research Center (Project 2 Disease Progress and Biomarkers)
Role: Principal Investigator
Funding: UNIV OF ROCHESTER
via NATL INST OF HLTH NINDS
Feb 2018
– Jan 2021
Pre-mRNA Misprocessing in Myotonic Dystrophy and Amyotrophic Lateral Sclerosis
Role: Other
Funding: MUSCULAR DYSTROPHY ASSO
Jan 2018
– Dec 2019
Congenital myotonic dystrophy:pathomechanism and therapeutic development
Role: Other
Funding: WYCK FOUNDATION
Sep 2017
– May 2022
Therapeutic strategies for microsatellite expansion diseases using RNA-targeting CRISPR/Cas
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO
via NATL INST OF HLTH NINDS
Aug 2017
– Apr 2022
Determining the factors that control dose-dependent splicing regulation by a master regulator
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Feb 2017
– Jan 2020
Novel Mouse Knockin Models for Myotonic Dystrophy
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Aug 2016
– Jun 2022
Molecular Characterization of ALS/FTD in a novel C9orf72 BAC mouse model.
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Feb 2016
– Jan 2018
Myotonic Dystrophy Type 2: Mouse Models, pathomechanism and therapy
Role: Principal Investigator
Funding: WYCK FOUNDATION
Jan 2015
– Jan 2018
MBI Research Program MGOLD2
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2013
– Jun 2019
Myotonic Dystrophy: Molecular Pathophysiology and CNS Effects
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Aug 2013
– Jul 2016
Circadian Clock Dysregulation in Myotonic Dystrophy
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Jul 2013
– Jun 2018
Research Program MGOLD project 2
Role: Principal Investigator
Funding: UF FOUNDATION
Aug 2010
– Jun 2016
RNA Dominance in Human Disease
Role: Principal Investigator
Funding: NATL INST OF HLTH
Jul 2006
ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH
Education
PhD
1979
·
University of California Berkeley
MA
1976
·
University of California Santa Barbara
Contact Details
Phones:
- Business:
- (352) 273-8076
Emails:
- Business:
- mswanson@ufl.edu
Addresses:
- Business Mailing:
-
2033 MOWRY RD
GAINESVILLE FL 32610 - Business Street:
-
Cancer Genetics Research Complex
College of Medicine, 2033 Mowry Rd
DEPT. OF MOLECULAR GENETICS AND MICROBIOLOGY
GAINESVILLE FL 326103610