Lukasz J Sznajder,
Research Assistant Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-8183
Business Email:
ljsznajder@ufl.edu
Research Profile
Open Researcher and Contributor ID (ORCID)
Publications
2023
Autistic traits in myotonic dystrophy type 1 due to MBNL inhibition and RNA mis-splicing.
Research square.
[DOI] 10.21203/rs.3.rs-3221704/v1.
[PMID] 37645891.
2023
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.
Brain : a journal of neurology.
[DOI] 10.1093/brain/awad148.
[PMID] 37143315.
2021
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1.
Nature biomedical engineering.
5(2):157-168
[DOI] 10.1038/s41551-020-00607-7.
[PMID] 32929188.
2020
Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood.
Nature communications.
11(1)
[DOI] 10.1038/s41467-020-15962-x.
[PMID] 32332745.
2019
Cell-type-specific dysregulation of RNA alternative splicing in short tandem repeat mouse knockin models of myotonic dystrophy.
Genes & development.
33(23-24):1635-1640
[DOI] 10.1101/gad.328963.119.
[PMID] 31624084.
2019
Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy.
International journal of molecular sciences.
20(13)
[DOI] 10.3390/ijms20133365.
[PMID] 31323950.
2018
Intron retention induced by microsatellite expansions as a disease biomarker.
Proceedings of the National Academy of Sciences of the United States of America.
115(16):4234-4239
[DOI] 10.1073/pnas.1716617115.
[PMID] 29610297.
2018
MBNL splicing activity depends on RNA binding site structural context.
Nucleic acids research.
46(17):9119-9133
[DOI] 10.1093/nar/gky565.
[PMID] 29955876.
2018
Myotonic Dystrophy and Developmental Regulation of RNA Processing.
Comprehensive Physiology.
8(2):509-553
[DOI] 10.1002/cphy.c170002.
[PMID] 29687899.
2017
Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.
Nucleic acids research.
45(4):1760-1775
[DOI] 10.1093/nar/gkw1158.
[PMID] 27903900.
2017
Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.
Genes & development.
31(11):1122-1133
[DOI] 10.1101/gad.300590.117.
[PMID] 28698297.
2017
Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-17816-x.
[PMID] 29242583.
2016
Mechanistic determinants of MBNL activity.
Nucleic acids research.
44(21):10326-10342
[PMID] 27733504.
2015
Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy.
Nucleic acids research.
43(6):3318-31
[DOI] 10.1093/nar/gkv163.
[PMID] 25753670.
2012
Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.
ACS chemical biology.
7(3):496-505
[DOI] 10.1021/cb200413a.
[PMID] 22252896.
2011
Northern blotting analysis of microRNAs, their precursors and RNA interference triggers.
BMC molecular biology.
12
[DOI] 10.1186/1471-2199-12-14.
[PMID] 21481235.
Grants
Feb 2018
– Jan 2021
Pre-mRNA Misprocessing in Myotonic Dystrophy and Amyotrophic Lateral Sclerosis
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Contact Details
Phones:
- Business:
- (352) 273-8183
Emails:
- Business:
- ljsznajder@ufl.edu
Addresses:
- Business Mailing:
-
PO BOX 103610
GAINESVILLE FL 326100001 - Business Street:
-
2033 MOWRY RD
GAINESVILLE FL 32610