Scott Tibbetts,
Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-5628
Business Email:
stibbe@ufl.edu
About Scott Tibbetts
Related Links:
Teaching Profile
Courses Taught
2020-2023
GMS7133 Advanced Molecular Virology
2018-2023
GMS6921 Immunology/Microbiology Journal Colloquy
2014-2023
GMS6121 Infectious Diseases
2013-2022
GMS6036 Molecular Virology III: DNA Viruses
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016-2018
GMS6034 Advanced Virology I: Genetics and RNA
2018
BMS6300 Fund Micro and Immuno
2021
BMS6816 Cancer Bio Clin Oncol
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-8889-1642
Publications
2023
DESIGN AND GENERATION OF A RECOMBINANT GAMMAHERPESVIRUS ENCODING shRNA FROM A NATIVE VIRAL tRNA PROMOTER
Trakya University Journal of Natural Sciences.
24(1):63-70
[DOI] 10.23902/trkjnat.1191873.
2023
Virology under the Microscope—a Call for Rational Discourse
mSphere.
8(2)
[DOI] 10.1128/msphere.00034-23.
[PMID] 36700653.
2023
Virology under the Microscope—a Call for Rational Discourse
mBio.
14(1)
[DOI] 10.1128/mbio.00188-23.
[PMID] 36700642.
2023
Virology under the Microscope—a Call for Rational Discourse
Journal of Virology.
97(2)
[DOI] 10.1128/jvi.00089-23.
[PMID] 36700640.
2022
A Polymorphism in the Epstein-Barr Virus EBER2 Noncoding RNA Drives In Vivo Expansion of Latently Infected B Cells
mBio.
13(3)
[DOI] 10.1128/mbio.00836-22.
[PMID] 35642944.
2022
Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses
Proceedings of the National Academy of Sciences.
119(32)
[DOI] 10.1073/pnas.2123362119.
[PMID] 35921433.
2021
Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68.
Annual review of virology.
8(1):349-371
[DOI] 10.1146/annurev-virology-011921-082615.
[PMID] 34586873.
2021
EBV miRNAs are potent effectors of tumor cell transcriptome remodeling in promoting immune escape
PLOS Pathogens.
17(5)
[DOI] 10.1371/journal.ppat.1009217.
[PMID] 33956915.
2021
Empirical Validation of Overlapping Virus lncRNAs and Coding Transcripts by Northern Blot.
Methods in molecular biology (Clifton, N.J.).
2348:243-253
[DOI] 10.1007/978-1-0716-1581-2_17.
[PMID] 34160812.
2020
Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-59269-9.
[PMID] 32047224.
2019
A Gammaherpesvirus MicroRNA Targets EWSR1 (Ewing Sarcoma Breakpoint Region 1) In Vivo To Promote Latent Infection of Germinal Center B Cells.
mBio.
10(4)
[DOI] 10.1128/mBio.00996-19.
[PMID] 31363027.
2019
Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.
Journal of virology.
93(6)
[DOI] 10.1128/JVI.01952-18.
[PMID] 30567979.
2019
Epstein–Barr virus EBER1 and murine gammaherpesvirus TMER4 share conserved in vivo function to promote B cell egress and dissemination
Proceedings of the National Academy of Sciences.
116(51):25392-25394
[DOI] 10.1073/pnas.1915752116.
[PMID] 31796588.
2019
Gammaherpesvirus Readthrough Transcription Generates a Long Non-Coding RNA That Is Regulated by Antisense miRNAs and Correlates with Enhanced Lytic Replication In Vivo.
Non-coding RNA.
5(1)
[DOI] 10.3390/ncrna5010006.
[PMID] 30634714.
2019
Gammaherpesvirus RNAs Come Full Circle.
mBio.
10(2)
[DOI] 10.1128/mBio.00071-19.
[PMID] 30940699.
2019
Genome-wide Transcript Structure Resolution Reveals Abundant Alternate Isoform Usage from Murine Gammaherpesvirus 68.
Cell reports.
27(13):3988-4002.e5
[DOI] 10.1016/j.celrep.2019.05.086.
[PMID] 31242428.
2019
Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery
PLOS Pathogens.
15(8)
[DOI] 10.1371/journal.ppat.1007843.
[PMID] 31393953.
2018
Connivance, Complicity, or Collusion? The Role of Noncoding RNAs in Promoting Gammaherpesvirus Tumorigenesis.
Trends in cancer.
4(11):729-740
[DOI] 10.1016/j.trecan.2018.09.005.
[PMID] 30352676.
2018
Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.
PLoS pathogens.
14(9)
[DOI] 10.1371/journal.ppat.1007319.
[PMID] 30252914.
2018
Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.
Biochemistry.
57(7):1096-1107
[DOI] 10.1021/acs.biochem.7b01171.
[PMID] 29227673.
2018
Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR-/-) That Is Blocked by Interleukin-10.
Viruses.
10(10)
[DOI] 10.3390/v10100518.
[PMID] 30249047.
2018
The Epstein Barr virus circRNAome.
PLoS pathogens.
14(8)
[DOI] 10.1371/journal.ppat.1007206.
[PMID] 30080890.
2018
Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice
PLOS Pathogens.
14(2)
[DOI] 10.1371/journal.ppat.1006843.
[PMID] 29390024.
2016
A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency.
mSphere.
1(2)
[PMID] 27110595.
2016
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.
Cell reports.
16(2):405-418
[DOI] 10.1016/j.celrep.2016.05.083.
[PMID] 27346349.
2016
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
The Journal of biological chemistry.
291(6):2874-87
[DOI] 10.1074/jbc.M115.704841.
[PMID] 26620556.
2016
Recent advances in understanding norovirus pathogenesis.
Journal of medical virology.
88(11):1837-43
[DOI] 10.1002/jmv.24559.
[PMID] 27110852.
2015
Emerging Roles of Herpesvirus microRNAs During In Vivo Infection and Pathogenesis.
Current pathobiology reports.
3(3):209-217
[PMID] 26246961.
2015
Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo.
mBio.
6(1):e01670-14
[DOI] 10.1128/mBio.01670-14.
[PMID] 25691585.
2015
Human norovirus culture in B cells.
Nature protocols.
10(12):1939-47
[DOI] 10.1038/nprot.2015.121.
[PMID] 26513671.
2015
Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice.
PLoS pathogens.
11(6)
[DOI] 10.1371/journal.ppat.1005001.
[PMID] 26107716.
2014
A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.
PLoS pathogens.
10(2)
[DOI] 10.1371/journal.ppat.1003916.
[PMID] 24516386.
2014
Enteric bacteria promote human and mouse norovirus infection of B cells.
Science (New York, N.Y.).
346(6210):755-9
[DOI] 10.1126/science.1257147.
[PMID] 25378626.
2014
Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo.
mBio.
5(3):e00981-14
[DOI] 10.1128/mBio.00981-14.
[PMID] 24865551.
2013
Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection.
Antimicrobial agents and chemotherapy.
57(9):4114-27
[DOI] 10.1128/AAC.02594-12.
[PMID] 23774438.
2012
Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo.
PLoS pathogens.
8(9)
[DOI] 10.1371/journal.ppat.1002906.
[PMID] 22969427.
2010
Immature and transitional B cells are latency reservoirs for a gammaherpesvirus.
Journal of virology.
84(24):13045-52
[DOI] 10.1128/JVI.01455-10.
[PMID] 20926565.
2010
Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication.
PLoS pathogens.
6(7)
[DOI] 10.1371/journal.ppat.1001001.
[PMID] 20686657.
2010
Use of a virus-encoded enzymatic marker reveals that a stable fraction of memory B cells expresses latency-associated nuclear antigen throughout chronic gammaherpesvirus infection.
Journal of virology.
84(15):7523-34
[DOI] 10.1128/JVI.02572-09.
[PMID] 20484501.
2008
A replication-defective gammaherpesvirus efficiently establishes long-term latency in macrophages but not in B cells in vivo.
Journal of virology.
82(17):8500-8
[DOI] 10.1128/JVI.00186-08.
[PMID] 18562537.
2006
A gamma-herpesvirus deficient in replication establishes chronic infection in vivo and is impervious to restriction by adaptive immune cells.
Virology.
353(1):210-9
[PMID] 16797052.
2006
Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.
PLoS pathogens.
2(5)
[PMID] 16733540.
2006
Gamma interferon blocks gammaherpesvirus reactivation from latency.
Journal of virology.
80(1):192-200
[PMID] 16352543.
2005
Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice.
Journal of virology.
79(23):14668-79
[PMID] 16282467.
2004
Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gammaherpesvirus latency.
Journal of virology.
78(13):6836-45
[PMID] 15194759.
2003
Effective vaccination against long-term gammaherpesvirus latency.
Journal of virology.
77(4):2522-9
[PMID] 12551990.
2003
Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection.
Journal of virology.
77(13):7696-701
[PMID] 12805472.
1999
Peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture.
Transplantation.
68(5):685-92
[PMID] 10507489.
Grants
Jun 2022
ACTIVE
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2021
ACTIVE
Gammaherpesvirus miRNA suppression of EWSR1 in GC B cell infection and lymphomagenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jul 2018
– Aug 2019
The Role of a Gammaherpesvirus Noncoding RNA in Dissemination, Chronic Infection and Virus-Induced Vasculitis
Role: Other
Funding: AMER HEART ASSOCIATION
Feb 2017
– Jan 2022
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Faculty
Funding: NATL INST OF HLTH NCI
Feb 2015
ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015
ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015
– Dec 2020
Role of MHV68 miRNAs in latency and pathogenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2006
– May 2023
Davis Cancer Researach Equipment
Role: Project Manager
Funding: UF FOUNDATION
Contact Details
Phones:
- Business:
- (352) 273-5628
Emails:
- Business:
- stibbe@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100266
GAINESVILLE FL 32610 - Business Street:
-
OFFICE R2-291
LAB R2-285
1200 Newell Dr.
GAINESVILLE FL 32610