Scott Tibbetts

Scott Tibbetts,

Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5628
Business Email: stibbe@ufl.edu

Teaching Profile

Courses Taught
2020-2023
GMS7133 Advanced Molecular Virology
2018-2023
GMS6921 Immunology/Microbiology Journal Colloquy
2014-2023
GMS6121 Infectious Diseases
2013-2022
GMS6036 Molecular Virology III: DNA Viruses
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016-2018
GMS6034 Advanced Virology I: Genetics and RNA
2018
BMS6300 Fund Micro and Immuno
2021
BMS6816 Cancer Bio Clin Oncol

Publications

2022
A Polymorphism in the Epstein-Barr Virus EBER2 Noncoding RNA Drives In Vivo Expansion of Latently Infected B Cells.
mBio. 13(3) [DOI] 10.1128/mbio.00836-22. [PMID] 35642944.
2021
Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68.
Annual review of virology. 8(1):349-371 [DOI] 10.1146/annurev-virology-011921-082615. [PMID] 34586873.
2021
EBV miRNAs are potent effectors of tumor cell transcriptome remodeling in promoting immune escape.
PLoS pathogens. 17(5) [DOI] 10.1371/journal.ppat.1009217. [PMID] 33956915.
2021
Empirical Validation of Overlapping Virus lncRNAs and Coding Transcripts by Northern Blot.
Methods in molecular biology (Clifton, N.J.). 2348:243-253 [DOI] 10.1007/978-1-0716-1581-2_17. [PMID] 34160812.
2020
Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-59269-9. [PMID] 32047224.
2019
A Gammaherpesvirus MicroRNA Targets EWSR1 (Ewing Sarcoma Breakpoint Region 1) In Vivo To Promote Latent Infection of Germinal Center B Cells.
mBio. 10(4) [DOI] 10.1128/mBio.00996-19. [PMID] 31363027.
2019
Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.
Journal of virology. 93(6) [DOI] 10.1128/JVI.01952-18. [PMID] 30567979.
2019
Epstein-Barr virus EBER1 and murine gammaherpesvirus TMER4 share conserved in vivo function to promote B cell egress and dissemination.
Proceedings of the National Academy of Sciences of the United States of America. 116(51):25392-25394 [DOI] 10.1073/pnas.1915752116. [PMID] 31796588.
2019
Gammaherpesvirus Readthrough Transcription Generates a Long Non-Coding RNA That Is Regulated by Antisense miRNAs and Correlates with Enhanced Lytic Replication In Vivo.
Non-coding RNA. 5(1) [DOI] 10.3390/ncrna5010006. [PMID] 30634714.
2019
Gammaherpesvirus RNAs Come Full Circle.
mBio. 10(2) [DOI] 10.1128/mBio.00071-19. [PMID] 30940699.
2019
Genome-wide Transcript Structure Resolution Reveals Abundant Alternate Isoform Usage from Murine Gammaherpesvirus 68.
Cell reports. 27(13):3988-4002.e5 [DOI] 10.1016/j.celrep.2019.05.086. [PMID] 31242428.
2019
Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery.
PLoS pathogens. 15(8) [DOI] 10.1371/journal.ppat.1007843. [PMID] 31393953.
2018
Connivance, Complicity, or Collusion? The Role of Noncoding RNAs in Promoting Gammaherpesvirus Tumorigenesis.
Trends in cancer. 4(11):729-740 [DOI] 10.1016/j.trecan.2018.09.005. [PMID] 30352676.
2018
Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.
PLoS pathogens. 14(9) [DOI] 10.1371/journal.ppat.1007319. [PMID] 30252914.
2018
Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.
Biochemistry. 57(7):1096-1107 [DOI] 10.1021/acs.biochem.7b01171. [PMID] 29227673.
2018
Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR-/-) That Is Blocked by Interleukin-10.
Viruses. 10(10) [DOI] 10.3390/v10100518. [PMID] 30249047.
2018
The Epstein Barr virus circRNAome.
PLoS pathogens. 14(8) [DOI] 10.1371/journal.ppat.1007206. [PMID] 30080890.
2018
Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.
PLoS pathogens. 14(2) [DOI] 10.1371/journal.ppat.1006843. [PMID] 29390024.
2016
A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency.
mSphere. 1(2) [PMID] 27110595.
2016
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.
Cell reports. 16(2):405-418 [DOI] 10.1016/j.celrep.2016.05.083. [PMID] 27346349.
2016
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
The Journal of biological chemistry. 291(6):2874-87 [DOI] 10.1074/jbc.M115.704841. [PMID] 26620556.
2016
Recent advances in understanding norovirus pathogenesis.
Journal of medical virology. 88(11):1837-43 [DOI] 10.1002/jmv.24559. [PMID] 27110852.
2015
Emerging Roles of Herpesvirus microRNAs During In Vivo Infection and Pathogenesis.
Current pathobiology reports. 3(3):209-217 [PMID] 26246961.
2015
Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo.
mBio. 6(1):e01670-14 [DOI] 10.1128/mBio.01670-14. [PMID] 25691585.
2015
Human norovirus culture in B cells.
Nature protocols. 10(12):1939-47 [DOI] 10.1038/nprot.2015.121. [PMID] 26513671.
2015
Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice.
PLoS pathogens. 11(6) [DOI] 10.1371/journal.ppat.1005001. [PMID] 26107716.
2014
A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.
PLoS pathogens. 10(2) [DOI] 10.1371/journal.ppat.1003916. [PMID] 24516386.
2014
Enteric bacteria promote human and mouse norovirus infection of B cells.
Science (New York, N.Y.). 346(6210):755-9 [DOI] 10.1126/science.1257147. [PMID] 25378626.
2014
Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo.
mBio. 5(3):e00981-14 [DOI] 10.1128/mBio.00981-14. [PMID] 24865551.
2013
Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection.
Antimicrobial agents and chemotherapy. 57(9):4114-27 [DOI] 10.1128/AAC.02594-12. [PMID] 23774438.
2012
Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo.
PLoS pathogens. 8(9) [DOI] 10.1371/journal.ppat.1002906. [PMID] 22969427.
2010
Immature and transitional B cells are latency reservoirs for a gammaherpesvirus.
Journal of virology. 84(24):13045-52 [DOI] 10.1128/JVI.01455-10. [PMID] 20926565.
2010
Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication.
PLoS pathogens. 6(7) [DOI] 10.1371/journal.ppat.1001001. [PMID] 20686657.
2010
Use of a virus-encoded enzymatic marker reveals that a stable fraction of memory B cells expresses latency-associated nuclear antigen throughout chronic gammaherpesvirus infection.
Journal of virology. 84(15):7523-34 [DOI] 10.1128/JVI.02572-09. [PMID] 20484501.
2008
A replication-defective gammaherpesvirus efficiently establishes long-term latency in macrophages but not in B cells in vivo.
Journal of virology. 82(17):8500-8 [DOI] 10.1128/JVI.00186-08. [PMID] 18562537.
2006
A gamma-herpesvirus deficient in replication establishes chronic infection in vivo and is impervious to restriction by adaptive immune cells.
Virology. 353(1):210-9 [PMID] 16797052.
2006
Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.
PLoS pathogens. 2(5) [PMID] 16733540.
2006
Gamma interferon blocks gammaherpesvirus reactivation from latency.
Journal of virology. 80(1):192-200 [PMID] 16352543.
2005
Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice.
Journal of virology. 79(23):14668-79 [PMID] 16282467.
2004
Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gammaherpesvirus latency.
Journal of virology. 78(13):6836-45 [PMID] 15194759.
2003
Effective vaccination against long-term gammaherpesvirus latency.
Journal of virology. 77(4):2522-9 [PMID] 12551990.
2003
Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection.
Journal of virology. 77(13):7696-701 [PMID] 12805472.
2002
Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus.
Journal of virology. 76(14):7125-32 [PMID] 12072512.
1999
Peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture.
Transplantation. 68(5):685-92 [PMID] 10507489.

Grants

Jun 2022 ACTIVE
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2021 ACTIVE
Gammaherpesvirus miRNA suppression of EWSR1 in GC B cell infection and lymphomagenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jul 2018 – Aug 2019
The Role of a Gammaherpesvirus Noncoding RNA in Dissemination, Chronic Infection and Virus-Induced Vasculitis
Role: Other
Funding: AMER HEART ASSOCIATION
Feb 2017 – Jan 2022
Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies
Role: Faculty
Funding: NATL INST OF HLTH NCI
Feb 2015 ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015 – Dec 2020
Role of MHV68 miRNAs in latency and pathogenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2006 ACTIVE
Davis Cancer Researach Equipment
Role: Project Manager
Funding: UF FOUNDATION

Contact Details

Phones:
Business:
(352) 273-5628
Emails:
Business:
stibbe@ufl.edu
Addresses:
Business Mailing:
PO Box 100266
GAINESVILLE FL 32610
Business Street:
OFFICE R2-291
LAB R2-285
1200 Newell Dr.
GAINESVILLE FL 32610