Lei Zhou,
Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-8169
Business Email:
leizhou@ufl.edu
About Lei Zhou
Related Links:
Teaching Profile
Courses Taught
2006-2013,2015-2023
GMS6014 Applications of Bioinformatics to Genetics
2014-2015,2017-2020
GMS6065 Fundamentals of Cancer Biology
2009-2010,2012-2017,2015-2022,2017-2023,2019-2023,2021-2023
GMS6232 Advanced Applications of Bioinformatics in Genetics
2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
MCB7979 Advanced Research
2015-2017
GMS6895 CTS Journal Club
2012-2016
GMS6920 Genetics Journal Colloquy
2016
GMS6644 Apoptosis
2007
GMS6181 Spec Topics Microbiol
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-8251-3974
Publications
2023
Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA’s role in regulating miR-999
Nature Communications.
14(1)
[DOI] 10.1038/s41467-023-37819-9.
[PMID] 37055443.
2022
Human Alpha 1 Antitrypsin Suppresses NF-κB Activity and Extends Lifespan in Adult Drosophila
Biomolecules.
12(10)
[DOI] 10.3390/biom12101347.
[PMID] 36291555.
2022
The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute
Cell Death & Differentiation.
29(5):1071-1073
[DOI] 10.1038/s41418-022-00976-3.
[PMID] 35352025.
2021
Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti
Communications Biology.
4(1)
[DOI] 10.1038/s42003-020-01614-9.
[PMID] 33452408.
2019
A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death.
Development (Cambridge, England).
146(9)
[DOI] 10.1242/dev.166603.
[PMID] 30952666.
2019
P53 and Apoptosis in the Drosophila Model.
Advances in experimental medicine and biology.
1167:105-112
[DOI] 10.1007/978-3-030-23629-8_6.
[PMID] 31520351.
2018
Anti-inflammaging effects of human alpha-1 antitrypsin.
Aging cell.
17(1)
[DOI] 10.1111/acel.12694.
[PMID] 29045001.
2017
Printing-Induced Cell Injury Evaluation During Laser Printing of 3T3 Mouse Fibroblasts
Biofabrication.
9(2)
[DOI] 10.1088/1758-5090/aa6ed9.
2017
Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis
Cancer Genetics.
216-217:20-28
[DOI] 10.1016/j.cancergen.2017.05.003.
[PMID] 29025592.
2016
HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.
Cell reports.
14(1):103-114
[DOI] 10.1016/j.celrep.2015.12.007.
[PMID] 26725110.
2016
Integrating Domain Specific Knowledge and Network Analysis to Predict Drug Sensitivity of Cancer Cell Lines.
PloS one.
11(9)
[DOI] 10.1371/journal.pone.0162173.
[PMID] 27607242.
2016
Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.
Nucleic acids research.
44(15):7173-88
[DOI] 10.1093/nar/gkw327.
[PMID] 27141965.
2015
An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia.
Oncogene.
34(18):2385-97
[DOI] 10.1038/onc.2014.160.
[PMID] 24931167.
2015
Corp Regulates P53 in Drosophila Melanogaster Via a Negative Feedback Loop
Plos Genetics.
11(7)
[DOI] 10.1371/journal.pgen.1005400.
[PMID] 26230084.
2015
Differential Temporal Effects of Sclerostin Antibody and Parathyroid Hormone on Cancellous and Cortical Bone and Quantitative Differences in Effects on the Osteoblast Lineage in Young Intact Rats
Bone.
81:380-391
[DOI] 10.1016/j.bone.2015.08.007.
[PMID] 26261096.
2015
Pro-apoptotic gene regulation and its activation by gamma-irradiation in the Caribbean fruit fly, Anastrepha suspensa.
Apoptosis : an international journal on programmed cell death.
20(1):1-9
[DOI] 10.1007/s10495-014-1055-3.
[PMID] 25433919.
2015
STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation.
Oncotarget.
6(33):34718-31
[DOI] 10.18632/oncotarget.5303.
[PMID] 26460617.
2014
hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells.
Cancer research.
74(3):775-86
[DOI] 10.1158/0008-5472.CAN-13-1400.
[PMID] 24247718.
2014
Leveraging biological replicates to improve analysis in ChIP-seq experiments.
Computational and structural biotechnology journal.
9
[DOI] 10.5936/csbj.201401002.
[PMID] 24688750.
2013
Genome-wide identification of chromatin transitional regions reveals diverse mechanisms defining the boundary of facultative heterochromatin.
PloS one.
8(6)
[DOI] 10.1371/journal.pone.0067156.
[PMID] 23840609.
2013
P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.
PLoS pathogens.
9(2)
[DOI] 10.1371/journal.ppat.1003137.
[PMID] 23408884.
2013
The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.
The Journal of biological chemistry.
288(38):27680-27691
[DOI] 10.1074/jbc.M113.482349.
[PMID] 23928305.
2012
(-)-Epigallocatechin-3-Gallate Sensitizes Human Promyelocytic Hl-60 Cells To X-Ray Irradiation and Alters Expression of Pro-Apoptotic Genes
The FASEB's Journal.
26
2012
C-Scan Photoacoustic Microscopy for in Vivo Imaging of Drosophila Pupae
Applied Physics Letters.
101(1)
[DOI] 10.1063/1.4732797.
2011
A Barrier-Only Boundary Element Delimits the Formation of Facultative Heterochromatin in Drosophila Melanogaster and Vertebrates
Molecular And Cellular Biology.
31(13):2729-2741
[DOI] 10.1128/MCB.05165-11.
[PMID] 21518956.
2011
Extra sex combs, chromatin, and cancer: exploring epigenetic regulation and tumorigenesis in Drosophila.
Journal of genetics and genomics = Yi chuan xue bao.
38(10):453-60
[DOI] 10.1016/j.jgg.2011.09.007.
[PMID] 22035866.
2011
In vivo monitoring of stem cells in Drosophila pupae using the radiative transfer equation-based fluorescence molecular tomography.
Molecular imaging and biology.
13(5):868-73
[DOI] 10.1007/s11307-010-0434-6.
[PMID] 20922571.
2011
Induction of reaper ortholog mx in mosquito midgut cells following baculovirus infection.
Cell death and differentiation.
18(8):1337-45
[DOI] 10.1038/cdd.2011.8.
[PMID] 21331076.
2010
Emergency Department Care in Evaluation of Nursing Home Patients
Journal of Investigative Medicine.
58
2010
Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway.
PloS one.
5(11)
[DOI] 10.1371/journal.pone.0014018.
[PMID] 21103379.
2010
Split Bond Ratings and Information Opacity Premiums
Financial Management.
39:515-532
2009
A Lepidopteran Orthologue of Reaper Reveals Functional Conservation and Evolution of Iap Antagonists
Insect Molecular Biology.
18(3):341-351
[DOI] 10.1111/j.1365-2583.2009.00878.x.
[PMID] 19523066.
2009
By Design Or By Chance: Cell Death During Drosophila Embryogenesis
Apoptosis.
14(8):935-942
[DOI] 10.1007/s10495-009-0360-8.
[PMID] 19466551.
2009
Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.
Cancer research.
69(23):9105-11
[DOI] 10.1158/0008-5472.CAN-09-2775.
[PMID] 19920201.
2008
Drosophila Muscleblind Is Involved in Troponin T Alternative Splicing and Apoptosis
PLoS One.
3(2)
[DOI] 10.1371/journal.pone.0001613.
[PMID] 18286170.
2008
Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos.
Developmental cell.
14(4):481-93
[DOI] 10.1016/j.devcel.2008.01.018.
[PMID] 18410726.
2008
Rax Is Required for Fly Neuronal Development and Mouse Embryogenesis
Mechanisms of Development.
125(9-10):777-785
[DOI] 10.1016/j.mod.2008.06.009.
[PMID] 18634873.
2007
BLISS 2.0: a web-based tool for predicting conserved regulatory modules in distantly-related orthologous sequences.
Bioinformatics (Oxford, England).
23(23):3249-50
[PMID] 17660203.
2006
BLISS: binding site level identification of shared signal-modules in DNA regulatory sequences.
BMC bioinformatics.
7
[PMID] 16756683.
2006
Expression of Pseudomonas aeruginosa toxin ExoS effectively induces apoptosis in host cells.
Infection and immunity.
74(12):6557-70
[PMID] 16966406.
2005
Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes.
EMBO reports.
6(8):769-74
[PMID] 16041319.
2005
The ‘unique key’ feature of the Iap-binding motifs in RHG proteins.
Cell death and differentiation.
12(8):1148-51
[PMID] 15905883.
2003
Distinct pathways mediate UV-induced apoptosis in Drosophila embryos.
Developmental cell.
4(4):599-605
[PMID] 12689597.
2003
JXP4BIGI: a generalized, Java XML-based approach for biological information gathering and integration.
Bioinformatics (Oxford, England).
19(18):2351-8
[PMID] 14668218.
2003
Molecular mechanisms of irradiation-induced apoptosis.
Frontiers in bioscience : a journal and virtual library.
8:d9-19
[PMID] 12456331.
2002
Drosophila sickle is a novel grim-reaper cell death activator.
Current biology : CB.
12(2):131-5
[PMID] 11818064.
Grants
Feb 2020
ACTIVE
OR-DRPD-UFLIPS-G-2019 Understanding the Functional mechanism of hAAT in Drosophila
Role: Principal Investigator
Funding: L&L BIOTECHNOLOGY
Jan 2018
– Dec 2021
An Imputation-Consistency Algorithm for Biomedical Complex Data Analysis
Role: Principal Investigator
Funding: PURDUE UNIV
via NATL INST OF HLTH NIGMS
Jan 2015
– Dec 2018
The regulation of cell death in vivo
Role: Principal Investigator
Funding: MASSACHUSETTS GENERAL HOSPITAL
via NATL INST OF HLTH NIGMS
Jul 2014
– Jan 2016
Seed Grant- "Integrating Omics Data with Domain Specific Knowledge for Predicting Cellular Sensitivity to Chemotherapy and Radiotherapy"
Role: Principal Investigator
Funding: *UF INFORMATICS INSTITUTE
Jan 2014
– Mar 2019
Rapid Induction of apoptosis against viral infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Contact Details
Phones:
- Business:
- (352) 273-8169
Emails:
- Business:
- leizhou@ufl.edu
Addresses:
- Business Mailing:
-
PO BOX 103633
GAINESVILLE FL 326100001 - Business Street:
-
PO BOX 103610
PO BOX 103610
1376 MOWRY RD
GAINESVILLE FL 326110001