Kenneth I Berns

Kenneth I Berns,

Distinguished Professor Emeritus

Department: HA-ADMINISTRATION
Business Phone: (352) 273-8072
Business Email: kberns@ufl.edu

Publications

2020
The Unusual Properties of the AAV Inverted Terminal Repeat.
Human gene therapy. 31(9-10):518-523 [DOI] 10.1089/hum.2020.017. [PMID] 32079423.
2019
Next Generation of Adeno-Associated Virus Vectors for Gene Therapy for Human Liver Diseases.
Gastroenterology clinics of North America. 48(2):319-330 [DOI] 10.1016/j.gtc.2019.02.005. [PMID] 31046978.
2017
AAV: An Overview of Unanswered Questions.
Human gene therapy. 28(4):308-313 [DOI] 10.1089/hum.2017.048. [PMID] 28335618.
2015
AAV’s Golden Jubilee.
Molecular therapy : the journal of the American Society of Gene Therapy. 23(5):807-808 [DOI] 10.1038/mt.2015.55. [PMID] 25943495.
2015
Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?
Human gene therapy. 26(12):779-81 [DOI] 10.1089/hum.2015.29014.kib. [PMID] 26690810.
2015
The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG).
Vaccine. 33(1):73-5 [DOI] 10.1016/j.vaccine.2014.09.035. [PMID] 25305565.
2014
Grand challenges for biosafety and biosecurity.
Frontiers in bioengineering and biotechnology. 2 [DOI] 10.3389/fbioe.2014.00035. [PMID] 25279374.
2013
My life with adeno-associated virus: a long time spent studying a short genome.
DNA and cell biology. 32(7):342-7 [DOI] 10.1089/dna.2013.2120. [PMID] 23781880.
2012
Public health and biosecurity. Adaptations of avian flu virus are a cause for concern.
Science (New York, N.Y.). 335(6069):660-1 [DOI] 10.1126/science.1217994. [PMID] 22294736.
2009
Adeno-associated virus site-specific integration is mediated by proteins of the nonhomologous end-joining pathway.
Journal of virology. 83(22):11655-64 [DOI] 10.1128/JVI.01040-09. [PMID] 19759155.
2008
Gene therapy using adeno-associated virus vectors.
Clinical microbiology reviews. 21(4):583-93 [DOI] 10.1128/CMR.00008-08. [PMID] 18854481.
2008
Good news on the clinical gene transfer front.
Human gene therapy. 19(5):429-30 [DOI] 10.1089/hum.2008.0519. [PMID] 18507511.
2007
Characterization of a bipartite recombinant adeno-associated viral vector for site-specific integration.
Human gene therapy. 18(9):787-97 [PMID] 17760515.
2006
Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults.
Human gene therapy. 17(12):1177-86 [PMID] 17115945.
2006
Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California).
Molecular vision. 12:532-80 [PMID] 16735995.
2005
Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Human gene therapy. 16(11):1247-54 [PMID] 16259558.
2005
Adeno-associated virus: a ubiquitous commensal of mammals.
Human gene therapy. 16(4):401-7 [PMID] 15871671.
2005
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy. 16(2):235-47 [PMID] 15761263.
2005
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America. 102(20):7251-6 [PMID] 15878989.
2004
Adeno-associated virus site-specific integration and AAVS1 disruption.
Journal of virology. 78(15):7874-82 [PMID] 15254160.
2004
Characterization of the mouse adeno-associated virus AAVS1 ortholog.
Journal of virology. 78(16):8917-21 [PMID] 15280500.
2004
DNA-dependent PK inhibits adeno-associated virus DNA integration.
Proceedings of the National Academy of Sciences of the United States of America. 101(7):2112-6 [PMID] 14766968.
2004
Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human beta-globin transgene in a centromeric region.
Genes to cells : devoted to molecular & cellular mechanisms. 9(11):1043-53 [PMID] 15507116.
2004
Range of retinal diseases potentially treatable by AAV-vectored gene therapy.
Novartis Foundation symposium. 255:179-88; discussion 188 [PMID] 14750604.
2003
Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.
Journal of the American Society of Nephrology : JASN. 14(4):947-58 [PMID] 12660329.
2002
A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.
Proceedings of the National Academy of Sciences of the United States of America. 99(19):12381-5 [PMID] 12221283.
2002
AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization.
Investigative ophthalmology & visual science. 43(6):1994-2000 [PMID] 12037010.
2002
Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization.
Proceedings of the National Academy of Sciences of the United States of America. 99(13):8909-14 [PMID] 12072560.
2002
Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.
Journal of virology. 76(11):5411-21 [PMID] 11991970.
2001
Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America. 98(7):4084-8 [PMID] 11274433.
2001
Recombinant angiostatin prevents retinal neovascularization in a murine proliferative retinopathy model.
Gene therapy. 8(8):646-8 [PMID] 11320411.
2001
Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors.
Gene therapy. 8(17):1299-306 [PMID] 11571566.
2001
Use of recombinant angiostatin to prevent retinal neovascularization.
Transactions of the American Clinical and Climatological Association. 112:68-75; discussion 75 [PMID] 11413784.
2000
A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts.
Oncogene. 19(29):3330-4 [PMID] 10918589.
2000
DNA sequence motifs which direct adeno-associated virus site-specific integration in a model system.
Journal of virology. 74(13):6213-6 [PMID] 10846109.
2000
Molecular biology of adeno-associated viruses.
Contributions to microbiology. 4:68-84 [PMID] 10941571.
2000
p27kip1-independent cell cycle regulation by MYC.
Oncogene. 19(42):4822-7 [PMID] 11039898.
1999
Adeno-associated virus (AAV) site-specific integration: formation of AAV-AAVS1 junctions in an in vitro system.
Proceedings of the National Academy of Sciences of the United States of America. 96(22):12849-54 [PMID] 10536011.
1999
Recombinant adeno-associated virus-mediated expression of O6-alkylguanine-DNA-alkyltransferase protects human epithelial and hematopoietic cells against chloroethylating agent toxicity.
Human gene therapy. 10(2):301-10 [PMID] 10022554.
1999
Simplified production of a recombinant human angiostatin derivative that suppresses intracerebral glial tumor growth.
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(11):3689-94 [PMID] 10589788.
1999
The Gordon Wilson Lecture. From basic virology to human gene therapy.
Transactions of the American Clinical and Climatological Association. 110:75-85 [PMID] 10344008.
1998
Role of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication.
Journal of virology. 72(1):420-7 [PMID] 9420241.
1998
Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanism.
Journal of virology. 72(7):6195-8 [PMID] 9621089.
1997
Site-specific integration by adeno-associated virus: a basis for a potential gene therapy vector.
Gene therapy. 4(1):4-5 [PMID] 9068788.
1996
Biology of adeno-associated virus.
Current topics in microbiology and immunology. 218:1-23 [PMID] 8794242.
1996
Capturing the promise of science in medical schools.
Academic medicine : journal of the Association of American Medical Colleges. 71(12):1314-23 [PMID] 9114889.
1996
In vitro replication of adeno-associated virus DNA: enhancement by extracts from adenovirus-infected HeLa cells.
Journal of virology. 70(7):4495-501 [PMID] 8676474.
1996
Preventing academic medical center from becoming an oxymoron.
Academic medicine : journal of the Association of American Medical Colleges. 71(2):117-20 [PMID] 8615921.
1996
Site-specific integration by adeno-associated virus.
Proceedings of the National Academy of Sciences of the United States of America. 93(21):11288-94 [PMID] 8876128.
1996
The recombination signals for adeno-associated virus site-specific integration.
Proceedings of the National Academy of Sciences of the United States of America. 93(15):7966-72 [PMID] 8755586.
1995
Adenovirus and adeno-associated virus as vectors for gene therapy.
Annals of the New York Academy of Sciences. 772:95-104 [PMID] 8546417.
1995
Minimum origin requirements for linear duplex AAV DNA replication in vitro.
Virology. 209(2):692-5 [PMID] 7778304.
1995
Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome.
Journal of virology. 69(11):6917-24 [PMID] 7474109.
1995
Regulated high-level human beta-globin gene expression in erythroid cells following recombinant adeno-associated virus-mediated gene transfer.
Gene therapy. 2(5):336-43 [PMID] 7671109.
1995
The cryptic life style of adeno-associated virus.
BioEssays : news and reviews in molecular, cellular and developmental biology. 17(3):237-45 [PMID] 7748178.
1994
Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein.
Journal of virology. 68(9):6029-37 [PMID] 8057478.
1994
Adeno-associated virus type 2: a latent life cycle.
Progress in nucleic acid research and molecular biology. 48:29-52 [PMID] 7938552.
1994
Cloning, expression, and partial purification of Rep78: an adeno-associated virus replication protein.
Virology. 200(2):566-73 [PMID] 8178443.
1994
Intermediates of adeno-associated virus DNA replication in vitro.
Journal of virology. 68(3):2011-5 [PMID] 8107263.
1994
Site-specific integration by adeno-associated virus is directed by a cellular DNA sequence.
Proceedings of the National Academy of Sciences of the United States of America. 91(21):10039-43 [PMID] 7937833.
1993
The remaining stocks of smallpox virus should be destroyed.
Science (New York, N.Y.). 262(5137):1223-4 [PMID] 8235651.
1992
Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination.
The EMBO journal. 11(13):5071-8 [PMID] 1334463.
1992
In vitro replication of adeno-associated virus DNA.
Proceedings of the National Academy of Sciences of the United States of America. 89(10):4673-7 [PMID] 1316616.
1991
In vitro rescue of an integrated hybrid adeno-associated virus/simian virus 40 genome.
Journal of molecular biology. 218(4):791-804 [PMID] 1850805.
1991
Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter.
Genomics. 10(3):831-4 [PMID] 1653762.
1990
Parvovirus replication.
Microbiological reviews. 54(3):316-29 [PMID] 2215424.
1990
Site-specific integration by adeno-associated virus.
Proceedings of the National Academy of Sciences of the United States of America. 87(6):2211-5 [PMID] 2156265.
1989
Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the rep protein.
Journal of virology. 63(10):4450-4 [PMID] 2550677.
1989
Interactions between the termini of adeno-associated virus DNA.
Journal of molecular biology. 206(1):91-100 [PMID] 2539485.
1989
Organization of adeno-associated virus DNA in latently infected Detroit 6 cells.
Virology. 170(2):460-7 [PMID] 2543124.
1988
Regulation of adeno-associated virus DNA replication.
Biochimica et biophysica acta. 951(2-3):425-9 [PMID] 2850017.
1988
Sequence and symmetry requirements within the internal palindromic sequences of the adeno-associated virus terminal repeat.
Virology. 166(2):316-27 [PMID] 2845646.
1988
The adeno-associated virus rep gene inhibits replication of an adeno-associated virus/simian virus 40 hybrid genome in cos-7 cells.
Journal of virology. 62(5):1705-12 [PMID] 2833621.
1987
Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes.
Molecular and cellular biology. 7(4):1320-5 [PMID] 3037312.
1987
Adeno-associated viruses: an update.
Advances in virus research. 32:243-306 [PMID] 3039813.
1987
Parvovirus gene regulation.
The Journal of general virology. 68 ( Pt 3):601-14 [PMID] 3546593.
1986
Positive and negative autoregulation of the adeno-associated virus type 2 genome.
Journal of virology. 60(1):251-8 [PMID] 3018288.
1985
Characteristics and taxonomy of Parvoviridae.
Intervirology. 23(2):61-73 [PMID] 3980186.
1985
Structure of simian virus 40-adeno-associated virus recombinant genomes.
Journal of virology. 56(2):457-65 [PMID] 2997468.
1984
Conformation takes precedence over sequence in adeno-associated virus DNA replication.
Molecular and cellular biology. 4(7):1416-9 [PMID] 6504049.
1984
Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants.
Journal of virology. 51(2):329-39 [PMID] 6086948.
1984
Recombination between simian virus 40 and adeno-associated virus: virion coinfection compared to DNA cotransfection.
Virology. 134(1):125-37 [PMID] 6324466.
1984
The genetics of adeno-associated virus.
Advances in experimental medicine and biology. 179:151-61 [PMID] 6098150.
1984
Unique events in parvovirus replication.
Microbiological sciences. 1(7):163-7 [PMID] 6101112.
1983
Nucleotide sequence and organization of the adeno-associated virus 2 genome.
Journal of virology. 45(2):555-64 [PMID] 6300419.
1983
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV.
Cell. 33(1):135-43 [PMID] 6088052.
1982
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells.
Proceedings of the National Academy of Sciences of the United States of America. 79(6):2077-81 [PMID] 6281795.
1982
Mapping of the 5′ termini of two adeno-associated virus 2 RNAs in the left half of the genome.
Journal of virology. 41(2):518-26 [PMID] 6281463.
1981
Inhibition of adenovirus-transformed cell oncogenicity by adeno-associated virus.
Virology. 113(2):521-33 [PMID] 6267797.
1981
Inverted terminal repetition in adeno-associated virus DNA: independence of the orientation at either end of the genome.
Journal of virology. 37(3):1083-6 [PMID] 6262528.
1980
Adenovirus early region 1b gene function required for rescue of latent adeno-associated virus.
Virology. 104(2):502-5 [PMID] 6249041.
1980
Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells.
Journal of virology. 33(2):739-48 [PMID] 6251245.
1980
Nucleotide sequence of the inverted terminal repetition in adeno-associated virus DNA.
Journal of virology. 34(2):402-9 [PMID] 6246271.
1979
Adeno-associated virus DNA replication.
Cold Spring Harbor symposia on quantitative biology. 43 Pt 2:781-7 [PMID] 226321.
1979
Adeno-associated virus DNA replication: nonunit-length molecules.
Virology. 93(1):57-68 [PMID] 219605.
1979
Adeno-associated viruses.
Advances in virus research. 25:407-49 [PMID] 230727.
1977
Evidence for two nucleotide sequence orientations within the terminal repetition of adeno-associated virus DNA.
Journal of virology. 24(2):627-34 [PMID] 916029.
1977
Origin and termination of adeno-associated virus DNA replication.
Virology. 78(2):488-99 [PMID] 867815.
1977
Structure and nucleotide sequence of the terminal regions of adeno-associated virus DNA.
Virology. 78(2):475-7 [PMID] 194395.
1976
Genome localization of adeno-associated virus RNA.
Journal of virology. 19(3):1044-53 [PMID] 972429.
1975
Detection of adeno-associated virus (AAV)-specific nucleotide sequences in DNA isolated from latently infected Detroit 6 cells.
Virology. 68(2):556-60 [PMID] 1198930.
1975
Study of the fine structure of adeno-associated virus DNA with bacterial restriction endonucleases.
Journal of virology. 16(3):712-9 [PMID] 1159899.
1974
Characterization and localization of the naturally occurring cross-links in vaccinia virus DNA.
Journal of molecular biology. 88(4):785-96 [PMID] 4427382.
1974
Letter: Visualization of the inverted terminal repetition in adeno-associated virus DNA.
Journal of molecular biology. 82(2):267-71 [PMID] 4816655.
1974
Molecular biology of the adeno-associated viruses.
Current topics in microbiology and immunology. 65:1-20 [PMID] 4613539.
1973
Arrangement of nucleotide sequences in adeno-associated virus DNA.
Journal of molecular biology. 79(2):207-25 [PMID] 4586409.
1972
Separation of two types of adeno-associated virus particles containing complementary polynucleotide chains.
Journal of virology. 9(2):394-6 [PMID] 5014934.
1970
Evidence for a single-stranded adenovirus-associated virus genome: isolation and separation of complementary single strands.
Journal of virology. 5(6):693-9 [PMID] 5429749.
1970
Natural occurrence of cross-linked vaccinia virus deoxyribonucleic acid.
Journal of virology. 5(3):299-304 [PMID] 5438108.
1969
Separation of a new deoxyribonucleic acid polymerase from vaccinia-infected HeLa cells.
Journal of virology. 4(1):15-23 [PMID] 5804948.
1965
ISOLATION OF HIGH MOLECULAR WEIGHT DNA FROM HEMOPHILUS INFLUENZAE.
Journal of molecular biology. 11:476-90 [PMID] 14267270.
1962
The utility of formaldehyde in stabilizing polynucleotide chains from bacteriophage DNA.
Journal of molecular biology. 4:309-12 [PMID] 13920751.
1961
The physical characterization of DNA molecules released from T2 and T4 bacteriophage.
Journal of molecular biology. 3:277-88 [PMID] 13776441.

Contact Details

Phones:
Business:
(352) 273-8072
Emails:
Business:
kberns@ufl.edu
Addresses:
Business Mailing:
MOLECULAR GENETICS AND MICROBIOLOGY
PO BOX 100266
UNIVERSITY OF FLORIDA
GAINESVILLE FL 326100266
Business Street:
1376 MOWRY ROAD
ROOM 115
CANCER/GENETICS RESEARCH COMPLEX
GAINESVILLE FL 32610