We study how enteric viral pathogens (rotavirus, norovirus, astrovirus…) infect and replicate in the human gastro-intestinal tract. We aim at defining how host/enteric pathogen interactions is coordinated at the molecular level in space and time and how these complex interactions can either lead to pathology development or resolution of viral infection. Our goal is to exploit these mechanisms to develop novel antiviral therapeutic approaches and pharmacological interventions to treat inflammatory bowel diseases. We use a multidisciplinary approach combining molecular and cellular biology, state-of-the-art live single molecule imaging, bio-engineering (to simulate the physiological microenvironment) and single cell transcriptomic approaches. Our integrative research approach allows us to address within a tissue how individual cell types communicate together to coordinate different antiviral strategies to ultimately lead to viral clearance while maintaining tissue homeostasis.
See more at: https://www.boulantlab.com/
- enteric virus, immune response, interferon, Organ-on-a-chip, single cell sequencing, hypoxia microenvironment, organoids