Lien T Nguyen

Lien T Nguyen,

Research Assistant Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5847
Business Email: lien.nguyen@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-5237-2576

Publications

2022
RAN proteins in neurodegenerative disease: Repeating themes and unifying therapeutic strategies.
Current opinion in neurobiology. 72:160-170 [DOI] 10.1016/j.conb.2021.11.001. [PMID] 34953315.
2021
Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice.
Human molecular genetics. 29(24):3900-3918 [DOI] 10.1093/hmg/ddaa279. [PMID] 33378537.
2021
The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats.
Human molecular genetics. 30(11):1020-1029 [DOI] 10.1093/hmg/ddab098. [PMID] 33856033.
2020
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Neuron. 105(4):645-662.e11 [DOI] 10.1016/j.neuron.2019.11.007. [PMID] 31831332.
2020
Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.
Proceedings of the National Academy of Sciences of the United States of America. 117(31):18591-18599 [DOI] 10.1073/pnas.2005748117. [PMID] 32690681.
2020
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.
Neuron. 108(4):784-796.e3 [DOI] 10.1016/j.neuron.2020.09.009. [PMID] 33022226.
2020
Taxonomic notes on the genus Vespa Linnaeus, 1758 (Hymenoptera: Vespidae: Vespinae) from Vietnam, with a new record of a species and an updated key to species.
Zootaxa. 4801(3) [DOI] 10.11646/zootaxa.4801.3.11. [PMID] 33056652.
2019
Taxonomic studies on the genus Orancistrocerus van der Vecht, 1963 (Hymenoptera: Vespidae: Eumeninae) from Vietnam, with description of a new species.
Zootaxa. 4563(3) [DOI] 10.11646/zootaxa.4563.3.11. [PMID] 31716537.
2016
A new record of the genus Discoelius Latreille, 1809 (Hymenoptera: Vespidae: Eumeninae) from Northern Vietnam with description of two new species.
Zootaxa. 4154(5):589-94 [DOI] 10.11646/zootaxa.4154.5.8. [PMID] 27615863.
2016
Contribution to the taxonomy of the genus Coeleumenes van der Vecht, 1963 (Hymenoptera: Vespidae: Eumeninae) from Vietnam, with description of a new species.
Zootaxa. 4121(2):175-80 [DOI] 10.11646/zootaxa.4121.2.7. [PMID] 27395217.
2016
Review of the Polistes (Polistella) “Stenopolistes” species-group (Hymenoptera: Vespidae: Polistinae) from Vietnam, with description of a new species and key to species.
Zootaxa. 4088(4):583-93 [DOI] 10.11646/zootaxa.4088.4.9. [PMID] 27394361.
2016
Two new species of the genus Eumenes Latreille, 1802 (Hymenoptera: Vespidae, Eumeninae) from Vietnam.
Zootaxa. 4093(4):583-8 [DOI] 10.11646/zootaxa.4093.4.11. [PMID] 27394517.
2015
Differential recognition of the ORF2 region in a complete genome sequence of porcine circovirus type 2 (PCV2) isolated from boar bone marrow in Korea.
Gene. 569(2):308-12 [DOI] 10.1016/j.gene.2015.04.055. [PMID] 25917618.
2015
Potter wasps of the genus Eumenes Latreille, 1802 (Hymenoptera: Vespidae: Eumeninae) from Vietnam, with description of a new species and key to species.
Zootaxa. 3974(4):564-72 [DOI] 10.11646/zootaxa.3974.4.7. [PMID] 26249925.
2015
Taxonomic notes on the genus Gribodia Zavattari, 1912 (Hymenoptera: Vespidae: Eumeninae) from Vietnam and China, with description of a new species.
Zootaxa. 4040(4):458-64 [DOI] 10.11646/zootaxa.4040.4.5. [PMID] 26624679.
2015
Taxonomic notes on the species of the genus Anterhynchium de Saussure, 1863 (Hymenoptera: Vespidae: Eumeninae) from Vietnam, with description of a new species.
Zootaxa. 3915(1):132-8 [DOI] 10.11646/zootaxa.3915.1.7. [PMID] 25662115.
2015
Two new species of the genus Pararrhynchium de Saussure (Hymenoptera: Vespidae: Eumeninae) from northern Vietnam.
Zootaxa. 3974(2):170-6 [DOI] 10.11646/zootaxa.3974.2.2. [PMID] 26249895.
2014
Analysis of the RdRp, intergenic and structural polyprotein regions, and the complete genome sequence of Kashmir bee virus from infected honeybees (Apis mellifera) in Korea.
Virus genes. 49(1):137-44 [DOI] 10.1007/s11262-014-1074-8. [PMID] 24824301.
2014
Two new species of the genus Okinawepipona Yamane (Hymenoptera: Vespidae: Eumeninae) from Vietnam and China.
Zootaxa. 3795:38-44 [DOI] 10.11646/zootaxa.3795.1.4. [PMID] 24870456.
2013
Analysis of the complete genome sequence and capsid region of black queen cell viruses from infected honeybees (Apis mellifera) in Korea.
Virus genes. 47(1):126-32 [DOI] 10.1007/s11262-013-0902-6. [PMID] 23526158.
2013
Phylogenetic analysis of black queen cell virus genotypes in South Korea.
Virus genes. 46(2):362-8 [DOI] 10.1007/s11262-012-0859-x. [PMID] 23239276.
2012
Phylogenetic analysis of benign Theileria species based on major piroplasm surface protein (MPSP) genes from ticks of grazing cattle in Korea.
Veterinary parasitology. 189(2-4):145-52 [DOI] 10.1016/j.vetpar.2012.04.038. [PMID] 22647464.
2012
Prevalence and distribution of six bee viruses in Korean Apis cerana populations.
Journal of invertebrate pathology. 109(3):330-3 [DOI] 10.1016/j.jip.2012.01.003. [PMID] 22273697.

Grants

Jul 2022 ACTIVE
Identifying and targeting novel repeat associated non-AUG (RAN) proteins in sporadic ALS
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Jul 2022 ACTIVE
Novel repeat associated non-AUG (RAN) proteins in sALS, sFTD and SBMA: shared pathological features and unifying therapeutic opportunities
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2020 ACTIVE
Identifying and understanding the role of repeat RNAs and RAN proteins in Alzheimer's disease
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA

Contact Details

Phones:
Business:
(352) 273-5847
Emails:
Addresses:
Business Mailing:
PO BOX 103610
GAINESVILLE FL 326110001
Business Street:
2033 MOWRY RD RM 225
GAINESVILLE FL 32610