Edward W Scott

Edward W Scott,

Professor & Director

Department: Molecular Genetics & Microbiology
Business Phone: (352) 846-1149
Business Email: escott@ufl.edu

Teaching Profile

Courses Taught
2016-2020
GMS6001 Fundamentals of Biomedical Sciences I
2020-2022
GMS6331 Stem Cell Biology
2008,2010-2022
GMS6336 Advanced Stem Cell Biology: Regenerative Medicine
2020-2022
GMS6335 Advanced Stem Cell Biology: Tissue Engineering
2018
GMS7979 Advanced Research
2018
GMS5905 Special Topics in Biomedical Sciences
2018
GMS7980 Research for Doctoral Dissertation
2014-2016,2021-2022
GMS6140 Principles of Immunology

Publications

2021
Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling.
British journal of pharmacology. 178(1):187-202 [DOI] 10.1111/bph.14945. [PMID] 31793661.
2021
The Value of Integrating Fluorescent Imaging and Immunohistochemistry for Future Anatomical Studies in Aesthetic Surgery: Lessons From the Cerebrospinal Fluid Circulatory System of Human Nerves and Brain.
Aesthetic surgery journal. 41(10):1197-1206 [DOI] 10.1093/asj/sjaa247. [PMID] 32827254.
2019
Chemokine signaling axis between endothelial and myeloid cells regulates development of pulmonary hypertension associated with pulmonary fibrosis and hypoxia.
American journal of physiology. Lung cellular and molecular physiology. 317(4):L434-L444 [DOI] 10.1152/ajplung.00156.2019. [PMID] 31364370.
2019
Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells.
Neoplasia (New York, N.Y.). 21(3):269-281 [DOI] 10.1016/j.neo.2018.12.007. [PMID] 30738331.
2018
M1 macrophages are required for murine cerebral aneurysm formation.
Journal of neurointerventional surgery. 10(1):93-97 [DOI] 10.1136/neurintsurg-2016-012911. [PMID] 28196918.
2018
Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension.
American journal of respiratory cell and molecular biology. 58(2):170-180 [DOI] 10.1165/rcmb.2017-0214OC. [PMID] 28862882.
2018
Vascular Endothelial Cell-Specific Connective Tissue Growth Factor (CTGF) Is Necessary for Development of Chronic Hypoxia-Induced Pulmonary Hypertension.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.00138. [PMID] 29535639.
2017
Extended time-lapse in vivo imaging of tibia bone marrow to visualize dynamic hematopoietic stem cell engraftment.
Leukemia. 31(7):1582-1592 [DOI] 10.1038/leu.2016.354. [PMID] 27890929.
2017
Stem Cell Reviews and Reports: Adult Stem Cells and Tissue Regeneration Section.
Stem cell reviews and reports. 13(1) [DOI] 10.1007/s12015-017-9724-6. [PMID] 28220455.
2016
“A small leak will sink a great ship”: hypoxia-inducible factor and group III pulmonary hypertension.
Receptors & clinical investigation. 3(1) [PMID] 27446973.
2016
Angiotensin II Regulation of Proliferation, Differentiation, and Engraftment of Hematopoietic Stem Cells.
Hypertension (Dallas, Tex. : 1979). 67(3):574-84 [DOI] 10.1161/HYPERTENSIONAHA.115.06474. [PMID] 26781279.
2016
Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology. 310(3):L249-62 [DOI] 10.1152/ajplung.00258.2015. [PMID] 26637636.
2015
A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche.
The American journal of pathology. 185(6):1552-63 [DOI] 10.1016/j.ajpath.2015.02.008. [PMID] 25843683.
2015
Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice.
Hepatology (Baltimore, Md.). 61(2):678-91 [DOI] 10.1002/hep.27425. [PMID] 25203810.
2015
Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells.
World journal of biological chemistry. 6(4):379-88 [DOI] 10.4331/wjbc.v6.i4.379. [PMID] 26629321.
2015
Drug-eluting microarrays to identify effective chemotherapeutic combinations targeting patient-derived cancer stem cells.
Proceedings of the National Academy of Sciences of the United States of America. 112(28):8732-7 [DOI] 10.1073/pnas.1505374112. [PMID] 26124098.
2015
Endothelial cell derived angiocrine support of acute myeloid leukemia targeted by receptor tyrosine kinase inhibition.
Leukemia research. 39(9):984-9 [DOI] 10.1016/j.leukres.2015.05.015. [PMID] 26189107.
2015
Generation of axolotl hematopoietic chimeras.
Journal of biological methods. 2(1) [PMID] 26366424.
2014
Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979). 63(3):542-50 [DOI] 10.1161/HYPERTENSIONAHA.113.02722. [PMID] 24366083.
2014
Angiotensin II Regulates Hematopoietic Stem Cell Proliferation, Differentiation and Engraftment Efficacy
Experimental Hematology. 42(8, 1)
2014
Angiotensin II Regulates Hematopoietic Stem Cell Proliferation, Differentiation and Engraftment Efficacy
Experimental Hematology. 42(8, 1)
2014
Conditional knockout of CTGF affects corneal wound healing.
Investigative ophthalmology & visual science. 55(4):2062-70 [DOI] 10.1167/iovs.13-12735. [PMID] 24627144.
2014
Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction: BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes.
Circulation research. 115(10):867-74 [DOI] 10.1161/CIRCRESAHA.115.304353. [PMID] 25136078.
2014
Functional integration of acute myeloid leukemia into the vascular niche.
Leukemia. 28(10):1978-1987 [DOI] 10.1038/leu.2014.109. [PMID] 24637335.
2014
Mapping hematopoiesis in a fully regenerative vertebrate: the axolotl.
Blood. 124(8):1232-41 [DOI] 10.1182/blood-2013-09-526970. [PMID] 24802774.
2014
Novel high-throughput in vitro model for identifying hemodynamic-induced inflammatory mediators of cerebral aneurysm formation.
Hypertension (Dallas, Tex. : 1979). 64(6):1306-13 [DOI] 10.1161/HYPERTENSIONAHA.114.03775. [PMID] 25225207.
2014
SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0085615. [PMID] 24465621.
2014
Stromal cell-derived factor-1 promoted angiogenesis and inflammatory cell infiltration in aneurysm walls.
Journal of neurosurgery. 120(1):73-86 [DOI] 10.3171/2013.9.JNS122074. [PMID] 24160472.
2013
Adaptation of endothelial cells to physiologically-modeled, variable shear stress.
PloS one. 8(2) [DOI] 10.1371/journal.pone.0057004. [PMID] 23457646.
2013
Regulation of Hematopoietic Stem/Progenitor Cell Differentiation and Engraftment By Angiotensin II
Experimental Hematology. 41
2013
Role of Microglia Activation in Neurogenic Hypertension
Glia. 61
2012
Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro.
Leukemia research. 36(5):619-24 [DOI] 10.1016/j.leukres.2012.01.020. [PMID] 22341701.
2012
CCN2/CTGF regulates neovessel formation via targeting structurally conserved cystine knot motifs in multiple angiogenic regulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(8):3365-79 [DOI] 10.1096/fj.11-200154. [PMID] 22611085.
2012
Gadolinium-doped silica nanoparticles encapsulating indocyanine green for near infrared and magnetic resonance imaging.
Small (Weinheim an der Bergstrasse, Germany). 8(18):2856-68 [DOI] 10.1002/smll.201200258. [PMID] 22744832.
2012
Proteolytic processing of connective tissue growth factor in normal ocular tissues and during corneal wound healing.
Investigative ophthalmology & visual science. 53(13):8093-103 [DOI] 10.1167/iovs.12-10419. [PMID] 23139278.
2012
Transition from colitis to cancer: high Wnt activity sustains the tumor-initiating potential of colon cancer stem cell precursors.
Cancer research. 72(19):5091-100 [DOI] 10.1158/0008-5472.CAN-12-1806. [PMID] 22902411.
2012
Vascular Disrupting Combretastatins Impair Bone Marrow Endothelial Cells By Depolymerizing the Microtubule Cytoskeleton
Blood. 120
2011
Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice.
Experimental eye research. 93(6):862-72 [DOI] 10.1016/j.exer.2011.09.020. [PMID] 21989111.
2011
Fluorescent and Paramagnetic Chitosan Nanoparticles That Exhibit High Magnetic Resonance Relaxivity: Synthesis, Characterization and in Vitro Studies
Journal of Biomedical Nanotechnology. 7(5):724-729 [DOI] 10.1166/jbn.2011.1335.
2011
Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia.
Blood. 118(19):5255-66 [DOI] 10.1182/blood-2011-03-341123. [PMID] 21937699.
2011
Monocyte chemotactic protein-1 promotes inflammatory vascular repair of murine carotid aneurysms via a macrophage inflammatory protein-1α and macrophage inflammatory protein-2-dependent pathway.
Circulation. 124(20):2243-52 [DOI] 10.1161/CIRCULATIONAHA.111.036061. [PMID] 22007074.
2011
Role of connective tissue growth factor in the retinal vasculature during development and ischemia.
Investigative ophthalmology & visual science. 52(12):8701-10 [DOI] 10.1167/iovs.11-7870. [PMID] 21969300.
2011
Serum Sdf1-a Levels Significantly Increase Following Stroke and Are Associated With Increased Hematopoetic Stem Cell Mobilization
. 42:E253-E254
2011
The Novel Trkb Agonist, 7,8-Dihydroxyflavone Enhances Stem Cell Mobilization After Stroke
. 42
2011
Tissue Plasminogen Activator Impairs Hematopoietic Stem Cell Function, Thus Potentially Limiting Stroke Recovery
. 42
2011
Ultra-high-field MRI real-time imaging of HSC engraftment of the bone marrow niche.
Leukemia. 25(8):1223-31 [DOI] 10.1038/leu.2011.72. [PMID] 21494252.
2010
A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation.
Neurosurgery. 66(3):544-50; discussion 550 [DOI] 10.1227/01.NEU.0000365616.46414.2B. [PMID] 20173550.
2010
lacZ as a genetic reporter for real-time MRI.
Magnetic resonance in medicine. 63(3):745-53 [DOI] 10.1002/mrm.22235. [PMID] 20146234.
2010
Leukemia regression by vascular disruption and antiangiogenic therapy.
Blood. 116(9):1539-47 [DOI] 10.1182/blood-2009-06-230474. [PMID] 20472832.
2010
Multimodal nanoparticulate bioimaging contrast agents.
Methods in molecular biology (Clifton, N.J.). 624:67-81 [DOI] 10.1007/978-1-60761-609-2_5. [PMID] 20217589.
2009
Aldehyde dehydrogenase activity as a functional marker for lung cancer.
Chemico-biological interactions. 178(1-3):48-55 [DOI] 10.1016/j.cbi.2008.09.029. [PMID] 18952074.
2009
Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer.
Cancer research. 69(20):8208-15 [DOI] 10.1158/0008-5472.CAN-09-1132. [PMID] 19808966.
2009
Aml Regression By Vascular Disruption With Oxi4503 and Anti-Angiogenesis With Bevacizumab.
Blood. 114
2009
Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger.
Blood. 114(19):4310-9 [DOI] 10.1182/blood-2009-03-211342. [PMID] 19717647.
2009
CD133 progenitor cells from the bone marrow contribute to retinal pigment epithelium repair.
Stem cells (Dayton, Ohio). 27(2):457-66 [DOI] 10.1634/stemcells.2008-0836. [PMID] 19038791.
2009
Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis.
Blood. 113(15):3577-84 [DOI] 10.1182/blood-2008-09-178913. [PMID] 19190246.
2009
Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor cells.
Leukemia. 23(12):2313-7 [DOI] 10.1038/leu.2009.219. [PMID] 19865109.
2009
Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair.
Molecular therapy : the journal of the American Society of Gene Therapy. 17(9):1594-604 [DOI] 10.1038/mt.2009.145. [PMID] 19584817.
2008
Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging.
Chemistry of materials : a publication of the American Chemical Society. 20(19):6087-6094 [PMID] 19466201.
2008
Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.
The American journal of pathology. 172(3):839-48 [DOI] 10.2353/ajpath.2008.070840. [PMID] 18276778.
2007
Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry.
Stem cells (Dayton, Ohio). 25(8):1881-7 [PMID] 17478582.
2007
Sites and kinetics of donor thrombopoiesis following transplantation of whole bone marrow and progenitor subsets.
Experimental hematology. 35(10):1567-79 [PMID] 17697746.
2007
The hunt for cancer-initiating cells: a history stemming from leukemia.
Leukemia. 21(8):1619-27 [PMID] 17541397.
2007
The role of the donor in the repair of the marrow vascular niche following hematopoietic stem cell transplant.
Stem cells (Dayton, Ohio). 25(11):2945-55 [PMID] 17656638.
2006
Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury.
Investigative ophthalmology & visual science. 47(5):2108-13 [PMID] 16639022.
2006
In vitro-derived “neural stem cells” function as neural progenitors without the capacity for self-renewal.
Stem cells (Dayton, Ohio). 24(3):731-8 [PMID] 16339644.
2006
Stem cell research.
Paediatric respiratory reviews. 7(2):135-40 [PMID] 16765300.
2005
Analysis of the vascular potential of hematopoietic stem cells.
Methods in molecular medicine. 105:369-80 [PMID] 15492408.
2005
Developmental differences in megakaryocyte maturation are determined by the microenvironment.
Stem cells (Dayton, Ohio). 23(9):1400-8 [PMID] 16210411.
2005
Ionizing radiation enhances the engraftment of transplanted in vitro-derived multipotent astrocytic stem cells.
Stem cells (Dayton, Ohio). 23(9):1276-85 [PMID] 16051984.
2005
SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
The Journal of clinical investigation. 115(1):86-93 [PMID] 15630447.
2005
Stem-like cells in bone sarcomas: implications for tumorigenesis.
Neoplasia (New York, N.Y.). 7(11):967-76 [PMID] 16331882.
2005
The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells.
Blood. 105(5):1916-22 [PMID] 15546953.
2004
Adult human hematopoietic cells provide functional hemangioblast activity.
Blood. 103(1):133-5 [PMID] 12969964.
2004
Bone marrow transdifferentiation in brain after transplantation: a retrospective study.
Lancet (London, England). 363(9419):1432-7 [PMID] 15121406.
2004
Molecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fcgamma receptor I promoter activation.
International immunology. 16(2):265-74 [PMID] 14734612.
2004
PU.1 supports proliferation of immature erythroid progenitors.
Leukemia research. 28(1):83-9 [PMID] 14630084.
2004
Stem cell fusion confusion.
Experimental hematology. 32(2):131-4 [PMID] 15102472.
2004
Stem cell plasticity or fusion: two approaches to targeted cell therapy.
Blood cells, molecules & diseases. 32(1):65-7 [PMID] 14757415.
2004
The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells.
Blood. 104(13):3894-900 [PMID] 15328162.
2004
The hemangioblast: cradle to clinic.
Experimental hematology. 32(10):885-90 [PMID] 15504543.
2004
Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone.
Archives of ophthalmology (Chicago, Ill. : 1960). 122(12):1801-7 [PMID] 15596583.
2003
An overview of stem cell research and regulatory issues.
Mayo Clinic proceedings. 78(8):993-1003 [PMID] 12911047.
2003
Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers.
Hepatology (Baltimore, Md.). 37(3):632-40 [PMID] 12601361.
2003
The contribution of adult hematopoietic stem cells to retinal neovascularization.
Advances in experimental medicine and biology. 522:37-45 [PMID] 12674209.
2003
The role of adult bone marrow-derived stem cells in choroidal neovascularization.
Investigative ophthalmology & visual science. 44(11):4908-13 [PMID] 14578416.
2002
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization.
Nature medicine. 8(6):607-12 [PMID] 12042812.
2002
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature. 416(6880):542-5 [PMID] 11932747.
2002
Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter.
Blood. 100(3):1078-80 [PMID] 12130529.
2000
PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells.
Blood. 95(3):879-85 [PMID] 10648399.
1999
A critical role for PU.1 in homing and long-term engraftment by hematopoietic stem cells in the bone marrow.
Blood. 94(4):1283-90 [PMID] 10438716.
1999
T cell development in PU.1-deficient mice.
Journal of immunology (Baltimore, Md. : 1950). 163(5):2681-7 [PMID] 10453009.
1998
Normal myeloid development requires both the glutamine-rich transactivation domain and the PEST region of transcription factor PU.1 but not the potent acidic transactivation domain.
Molecular and cellular biology. 18(7):4347-57 [PMID] 9632818.
1998
Role of PU.1 in hematopoiesis.
Stem cells (Dayton, Ohio). 16(1):25-37 [PMID] 9474745.
1997
PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors.
Immunity. 6(4):437-47 [PMID] 9133423.
1995
PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.
Immunity. 3(6):703-14 [PMID] 8777716.
1994
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.
Science (New York, N.Y.). 265(5178):1573-7 [PMID] 8079170.
1993
Concerted action of the transcriptional activators REB1, RAP1, and GCR1 in the high-level expression of the glycolytic gene TPI.
Molecular and cellular biology. 13(1):543-50 [PMID] 8417350.
1992
Carotid endarterectomy complicated by vein patch rupture.
Neurosurgery. 31(2):373-6; discussion 376 [PMID] 1513447.
1992
Characterization of the DNA-binding activity of GCR1: in vivo evidence for two GCR1-binding sites in the upstream activating sequence of TPI of Saccharomyces cerevisiae.
Molecular and cellular biology. 12(6):2690-700 [PMID] 1588965.
1991
Correlative electrophysiological and behavioral evaluation following L5 lesions in the cat: a model of spasticity.
Experimental neurology. 114(2):206-15 [PMID] 1748195.
1990
Characterization of TPI gene expression in isogeneic wild-type and gcr1-deletion mutant strains of Saccharomyces cerevisiae.
Nucleic acids research. 18(23):7099-107 [PMID] 2263469.
1990
Type I fractures of the odontoid process: implications for atlanto-occipital instability. Case report.
Journal of neurosurgery. 72(3):488-92 [PMID] 2303882.
1989
Spinal subarachnoid hematoma complicating lumbar puncture: diagnosis and management.
Neurosurgery. 25(2):287-92; discussion 292 [PMID] 2770992.
1987
Pediatric diencephalic gliomas–a review of 18 cases.
Pediatric neuroscience. 13(5):225-32 [PMID] 3332816.
1982
Transplantable canine glioma model for use in experimental neuro-oncology.
Neurosurgery. 11(3):372-81 [PMID] 6290929.

Grants

Jul 2019 ACTIVE
Extramedullary Hematopoiesis and the Splenic Niche
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2018 ACTIVE
Regenerative Medicine Training Grant
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2017 – Dec 2019
Role of CXCR2-mediated cell trafficking in pulmonary hypertension
Role: Other
Funding: AMER LUNG ASSO
Jun 2017 – Dec 2019
Role of myeloid-derived suppressor cell trafficking in development of pulmonary hypertension
Role: Other
Funding: GILEAD SCIENCES
Mar 2017 – Dec 2020
Initiating Mechanisms of Cancer Cachexia
Role: Co-Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Jul 2015 – May 2022
Axolotl Hematopoiesis: A Regeneration Model
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2014 – Dec 2016
Role of the Microenvironment in Acute Myeloid Leukemia
Role: Project Manager
Funding: LEUKEMIA & LYMPHOMA SOC
Jul 2012 – Jun 2018
Training Program in Regenerative Medicine
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Mar 2012 – Aug 2020
UFRCC for Cardiovascular Cell Therapy Research Network
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jun 2001 ACTIVE
01040902
Role: Project Manager
Funding: GRIFOLS SA

Contact Details

Phones:
Business:
(352) 846-1149
Emails:
Business:
escott@ufl.edu
Addresses:
Business Mailing:
1600 SW ARCHER RD # 100201
ARB R4-254
GAINESVILLE FL 326103003
Business Street:
ROOM R4-254 ACADEMIC RESEARCH BUILDING
1600 SW ARCHER RD # 100266
MCKNIGHT BRAIN INSTITUTE
GAINESVILLE FL 326103003