Margaret "Peggy" Wallace,
Professor
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About Margaret "Peggy" Wallace
Fun Fact: I love all kinds of animals except wasps (and maybe scorpions and certain spiders). I am a human molecular geneticist, and the lab studies neurofibromatosis type 1 (NF1), a common dominant tumor syndrome. This progressive condition is caused by mutations in the NF1 tumor suppressor gene, encoding a large protein that is not well understood. We utilize genetic and cell biology approaches, using samples donated from patients. Both the mutation repertoire and the clinical features are heterogeneous, and we are testing for phenotype-genotype correlations within families with NF1. I am also involved in projects aimed at understanding genetic contributors of multifactorial disorders, such as in pain-related conditions.
Teaching Profile
Courses Taught
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GMS6224 – Foundations in Precision Medicine: Medical Molecular Genetics
College of Medicine
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GMS6001 – Fundamentals of Biomedical Sciences I
College of Medicine
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GMS6920 – Genetics Journal Colloquy
College of Medicine
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BMS6003 – Genetics and Health
College of Medicine
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GMS6065 – Fundamentals of Cancer Biology
College of Medicine
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GMS6012 – Human Genetics
College of Medicine
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GMS5905 – Special Topics in Biomedical Sciences
College of Medicine
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GMS7980 – Research for Doctoral Dissertation
College of Medicine
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GMS6895 – CTS Journal Club
College of Medicine
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GMS6015 – Human Genetics II
College of Medicine
Clinical Profile
Areas of Interest
- Neurofibromatosis-1
Research Profile
The lab works on neurofibromatosis (NF) as well as other human genetics projects (Mendelian disorders and multifactorial traits). The lab focuses on finding and characterizing genes and their mutations/variants/mechanisms that contribute to health and disease, through approaches of molecular genetics/genomics, cell biology, and animal models. Besides NF, projects have focused on genetics of pain, taste, vitiligo, cardiomyopathy, and cataracts. Dr. Wallace works closely with clinicians, and recruits her own subjects as well. Approaches in the lab include mutation analysis (including exome), variant characterization to evaluate potential pathogenesis, genetic association, RNA-level analyses, and cell culture from primary tissues and cell immortalization.
0000-0002-5202-8895
Areas of Interest
- Genetics
Publications
Academic Articles
Grants
Education
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Ph.D., Medical Genetics
Indiana University, School of Medicine
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B.S. in Mathematics and Statistics
Miami University
Contact Details
- Business:
- (352) 214-7123
- Business:
- peggyw@ufl.edu
- Business Mailing:
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UF Molecular Genetics and MIcrobiology
PO Box 100266
GAINESVILLE FL 32610 - Business Street:
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UF Molecular Genetics
ARB R2-231
1200 Newell Dr.
GAINESVILLE FL 32610