Margaret ( Wallace,
Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 214-7123
Business Email:
peggyw@ufl.edu
About Margaret ( Wallace
Margaret “Peggy” Wallace earned her Ph.D. in Medical Genetics at Indiana University School of Medicine in 1987, followed by postdoctoral work at the University of Michigan, where she helped clone the NF1 (neurofibromatosis type 1) gene in Dr. Francis Collins’ lab in 1990. Her own molecular genetics lab was established at the University of Florida College of Medicine in 1991, first in Pediatric Genetics, and now with a primary appointment in Molecular Genetics and Microbiology. Dr. Wallace is also involved in graduate student and medical student education.
Related Links:
Teaching Profile
Courses Taught
2019-2023
GMS6224 Foundations in Precision Medicine: Medical Molecular Genetics
2013-2014,2016-2021
GMS6001 Fundamentals of Biomedical Sciences I
2008-2023
GMS6920 Genetics Journal Colloquy
2006-2007,2019-2023
BMS6003 Genetics and Health
2014-2015,2017-2022,2022
GMS6065 Fundamentals of Cancer Biology
2007,2010-2012,2012-2016,2015-2023
GMS6012 Human Genetics
2011-2019,2021-2023
GMS5905 Special Topics in Biomedical Sciences
2018
GMS7980 Research for Doctoral Dissertation
2015-2017
GMS6895 CTS Journal Club
2006,2011-2014,2014-2016,2016
GMS6015 Human Genetics II
Clinical Profile
Areas of Interest
- Neurofibromatosis-1
Research Profile
The lab works on neurofibromatosis (NF) as well as other human genetics projects (Mendelian disorders and multifactorial traits). The lab focuses on finding and characterizing genes and their mutations/variants/mechanisms that contribute to health and disease, through approaches of molecular genetics/genomics, cell biology, and animal models. Besides NF, projects have focused on genetics of pain, taste, vitiligo, cardiomyopathy, and cataracts. Dr. Wallace works closely with clinicians, and recruits her own subjects as well. Approaches in the lab include mutation analysis (including exome), variant characterization to evaluate potential pathogenesis, genetic association, RNA-level analyses, and cell culture from primary tissues and cell immortalization.
Open Researcher and Contributor ID (ORCID)
0000-0002-5202-8895
Areas of Interest
- Genetics
Publications
2023
Biopsychosocial influence on shoulder pain: results from a randomized preclinical trial of exercise-induced muscle injury.
Pain.
164(2):305-315
[DOI] 10.1097/j.pain.0000000000002700.
[PMID] 35604152.
2022
A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
Molecular Cancer Therapeutics.
21(7):1246-1258
[DOI] 10.1158/1535-7163.mct-21-0947.
2022
Analysis of AVPR1A, thermal and pressure pain thresholds, and stress in sickle cell disease.
Frontiers in pain research (Lausanne, Switzerland).
3
[DOI] 10.3389/fpain.2022.1060245.
[PMID] 36688082.
2022
HUMAN STUDY COMT and DRD3 haplotype-associated pain intensity and acute care utilization in adult sickle cell disease.
Experimental biology and medicine (Maywood, N.J.).
247(17):1601-1608
[DOI] 10.1177/15353702221080716.
[PMID] 35285297.
2022
Targeted exon skipping of NF1 exon 17 as a therapeutic for neurofibromatosis type I.
Molecular therapy. Nucleic acids.
28:261-278
[DOI] 10.1016/j.omtn.2022.03.011.
[PMID] 35433111.
2021
Effects of Patient and Surgery Characteristics on Persistent Postoperative Pain: A Mediation Analysis.
The Clinical journal of pain.
37(11):803-811
[DOI] 10.1097/AJP.0000000000000979.
[PMID] 34475340.
2021
Sensory and Psychological Factors Predict Exercise-Induced Shoulder Injury Responses in a High-Risk Phenotype Cohort.
The journal of pain.
22(6):669-679
[DOI] 10.1016/j.jpain.2020.12.002.
[PMID] 33400997.
2021
Slow Dynamics of Acute Postoperative Pain Intensity Time Series Determined via Wavelet Analysis Are Associated With the Risk of Severe Postoperative Day 30 Pain.
Anesthesia and analgesia.
132(5):1465-1474
[DOI] 10.1213/ANE.0000000000005385.
[PMID] 33591118.
2021
Survival and NF1 Analysis in a Cohort of Orthopedics Patients with Malignant Peripheral Nerve Sheath Tumors
Sarcoma.
2021:1-6
[DOI] 10.1155/2021/9386823.
[PMID] 34646065.
2020
Genetics of human malignant peripheral nerve sheath tumors.
Neuro-oncology advances.
2(Suppl 1):i50-i61
[DOI] 10.1093/noajnl/vdz049.
[PMID] 32642732.
2019
EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer
Proceedings of the National Academy of Sciences.
116(13):6075-6080
[DOI] 10.1073/pnas.1814634116.
[PMID] 30867289.
2019
Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1-associated atypical neurofibromas.
Neuro-oncology.
21(8):981-992
[DOI] 10.1093/neuonc/noz028.
[PMID] 30722027.
2018
A porcine model of neurofibromatosis type 1 that mimics the human disease.
JCI insight.
3(12)
[DOI] 10.1172/jci.insight.120402.
[PMID] 29925695.
2018
Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury
Journal of Pain Research.
Volume 11:2497-2508
[DOI] 10.2147/jpr.s171498.
2017
Biopsychosocial influence on shoulder pain: Rationale and protocol for a pre-clinical trial.
Contemporary clinical trials.
56:9-17
[DOI] 10.1016/j.cct.2017.03.005.
[PMID] 28315479.
2017
The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas.
Oncogene.
36(22):3168-3177
[DOI] 10.1038/onc.2016.464.
[PMID] 28068329.
2017
Versatile and precise gene-targeting strategies for functional studies in mammalian cell lines.
Methods (San Diego, Calif.).
121-122:45-54
[DOI] 10.1016/j.ymeth.2017.05.003.
[PMID] 28499832.
2014
Investigation of Gene X Gene Interactions in a Model of Exercise Induced Shoulder Pain
Journal of Pain.
15(4, 1)
2014
Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.
The American journal of pathology.
184(7):2082-98
[DOI] 10.1016/j.ajpath.2014.04.006.
[PMID] 24832557.
2008
Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings.
Pain.
136(1-2):53-61
[PMID] 17686583.
2008
Novel Tas2R Snp Associations With Taste Sensation, Liking Or Intake for Alcoholic and Bitter Non-Alcoholic Beverages
Chemical Senses.
33
2003
Routine cytogenetic and FISH studies for 17p11/15q11 duplications and subtelomeric rearrangement studies in children with autism spectrum disorders.
American journal of medical genetics. Part A.
117A(2):105-11
[PMID] 12567405.
2002
RT-PCR splicing analysis of the NF1 open reading frame
Human Genetics.
110(5):495-502
[DOI] 10.1007/s00439-002-0714-6.
[PMID] 12073021.
2001
Randomized, placebo-controlled clinical trial of oral azithromycin prophylaxis against respiratory infections in a high-risk, young adult population.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
33(7):983-9
[PMID] 11528569.
1997
Four frameshift mutations in neurofibromatosis type 1 caused by small insertions.
Journal of medical genetics.
34(7):579-81
[PMID] 9222967.
1997
Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse.
Human molecular genetics.
6(7):1091-8
[PMID] 9215680.
1997
NF1 mutation analysis using a combined heteroduplex/SSCP approach.
Human mutation.
9(6):548-54
[PMID] 9195229.
1997
Physical mapping of the chromosome 7 breakpoint region in an SLOS patient with t(7;20) (q32.1;q13.2).
American journal of medical genetics.
68(3):279-81
[PMID] 9024559.
1996
A multiplex-PCR test for EVI2A and EVI2B polymorphisms within the human NF1 gene.
Mammalian genome : official journal of the International Mammalian Genome Society.
7(3):233-4
[PMID] 8833251.
1996
Somatic mosaicism in a patient with neurofibromatosis type 1.
American journal of human genetics.
58(3):484-90
[PMID] 8644707.
1995
Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene.
Nature genetics.
11(1):90-2
[PMID] 7550323.
1995
Identification of a yeast artificial chromosome clone spanning a translocation breakpoint at 7q32.1 in a Smith-Lemli-Opitz syndrome patient.
American journal of human genetics.
56(6):1411-6
[PMID] 7762564.
1994
A PCR-based test for a polymorphism within the human NF1 gene.
Clinical genetics.
45(6)
[PMID] 7923863.
1994
Confirmation of linkage of supravalvular aortic stenosis to the elastin gene on chromosome 7q.
The American journal of cardiology.
74(12):1281-3
[PMID] 7977109.
1994
Neurofibromatosis type 1.
European journal of cancer (Oxford, England : 1990).
30A(13):1974-81
[PMID] 7734210.
Grants
May 2023
ACTIVE
Susceptibility Patterns for Grade C Periodontitis in Young Individuals
Role: Principal Investigator
Funding: UNIV OF KENTUCKY
via NATL INST OF HLTH NIDCR
Dec 2022
– May 2023
Professional Service Agreement
Role: Principal Investigator
Funding: INDIANA UNIV
Oct 2022
ACTIVE
Study of NF1 in Families
Role: Principal Investigator
Funding: CHILDRENS TUMOR FOU
Apr 2021
– Dec 2022
UFF UF Neurofibromatosis Research: Wallace Genetics Bank
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2020
– Jul 2021
Contributions of biopsychosocial factors in sickle cell disease pain
Role: Other
Funding: NATL INST OF HLTH NHLBI
May 2020
– May 2022
Analysis of Clinical and Molecular Parameters in MPNST
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Jul 2018
– Jun 2022
Genetic Studies of Neurofibromatosis
Role: Principal Investigator
Funding: JOHNS HOPKINS UNIVERSITY
via BLOOMBERG FAMILY FOU – PHILANTHROPIES
Jan 2017
ACTIVE
Distribution of Immortalized Schwann Cell Lines
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Sep 2016
– Apr 2022
BIOPSYCHOSOCIAL INFLUENCE ON SHOULDER PAIN
Role: Co-Investigator
Funding: DUKE UNIVERSITY
via NATL INST OF HLTH NIAMS
Jul 2015
– Jun 2021
Finding Good TEMporal PostOperative pain Signatures (TEMPOS)
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jun 2015
– Jun 2018
Wallace CTF Contract
Role: Principal Investigator
Funding: CHILDRENS TUMOR FOU
Jun 2014
– Nov 2021
Mechanisms and Treatment Response of Aggressive Periodontitis in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jun 2013
– May 2016
Development of a Plexiform Neurofibroma Cellular Assay for High-Throughput Screening
Role: Principal Investigator
Funding: JOHNS HOPKINS UNIVERSITY
Jan 2008
– Oct 2020
UF Fibromatosis Research
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2002
ACTIVE
92050504
Role: Project Manager
Funding: HAYWARD FOU, JOHN & WINIFRED
Education
Ph.D., Medical Genetics
1982-1987
·
Indiana University, School of Medicine
B.S. in Mathematics and Statistics
1982
·
Miami University
Contact Details
Phones:
- Business:
- (352) 214-7123
Emails:
- Business:
- peggyw@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100266
GAINESVILLE FL 32610 - Business Street:
-
RG-293, RG-285 ARB
GAINESVILLE FL 32610