About Margaret ( Wallace
Margaret “Peggy” Wallace earned her Ph.D. in Medical Genetics at Indiana University School of Medicine in 1987, followed by postdoctoral work at the University of Michigan, where she helped clone the NF1 (neurofibromatosis type 1) gene in Dr. Francis Collins’ lab in 1990. Her own molecular genetics lab was established at the University of Florida College of Medicine in 1991, first in Pediatric Genetics, and now with a primary appointment in Molecular Genetics and Microbiology. Dr. Wallace is also involved in graduate student and medical student education.
The lab works on neurofibromatosis (NF) as well as other human genetics projects (Mendelian disorders and multifactorial traits). The lab focuses on finding and characterizing genes and their mutations/variants/mechanisms that contribute to health and disease, through approaches of molecular genetics/genomics, cell biology, and animal models. Besides NF, projects have focused on genetics of pain, taste, vitiligo, cardiomyopathy, and cataracts. Dr. Wallace works closely with clinicians, and recruits her own subjects as well. Approaches in the lab include mutation analysis (including exome), variant characterization to evaluate potential pathogenesis, genetic association, RNA-level analyses, and cell culture from primary tissues and cell immortalization.