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UF Health University of Florida
Department of Molecular Genetics & Microbiology College of Medicine
Contact The Department
Lizi Wu

Lizi Wu,

Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-8205
Business Email: lzwu@ufl.edu

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About Lizi Wu

We study cancer cell signaling with expertise in signal transduction, genetic and epigenetic regulation, and animal models. Our current research is centered on two families of transcriptional co-activators, MAML and CRTC, which are essential components of Notch receptor signaling and LKB1-CRTC/CREB signaling pathways, respectively. We are investigating the molecular regulation and the roles of deregulated cell signaling in cancer generation and progression, with the goal of gaining molecular insights into cancer pathogenesis and identifying novel cancer diagnostic and therapeutic targets. We have 3 main projects: identification and functional characterization of a family of MAML transcriptional co-activators; identification, functional characterization, and targeting of CRTC1-MAML2 fusion oncogene; and investigations into deregulated LKB1-CRTC signaling in human cancers. Each project is expected to enhance our understanding of the roles and mechanisms of signaling in cancers, and such knowledge will help with diagnosis and treatment of tumors.

Related Links:
Lab and Research Information
TICaRT T32 program
UFHCI MOO program
Additional Positions:
Co-director, Team-based Interdisciplinary Cancer Research Training (TICaRT) T32 Program
2021 – current · UF Health Cancer Institute
Co-leader, the Mechanisms of Oncogenesis (MOO) program
2020 – current · UF Health Cancer Institute

Teaching Profile

Courses Taught

  1. GMS7194 – Biotechnology Seminar

    College of Medicine

  2. GMS6036 – Molecular Virology III: DNA Viruses

    College of Medicine

  3. GMS6065 – Fundamentals of Cancer Biology

    College of Medicine

  4. GMS6338 – Recent Advances in Cancer Metastasis

    College of Medicine

  5. GMS7980 – Research for Doctoral Dissertation

    College of Medicine

  6. ZOO7980 – Research for Doctoral Dissertation

    College of Liberal Arts and Sciences

  7. GMS6051 – Signal Transduction

    College of Medicine

  8. GMS5905 – Special Topics in Biomedical Sciences

    College of Medicine

  9. GMS6905 – Independent Studies in Medical Sciences

    College of Medicine

  10. BMS6003 – Genetics and Health

    College of Medicine

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-0076-2617

Publications

Academic Articles

Grants

Contact Details

Phones:
Business:
(352) 273-8205
Emails:
Business:
lzwu@ufl.edu
Addresses:
Business Mailing:
CGRC Room 362
2033 Mowry Road
 Gainesville FL 32610
Business Street:
PO BOX 103610
Cancer & Genetics Research Complex
2033 MOWRY ROAD
 GAINESVILLE FL 326110001