Lizi Wu

Lizi Wu,

Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-8205
Business Email: lzwu@ufl.edu

Teaching Profile

Courses Taught
2009-2023
GMS7194 Biotechnology Seminar
2013-2023
GMS6036 Molecular Virology III: DNA Viruses
2014-2015,2017-2023
GMS6065 Fundamentals of Cancer Biology
2014,2017-2023
GMS6338 Recent Advances in Cancer Metastasis
2018
GMS7980 Research for Doctoral Dissertation
2018
ZOO7980 Research for Doctoral Dissertation
2013,2015-2017,2017
GMS6051 Signal Transduction
2011-2012
GMS5905 Special Topics in Biomedical Sciences
2010
GMS6905 Independent Studies in Medical Sciences

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-0076-2617

Publications

2022
Epithelial-Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress.
Cells. 11(14) [DOI] 10.3390/cells11142208. [PMID] 35883651.
2022
PROTAC therapy as a new targeted therapy for lung cancer.
Molecular therapy : the journal of the American Society of Gene Therapy. 31(3):647-656 [DOI] 10.1016/j.ymthe.2022.11.011. [PMID] 36415148.
2021
Author response: Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation
. [DOI] 10.7554/elife.66095.sa2.
2021
Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation.
eLife. 10 [DOI] 10.7554/eLife.66095.
2021
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.
Nucleic acids research. [DOI] 10.1093/nar/gkab415. [PMID] 34048572.
2021
Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma
Signal Transduction and Targeted Therapy. 6(1) [DOI] 10.1038/s41392-020-00388-0. [PMID] 33473104.
2021
The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma.
JCI insight. 6(7) [DOI] 10.1172/jci.insight.139497. [PMID] 33830080.
2020
Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration
The FASEB's Journal. 34(4):4970-4983 [DOI] 10.1096/fj.201902382R. [PMID] 32057145.
2019
MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma
Oral oncology. 98:147-155 [DOI] 10.1016/j.oraloncology.2019.09.005. [PMID] 31606723.
2018
CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells
Oncogene. 37(14):1885-1895 [DOI] 10.1038/s41388-017-0104-0. [PMID] 29353885.
2018
Notch1 activation enhances proliferation via activation of cdc2 and delays differentiation of myeloid progenitors.
Leukemia Research. 72:34-44 [DOI] 10.1016/j.leukres.2018.07.022. [PMID] 30086426.
2018
Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer
Journal of the National Cancer Institute. 111(7):664-674 [DOI] 10.1093/jnci/djy166. [PMID] 30423141.
2016
cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth.
The Journal of clinical investigation. 126(6):2267-79 [DOI] 10.1172/JCI85250. [PMID] 27140397.
2016
Epithelial-To-Mesenchymal Transition Confers Pericyte Properties on Cancer Cells
The Journal of clinical investigation. 126(11):4174-4186 [DOI] 10.1172/JCI86623. [PMID] 27721239.
2016
Mof Acetylates the Histone Demethylase Lsd1 to Suppress Epithelial-To-Mesenchymal Transition
Cell Reports. 15(12):2665-2678 [DOI] 10.1016/j.celrep.2016.05.050.
2015
A Microrna-1280/Jag2 Network Comprises a Novel Biological Target in High-Risk Medulloblastoma
Oncotarget. 6(5):2709-2724
2015
Fbxo11 Promotes Ubiquitination of the Snail Family of Transcription Factors in Cancer Progression and Epidermal Development
Cancer Letters. 362(1):70-82 [DOI] 10.1016/j.canlet.2015.03.037. [PMID] 25827072.
2015
Gene Expression Profiling Analysis of Crtc1-Maml2 Fusion Oncogene-Induced Transcriptional Program in Human Mucoepidermoid Carcinoma Cells
Bmc Cancer. 15 [DOI] 10.1186/s12885-015-1827-3. [PMID] 26503699.
2015
Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer
Journal of the National Cancer Institute. 107(1) [DOI] 10.1093/jnci/dju358. [PMID] 25465874.
2014
A Unifying Gene Signature for Adenoid Cystic Cancer Identifies Parallel Myb-Dependent and Myb-Independent Therapeutic Targets
Oncotarget. 5(24):12528-12542
2014
CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.
Leukemia. 28(1):155-65 [DOI] 10.1038/leu.2013.115. [PMID] 23588715.
2014
Crtc1/Maml2 Gain-Of-Function Interactions With Myc Create a Gene Signature Predictive of Cancers With Creb-Myc Involvement
Proceedings of the National Academy of Sciences. 111(32):E3260-E3268 [DOI] 10.1073/pnas.1319176111. [PMID] 25071166.
2013
Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells
The Scientific World Journal. 2013:1-6 [DOI] 10.1155/2013/178708. [PMID] 24453806.
2013
Brief Report: Blockade of Notch Signaling in Muscle Stem Cells Causes Muscular Dystrophic Phenotype and Impaired Muscle Regeneration
Stem cells (Dayton, Ohio). 31(4):823-828 [DOI] 10.1002/stem.1319. [PMID] 23307608.
2013
DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia.
Oncogene. 32(40):4845-53 [DOI] 10.1038/onc.2012.482. [PMID] 23108395.
2013
Overexpression of Six1 leads to retardation of myogenic differentiation in C2C12 myoblasts.
Molecular biology reports. 40(1):217-23 [DOI] 10.1007/s11033-012-2052-7. [PMID] 23079703.
2013
Proteomic and Functional Analyses Reveal the Role of Chromatin Reader Sfmbt1 in Regulating Epigenetic Silencing and the Myogenic Gene Program
Journal of Biological Chemistry. 288(9):6238-6247 [DOI] 10.1074/jbc.M112.429605. [PMID] 23349461.
2013
The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.
The Journal of biological chemistry. 288(38):27680-27691 [DOI] 10.1074/jbc.M113.482349. [PMID] 23928305.
2012
Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.
Oncogene. 31(4):469-79 [DOI] 10.1038/onc.2011.247. [PMID] 21706049.
2012
Crm1 Blockade By Novel Inhibitors of Nuclear Export (Sines) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis
Blood. 120
2012
Dna Methyltransferase Inhibitor Cda-Ii Inhibits Myogenic Differentiation
Biochemical and Biophysical Research Communications. 422(3):522-526 [DOI] 10.1016/j.bbrc.2012.05.068. [PMID] 22627135.
2012
Notch1-mediated tumor suppression in cervical cancer with the involvement of SST signaling and its application in enhanced SSTR-targeted therapeutics.
The oncologist. 17(2):220-32 [DOI] 10.1634/theoncologist.2011-0269. [PMID] 22291092.
2011
Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation.
Proceedings of the National Academy of Sciences of the United States of America. 108(37):15231-6 [DOI] 10.1073/pnas.1104662108. [PMID] 21896759.
2010
Essential Role for the Maml1 Co-Activator in T-All.
Blood. 116
2010
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
Genes & cancer. 1(8):822-35 [DOI] 10.1177/1947601910383564. [PMID] 21127729.
2010
Mammalian Target of Rapamycin Regulates Murine and Human Cell Differentiation Through Stat3/P63/Jagged/Notch Cascade
The Journal of clinical investigation. 120(1):103-114 [DOI] 10.1172/JCI37964. [PMID] 20038814.
2010
Notch1 and Notch3 Coordinate Esophageal Squamous Differentiation Through a Csl-Dependent Transcriptional Network
Gastroenterology. 139(6):2113-2123 [DOI] 10.1053/j.gastro.2010.08.040. [PMID] 20801121.
2010
The Mastermind-Like 1 (Maml1) Co-Activator Regulates Constitutive Nf-Kappa B Signaling and Cell Survival
Journal of Biological Chemistry. 285(19):14356-14365 [DOI] 10.1074/jbc.M109.078865. [PMID] 20231278.
2007
The notch regulator MAML1 interacts with p53 and functions as a coactivator.
The Journal of biological chemistry. 282(16):11969-81 [PMID] 17317671.
2007
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Blood. 110(10):3618-23 [PMID] 17699740.
2006
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Genes & development. 20(6):675-88 [PMID] 16510869.
2005
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
The EMBO journal. 24(13):2391-402 [PMID] 15961999.
2004
Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.
Gene. 328:153-65 [PMID] 15019995.
2004
Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
Seminars in cancer biology. 14(5):348-56 [PMID] 15288260.
2003
Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(29):9547-56 [PMID] 14573534.
2003
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Nature genetics. 33(2):208-13 [PMID] 12539049.
2002
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Molecular and cellular biology. 22(21):7688-700 [PMID] 12370315.
2001
The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.
The Journal of biological chemistry. 276(48):44889-97 [PMID] 11572863.
2000
Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling.
Journal of cell science. 113 Pt 23:4313-8 [PMID] 11069775.
2000
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Nature genetics. 26(4):484-9 [PMID] 11101851.
1999
Identification of two major histocompatibility complex class Ib genes, Q7 and Q9, as the Ped gene in the mouse.
Biology of reproduction. 60(5):1114-9 [PMID] 10208972.
1998
Differential expression of Ped gene candidates in preimplantation mouse embryos.
Biology of reproduction. 59(4):941-52 [PMID] 9746747.
1998
Ooplasmic transfer in mature human oocytes.
Molecular human reproduction. 4(3):269-80 [PMID] 9570273.
1998
Role of the Ped gene and apoptosis genes in control of preimplantation development.
Journal of assisted reproduction and genetics. 15(5):331-7 [PMID] 9604770.
1996
Sequence and transcription of Qa-2-encoding genes in mouse lymphocytes and blastocysts.
Immunogenetics. 45(2):97-107 [PMID] 8952959.
1995
Mapping of the SLA complex class III region by pulsed field gel electrophoresis.
Mammalian genome : official journal of the International Mammalian Genome Society. 6(9):607-10 [PMID] 8535067.

Grants

Jun 2023 ACTIVE
UF Health Cancer Center Support Grant
Role: Other
Funding: NATL INST OF HLTH NCI
Apr 2023 ACTIVE
Elucidating and targeting INSL4 signaling in lung cancer
Role: Principal Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Aug 2022 ACTIVE
Embedded Printing of Human Respiratory Model with Air-Liquid Interface for COVID-19 Research
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Apr 2021 ACTIVE
Team-based Interdisciplinary Cancer Research Training Program
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Aug 2020 ACTIVE
Signaling and Targeting of CRTC1-MAML2 Fusion Oncoprotein in Salivary Gland
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCR
Feb 2019 ACTIVE
Aberrant CRTC activation as a unique vulnerability of lung cancer with LKB1 inactivation
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Sep 2018 – Aug 2021
OR-DRPD-ROF2018: Identification of the first extracellular nicotinamide adenine dinucleotide-binding receptor in animal cells
Role: Co-Investigator
Funding: UF RESEARCH
Apr 2015 – Mar 2018
A novel noncoding RNA and human lung cancers with inactivated LKB1 signaling
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Aug 2014 – May 2020
Signaling and targeting of CRTC1-MAML2 fusion oncoprotein in salivary gland tumor
Role: Principal Investigator
Funding: NATL INST OF HLTH
Feb 2012 – Mar 2018
Sponholtz Family Cancer Research Fund – #F14006
Role: Project Manager
Funding: UF FOUNDATION
Mar 2006 – May 2023
Davis Cancer Researach Equipment
Role: Project Manager
Funding: UF FOUNDATION

Contact Details

Phones:
Business:
(352) 273-8205
Emails:
Business:
lzwu@ufl.edu
Addresses:
Business Mailing:
CGRC Room 362
2033 Mowry Road
Gainesville FL 32610
Business Street:
PO BOX 103610
Cancer & Genetics Research Complex
2033 MOWRY ROAD
GAINESVILLE FL 326110001