Tao Zu,
Research Assistant Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 273-5847
Business Email:
taozu@ufl.edu
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-7606-206X
Publications
2023
Staufen Impairs Autophagy in Neurodegeneration.
Annals of neurology.
93(2):398-416
[DOI] 10.1002/ana.26515.
[PMID] 36151701.
2021
CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity
EMBO Molecular Medicine.
13(11)
[DOI] 10.15252/emmm.202114095.
[PMID] 34632710.
2021
Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice.
Human molecular genetics.
29(24):3900-3918
[DOI] 10.1093/hmg/ddaa279.
[PMID] 33378537.
2021
The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats.
Human molecular genetics.
30(11):1020-1029
[DOI] 10.1093/hmg/ddab098.
[PMID] 33856033.
2020
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Neuron.
105(4):645-662.e11
[DOI] 10.1016/j.neuron.2019.11.007.
[PMID] 31831332.
2020
Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.
Proceedings of the National Academy of Sciences of the United States of America.
117(31):18591-18599
[DOI] 10.1073/pnas.2005748117.
[PMID] 32690681.
2020
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.
Neuron.
108(4):784-796.e3
[DOI] 10.1016/j.neuron.2020.09.009.
[PMID] 33022226.
2018
Repeat-Associated Non-ATG Translation in Neurological Diseases.
Cold Spring Harbor perspectives in biology.
10(12)
[DOI] 10.1101/cshperspect.a033019.
[PMID] 29891563.
2018
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F.
The EMBO journal.
37(19)
[DOI] 10.15252/embj.201899023.
[PMID] 30206144.
2017
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.
Neuron.
95(6):1292-1305.e5
[DOI] 10.1016/j.neuron.2017.08.039.
[PMID] 28910618.
2016
C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD.
Neuron.
90(3):521-34
[DOI] 10.1016/j.neuron.2016.04.005.
[PMID] 27112499.
2015
RAN Translation in Huntington Disease.
Neuron.
88(4):667-77
[DOI] 10.1016/j.neuron.2015.10.038.
[PMID] 26590344.
2014
Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion.
Neurobiology of aging.
35(10):2419.e17-21
[DOI] 10.1016/j.neurobiolaging.2014.04.009.
[PMID] 24819148.
2014
Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
34(30):9891-904
[DOI] 10.1523/JNEUROSCI.0876-14.2014.
[PMID] 25057192.
2013
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.
Proceedings of the National Academy of Sciences of the United States of America.
110(51):E4968-77
[DOI] 10.1073/pnas.1315438110.
[PMID] 24248382.
2011
Non-Atg-Initiated Translation Directed By Microsatellite Expansions
Proceedings of the National Academy of Sciences.
108(1):260-265
[DOI] 10.1073/pnas.1013343108.
[PMID] 21173221.
2008
Antisense RNA sequences modulating the ataxin-1 message: molecular model of gene therapy for spinocerebellar ataxia type 1, a dominant-acting unstable trinucleotide repeat disease.
Cell transplantation.
17(7):723-34
[PMID] 19044200.
2008
The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7.
Proceedings of the National Academy of Sciences of the United States of America.
105(4):1291-6
[DOI] 10.1073/pnas.0711257105.
[PMID] 18216249.
2006
Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.
Nature genetics.
38(7):758-69
[PMID] 16804541.
2006
RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Cell.
127(4):697-708
[PMID] 17110330.
2006
Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
26(39):9975-82
[PMID] 17005861.
2004
Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
24(40):8853-61
[PMID] 15470152.
2003
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Neuron.
38(3):375-87
[PMID] 12741986.
Grants
Sep 2022
ACTIVE
Molecular effects of metformin, PKR and TBI on C9orf72 ALS/FTD
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Contact Details
Phones:
- Business:
- (352) 273-5847
Emails:
- Business:
- taozu@ufl.edu
Addresses:
- Business Mailing:
-
PO BOX 103610
GAINESVILLE FL 326100001 - Business Street:
-
PO BOX 103610
GAINESVILLE FL 326100001